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PREP Gene

protein-coding GIFtS: 65

GC06M105832

prolyl endopeptidase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.21.26 ^³
MGC16060 ^²
OTTHUMP00000016916 ^²
OTTHUMP00000040498 ^²
PE ^², ³
PEP ^², ³

Descriptions
Post-proline cleaving enzyme ^², ³
dJ355L5.1 (prolyl endopeptidase) ^²
prolyl endopeptidase ^²
prolyl oligopeptidase ^²

External Ids
HGNC: 9358¹
Entrez Gene: 5550²
UniProtKB: P48147³
Ensembl: ENSG00000085377⁷

Search outside databases for aliases for PREP gene

Previous GC identifers: GC06M105561 GC06M105748 GC06M105771

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PREP:

The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on

the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids

long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of

peptide hormones and neuropeptides. [provided by RefSeq]

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147

Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are

up to approximately 30 amino acids long

Gene Wiki entry for PREP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PREP gene

Entrez Gene cytogenetic band: 6q22 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q22

PREP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M105832: (about GC identifiers)

Start:	105,832,199 bp from pter
End:	105,957,662 bp from pter
Size:	125,464 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147 (See protein sequence)

Recommended Name: Prolyl endopeptidase

Size: 710 amino acids; 80700 Da

Subunit: Monomer

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

3DDU (3D)

Secondary accessions: Q8N6D4

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002717.3

ENSEMBL proteins:

ENSP00000358106 ENSP00000358100

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for PREP (Prolyl Oligopeptidase/PREP)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Prolyl Endopeptidase)
	Human Recombinant Proteins from Abnova (PREP)

OriGene Purified Recombinant Human Protein: PREP

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	9695945

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Antibodies for PREP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for PREP (Prolyl Oligopeptidase/PREP)
	Antibodies from Abcam (Prolyl Endopeptidase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PREP)
	Novus Biologicals Antibodies for PREP

Assays for PREP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P48147

ProtoNet protein and cluster: P48147

2 Blocks protein families:

IPB002470 Prolyl oligopeptidase serine protease (S9A) signature

IPB002471 Prolyl endopeptidase

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147

Similarity: Belongs to the peptidase S9A family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PREP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002726

Applied Biosystems Silencer® siRNAs for PREP

Sigma-Aldrich siRNA and siRNA Panels for PREP

Sigma-Aldrich shRNA for PREP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PREP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002726
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002726
untagged cDNA clone in CMV expression vector: NM_002726

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002726

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147

Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are

up to approximately 30 amino acids long

Catalytic activity: Hydrolysis of Pro- -Xaa >> Ala- -Xaa in oligopeptides

Enzyme Number (IUBMB): EC 3.4.21.26

Genatlas biochemistry entry for PREP:

prolyl oligopeptidase,alpha/beta hydrolase fold family

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	TAS	9695945
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for PREP (Your Favorite Gene powered by Ingenuity)

Lysine Degradation

GeneDecks PREP for the pathways selected above

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5/20 Interacting proteins for PREP (ENSP00000358106³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PGPEP1	ENSP00000252813³	STRING (score=.938)
DPP8	ENSP00000339208³	STRING (score=.935)
DPP4	ENSP00000353731³	STRING (score=.934)
DPP9	ENSP00000350583³	STRING (score=.926)
TRH	ENSP00000303452³	STRING (score=.889)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	9695945

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PREP

Browse Small Molecules at Sigma-Aldrich

Compounds for PREP available from Tocris Bioscience

Compound	Action	CAS number
Y-29794 oxalate	Prolyl endopeptidase inhibitor	[129184-48-1]

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10/21 Novoseek chemical compound relationships for PREP gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
poststatin	92.39	12	8931723 (3), 8931724 (2), 8968396 (2), 8931725 (2) (see all 6)
z-pro-prolinal	90.51	7	16942854 (2), 1980725 (1), 18927208 (1), 2162536 (1) (see all 5)
proline	75.27	40	15509157 (2), 8652620 (1), 8951032 (1), 15217351 (1) (see all 28)
gluten	66.85	10	16206502 (2), 16136593 (1), 16690904 (1), 18836204 (1) (see all 7)
gliadin	57.64	7	15143130 (3), 14600421 (1), 16143118 (1), 16230098 (1) (see all 5)
deae-cellulose	33.24	1	11137456 (1)
tripeptide	26.87	2	8652620 (1), 2175370 (1)
lithium	22.28	6	10329620 (1), 15005755 (1), 17324276 (1), 12015604 (1)
ethylacetate	16.83	1	14723335 (1)
histidine	15.69	2	2064618 (1), 7932578 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PREP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002726

