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Aliases for POLE2 Gene

Aliases for POLE2 Gene

  • Polymerase (DNA) Epsilon 2, Accessory Subunit 2 3
  • DNA Polymerase Epsilon Subunit B 2 3 4
  • Polymerase (DNA Directed), Epsilon 2, Accessory Subunit 3 5
  • Polymerase (DNA Directed), Epsilon 2 (P59 Subunit) 2 3
  • DNA Polymerase II Subunit 2 3 4
  • EC 2.7.7.7 4 63
  • DPE2 3 4

External Ids for POLE2 Gene

Previous GeneCards Identifiers for POLE2 Gene

  • GC14M047432
  • GC14M043906
  • GC14M048100
  • GC14M049180
  • GC14M050110
  • GC14M030227

Summaries for POLE2 Gene

GeneCards Summary for POLE2 Gene

POLE2 (Polymerase (DNA) Epsilon 2, Accessory Subunit) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and DNA strand elongation. GO annotations related to this gene include DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for POLE2 Gene

  • Participates in DNA repair and in chromosomal DNA replication.

Gene Wiki entry for POLE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLE2 Gene

Genomics for POLE2 Gene

Regulatory Elements for POLE2 Gene

Enhancers for POLE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around POLE2 on UCSC Golden Path with GeneCards custom track

Promoters for POLE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around POLE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for POLE2 Gene

Chromosome:
14
Start:
49,643,552 bp from pter
End:
49,688,422 bp from pter
Size:
44,871 bases
Orientation:
Minus strand

Genomic View for POLE2 Gene

Genes around POLE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
POLE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for POLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLE2 Gene

Proteins for POLE2 Gene

  • Protein details for POLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56282-DPOE2_HUMAN
    Recommended name:
    DNA polymerase epsilon subunit 2
    Protein Accession:
    P56282
    Secondary Accessions:
    • A0AV55
    • A4FU92
    • A4LBB7
    • A6NH58
    • B4DDE6
    • O43560

    Protein attributes for POLE2 Gene

    Size:
    527 amino acids
    Molecular mass:
    59537 Da
    Quaternary structure:
    • Component of the epsilon DNA polymerase complex consisting of four subunits: POLE, POLE2, POLE3 and POLE4.
    Miscellaneous:
    • In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

    Three dimensional structures from OCA and Proteopedia for POLE2 Gene

    Alternative splice isoforms for POLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLE2 Gene

Proteomics data for POLE2 Gene at MOPED

Selected DME Specific Peptides for POLE2 Gene

Post-translational modifications for POLE2 Gene

  • Ubiquitination at Lys 270 and Lys 523
  • Modification sites at PhosphoSitePlus

Other Protein References for POLE2 Gene

Domains & Families for POLE2 Gene

Gene Families for POLE2 Gene

Protein Domains for POLE2 Gene

Suggested Antigen Peptide Sequences for POLE2 Gene

Graphical View of Domain Structure for InterPro Entry

P56282

UniProtKB/Swiss-Prot:

DPOE2_HUMAN :
  • Belongs to the DNA polymerase epsilon subunit B family.
Family:
  • Belongs to the DNA polymerase epsilon subunit B family.
genes like me logo Genes that share domains with POLE2: view

Function for POLE2 Gene

Molecular function for POLE2 Gene

GENATLAS Biochemistry:
polymerase (DNA directed) epsilon 2,59kDa,potential adaptor between the catalytic subunit and other accessory proteins
UniProtKB/Swiss-Prot CatalyticActivity:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function:
Participates in DNA repair and in chromosomal DNA replication.

Enzyme Numbers (IUBMB) for POLE2 Gene

genes like me logo Genes that share phenotypes with POLE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for POLE2

miRNA for POLE2 Gene

miRTarBase miRNAs that target POLE2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for POLE2 Gene

Localization for POLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLE2 Gene COMPARTMENTS Subcellular localization image for POLE2 gene
Compartment Confidence
nucleus 5
mitochondrion 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for POLE2 Gene

Pathways & Interactions for POLE2 Gene

SuperPathways for POLE2 Gene

genes like me logo Genes that share pathways with POLE2: view

Gene Ontology (GO) - Biological Process for POLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0000722 telomere maintenance via recombination TAS --
GO:0006260 DNA replication IEA,TAS 9405441
GO:0042276 error-prone translesion synthesis IBA --
genes like me logo Genes that share ontologies with POLE2: view

No data available for SIGNOR curated interactions for POLE2 Gene

Drugs & Compounds for POLE2 Gene

(6) Drugs for POLE2 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Target, inhibitor Apoptosis inducer in CLL cells 68
Cytarabine Approved, Investigational Pharma 1054
dctp Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
dgtp Experimental Pharma 0

(2) Additional Compounds for POLE2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
365-08-2

(1) ApexBio Compounds for POLE2 Gene

Compound Action Cas Number
Cytarabine 147-94-4
genes like me logo Genes that share compounds with POLE2: view

