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POLR2D Gene

protein-coding   GIFtS: 60
GCID: GC02M128663

Polymerase (RNA) II (DNA Directed) Polypeptide D

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polymerase (RNA) II (DNA Directed) Polypeptide D1 2     HSRBP42
RNA Polymerase II Subunit HsRBP41 2     HSRPB42
RPB162 3     RBP42
DNA-Directed RNA Polymerase II Subunit D2 3     DNA-Directed RNA Polymerase II 16 KDa Polypeptide2
RNA Polymerase II 16 KDa Subunit2 3     DNA-Directed RNA Polymerase II Subunit RPB42
RNA Polymerase II Subunit B42 3     

External Ids:    HGNC: 91911   Entrez Gene: 54332   Ensembl: ENSG000001442317   OMIM: 6060175   UniProtKB: O155143   

Export aliases for POLR2D gene to outside databases

Previous GC identifers: GC02M125901 GC02M126528 GC02M128509 GC02M128697 GC02M128320 GC02M128606 GC02M120910 GC02M128608 GC02M128620 GC02M128637 GC02M128649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for POLR2D Gene:
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing
messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal
growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained
within the 3' untranslated region of the transcript from this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for POLR2D Gene:
POLR2D (polymerase (RNA) II (DNA directed) polypeptide D) is a protein-coding gene. GO annotations related to this gene include DNA-directed RNA polymerase activity and nucleotide binding.

UniProtKB/Swiss-Prot: RPB4_HUMAN, O15514
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds
to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to
lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site
cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)

Gene Wiki entry for POLR2D (RNA polymerase II subunit B4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the POLR2D gene promoter:
         SRF   HOXA9   HOXA9B   CUTL1   Meis-1b   POU2F1   POU2F1a   ZIC2/Zic2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPOLR2D promoter sequence
   Search Chromatin IP Primers for POLR2D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat POLR2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21

POLR2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
POLR2D gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128663:  view genomic region     (about GC identifiers)

Start:
128,603,840 bp from pter      End:
128,615,731 bp from pter
Size:
11,892 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPB4_HUMAN, O15514 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase II subunit RPB4  
Size: 142 amino acids; 16311 Da
Subunit: Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a
subcomplex that protrudes from the 10-subunit Pol II core complex
1 PDB 3D structure from and Proteopedia for POLR2D:
2C35 (3D)    
Secondary accessions: Q52LT4

Explore the universe of human proteins at neXtProt for POLR2D: NX_O15514

Explore proteomics data for POLR2D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See POLR2D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004796.1  
    ENSEMBL proteins: 
     ENSP00000272645   ENSP00000387323   ENSP00000387117  
    Reactome Protein details: O15514

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    ProSpec Recombinant Protein for POLR2D
    Cloud-Clone Corp. Proteins for POLR2D

     
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    antibodies-online proteins for POLR2D (4 products) 

     
    antibodies-online peptides for POLR2D

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    antibodies-online antibodies for POLR2D (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POLR: RNA polymerase subunits

    3 InterPro protein domains:
     IPR010997 HRDC-like
     IPR005574 RNA_pol_II_Rpb4
     IPR006590 RNA_pol_II_Rpb4_core

    Graphical View of Domain Structure for InterPro Entry O15514

    ProtoNet protein and cluster: O15514

    1 Blocks protein domain: IPB005574 RNA polymerase Rpb4

    UniProtKB/Swiss-Prot: RPB4_HUMAN, O15514
    Similarity: Belongs to the eukaryotic RPB4 RNA polymerase subunit family


    Find genes that share domains with POLR2D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPB4_HUMAN, O15514
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional
    non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is
    composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds
    to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to
    lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site
    cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)

         Genatlas biochemistry entry for POLR2D:
    polymerase II,RNA DNA directed,polypeptide D likely associating with POLR2G (RPB7)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0003899DNA-directed RNA polymerase activity IMP9528765
         
