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PTGS1 Gene

protein-coding GIFtS: 71

GC09P124173

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
COX-1 ^³
COX1 ^¹, ², ³, ⁵
COX3 ^², ⁵
Cyclooxygenase-1 ^³
EC 1.14.99.1 ^³
OTTHUMP00000022052 ^²
OTTHUMP00000022053 ^²
PCOX1 ^², ⁵
PGG/HS ^²
PGHS-1 ^¹, ², ³
PGHS1 ^², ⁵
PHS1 ^²
PTGHS ^¹, ²

Descriptions
PGH synthase 1 ^³
PHS 1 ^³
Prostaglandin H2 synthase 1 ^³
Prostaglandin-endoperoxide synthase 1 ^², ³
prostaglandin G/H synthase and cyclooxygenase ^²
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) ^²

External Ids
HGNC: 9604¹
Entrez Gene: 5742²
UniProtKB: P23219³
Ensembl: ENSG00000095303⁷

Search outside databases for aliases for PTGS1 gene

Previous GC identifers: GC09P116237 GC09P116779 GC09P118586 GC09P120509 GC09P122212

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTGS1:

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in

prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two

isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of

expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in

endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1

is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative

splicing of this gene generates two transcript variants. The expression of these two transcripts

is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219

Function: May play an important role in regulating or promoting cell proliferation in some normal

and neoplastically transformed cells

Gene Wiki entry for PTGS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PTGS1 gene

Entrez Gene cytogenetic band: 9q32-q33.3 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q33.3

PTGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P124173: (about GC identifiers)

Start:	124,173,050 bp from pter
End:	124,197,802 bp from pter
Size:	24,753 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219 (See protein sequence)

Recommended Name: Prostaglandin G/H synthase 1 precursor

Size: 599 amino acids; 68656 Da

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)

Subunit: Homodimer

Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum

membrane; Peripheral membrane protein

Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase

Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin

Sequence caution: Sequence=CAI14716.1; Type=Erroneous gene model prediction;

Secondary accessions: Q15122 Q5T7T6 Q5T7T7 Q5T7T8

Alternative splicing: 2 isoforms: P23219-1 P23219-2

REFSEQ proteins (2 alternative transcripts):

NP_000953.2 NP_542158.1

ENSEMBL proteins:

ENSP00000362802 ENSP00000223423 ENSP00000354612

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cox 1+2, COX1 / Cyclooxygenase 1)
	Human Recombinant Proteins from Abnova (PTGS1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	ISS	--

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Antibodies for PTGS1:

	Invitrogen Antibodies for PTGS1
	Millipore Mono- and Polyclonal Antibodies for the study of PTGS1
	Sigma-Aldrich Antibodies for PTGS1
	R&D Systems Antibodies for PTGS1 (COX-1)
	Cell Signaling Technology (CST) Antibodies for PTGS1 (Cox1)
	Antibodies from Abcam (Cox 1+2, COX1 / Cyclooxygenase 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for PTGS1

Assays for PTGS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P23219

ProtoNet protein and cluster: P23219

3 Blocks protein families:

IPB002007 Animal haem peroxidase signature

IPB006210 Type I EGF

IPB010255 Haem peroxidase

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219

Similarity: Belongs to the prostaglandin G/H synthase family

Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTGS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTGS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000962

Applied Biosystems Silencer® siRNAs for PTGS1

Sigma-Aldrich siRNA and siRNA Panels for PTGS1

Sigma-Aldrich shRNA Panels and shRNA for PTGS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PTGS1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000962
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000962
untagged cDNA clones in CMV expression vector (see all 2): NM_000962

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000962

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219

Function: May play an important role in regulating or promoting cell proliferation in some normal

and neoplastically transformed cells

Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O

Enzyme Number (IUBMB): EC 1.14.99.1

Genatlas biochemistry entry for PTGS1:

prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a

dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of

inflammation

12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ptgs1):

	digestive/alimentary	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	renal/urinary system
reproductive system	respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004601	peroxidase activity	IEA	--
GO:0004666	prostaglandin-endoperoxide synthase activity	TAS	9630216
GO:0008289	lipid binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for PTGS1 (Your Favorite Gene powered by Ingenuity)

Endothelin-1 Signaling
Arachidonic Acid Metabolism
Eicosanoid Signaling

GeneDecks PTGS1 for the pathways selected above

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UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219

Pathway: Lipid metabolism; prostaglandin biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for PTGS1

