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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PON3 Gene

protein-coding   GIFtS: 59
GCID: GC07M094989

paraoxonase 3
 Explore 15 diseases affiliated with
PON3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PON3    

Aliases
for PON3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Paraoxonase 31 2
Paraoxanase-31
Serum Paraoxonase/Lactonase 32
EC 3.1.1.23
EC 3.1.1.813
EC 3.1.8.13

External Ids:    HGNC: 92061   Entrez Gene: 54462   Ensembl: ENSG000001058527   OMIM: 6027205   UniProtKB: Q151663   

Export aliases for PON3 gene to outside databases

Previous GC identifers: GC07M093524 GC07M094587 GC07M094601 GC07M094633 GC07M094827 GC07M089596


Summaries
for PON3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PON3:
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family
members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The
protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function
that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which
encode different protein isoforms have been described; however, only one has been fully characterized. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166
Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes
lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with
aliphatic substituents but not simple lactones or those with polar substituents

Gene Wiki entry for PON3


Genomic Views
for PON3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PON3 gene promoter:
         c-Fos   AP-1   JunB   FosB   Fra-1   POU6F1 (c2)   LCR-F1   GATA-1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PON3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PON3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PON3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

PON3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PON3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M094989:  view genomic region     (about GC identifiers)

Start:
 94,989,184 bp from pter      End:
 95,025,687 bp from pter
Size:
 36,504 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 94,318,186-94,354,692     

Proteins
for PON3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166 (See protein sequence)
Recommended Name: Serum paraoxonase/lactonase 3  
Size: 354 amino acids; 39607 Da
Cofactor: Binds 2 calcium ions per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Secreted, extracellular space (By similarity)
Secondary accessions: A4D1H8 O75855 O76060 Q6IRU9 Q8IX97 Q9BZH9

Explore the universe of human proteins at neXtProt for PON3: NX_Q15166

Post-translational modifications:

  • The signal sequence is not cleaved (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15166

    • PON3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000931.1  
    ENSEMBL proteins: 
     ENSP00000265627   ENSP00000413276   ENSP00000403850   ENSP00000393174   ENSP00000390253  
     ENSP00000391072  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PON3
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    Novus Biologicals PON3 Protein
    Novus Biologicals PON3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PON3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005615extracellular space IEA--
    GO:0005792microsome ----
    GO:0043231intracellular membrane-bounded organelle IEA--


    PON3 for ontologies           About GeneDecksing



    PON3 Antibody Products: 
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    Abcam antibodies for PON3 
    Uscn Antibodies for PON3
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    Uscn ELISAs and CLIAs for PON3

    Protein Domains /
    Families
    for PON3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PON3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008364 Paraoxonase2
     IPR002640 Arylesterase
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry Q15166

    ProtoNet protein and cluster: Q15166

    1 Blocks protein family: IPB002640 Arylesterase

    UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166
    Similarity: Belongs to the paraoxonase family


    Function
    for PON3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PON3_HUMAN, Q15166
    Function: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes
    lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with
    aliphatic substituents but not simple lactones or those with polar substituents
    Catalytic activity: A phenyl acetate + H(2)O = a phenol + acetate
    Catalytic activity: An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol
    Catalytic activity: An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine

         Genatlas biochemistry entry for PON3:
    paraoxonase-like sequence 2(PON3)

    Enzyme Numbers (IUBMB): EC 3.1.1.21 EC 3.1.1.811 EC 3.1.8.11

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PON3 (see all 7)
    OriGene shRNA RFP: PON3
    OriGene siRNA: PON3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PON3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PON3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PON3 (see all 3)
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for PON3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004063aryldialkylphosphatase activity IEA--
    GO:0004064arylesterase activity NAS8661009
    GO:00187333,4-dihydrocoumarin hydrolase activity IEA--
    GO:0042803protein homodimerization activity IDA15772423
    GO:0046872metal ion binding IEA--


    PON3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PON3:
     Increased gamma-H2AX phosphory  Increased number of cells in m 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pon3):
     embryogenesis  growth/size  mortality/aging 

    PON3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PON3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phase I, non P450
    		Phase I, non P4501.00
    2Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for PON3 
        Phase I, non P450


