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PTGS1 Gene

protein-coding   GIFtS: 71

GC09P124173
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
COX-1 3
COX1 1, 2, 3, 5
COX3 2, 5
Cyclooxygenase-1 3
EC 1.14.99.1 3
OTTHUMP00000022052 2
OTTHUMP00000022053 2
PCOX1 2, 5
PGG/HS 2
PGHS-1 1, 2, 3
PGHS1 2, 5
PHS1 2
PTGHS 1, 2
Descriptions
PGH synthase 1 3
PHS 1 3
Prostaglandin H2 synthase 1 3
Prostaglandin-endoperoxide synthase 1 2, 3
prostaglandin G/H synthase and cyclooxygenase 2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H
synthase and cyclooxygenase) 2
External Ids
HGNC: 96041
Entrez Gene: 57422
UniProtKB: P232193
Ensembl: ENSG000000953037
Search outside databases for aliases for PTGS1 gene

Previous GC identifers: GC09P116237 GC09P116779 GC09P118586 GC09P120509 GC09P122212

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PTGS1:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in
prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two
isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of
expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in
endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1
is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative
splicing of this gene generates two transcript variants. The expression of these two transcripts
is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq]

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Function: May play an important role in regulating or promoting cell proliferation in some normal
and neoplastically transformed cells

Gene Wiki entry for PTGS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PTGS1 gene  

Entrez Gene cytogenetic band: 9q32-q33.3   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q33.3

PTGS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P124173:     (about GC identifiers)

Start:
124,173,050 bp from pter
End:
124,197,802 bp from pter
Size:
24,753 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219 (See protein sequence)
Recommended Name: Prostaglandin G/H synthase 1 precursor  
Size: 599 amino acids; 68656 Da
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum
membrane; Peripheral membrane protein
Miscellaneous: This enzyme acts both as a dioxygenase and as a peroxidase
Miscellaneous: This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin
Sequence caution: Sequence=CAI14716.1; Type=Erroneous gene model prediction;
Secondary accessions: Q15122 Q5T7T6 Q5T7T7 Q5T7T8
Alternative splicing: 2 isoforms:  P23219-1   P23219-2   

REFSEQ proteins (2 alternative transcripts): 
NP_000953.2  NP_542158.1  


ENSEMBL proteins: 
ENSP00000362802 ENSP00000223423 ENSP00000354612 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Cox 1+2, COX1 / Cyclooxygenase 1)
Human Recombinant Proteins from Abnova (PTGS1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus ISS--
GO:0005737 cytoplasm ISS--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
GO:0005792 microsome ISS--
About this table

Antibodies for PTGS1: 
Invitrogen Antibodies for PTGS1
Millipore Mono- and Polyclonal Antibodies for the study of PTGS1
Sigma-Aldrich Antibodies for PTGS1
R&D Systems Antibodies for PTGS1 (COX-1)
Cell Signaling Technology (CST) Antibodies for PTGS1  (Cox1)
Antibodies from Abcam (Cox 1+2, COX1 / Cyclooxygenase 1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for PTGS1

Assays for PTGS1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/6 InterPro domains/families (see all 6 ):
 IPR002007 Haem_peroxidase_animal
 IPR000742 EGF_3
 IPR013032 EGF-like_reg_CS
 IPR006209 EGF
 IPR019791 Haem_peroxidase_animal_sg


   GeneDecks  PTGS1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P23219

ProtoNet protein and cluster: P23219

3 Blocks protein families:
IPB002007 Animal haem peroxidase signature
IPB006210 Type I EGF
IPB010255 Haem peroxidase


UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Similarity: Belongs to the prostaglandin G/H synthase family
Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PTGS1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PTGS1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000962

              Applied Biosystems Silencer® siRNAs for PTGS1

              Sigma-Aldrich siRNA and siRNA Panels for PTGS1  
                     Sigma-Aldrich shRNA Panels and shRNA for PTGS1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PTGS1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000962 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000962

UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Function: May play an important role in regulating or promoting cell proliferation in some normal
and neoplastically transformed cells
Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Enzyme Number (IUBMB): EC 1.14.99.1 

Genatlas biochemistry entry for PTGS1:
prostaglandin G/H synthase 1,constitutively expressed in a wide range of tissues,acting first as a
dioxygenase,then as a peroxidase (lipocalin family,Kernel group),monomer,potent mediator of
inflammation

12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ptgs1):

digestive/alimentaryendocrine/exocrine glandhematopoietic systemhomeostasis/metabolism
immune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/agingrenal/urinary system
reproductive systemrespiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0004601 peroxidase activity IEA--
GO:0004666 prostaglandin-endoperoxide synthase activity TAS9630216
GO:0008289 lipid binding IEA--
GO:0016491 oxidoreductase activity IEA--
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


3 Millipore Pathways for PTGS1
 Prostaglandin 2 biosynthesis and metabolism FM
 HETE and HPETE biosynthesis and metabolism
 Neurophysiological process PGE2-induced pain processing

   GeneDecks  PTGS1 for the pathways selected above  
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for  PTGS1  (Your Favorite Gene powered by Ingenuity) 
 Endothelin-1 Signaling
 Arachidonic Acid Metabolism
 Eicosanoid Signaling

   GeneDecks  PTGS1 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for PTGS1):
 hsa00590 Arachidonic acid metabolism

   GeneDecks  PTGS1 for the pathways selected above  
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UniProtKB/Swiss-Prot: PGH1_HUMAN, P23219
Pathway: Lipid metabolism; prostaglandin biosynthesis

 Gene Network CentralTM Interacting Genes and Proteins Network for  PTGS1 


5/52 Interacting proteins for PTGS1 (ENSP000003546123) via UniProtKB, MINT, and/or STRING (see all 52 )

InteractantInteraction Details
GeneCardExternal ID(s)
TBXAS1ENSP000003380873STRING (score=.984)
PLA2G1BENSP000003122863STRING (score=.978)
PLA2G4AENSP000003564363STRING (score=.978)
PTGESENSP000003423853STRING (score=.972)
PTGISENSP000002440433STRING (score=.972)
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5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001516 prostaglandin biosynthetic process ISS--
GO:0006633 fatty acid biosynthetic process IEA--
GO:0006979 response to oxidative stress IEA--
GO:0008217 regulation of blood pressure ISS--
GO:0055114 oxidation reduction IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PTGS1
Sigma-Aldrich Small Molecules for PTGS1:
Inhibitor

Compounds for PTGS1 available from Tocris Bioscience
CompoundAction CAS number
TenidapNSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3[120210-48-2]
FR 122047 hydrochlorideCyclooxygenase (COX-1) inhibitor[130717-51-0]
PiroxicamCyclooxygenase (COX-1) inhibitor[36322-90-4]
(S)-(+)-IbuprofenCyclooxygenase inhibitor (COX-1 > COX-2)[51146-56-6]
SC 560Cyclooxygenase (COX-1) inhibitor[188817-13-2]
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10/24 Novoseek chemical compound relationships for PTGS1 gene (see all 24 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
prostaglandin 91.02 281 9461646 (4), 15035793 (3), 10609518 (2), 7947975 (2) (see all 99)
arachidonic acid 89.30 264 10358065 (5), 7737984 (4), 10551587 (3), 10206978 (3) (see all 99)
prostaglandin-h2 82.09 31 17878511 (2), 8652509 (1), 10734173 (1), 11081405 (1) (see all 19)
txb2 81.18 89 16890573 (3), 8737748 (3), 10450786 (2), 9146894 (2) (see all 53)
licofelone 79.65 12 18550688 (2), 11550975 (2), 15044038 (2), 12005204 (1) (see all 8)
thromboxane 78.44 62 17189713 (3), 19110389 (3), 9262230 (1), 10639016 (1) (see all 42)
thromboxane a2 74.94 97 18514074 (4), 10903770 (3), 10480288 (3), 19346231 (3) (see all 42)
pgd2 67.06 12 9721692 (1), 10206978 (1), 15951536 (1), 12199620 (1) (see all 10)
6-ketoprostaglandin f1alpha 65.57 7 8263161 (1), 17978563 (1), 19298395 (1), 8027246 (1) (see all 7)
(+-)-pgf2-alpha 64.63 7 17191216 (1), 12199620 (1), 12593597 (1), 16140261 (1) (see all 6)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PTGS1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PTGS1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000962