Transcripts for POLE2 Gene

Unigene Clusters for POLE2 Gene

Polymerase (DNA directed), epsilon 2, accessory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for POLE2 Gene

No ASD Table

Relevant External Links for POLE2 Gene

GeneLoc Exon Structure for
POLE2
ECgene alternative splicing isoforms for
POLE2

Expression for POLE2 Gene

mRNA expression in normal human tissues for POLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for POLE2 Gene

This gene is overexpressed in Heart (56.1) and Fetal ovary (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLE2 Gene



SOURCE GeneReport for Unigene cluster for POLE2 Gene Hs.162777

genes like me logo Genes that share expression patterns with POLE2: view

Protein tissue co-expression partners for POLE2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLE2 Gene

Orthologs for POLE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for POLE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia POLE2 35
  • 92.73 (n)
  • 94.88 (a)
POLE2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLE2 35
  • 91.52 (n)
  • 93.55 (a)
mouse
(Mus musculus)
Mammalia Pole2 35
  • 86.27 (n)
  • 90.13 (a)
Pole2 16
Pole2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia POLE2 35
  • 99.56 (n)
  • 99.05 (a)
POLE2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pole2 35
  • 86.53 (n)
  • 90.89 (a)
oppossum
(Monodelphis domestica)
Mammalia POLE2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia POLE2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves POLE2 35
  • 78.05 (n)
  • 82.16 (a)
POLE2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia POLE2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pole2 35
  • 76.09 (n)
  • 81.02 (a)
Str.3481 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1015 35
zebrafish
(Danio rerio)
Actinopterygii pole2 35
  • 65.4 (n)
  • 73.24 (a)
pole2 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6430 35
fruit fly
(Drosophila melanogaster)
Insecta CG10489 37
  • 44 (a)
Pole2 35
  • 49.12 (n)
  • 42.86 (a)
Pole2 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004614 35
  • 50.23 (n)
  • 42.07 (a)
worm
(Caenorhabditis elegans)
Secernentea F08B4.5 37
  • 30 (a)
pole-2 35
  • 47.19 (n)
  • 31.73 (a)
pole-2 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPB2 36
  • 21 (a)
OneToOne
DPB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DPB2 35
  • 48.31 (n)
  • 39.53 (a)
rice
(Oryza sativa)
Liliopsida Os05g0160800 35
  • 49.77 (n)
  • 40.06 (a)
Species with no ortholog for POLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for POLE2 Gene

ENSEMBL:
Gene Tree for POLE2 (if available)
TreeFam:
Gene Tree for POLE2 (if available)

Paralogs for POLE2 Gene

Pseudogenes.org Pseudogenes for POLE2 Gene

genes like me logo Genes that share paralogs with POLE2: view

No data available for Paralogs for POLE2 Gene

Variants for POLE2 Gene

Sequence variations from dbSNP and Humsavar for POLE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34857719 - 49,674,422(-) AGAGC(A/C)CGTTT intron-variant, nc-transcript-variant, reference, missense
rs34574266 - 49,650,396(+) TACCT(C/G)TTTAT nc-transcript-variant, reference, missense
rs45515094 - 49,647,317(-) TTATC(C/T)TTCTA nc-transcript-variant, reference, missense
rs7141539 -- 49,644,354(+) aaaaa(A/T)aaaaa intron-variant
rs8017401 -- 49,643,253(+) ccgag(A/T)agctg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for POLE2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
esv2748707 CNV Deletion 23290073
esv3082 CNV Deletion 18987735
esv1091889 CNV Deletion 17803354
esv2748709 CNV Deletion 23290073

Variation tolerance for POLE2 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for POLE2 Gene

HapMap Linkage Disequilibrium report
POLE2
Human Gene Mutation Database (HGMD)
POLE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLE2 Gene

Disorders for POLE2 Gene

Relevant External Links for POLE2

Genetic Association Database (GAD)
POLE2
Human Genome Epidemiology (HuGE) Navigator
POLE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
POLE2

No disorders were found for POLE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for POLE2 Gene

Publications for POLE2 Gene

  1. The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. (PMID: 9443964) Jokela M. … Syvaeoja J.E. (Nucleic Acids Res. 1998) 2 3 4 67
  2. Mechanisms of anti-cancer action and pharmacology of clofarabine. (PMID: 19576186) Zhenchuk A. … Albertioni F. (Biochem. Pharmacol. 2009) 25 26
  3. The solution structure of the amino-terminal domain of human DNA polymerase epsilon subunit B is homologous to C-domains of AAA+ proteins. (PMID: 18676977) Nuutinen T. … Syvaoja J.E. (Nucleic Acids Res. 2008) 3 23
  4. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. (PMID: 9405441) Li Y. … Linn S. (J. Biol. Chem. 1997) 2 3
  5. DNA Polymerases as targets for gene therapy of hepatocellular carcinoma. (PMID: 25924900) Liu H. … Jia Z. (BMC Cancer 2015) 3

Products for POLE2 Gene

Sources for POLE2 Gene

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