    Find genes that share ontologies with POLR2D           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for POLR2D:
     Decreased Wnt reporter activit  Decreased viability  Increased S DNA content  S arrest 
     Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for POLR2D

    miRNA
    Products:
        
    miRTarBase miRNAs that target POLR2D:
    hsa-mir-186-5p (MIRT045220), hsa-mir-421 (MIRT016121), hsa-mir-196a-5p (MIRT026057), hsa-let-7d-5p (MIRT032142), hsa-mir-1229-3p (MIRT036289), hsa-mir-24-3p (MIRT030510)

    Block miRNA regulation of human, mouse, rat POLR2D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate POLR2D (see all 11):
    hsa-miR-98 hsa-let-7d hsa-miR-3120-3p hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidPOLR2D 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat POLR2D

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPB4_HUMAN, O15514: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9852112
    GO:0005654nucleoplasm TAS--
    GO:0005665DNA-directed RNA polymerase II, core complex IDA9528765

    Find genes that share ontologies with POLR2D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for POLR2D About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    2Formation of RNA Pol II elongation complex
    mRNA Capping0.93
    HIV elongation arrest and recovery0.73
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Tat-mediated HIV elongation arrest and recovery0.72
    Formation of the Early Elongation Complex0.77
    Transcription of the HIV genome0.71
    3DNA Repair
    Transcription-coupled NER (TC-NER)0.90
    Formation of transcription-coupled NER (TC-NER) repair complex0.65
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    Dual incision reaction in TC-NER0.65
    4mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    5HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91


    Find genes that share SuperPaths with POLR2D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for POLR2D
        Assembly of RNA Polymerase-II Initiation Complex
    Transcription of mRNA

    3 GeneGo (Thomson Reuters) Pathways for POLR2D
        DNA damage Role of Brca1 and Brca2 in DNA repair
    ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    Selected Reactome Pathways for POLR2D (see all 31)
        Pausing and recovery of Tat-mediated HIV elongation
    Tat-mediated HIV elongation arrest and recovery
    Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    Selected Kegg Pathways  (Kegg details for POLR2D) (see all 6):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for POLR2D
    Interactions:

        GeneGlobe Interaction Network for POLR2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for POLR2D (O155143 ENSP000002726454) via UniProtKB, MINT, STRING, and/or I2D (see all 337)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CP193873, ENSP000002192524I2D: score=5 STRING: ENSP00000219252
    POLR2GP624873, ENSP000003017884I2D: score=5 STRING: ENSP00000301788
    POLR2HP524343, ENSP000002962234I2D: score=4 STRING: ENSP00000296223
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    MED29Q9NX703, ENSP000003143434I2D: score=2 STRING: ENSP00000314343
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006281DNA repair TAS--
    GO:0006283transcription-coupled nucleotide-excision repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006351transcription, DNA-templated ----

    Find genes that share ontologies with POLR2D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for POLR2D (RPB4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for POLR2D gene: 
    NM_004805.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272645(uc002tpj.3) ENST00000409955 ENST00000487079 ENST00000409698

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate POLR2D (see all 11):
    hsa-miR-98 hsa-let-7d hsa-miR-3120-3p hsa-let-7c hsa-let-7i hsa-let-7g hsa-let-7e hsa-let-7b
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    Selected AceView cDNA sequences (see all 209):

    AI538216 NM_004805 CR590602 CB161125 CA430646 CR597179 BM453845 CB990168 
    AW198159 AA582562 AW085725 CA437991 AL581133 U85510 BC010427 CB161206 
    AW246687 BE385316 BQ674819 BQ921030 CA426573 CB119029 BC017205 CA489835 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for POLR2D (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -           -                                       
    SP2:                    -                                       
    SP3:        -     -     -                                       
    SP4:        -           -     -                                 
    SP5:        -                                                   


    ECgene alternative splicing isoforms for POLR2D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    POLR2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCCACCA
    POLR2D Expression
    About this image