              Sigma-Aldrich siRNA and siRNA Panels for PTGS1  
                     Sigma-Aldrich shRNA Panels and shRNA for PTGS1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000962  NM_080591  

REFSEQ mRNAs for PTGS1 gene (2 alternative transcripts): 

NM_000962.2   NM_080591.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000962  NM_080591  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000962
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000962 

Additional cDNA sequence: 

AF086438.1 AF129755.1 AJ420464.1 AK290022.1 AK295221.1 AK304403.1 AK308222.1 BC029840.1 
DQ180740.1 DQ180741.1 DQ180742.1 M59979.1 S36219.1 S36271.1 S78220.1 U63846.1 

12 DOTS entries:

DT.446317  DT.100767562  DT.121193472  DT.101957346  DT.100767557  DT.101982936  DT.121193484  DT.75197219 
DT.100767561  DT.100767556  DT.97797260  DT.91965381 

24/156 AceView cDNA sequences (see all 156 ):

CD014048 S36219 BF064148 BM990424 AA630760 AI863410 AI567867 CB216527 
AI885487 BU733396 BF718263 CA444725 BF477437 BM679302 AI076274 AU279462 
NM_000962 NM_080591 BQ014239 AL556508 AL709654 N54739 BM728404 AA345128 

highest scoring ESTs for PTGS1:

M59979 AA037294 AA278216 AI202433 AI424408 AI467819 AI740976 AI806507 AV734203 AV744257 

Unigene Cluster for PTGS1:

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Hs.201978  [show with all ESTs]
Unigene Representative Sequence: NM_000962


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PTGS1 (see all 8 )

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1:                                                                                                                                    
SP2:                                -     -                                                                                             
SP3:                                -     -     -                                                     -                                 
SP4:                                -     -                       -                                                                     
SP5:                                -     -                                                                                             

About this scheme

ECgene alternative splicing isoforms for PTGS1

3 Ensembl transcripts including schematic representations:
ENST00000373698  ENST00000223423  ENST00000362012  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PTGS1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PTGS1

1 / 2 / 3

10 probe-sets matching PTGS1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

37969_at2, 3 U95-A 1 1.00 1.00 0.68 1.01 M59979 1.00 1.00 1.00 1
89844_at2, 3 U95-E 1 1.00 1.00 0.92 1.03 AI806507 0.80 1.00 0.91 1

215813_s_at2, 3 U133-A 1 1.00 1.00 -- -- S36219 0.80 1.00 0.91 1

205128_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000962 0.60 1.00 0.82 1

205127_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000962 0.60 1.00 0.82 1

238669_at2, 3 U133-B 1 0.82 1.00 -- -- BE613133 0.40 1.00 0.76 1

215813_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205128_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205127_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

238669_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
GeneDecks  PTGS1 for binary patterns associated with the probe-sets selected above  
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About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AAGCTAATAA

SOURCE GeneReport for Unigene cluster: Hs.201978

Expression variation in blood from EXPOLDB for PTGS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PTGS1 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 89.55(n)
92.54(a)
403544  NM_001003023.1  NP_001003023.1 
chimpanzee
(Pan troglodytes)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 99.12(n)
98.77(a)
464713  XM_520238.2  XP_520238.2 
cow
(Bos taurus)
PTGS11   -- prostaglandin-endoperoxide synthase 1 (prostaglandin more 88.65(n)
91.15(a)
282022  XM_864482.2  XP_869575.1 
rat
(Rattus norvegicus)
Ptgs11   -- prostaglandin-endoperoxide synthase 1 84.14(n)
86.93(a)
24693  NM_017043.1  NP_058739.1 
mouse
(Mus musculus)
Ptgs11, 5 2 (29.00 cM)5
prostaglandin-endoperoxide synthase 11, 5 85.59(n)1
89.78(a)1
192241  NM_008969.31  NP_032995.11 
 AK0464575  AK1341635  (see all 36)
About this table        Species with no ortholog for PTGS1