Sigma-Aldrich siRNA and siRNA Panels for PREP

Sigma-Aldrich shRNA for PREP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002726

REFSEQ mRNAs for PREP gene:

NM_002726.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002726

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002726
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002726
                                 untagged cDNA clone in CMV expression vector: NM_002726

Additional cDNA sequence:

AB020018.1 AB028867.1 AK314195.1 AY660966.1 BC030636.2 D21102.1 X74496.1

7 DOTS entries:

DT.100783673 DT.453965 DT.100000836 DT.121318525 DT.121318533 DT.97802437 DT.95179708

24/166 AceView cDNA sequences (see all 166 ):

BM791205 BM793693 BG744822 NM_002726 AA338078 BU931903 AI888722 BI859849

BM828521 CA430997 AA860678 AA594106 BM703107 H97083 BQ889182 BF724523

BU624788 BU617058 BX641834 AI289497 BM016994 CA308061 CD108093 CA444751

highest scoring ESTs for PREP:

X74496 AU100064 AB020018 AB028867 AU127208 BE386750 BG744158 BG761528 BI550256 BM473133

Unigene Cluster for PREP:

Prolyl endopeptidase

Hs.436564 [show with all ESTs]

Unigene Representative Sequence: NM_002726

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000369110 ENST00000369104

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PREP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PREP

¹ / ² / ³

5 probe-sets matching PREP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37950_at²^{, 3}	U133-A	1	1.00	1.00	1.00	1.00	X74496	1.00	0.90	0.95	1
37950_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X74496	1.00	0.90	0.95	1
204117_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002726	0.60	1.00	0.82	1
37950_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204117_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PREP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGAAGACTT

SOURCE GeneReport for Unigene cluster: Hs.436564
Expression variation in blood from EXPOLDB for PREP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PREP gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PREP¹	--	prolyl endopeptidase	90.82(n) 96.89(a)	481945 XM_863250.1 XP_868343.1
chimpanzee (Pan troglodytes)	PREP¹	--	prolyl endopeptidase	99.3(n) 99.58(a)	462903 XM_518657.2 XP_518657.2
cow (Bos taurus)	PREP¹	--	prolyl endopeptidase	90.46(n) 95.49(a)	286818 NM_174772.1 NP_777197.1
rat (Rattus norvegicus)	Prep¹	--	prolyl endopeptidase	87.12(n) 95.35(a)	83471 NM_031324.1 NP_112614.1
mouse (Mus musculus)	Prep^{1, 5}	10 (28.50 cM)⁵	prolyl endopeptidase^{1, 5}	88.29(n)¹ 95.91(a)¹	19072¹ NM_011156.2¹ NP_035286.1¹ AA013993⁵ AA409851⁵ (see all 35)

About this table Species with no ortholog for PREP

ENSEMBL Gene Tree for PREP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PREP gene

PREPL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/700 NCBI SNPs in PREP are shown (see all 700 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 262)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1051484^1,2	A,C,F,H	105832729(+)	`GTCGAC/TGTTCA`	1	V/I	mis¹ ese³		24		MN NA EA EU WA	3348
	rs3799990^1,2	C,F,H	105832253(+)	`GTTGCC/TCCTCA`	1	--	ut3¹		13		EA NA EU WA	2440
	rs12192054^1,2	C,F,H	105883559(+)	`GCATAA/CGACCA`	1	L/V	mis¹ ese³		8		EU EA WA	838
	rs9486079^1,2	C,F,H	105958671(+)	`TAAACT/GTGTGT`	1	--	ng3¹		8		EU EA WA NA	778
--	rs2308160^1,2	F	105832086(-)	`CTGTC-/TGTC AGAGG`	1	--	ng5¹		4		EU NA EA	342
	rs1149304^1,2	A	105831734(-)	`AAAAAA/GAAAAG`	1	--	ng5¹		0	--	--	--	--
	rs9486069^1,2	A,C,F,H	105928142(+)	`AACGCA/GTAACC`	1	Y/Y	syn¹ ese³		4		EU EA WA	416
	rs6902415^1,2	C,F,H	105883485(+)	`AGCGGG/AAAGGT`	1	F/F	syn¹		4		EU EA WA	418
	rs1190050^1,2	A,C,F,H,O	105849335(+)	`CTTGTA/GGCTCC`	1	--	int¹		13		MN EU EA WA NA	1234
--	rs1149306^1,2	A,C,F,H,O	105853289(+)	`TAACTT/GGGAAG`	1	--	int¹		8		MN EU EA WA NA	746

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HapMap Linkage Disequilibrium images for PREP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600400