5/52 Interacting proteins for PTGS1 (ENSP00000354612³) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBXAS1	ENSP00000338087³	STRING (score=.984)
PLA2G1B	ENSP00000312286³	STRING (score=.978)
PLA2G4A	ENSP00000356436³	STRING (score=.978)
PTGES	ENSP00000342385³	STRING (score=.972)
PTGIS	ENSP00000244043³	STRING (score=.972)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001516	prostaglandin biosynthetic process	ISS	--
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0006979	response to oxidative stress	IEA	--
GO:0008217	regulation of blood pressure	ISS	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PTGS1

Sigma-Aldrich Small Molecules for PTGS1:

Inhibitor

Compounds for PTGS1 available from Tocris Bioscience

Compound	Action	CAS number
Tenidap	NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3	[120210-48-2]
FR 122047 hydrochloride	Cyclooxygenase (COX-1) inhibitor	[130717-51-0]
Piroxicam	Cyclooxygenase (COX-1) inhibitor	[36322-90-4]
(S)-(+)-Ibuprofen	Cyclooxygenase inhibitor (COX-1 > COX-2)	[51146-56-6]
SC 560	Cyclooxygenase (COX-1) inhibitor	[188817-13-2]

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10/24 Novoseek chemical compound relationships for PTGS1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostaglandin	91.02	281	9461646 (4), 15035793 (3), 10609518 (2), 7947975 (2) (see all 99)
arachidonic acid	89.30	264	10358065 (5), 7737984 (4), 10551587 (3), 10206978 (3) (see all 99)
prostaglandin-h2	82.09	31	17878511 (2), 8652509 (1), 10734173 (1), 11081405 (1) (see all 19)
txb2	81.18	89	16890573 (3), 8737748 (3), 10450786 (2), 9146894 (2) (see all 53)
licofelone	79.65	12	18550688 (2), 11550975 (2), 15044038 (2), 12005204 (1) (see all 8)
thromboxane	78.44	62	17189713 (3), 19110389 (3), 9262230 (1), 10639016 (1) (see all 42)
thromboxane a2	74.94	97	18514074 (4), 10903770 (3), 10480288 (3), 19346231 (3) (see all 42)
pgd2	67.06	12	9721692 (1), 10206978 (1), 15951536 (1), 12199620 (1) (see all 10)
6-ketoprostaglandin f1alpha	65.57	7	8263161 (1), 17978563 (1), 19298395 (1), 8027246 (1) (see all 7)
(+-)-pgf2-alpha	64.63	7	17191216 (1), 12199620 (1), 12593597 (1), 16140261 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PTGS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTGS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000962

Sigma-Aldrich siRNA and siRNA Panels for PTGS1

Sigma-Aldrich shRNA Panels and shRNA for PTGS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000962 NM_080591

REFSEQ mRNAs for PTGS1 gene (2 alternative transcripts):

NM_000962.2 NM_080591.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000962 NM_080591

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000962

Additional cDNA sequence:

AF086438.1 AF129755.1 AJ420464.1 AK290022.1 AK295221.1 AK304403.1 AK308222.1 BC029840.1

DQ180740.1 DQ180741.1 DQ180742.1 M59979.1 S36219.1 S36271.1 S78220.1 U63846.1

12 DOTS entries:

DT.446317 DT.100767562 DT.121193472 DT.101957346 DT.100767557 DT.101982936 DT.121193484 DT.75197219

DT.100767561 DT.100767556 DT.97797260 DT.91965381

24/156 AceView cDNA sequences (see all 156 ):

CD014048 S36219 BF064148 BM990424 AA630760 AI863410 AI567867 CB216527

AI885487 BU733396 BF718263 CA444725 BF477437 BM679302 AI076274 AU279462

NM_000962 NM_080591 BQ014239 AL556508 AL709654 N54739 BM728404 AA345128

highest scoring ESTs for PTGS1:

M59979 AA037294 AA278216 AI202433 AI424408 AI467819 AI740976 AI806507 AV734203 AV744257

Unigene Cluster for PTGS1:

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Hs.201978 [show with all ESTs]

Unigene Representative Sequence: NM_000962

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	·	14d
SP1:
SP2:											-		-
SP3:											-		-		-																		-
SP4:											-		-								-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for PTGS1

3 Ensembl transcripts including schematic representations:

ENST00000373698 ENST00000223423 ENST00000362012

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PTGS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PTGS1

¹ / ² / ³

10 probe-sets matching PTGS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37969_at²^{, 3}	U95-A	1	1.00	1.00	0.68	1.01	M59979	1.00	1.00	1.00	1
89844_at²^{, 3}	U95-E	1	1.00	1.00	0.92	1.03	AI806507	0.80	1.00	0.91	1
215813_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S36219	0.80	1.00	0.91	1
205128_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000962	0.60	1.00	0.82	1
205127_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000962	0.60	1.00	0.82	1
238669_at²^{, 3}	U133-B	1	0.82	1.00	--	--	BE613133	0.40	1.00	0.76	1
215813_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205128_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205127_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238669_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