ENSEMBL Gene Tree for PTGS1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PTGS1 gene
PTGS22  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/272 NCBI SNPs in PTGS1 are shown (see all 272 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 153)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs13303441,2
A,C,F,H124171509(-) GCACTA/GATGGG 2 -- ng5112Minor allele frequency- G:0.43EA WA NS 2484
rs80461,2
A,C,F,H124195229(+) AAGGAA/GGTGGG 2 -- ut315Minor allele frequency- G:0.10NS MN EA 428
rs103061831,2
C,F,H124194731(+) ATGCTC/AATTTT 2 -- ut3110Minor allele frequency- A:0.12NS EU EA WA 932
rs57891,2
C,F,H124183794(+) ACAATC/ATGGAG 2 M/L mis122Minor allele frequency- A:0.02NA MN CSAM EA EU WA NS 2120
--
rs103061941,2
C,F,H124197019(+) gtaatC/AaagCC 2 -- ut3112Minor allele frequency- A:0.05NS EU EA WA 1172
rs103061081,2
C,F,H124171301(+) ATCTGT/CGGTGC 2 -- ng5116Minor allele frequency- C:0.04NS EU EA WA 1590
rs38427871,2
C,F,H124173328(+) GCTCCC/TGCCGC 2 P/L mis1 ese36Minor allele frequency- T:0.07NA NS EU WA 518
rs12369131,2
C,F,H124173300(+) TGCTCC/TGGTTC 2 W/R mis19Minor allele frequency- T:0.07NA NS MN EU EA WA 874
rs103061911,2
C,F,H124195678(+) AAACAA/GCTTCC 2 -- ut3111Minor allele frequency- G:0.04NS EU EA 1042
rs38427891,2
C,F,H124180062(+) TGACCG/ACTACC 2 H/R mis1 ese36Minor allele frequency- A:0.01NA NS EU WA 484
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HapMap Linkage Disequilibrium images for PTGS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 176805

10/94 Novoseek disease relationships for PTGS1 gene (see all 94 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 71.58 151 16982919 (3), 10628589 (2), 9146894 (2), 18220787 (2) (see all 99)
osteoarthritis 62.29 21 15337183 (2), 11041909 (2), 10719816 (1), 14752171 (1) (see all 15)
gastrointestinal complications 58.30 3 10377455 (1), 14602052 (1)
colon cancer 57.35 17 19258012 (4), 16091009 (2), 7780968 (2), 16984374 (2) (see all 11)
intestinal polyps 55.53 5 12941808 (3), 16984374 (1)
ulcer 53.03 28 16247187 (3), 11519793 (2), 17926541 (2), 11136275 (2) (see all 15)
rheumatoid arthritis 52.81 11 10719816 (2), 15167967 (1), 9433877 (1), 10390126 (1) (see all 9)
nasal polyps 51.95 29 16517580 (4), 15921208 (4), 15480320 (2), 19132974 (2) (see all 11)
arthritis 51.50 12 11550975 (2), 10193996 (1), 9714356 (1), 10225538 (1) (see all 9)
polyps 50.57 31 12941808 (4), 11584208 (2), 11495083 (2), 19251796 (1) (see all 11)
About this table

Human Gene Mutation Database: PTGS1
Genetic Association Database: PTGS1
Human Genome Epidemiology Navigator: PTGS1 (44 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/1099 PubMed articles for PTGS1 gene (see all 1099 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5742 HGNC: 9604 AceView: PTGS1 Ensembl:ENSG00000095303 euGenes: HUgn5742
ECgene: PTGS1 H-InvDB: PTGS1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for PTGS1 Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPshttp://pga.gs.washington.edu/data/ptgs1/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



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