    POLR2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Testis (Reproductive System)
    POLR2D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    POLR2D Protein Expression
        Custom PCR Arrays for POLR2D
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for POLR2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for POLR2D gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Polr2d1 , 5 polymerase (RNA) II (DNA directed) polypeptide D1, 5 87.56(n)1
    100(a)1
      18 (17.85 cM)5
    692411  NM_027002.31  NP_081278.11 
     317891595 
    chicken
    (Gallus gallus)
    Aves POLR2D1 polymerase (RNA) II (DNA directed) polypeptide D 83.1(n)
    97.18(a)
      424754  NM_001277409.1  NP_001264338.1 
    lizard
    (Anolis carolinensis)
    Reptilia POLR2D6
    polymerase (RNA) II (DNA directed) polypeptide D
    96(a)
    1 ↔ 1
    3(36328227-36335796)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80562 Xenopus laevis transcribed sequence with moderate similarity more 79.23(n)    CB942419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570843982   -- 77.92(n)    57084398 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rpb41 Rpb4 68.46(n)
    77.69(a)
      14462484  NM_001014633.3  NP_001014633.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F43E2.23
    rpb-41
    rpb-41 57(a)3
    58.39(n)1
    58.87(a)1
      II(7371817-7372676)3
    1742081  NM_063143.41  NP_495544.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPB4(YJL140W)4 RNA polymerase II subunit B32; forms two subunit dissociable more   --   10(150961-151626) 853301  NP_012395.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRPB41 NRPB4 51.52(n)
    43.18(a)
      830853  NM_121029.2  NP_196554.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01169001 Os02g0116900 49.75(n)
    41.67(a)
      4328083  NM_001052218.1  NP_001045683.1 


    ENSEMBL Gene Tree for POLR2D (if available)
    TreeFam Gene Tree for POLR2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for POLR2D gene

    Find genes that share paralogs with POLR2D           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for POLR2D
    PGOHUM00000240870 PGOHUM00000233534


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for POLR2D (see all 339)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932981771,2
    --128603404(+) ACTATA/TTATCA 1 -- ds50010--------
    rs754782871,2
    C,F--128603482(+) TACTAT/CTATCC 1 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1833292991,2
    --128603527(+) AGAAGC/TGAAGT 1 -- ds50010--------
    rs728488361,2
    C,F--128603528(+) GAAGCG/TAAGTT 1 -- ds50015Minor allele frequency- T:0.10CSA WA NA EA 362
    rs728488371,2
    C,F--128603599(+) CGAGGC/TGGGAG 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1119941701,2
    C,F--128603604(+) TGGGAG/CGATCA 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1887868071,2
    --128603671(+) AAACAC/TAAAAA 1 -- ds50010--------
    rs1121410911,2
    C,F--128603678(+) AAAAAC/TTAGCC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs116745131,2
    C,F,H--128603688(+) caggcG/Atggtg 1 -- ds50012Minor allele frequency- A:0.25NA WA 4
    rs1929285541,2
    --128603824(+) CTCAAA/TAAATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for POLR2D (128603840 - 128615731 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for POLR2D: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing POLR2D
    DNA2.0 Custom Variant and Variant Library Synthesis for POLR2D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606017    OMIM disorders: --


    Find genes that share disorders with POLR2D           About GenesLikeMe

    Genetic Association Database (GAD): POLR2D
    Human Genome Epidemiology (HuGE) Navigator: POLR2D (1 document)

    Export disorders for POLR2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for POLR2D gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with POLR2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II. (PubMed id 9528765)1, 2, 3 Khazak V....Golemis E.A. (Mol. Cell. Biol. 1998)
    2. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    3. Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II. (PubMed id 16282592)1, 2 Meka H.... Brick P. (Nucleic Acids Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. (PubMed id 9852112)1, 2 Kershnar E.... Chiang C.-M. (J. Biol. Chem. 1998)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. (PubMed id 22422068)1 Dahiya S....Wigdahl B. (J. Gen. Virol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5433 HGNC: 9191 AceView: POLR2D Ensembl:ENSG00000144231 euGenes: HUgn5433
    ECgene: POLR2D Kegg: 5433 H-InvDB: POLR2D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for POLR2D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for POLR2D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for POLR2D gene:
    Search GeneIP for patents involving POLR2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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