GeneDecks PTGS1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGCTAATAA

SOURCE GeneReport for Unigene cluster: Hs.201978
Expression variation in blood from EXPOLDB for PTGS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PTGS1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PTGS1¹	--	prostaglandin-endoperoxide synthase 1 (prostaglandin more	89.55(n) 92.54(a)	403544 NM_001003023.1 NP_001003023.1
chimpanzee (Pan troglodytes)	PTGS1¹	--	prostaglandin-endoperoxide synthase 1 (prostaglandin more	99.12(n) 98.77(a)	464713 XM_520238.2 XP_520238.2
cow (Bos taurus)	PTGS1¹	--	prostaglandin-endoperoxide synthase 1 (prostaglandin more	88.65(n) 91.15(a)	282022 XM_864482.2 XP_869575.1
rat (Rattus norvegicus)	Ptgs1¹	--	prostaglandin-endoperoxide synthase 1	84.14(n) 86.93(a)	24693 NM_017043.1 NP_058739.1
mouse (Mus musculus)	Ptgs1^{1, 5}	2 (29.00 cM)⁵	prostaglandin-endoperoxide synthase 1^{1, 5}	85.59(n)¹ 89.78(a)¹	19224¹ NM_008969.3¹ NP_032995.1¹ AK046457⁵ AK134163⁵ (see all 36)

About this table Species with no ortholog for PTGS1

ENSEMBL Gene Tree for PTGS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PTGS1 gene

PTGS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/272 NCBI SNPs in PTGS1 are shown (see all 272 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 153)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1330344^1,2	A,C,F,H	124171509(-)	`GCACTA/GATGGG`	2	--	ng5¹		12	EA WA NS	2484
	rs8046^1,2	A,C,F,H	124195229(+)	`AAGGAA/GGTGGG`	2	--	ut3¹		5	NS MN EA	428
	rs10306183^1,2	C,F,H	124194731(+)	`ATGCTC/AATTTT`	2	--	ut3¹		10	NS EU EA WA	932
	rs5789^1,2	C,F,H	124183794(+)	`ACAATC/ATGGAG`	2	M/L	mis¹		22	NA MN CSAM EA EU WA NS	2120
--	rs10306194^1,2	C,F,H	124197019(+)	`gtaatC/AaagCC`	2	--	ut3¹		12	NS EU EA WA	1172
	rs10306108^1,2	C,F,H	124171301(+)	`ATCTGT/CGGTGC`	2	--	ng5¹		16	NS EU EA WA	1590
	rs3842787^1,2	C,F,H	124173328(+)	`GCTCCC/TGCCGC`	2	P/L	mis¹ ese³		6	NA NS EU WA	518
	rs1236913^1,2	C,F,H	124173300(+)	`TGCTCC/TGGTTC`	2	W/R	mis¹		9	NA NS MN EU EA WA	874
	rs10306191^1,2	C,F,H	124195678(+)	`AAACAA/GCTTCC`	2	--	ut3¹		11	NS EU EA	1042
	rs3842789^1,2	C,F,H	124180062(+)	`TGACCG/ACTACC`	2	H/R	mis¹ ese³		6	NA NS EU WA	484

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HapMap Linkage Disequilibrium images for PTGS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176805

10/94 Novoseek disease relationships for PTGS1 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	71.58	151	16982919 (3), 10628589 (2), 9146894 (2), 18220787 (2) (see all 99)
osteoarthritis	62.29	21	15337183 (2), 11041909 (2), 10719816 (1), 14752171 (1) (see all 15)
gastrointestinal complications	58.30	3	10377455 (1), 14602052 (1)
colon cancer	57.35	17	19258012 (4), 16091009 (2), 7780968 (2), 16984374 (2) (see all 11)
intestinal polyps	55.53	5	12941808 (3), 16984374 (1)
ulcer	53.03	28	16247187 (3), 11519793 (2), 17926541 (2), 11136275 (2) (see all 15)
rheumatoid arthritis	52.81	11	10719816 (2), 15167967 (1), 9433877 (1), 10390126 (1) (see all 9)
nasal polyps	51.95	29	16517580 (4), 15921208 (4), 15480320 (2), 19132974 (2) (see all 11)
arthritis	51.50	12	11550975 (2), 10193996 (1), 9714356 (1), 10225538 (1) (see all 9)
polyps	50.57	31	12941808 (4), 11584208 (2), 11495083 (2), 19251796 (1) (see all 11)

