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Aliases for PYROXD1 Gene

Aliases for PYROXD1 Gene

  • Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 2 3
  • EC 1.8.1.- 4
  • EC 1.8.1 64

External Ids for PYROXD1 Gene

Summaries for PYROXD1 Gene

GeneCards Summary for PYROXD1 Gene

PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYROXD1 Gene

Genomics for PYROXD1 Gene

Genomic Location for PYROXD1 Gene

Start:
21,437,604 bp from pter
End:
21,471,252 bp from pter
Size:
33,649 bases
Orientation:
Plus strand

Genomic View for PYROXD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PYROXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYROXD1 Gene

Regulatory Elements for PYROXD1 Gene

Proteins for PYROXD1 Gene

  • Protein details for PYROXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WU10-PYRD1_HUMAN
    Recommended name:
    Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
    Protein Accession:
    Q8WU10
    Secondary Accessions:
    • A6NKI6
    • B3KWN8
    • Q9H6P1

    Protein attributes for PYROXD1 Gene

    Size:
    500 amino acids
    Molecular mass:
    55793 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15214.1; Type=Frameshift; Positions=445; Evidence={ECO:0000305};

    Alternative splice isoforms for PYROXD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PYROXD1 Gene

Proteomics data for PYROXD1 Gene at MOPED

Post-translational modifications for PYROXD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys142

Other Protein References for PYROXD1 Gene

Domains for PYROXD1 Gene

Protein Domains for PYROXD1 Gene

UniProtKB/Swiss-Prot:

PYRD1_HUMAN
Family:
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.:
    • Q8WU10
genes like me logo Genes that share domains with PYROXD1: view

No data available for Gene Families for PYROXD1 Gene

Function for PYROXD1 Gene

Enzyme Numbers (IUBMB) for PYROXD1 Gene

Gene Ontology (GO) - Molecular Function for PYROXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PYROXD1: view

Phenotypes for PYROXD1 Gene

GenomeRNAi human phenotypes for PYROXD1:
genes like me logo Genes that share phenotypes with PYROXD1: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PYROXD1 Gene

Localization for PYROXD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PYROXD1 Gene COMPARTMENTS Subcellular localization image for PYROXD1 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PYROXD1 Gene

Pathways for PYROXD1 Gene

SuperPathways for PYROXD1 Gene

No Data Available

Interacting Proteins for PYROXD1 Gene

Gene Ontology (GO) - Biological Process for PYROXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PYROXD1: view

No data available for Pathways by source for PYROXD1 Gene

Compounds for PYROXD1 Gene

(2) HMDB Compounds for PYROXD1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
22594-61-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with PYROXD1: view

Transcripts for PYROXD1 Gene

Unigene Clusters for PYROXD1 Gene

Pyridine nucleotide-disulphide oxidoreductase domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYROXD1 Gene

No ASD Table

Relevant External Links for PYROXD1 Gene

GeneLoc Exon Structure for
PYROXD1
ECgene alternative splicing isoforms for
PYROXD1

Expression for PYROXD1 Gene

mRNA expression in normal human tissues for PYROXD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYROXD1 Gene

SOURCE GeneReport for Unigene cluster for PYROXD1 Gene Hs.709545

genes like me logo Genes that share expressions with PYROXD1: view

Orthologs for PYROXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYROXD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PYROXD1 36
  • 99.4 (n)
  • 99.4 (a)
PYROXD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PYROXD1 36
  • 89.53 (n)
  • 89.6 (a)
PYROXD1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PYROXD1 36
  • 89.41 (n)
  • 87.29 (a)
PYROXD1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pyroxd1 36
  • 83.17 (n)
  • 85.51 (a)
Pyroxd1 16
Pyroxd1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PYROXD1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 58 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pyroxd1 36
  • 83.43 (n)
  • 85.71 (a)
chicken
(Gallus gallus)
Aves PYROXD1 36
  • 75.96 (n)
  • 77.78 (a)
PYROXD1 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PYROXD1 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16405 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pyroxd1 36
  • 63.08 (n)
  • 68.32 (a)
Str.19896 36
zebrafish
(Danio rerio)
Actinopterygii ryroxd1 36
  • 65.2 (n)
  • 66.11 (a)
ryroxd1 37
  • 65 (a)
OneToOne
zgc73254 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008042 36
  • 54.26 (n)
  • 52.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10721 36
  • 52.96 (n)
  • 48.67 (a)
CG10721 37
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C26D10.3 36
  • 45.33 (n)
  • 34.44 (a)
C26D10.3 37
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6258 36
Species with no ortholog for PYROXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PYROXD1 Gene

ENSEMBL:
Gene Tree for PYROXD1 (if available)
TreeFam:
Gene Tree for PYROXD1 (if available)

Paralogs for PYROXD1 Gene

Pseudogenes.org Pseudogenes for PYROXD1 Gene

genes like me logo Genes that share paralogs with PYROXD1: view

No data available for Paralogs for PYROXD1 Gene

Variants for PYROXD1 Gene

Sequence variations from dbSNP and Humsavar for PYROXD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs714356 -- 21,444,312(+) TGAGT(A/G)CCTAT intron-variant
rs714357 -- 21,444,580(+) CAAGT(A/G)GCCTT intron-variant
rs738027 -- 21,439,423(+) GGAGA(A/G)AGTAA intron-variant
rs738028 -- 21,439,472(+) CTGAG(A/T)AGAAT intron-variant
rs738029 -- 21,439,612(+) AAAAA(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYROXD1 Gene

Variant ID Type Subtype PubMed ID
nsv526789 CNV Loss 19592680
nsv898895 CNV Loss 21882294
nsv898896 CNV Gain 21882294
nsv469163 CNV Loss 19166990

Relevant External Links for PYROXD1 Gene

HapMap Linkage Disequilibrium report
PYROXD1

Disorders for PYROXD1 Gene

Relevant External Links for PYROXD1

Genetic Association Database (GAD)
PYROXD1
Human Genome Epidemiology (HuGE) Navigator
PYROXD1
genes like me logo Genes that share disorders with PYROXD1: view

No data available for UniProtKB/Swiss-Prot for PYROXD1 Gene

Publications for PYROXD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for PYROXD1 Gene

Sources for PYROXD1 Gene

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