10/14 Novoseek disease relationships for PREP gene (see all 14 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
celiac disease	66.33	10	16206502 (2), 16143118 (2), 18836204 (2), 16136593 (1) (see all 7)
memory disorders	52.21	3	12202494 (1), 12228249 (1), 10747969 (1)
amnesia	44.94	2	15713471 (1), 11915948 (1)
trypanosomiasis	42.77	1	11915948 (1)
alzheimers disease	34.87	5	16187206 (1), 11711876 (1), 17703733 (1), 16390203 (1) (see all 5)
neurodegenerative diseases	15.71	2	16092940 (1), 16086671 (1)
major depression	11.84	5	8038298 (2), 8570777 (1), 9802123 (1)
schizophrenia	11.71	2	10363664 (1), 9802123 (1)
fibromyalgia	6.61	3	9723150 (2), 11543693 (1)
psychiatric disorder	3.70	7	10363664 (1), 15296652 (1), 9802123 (1), 18547158 (1)

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Human Genome Epidemiology Navigator: PREP (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

Study Identifies Factors Associated with False Negative Breast Biopsy Readings: Presented at ASCP

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/196 PubMed articles for PREP gene (see all 196 ):

Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (PubMed id 7959018)^{1, 2, 3, 4} Vanhoof G.... Scharpe S. (1994)
The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. (PubMed id 7588785)^{1, 3, 4} Goossens F....Scharpe S. (1995)
Molecular cloning and characterization of prolyl endopeptidase from human T cells. (PubMed id 8089089)^{1, 3, 4} Shirasawa Y.... Hirashima A. (1994)
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. (PubMed id 16092940)^{1, 3} Schulz I....Rossner S. (2005)
Distribution of prolyl endopeptidase activities in rat and human brain. (PubMed id 11792464)^{1, 3} Irazusta J....Casis L. (2002)
Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. (PubMed id 15380924)^{1, 3} Valdivia A....Casis L. (2004)
Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates. (PubMed id 11137456)^{1, 3} Quinto B.M....Casarini D.E. (2000)
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. (PubMed id 9695945)^{1, 3} Fulop V....Polgar L. (1998)
Subregional mapping of the human lymphocyte prolyl oligopeptidase gene (PREP) to human chromosome 6q22. (PubMed id 8893811)^{1, 3} Goossens F.J....Scharpe S.L. (1996)
Distribution of immunoreactive prolyl oligopeptidase in human and rat brain. (PubMed id 17401647)^{1, 3} Myohanen T.T....Mannisto P.T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5550	HGNC: 9358	AceView: PREP	Ensembl:ENSG00000085377	euGenes: HUgn5550
ECgene: PREP	H-InvDB: PREP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PREP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PREP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PREP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PREP		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PREP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PREP)
	Antibodies (PREP)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Prolyl Endopeptidase)
	Antibodies (Prolyl Endopeptidase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for PREP

	Drugs for PREP
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PREP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PREP Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PREP

Summaries
for PREP

Genomic Location
for PREP

Proteins
for PREP

Protein Domains/
Families
for PREP

Gene Function
for PREP

Pathways & Interactions
for PREP

Drugs & Compounds
for PREP

Transcripts
for PREP

Expression
for PREP

Orthologs
for PREP

Paralogs
for PREP

SNPs/Variants
for PREP

Disorders & Mutations
for PREP

Medical News
for PREP

Publications
for PREP

Search for PREP

Genome Databases showing PREP

Other Databases showing PREP

Specialized Databases showing PREP

Licensable Technologies
for PREP

Services
for PREP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PREP Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PREP

Summariesfor PREP

Genomic Locationfor PREP

Proteinsfor PREP

Protein Domains/Familiesfor PREP

Gene Functionfor PREP

Pathways & Interactionsfor PREP

Drugs & Compoundsfor PREP

Transcriptsfor PREP

Expression for PREP

Orthologsfor PREP

Paralogsfor PREP

SNPs/Variantsfor PREP

Disorders & Mutationsfor PREP

Medical Newsfor PREP

Publicationsfor PREP

Search for PREP

Genome Databases showing PREP

Other Databases showing PREP

Specialized Databases showing PREP

Licensable Technologiesfor PREP

Servicesfor PREP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PREP

Summaries
for PREP

Genomic Location
for PREP

Proteins
for PREP

Protein Domains/
Families
for PREP

Gene Function
for PREP

Pathways & Interactions
for PREP

Drugs & Compounds
for PREP

Transcripts
for PREP

Expression
for PREP

Orthologs
for PREP

Paralogs
for PREP

SNPs/Variants
for PREP

Disorders & Mutations
for PREP

Medical News
for PREP

Publications
for PREP

Licensable Technologies
for PREP

Services
for PREP