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Aliases for PYROXD1 Gene

Aliases for PYROXD1 Gene

  • Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 2 3 5
  • EC 1.8.1.- 4
  • EC 1.8.1 63

External Ids for PYROXD1 Gene

Previous GeneCards Identifiers for PYROXD1 Gene

  • GC12P021482
  • GC12P021590

Summaries for PYROXD1 Gene

GeneCards Summary for PYROXD1 Gene

PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYROXD1 Gene

Genomics for PYROXD1 Gene

Regulatory Elements for PYROXD1 Gene

Enhancers for PYROXD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PYROXD1 on UCSC Golden Path with GeneCards custom track

Promoters for PYROXD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PYROXD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PYROXD1 Gene

21,437,604 bp from pter
21,471,252 bp from pter
33,649 bases
Plus strand

Genomic View for PYROXD1 Gene

Genes around PYROXD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PYROXD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PYROXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYROXD1 Gene

Proteins for PYROXD1 Gene

  • Protein details for PYROXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NKI6
    • B3KWN8
    • Q9H6P1

    Protein attributes for PYROXD1 Gene

    500 amino acids
    Molecular mass:
    55793 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=BAB15214.1; Type=Frameshift; Positions=445; Evidence={ECO:0000305};

    Alternative splice isoforms for PYROXD1 Gene


neXtProt entry for PYROXD1 Gene

Proteomics data for PYROXD1 Gene at MOPED

Post-translational modifications for PYROXD1 Gene

  • Ubiquitination at Lys 142
  • Modification sites at PhosphoSitePlus

Other Protein References for PYROXD1 Gene

Domains & Families for PYROXD1 Gene

Protein Domains for PYROXD1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
genes like me logo Genes that share domains with PYROXD1: view

No data available for Gene Families for PYROXD1 Gene

Function for PYROXD1 Gene

Enzyme Numbers (IUBMB) for PYROXD1 Gene

Gene Ontology (GO) - Molecular Function for PYROXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PYROXD1: view
genes like me logo Genes that share phenotypes with PYROXD1: view

Animal Models for PYROXD1 Gene

MGI Knock Outs for PYROXD1:

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PYROXD1 Gene

Localization for PYROXD1 Gene

Subcellular locations from

Jensen Localization Image for PYROXD1 Gene COMPARTMENTS Subcellular localization image for PYROXD1 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PYROXD1 Gene

Pathways & Interactions for PYROXD1 Gene

SuperPathways for PYROXD1 Gene

No Data Available

Interacting Proteins for PYROXD1 Gene

Gene Ontology (GO) - Biological Process for PYROXD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PYROXD1 Gene

Drugs & Compounds for PYROXD1 Gene

(1) Drugs for PYROXD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for PYROXD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononate
  • 2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonate
  • 2-Oxo-3-deoxy-D-glycero-galactononulosonic acid
genes like me logo Genes that share compounds with PYROXD1: view

Transcripts for PYROXD1 Gene

Unigene Clusters for PYROXD1 Gene

Pyridine nucleotide-disulphide oxidoreductase domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PYROXD1 Gene

No ASD Table

Relevant External Links for PYROXD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYROXD1 Gene

mRNA expression in normal human tissues for PYROXD1 Gene

Protein differential expression in normal tissues from HIPED for PYROXD1 Gene

This gene is overexpressed in Retina (23.3), Testis (7.6), and Islet of Langerhans (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYROXD1 Gene

SOURCE GeneReport for Unigene cluster for PYROXD1 Gene Hs.709545

genes like me logo Genes that share expression patterns with PYROXD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PYROXD1 Gene

Orthologs for PYROXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYROXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PYROXD1 35
  • 89.53 (n)
  • 89.6 (a)
  • 89 (a)
(Canis familiaris)
Mammalia PYROXD1 35
  • 89.41 (n)
  • 87.29 (a)
  • 86 (a)
(Mus musculus)
Mammalia Pyroxd1 35
  • 83.17 (n)
  • 85.51 (a)
Pyroxd1 16
Pyroxd1 36
  • 85 (a)
(Pan troglodytes)
Mammalia PYROXD1 35
  • 99.4 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pyroxd1 35
  • 83.43 (n)
  • 85.71 (a)
(Monodelphis domestica)
Mammalia PYROXD1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 77 (a)
-- 36
  • 72 (a)
(Gallus gallus)
Aves PYROXD1 35
  • 75.96 (n)
  • 77.78 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia PYROXD1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pyroxd1 35
  • 63.08 (n)
  • 68.32 (a)
Str.19896 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16405 35
(Danio rerio)
Actinopterygii ryroxd1 35
  • 65.2 (n)
  • 66.11 (a)
zgc73254 35
ryroxd1 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008042 35
  • 54.26 (n)
  • 52.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10721 35
  • 52.96 (n)
  • 48.67 (a)
CG10721 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C26D10.3 35
  • 45.33 (n)
  • 34.44 (a)
C26D10.3 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6258 35
Species with no ortholog for PYROXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PYROXD1 Gene

Gene Tree for PYROXD1 (if available)
Gene Tree for PYROXD1 (if available)

Paralogs for PYROXD1 Gene Pseudogenes for PYROXD1 Gene

genes like me logo Genes that share paralogs with PYROXD1: view

No data available for Paralogs for PYROXD1 Gene

Variants for PYROXD1 Gene

Sequence variations from dbSNP and Humsavar for PYROXD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1963330 -- 21,445,261(+) AGTGT(A/G)TAAAA intron-variant
rs1963817 -- 21,445,330(+) TTAAT(C/T)TCTTG intron-variant
rs2058463 -- 21,437,623(+) GGATT(A/C)TCTGG nc-transcript-variant, utr-variant-5-prime
rs2058464 -- 21,437,687(+) TCCCG(C/T)TGCTC nc-transcript-variant, utr-variant-5-prime
rs2058465 -- 21,438,139(+) ttttt(A/C/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYROXD1 Gene

Variant ID Type Subtype PubMed ID
nsv526789 CNV Loss 19592680
nsv898895 CNV Loss 21882294
nsv898896 CNV Gain 21882294
nsv469163 CNV Loss 19166990

Variation tolerance for PYROXD1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PYROXD1 Gene

Disorders for PYROXD1 Gene

Relevant External Links for PYROXD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PYROXD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PYROXD1 Gene

Publications for PYROXD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for PYROXD1 Gene

Sources for PYROXD1 Gene