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Human Gene Mutation Database: PTGS1
Genetic Association Database: PTGS1
Human Genome Epidemiology Navigator: PTGS1 (44 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1099 PubMed articles for PTGS1 gene (see all 1099 ):

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. (PubMed id 1907252)^{2, 3, 4} Funk C.D....Fitzgerald G.A. (1991)
Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. (PubMed id 2512924)^{2, 3, 4} Yokoyama C. and Tanabe T. (1989)
Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. (PubMed id 15041270)^{1, 3, 6} Hillarp A....Mattiasson I. (2003)
Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. (PubMed id 12192304)^{1, 3, 4} Scott B.T....Long G.L. (2002)
Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy. (PubMed id 16055872)^{1, 3, 6} Shi J....Kedda M.A. (2005)
A study of the combined effect of the CLDN5 locus and the genes for the phospholipid metabolism pathway in schizophrenia. (PubMed id 16181776)^{3, 6} Wei J. and Hemmings G.P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps. (PubMed id 15159324)^{3, 6} Ulrich C.M....Potter J.D. (2004)
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{3, 4} Goodman J.E.... Harris C.C. (2004)
Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. (PubMed id 1587858)^{3, 4} Diaz A.... Jimenez S.A. (1992)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5742	HGNC: 9604	AceView: PTGS1	Ensembl:ENSG00000095303	euGenes: HUgn5742
ECgene: PTGS1	H-InvDB: PTGS1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PTGS1	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ptgs1/

Licensable Technologies for PTGS1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PTGS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PTGS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PTGS1		Antibodies for PTGS1
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Antibodies & Assays for PTGS1 (Cox1)

	Recombinant Proteins (Cox 1+2, COX1 / Cyclooxygenase 1)
	Antibodies (Cox 1+2, COX1 / Cyclooxygenase 1)

Search OriGene for PTGS1

Tocris compounds for PTGS1

	Drugs for PTGS1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PTGS1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PTGS1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for PTGS1

Summaries
for PTGS1

Genomic Location
for PTGS1

Proteins
for PTGS1

Protein Domains/
Families
for PTGS1

Gene Function
for PTGS1

Pathways & Interactions
for PTGS1

Drugs & Compounds
for PTGS1

Transcripts
for PTGS1

Expression
for PTGS1

Orthologs
for PTGS1

Paralogs
for PTGS1

SNPs/Variants
for PTGS1

Disorders & Mutations
for PTGS1

Medical News
for PTGS1

Publications
for PTGS1

Search for PTGS1

Genome Databases showing PTGS1

Other Databases showing PTGS1

Specialized Databases showing PTGS1

Licensable Technologies
for PTGS1

Services
for PTGS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PTGS1 (Gene Symbol)
COX-1
COX1
COX3
Cyclooxygenase-1
EC 1.14.99.1
OTTHUMP00000022052
OTTHUMP00000022053
PCOX1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
PGH synthase 1
PHS 1
Prostaglandin H2 synthase 1
Prostaglandin-endoperoxide synthase 1
prostaglandin G/H synthase and cyclooxygenase
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

PTGS1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor PTGS1

Summariesfor PTGS1

Genomic Locationfor PTGS1

Proteinsfor PTGS1

Protein Domains/Familiesfor PTGS1

Gene Functionfor PTGS1

Pathways & Interactionsfor PTGS1

Drugs & Compoundsfor PTGS1

Transcriptsfor PTGS1

Expression for PTGS1

Orthologsfor PTGS1

Paralogsfor PTGS1

SNPs/Variantsfor PTGS1

Disorders & Mutationsfor PTGS1

Medical Newsfor PTGS1

Publicationsfor PTGS1

Search for PTGS1

Genome Databases showing PTGS1

Other Databases showing PTGS1

Specialized Databases showing PTGS1

Licensable Technologiesfor PTGS1

Servicesfor PTGS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PTGS1

Summaries
for PTGS1

Genomic Location
for PTGS1

Proteins
for PTGS1

Protein Domains/
Families
for PTGS1

Gene Function
for PTGS1

Pathways & Interactions
for PTGS1

Drugs & Compounds
for PTGS1

Transcripts
for PTGS1

Expression
for PTGS1

Orthologs
for PTGS1

Paralogs
for PTGS1

SNPs/Variants
for PTGS1

Disorders & Mutations
for PTGS1

Medical News
for PTGS1

Publications
for PTGS1

Licensable Technologies
for PTGS1

Services
for PTGS1