    1         Kegg Pathway  (Kegg details for PON3):
        Metabolic pathways


    PON3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PON3

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009605response to external stimulus NAS8661009
    GO:0010124phenylacetate catabolic process IEA--
    GO:0019439aromatic compound catabolic process IDA15772423
    GO:0046226coumarin catabolic process IEA--
    GO:0046395carboxylic acid catabolic process IDA15772423


    PON3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PON3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PON3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PON3

    10/19 HMDB Compounds for PON3 (see all 19)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    4-Nitrophenol1-Hydroxy-4-nitrobenzene (see all 8)100-02-7--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Acetic acidAcetate (see all 12)64-19-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DiethylthiophosphateDETP (see all 6)5871-17-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--

    2 DrugBank Compounds for PON3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Edetic AcidCaEDTA (see all 8)62-33-9enzymeinhibitor17292339
    Lovastatin6 alpha-Methylcompactin (see all 4)75330-75-5enzymesubstrate10931838

    4 Novoseek chemical compound relationships for PON3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phenylacetate 83.7 1 11304470 (1)
    paraoxon 76.9 1 11304470 (1)
    lovastatin 36.5 1 15772423 (1)
    cholesterol 33.1 2 18585453 (2)

    Search CenterWatch for drugs/clinical trials and news about PON3 

    Transcripts
    for PON3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PON3 gene: 
    NM_000940.2  

    Unigene Cluster for PON3:

    Paraoxonase 3
    Hs.440967  [show with all ESTs]
    Unigene Representative Sequence: CD014095
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265627(uc003unt.3) ENST00000427422 ENST00000451904 ENST00000418617
    ENST00000442770 ENST00000456855 ENST00000492800 ENST00000460248 ENST00000482624(uc011kii.2)
    ENST00000475439

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PON3
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PON3 (see all 7)
    OriGene shRNA RFP: PON3
    OriGene siRNA: PON3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PON3
    Clone
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    GenScript: all cDNA clones in your preferred vector: PON3 (NM_000940)
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    Primer
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    Additional cDNA sequence: 

    AF320003.1 AF329433.1 AK304282.1 BC020908.1 BC070374.1 L48516.1 

    18 DOTS entries:

    DT.313453  DT.92425664  DT.92425663  DT.101983699  DT.40121264  DT.101983703  DT.92425666  DT.100731698 
    DT.100738978  DT.100762569  DT.101983700  DT.101983701  DT.40121265  DT.92425659  DT.92425662  DT.100653477 
    DT.101983702  DT.75151092 

    24/80 AceView cDNA sequences (see all 80):

    AI866611 AI866606 AV653103 BF513914 BF059348 CD014095 NM_000940 AA256367 
    CD014100 AV660412 CD014102 AI674127 CD014098 CB160649 AV720018 AI033844 
    CD014096 AF329433 BU071352 AI074616 AI247797 T81888 AV648699 T71213 

    GeneLoc Exon Structure


    Expression
    for PON3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PON3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAAATTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PON3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PON3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PON3

    SOURCE GeneReport for Unigene cluster: Hs.440967
        SABiosciences Expression via Pathway-Focused PCR Array including PON3: 
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PON3

    Orthologs
    for PON3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PON3 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PON26
    		 Uncharacterized protein
    		 61(a)
    		 1 → many
    		 2(23811551-23827703)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 57(a)
    		 1 → many
    		 6(22507087-22522423)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1123746
    zgc:775566
    (see all 3)    		 zgc:77556
    (see all 3)    		 49(a)
    49(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 16(26896251-26907913)
    16(26909176-26912212)
    worm
    (Caenorhabditis elegans)    		 Secernentea poml-21 Protein POML-2 44.54(n)
    30.68(a)    		   171999  NM_058905.3  NP_491306.1 


    ENSEMBL Gene Tree for PON3 (if available)
    TreeFam Gene Tree for PON3 (if available) 

    Paralogs
    for PON3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PON3 gene
    PON12  PON22  
    2 SIMAP similar genes for PON3 using alignment to 5 protein entries:     PON3_HUMAN (see all proteins):
    PON2    PON1

