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Aliases for PYROXD1 Gene

Aliases for PYROXD1 Gene

  • Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1 2 3
  • EC 1.8.1.- 4
  • EC 1.8.1 63

External Ids for PYROXD1 Gene

Previous GeneCards Identifiers for PYROXD1 Gene

  • GC12P021482
  • GC12P021590

Summaries for PYROXD1 Gene

GeneCards Summary for PYROXD1 Gene

PYROXD1 (Pyridine Nucleotide-Disulphide Oxidoreductase Domain 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYROXD1 Gene

Genomics for PYROXD1 Gene

Regulatory Elements for PYROXD1 Gene

Genomic Location for PYROXD1 Gene

21,437,604 bp from pter
21,471,252 bp from pter
33,649 bases
Plus strand

Genomic View for PYROXD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PYROXD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYROXD1 Gene

Proteins for PYROXD1 Gene

  • Protein details for PYROXD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NKI6
    • B3KWN8
    • Q9H6P1

    Protein attributes for PYROXD1 Gene

    500 amino acids
    Molecular mass:
    55793 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=BAB15214.1; Type=Frameshift; Positions=445; Evidence={ECO:0000305};

    Alternative splice isoforms for PYROXD1 Gene


neXtProt entry for PYROXD1 Gene

Proteomics data for PYROXD1 Gene at MOPED

Post-translational modifications for PYROXD1 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for PYROXD1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PYROXD1

Domains for PYROXD1 Gene

Protein Domains for PYROXD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
  • Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
genes like me logo Genes that share domains with PYROXD1: view

No data available for Gene Families for PYROXD1 Gene

Function for PYROXD1 Gene

Enzyme Numbers (IUBMB) for PYROXD1 Gene

Gene Ontology (GO) - Molecular Function for PYROXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PYROXD1: view

Phenotypes for PYROXD1 Gene

GenomeRNAi human phenotypes for PYROXD1:
genes like me logo Genes that share phenotypes with PYROXD1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PYROXD1 Gene

Localization for PYROXD1 Gene

Subcellular locations from

Jensen Localization Image for PYROXD1 Gene COMPARTMENTS Subcellular localization image for PYROXD1 gene
Compartment Confidence
cytosol 3
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PYROXD1 Gene

Pathways for PYROXD1 Gene

SuperPathways for PYROXD1 Gene

No Data Available

Interacting Proteins for PYROXD1 Gene

Gene Ontology (GO) - Biological Process for PYROXD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PYROXD1: view

No data available for Pathways by source for PYROXD1 Gene

Compounds for PYROXD1 Gene

(2) HMDB Compounds for PYROXD1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid
  • 2-KDN
  • 1H-Purin-6-amine flavin dinucleotide
genes like me logo Genes that share compounds with PYROXD1: view

Transcripts for PYROXD1 Gene

Unigene Clusters for PYROXD1 Gene

Pyridine nucleotide-disulphide oxidoreductase domain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYROXD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYROXD1 Gene

No ASD Table

Relevant External Links for PYROXD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYROXD1 Gene

mRNA expression in normal human tissues for PYROXD1 Gene

Protein differential expression in normal tissues for PYROXD1 Gene

This gene is overexpressed in Retina (23.3), Testis (7.6), and Islet of Langerhans (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYROXD1 Gene

SOURCE GeneReport for Unigene cluster for PYROXD1 Gene Hs.709545

genes like me logo Genes that share expressions with PYROXD1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for PYROXD1 Gene

Orthologs for PYROXD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYROXD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PYROXD1 35
  • 89.53 (n)
  • 89.6 (a)
  • 89 (a)
(Canis familiaris)
Mammalia PYROXD1 35
  • 89.41 (n)
  • 87.29 (a)
  • 86 (a)
(Mus musculus)
Mammalia Pyroxd1 35
  • 83.17 (n)
  • 85.51 (a)
Pyroxd1 16
Pyroxd1 36
  • 85 (a)
(Pan troglodytes)
Mammalia PYROXD1 35
  • 99.4 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pyroxd1 35
  • 83.43 (n)
  • 85.71 (a)
(Monodelphis domestica)
Mammalia PYROXD1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 77 (a)
-- 36
  • 72 (a)
(Gallus gallus)
Aves PYROXD1 35
  • 75.96 (n)
  • 77.78 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia PYROXD1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pyroxd1 35
  • 63.08 (n)
  • 68.32 (a)
Str.19896 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16405 35
(Danio rerio)
Actinopterygii ryroxd1 35
  • 65.2 (n)
  • 66.11 (a)
zgc73254 35
ryroxd1 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008042 35
  • 54.26 (n)
  • 52.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10721 35
  • 52.96 (n)
  • 48.67 (a)
CG10721 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea C26D10.3 35
  • 45.33 (n)
  • 34.44 (a)
C26D10.3 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6258 35
Species with no ortholog for PYROXD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PYROXD1 Gene

Gene Tree for PYROXD1 (if available)
Gene Tree for PYROXD1 (if available)

Paralogs for PYROXD1 Gene Pseudogenes for PYROXD1 Gene

genes like me logo Genes that share paralogs with PYROXD1: view

No data available for Paralogs for PYROXD1 Gene

Variants for PYROXD1 Gene

Sequence variations from dbSNP and Humsavar for PYROXD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs714356 -- 21,444,312(+) TGAGT(A/G)CCTAT intron-variant
rs714357 -- 21,444,580(+) CAAGT(A/G)GCCTT intron-variant
rs738027 -- 21,439,423(+) GGAGA(A/G)AGTAA intron-variant
rs738028 -- 21,439,472(+) CTGAG(A/T)AGAAT intron-variant
rs738029 -- 21,439,612(+) AAAAA(A/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PYROXD1 Gene

Variant ID Type Subtype PubMed ID
nsv526789 CNV Loss 19592680
nsv898895 CNV Loss 21882294
nsv898896 CNV Gain 21882294
nsv469163 CNV Loss 19166990

Relevant External Links for PYROXD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYROXD1 Gene

Disorders for PYROXD1 Gene

Relevant External Links for PYROXD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PYROXD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PYROXD1 Gene

Publications for PYROXD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for PYROXD1 Gene

Sources for PYROXD1 Gene

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