    PON3 for paralogs           About GeneDecksing



    Genomic Variants
    for PON3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/699 NCBI SNPs in PON3 are shown (see all 699)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs178826431,2
    		C,--94317976(-) TAACTG/AGGTCC 1 -- ds50012Minor allele frequency- A:0.01NS 82
    rs2000196281,2
    		C--94318298(+) CTCACA/GGTACA 2 R C mis11Minor allele frequency- G:0.00EU 1321
    rs737099621,2
    		C,--94318724(+) CTCTTA/GTTTAG 1 -- int12Minor allele frequency- G:0.07WA 120
    rs178787981,2
    		C,F,--94318746(-) AGGACC/TACCAT 1 -- int13Minor allele frequency- T:0.13NS WA 210
    rs178790791,2
    		C,--94318796(-) TTTCTC/GTCCCC 1 -- int1 trp32Minor allele frequency- G:0.01NS 92
    rs734327721,2
    		C,--94318947(+) TTCATT/CTGACA 1 -- int14Minor allele frequency- C:0.07WA NA EA 360
    rs178829551,2
    		C,F,--94319107(-) TTCTAA/TTTGTT 1 -- int13Minor allele frequency- T:0.13NS WA 212
    rs178832351,2
    		C,--94319126(-) AGACTC/TGTAAC 1 -- int12Minor allele frequency- T:0.01NS 94
    rs77787711,2
    		C,F,H,--94319338(+) GATACG/AAAAAA 1 -- int111Minor allele frequency- A:0.06NS EA NA WA 728
    rs77976941,2
    		C,F,H,--94319406(+) CATTGT/CGGTTG 1 -- int112Minor allele frequency- C:0.06NS EA NA WA 758

    HapMap Linkage Disequilibrium report for PON3 (94989184 - 95025687 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PON3: --
    Human Gene Mutation Database (HGMD): PON3

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    Disorders / Diseases
    for PON3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PON3 for disorders           About GeneDecksing

    OMIM gene information: 602720    OMIM disorders: --

    15 diseases for PON3:    About MalaCards
    atherosclerosis    coronary heart disease    amyotrophic lateral sclerosis    myocardial infarction
    lateral sclerosis    acute myocardial infarction    cataract    hepatocellular carcinoma
    alzheimer's disease    dementia    colorectal cancer    obesity
    cholesterol    carcinoma    alcoholism

    1 disease from the University of Copenhagen DISEASES database for PON3:
    Atherosclerosis

    4 Novoseek disease relationships for PON3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 60 13 17446441 (3), 17379834 (2), 11304457 (1), 19359600 (1) (see all 9)
    coronary heart disease 43.4 2 11803456 (1), 16120573 (1)
    cardiovascular diseases 37.3 2 11803456 (1), 19082953 (1)
    stroke 0 1 16239632 (1)

    Genetic Association Database (GAD): PON3
    Human Genome Epidemiology (HuGE) Navigator: PON3 (36 documents)

    Export disorders for PON3 gene to outside databases

    Publications
    for PON3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PON3 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with PON3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. (PubMed id 8661009)1, 2, 3, 9 Primo-Parmo S.L.... La Du B.N. (1996)
    2. Identification of paraoxonase 3 gene (PON3) missense mutations in a population of southern Italy. (PubMed id 14757195)1, 4, 9 Campo S....Saitta A. (2004)
    3. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (PubMed id 15772423)1, 2, 9 Draganov D.I....La Du B.N. (2005)
    4. Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women. (PubMed id 16117861)1, 4, 9 Su S.Y....Gu D.F. (2005)
    5. [Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese] (PubMed id 16078734)1, 4, 9 Wang X.L....Gu D.F. (2005)
    6. PON1 M/L55 mutation protects high-risk patients against coronary artery disease. (PubMed id 14996478)1, 4, 9 Oliveira S.A....Annichino-Bizzacchi J.M. (2004)
    7. Human paraoxonase gene cluster polymorphisms as predictors of coronary heart disease risk in the prospective Northwick Park Heart Study II. (PubMed id 14636952)1, 4, 9 Robertson K.S....Humphries S.E. (2003)
    8. Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population. (PubMed id 12588779)1, 4, 9 Wang X....Gu D. (2003)
    9. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. (PubMed id 16319130)1, 4 Erlich P.M....Farrer L.A. (2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)

    External Searches for PON3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PON3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5446 HGNC: 9206 AceView: PON3 Ensembl:ENSG00000105852 euGenes: HUgn5446
    ECgene: PON3 Kegg: 5446 H-InvDB: PON3

    Other Databases showing PON3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PON3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PON3 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/pon3/

    Intellectual Property
    for PON3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PON3 gene:
    Search GeneIP for patents involving PON3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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