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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PLA2G2E Gene

protein-coding GIFtS: 54
GCID: GC01M020247

phospholipase A2, group IIE

Explore 5 diseases affiliated with
PLA2G2E via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phospholipase A2, Group IIE¹ ²
Phosphatidylcholine 2-Acylhydrolase 2E² ³
GIIE SPLA2² ³
SPLA2-IIE¹
Group IIE Secretory Phospholipase A2²
EC 3.1.1.4³

External Ids:	HGNC: 13414¹	Entrez Gene: 30814²	Ensembl: ENSG00000188784⁷	UniProtKB: Q9NZK7³

Export aliases for PLA2G2E gene to outside databases

Previous GC identifers: GC01M019816 GC01M019281 GC01M019392 GC01M019716 GC01M019992 GC01M020119 GC01M018492

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PA2GE_HUMAN, Q9NZK7

Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a

preference for arachidonic-containing phospholipids

summary for PLA2G2E:

Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic

molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which

cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates

lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+

concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including

roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PLA2G2E gene promoter:
Pax-6 Tal-1beta HNF-4alpha1 FOXL1 HEN1 COMP1 FOXJ2 (long isoform) FOXJ2 ITF-2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PLA2G2E promoter sequence

Search SABiosciences Chromatin IP Primers for PLA2G2E

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G2E

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13

PLA2G2E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G2E gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M020247: view genomic region (about GC identifiers)

Start:	20,246,502 bp from pter	End:	20,250,110 bp from pter
Size:	3,609 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PA2GE_HUMAN, Q9NZK7 (See protein sequence)

Recommended Name: Group IIE secretory phospholipase A2 precursor

Size: 142 amino acids; 15989 Da

Cofactor: Binds 1 calcium ion per subunit

Subcellular location: Secreted

Secondary accessions: Q5VXJ8

Explore the universe of human proteins at neXtProt for PLA2G2E: NX_Q9NZK7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NZK7

PLA2G2E Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055404.1

ENSEMBL proteins:

ENSP00000364257

Reactome Protein details: Q9NZK7
Human Recombinant Protein Products:

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	Uscn Proteins for PLA2G2E

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

PLA2G2E for ontologies About GeneDecksing

PLA2G2E Antibody Products:

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	Uscn Antibodies for PLA2G2E
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Assay Products for PLA2G2E:

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	GenScript Custom Assay Services for PLA2G2E
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	Uscn ELISAs and CLIAs for PLA2G2E

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PLA2G2E for domains About GeneDecksing

3 InterPro domains/families:

IPR016090 PLipase_A2

IPR001211 PLipase_A2_euk

IPR013090 PLipase_A2_AS

Graphical View of Domain Structure for InterPro Entry Q9NZK7

ProtoNet protein and cluster: Q9NZK7

1 Blocks protein family: IPB001211 Phospholipase A2

UniProtKB/Swiss-Prot: PA2GE_HUMAN, Q9NZK7

Similarity: Belongs to the phospholipase A2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PA2GE_HUMAN, Q9NZK7

Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a

preference for arachidonic-containing phospholipids

Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

Enzyme Number (IUBMB): EC 3.1.1.4¹

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PLA2G2E (see all 7) OriGene shRNA RFP: PLA2G2E OriGene siRNA: PLA2G2E
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Gene Editing
Products:

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		Search LifeMap BioReagents cell lines for PLA2G2E

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PLA2G2E

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004623	phospholipase A2 activity	IEA	--
GO:0005509	calcium ion binding	IEA	--

PLA2G2E for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PLA2G2E:

Small cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Acyl chain remodelling of PE

Acyl chain remodelling of PE	1.00	Acyl chain remodelling of PG	0.54
Acyl chain remodelling of PC	0.85	phospholipases	0.39
Acyl chain remodelling of PS	0.74	Synthesis of PA	0.31
Acyl chain remodelling of PI	0.62

alpha-Linolenic acid metabolism

	alpha-Linolenic acid metabolism	1.00			Ether lipid metabolism	0.44
	Linoleic acid metabolism	0.52			Fat digestion and absorption	0.32

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Immune response CD16 signaling in NK cells

Immune response CD16 signaling in NK cells

1.00

Immune response_CD16 signaling in NK cells

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PLA2G2E

Immune response CD16 signaling in NK cells

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G2E (see all 7)

	Chemokine Signaling
	DHA Signaling
	Antioxidant Action of Vitamin-C
	cAMP Pathway
	Phospholipase-C Pathway

1 GeneGo (Thomson Reuters) Pathway for PLA2G2E

Immune response CD16 signaling in NK cells

1 BioSystems Pathway for PLA2G2E

phospholipases

5/10 Reactome Pathways for PLA2G2E (see all 10)

	Acyl chain remodelling of PE
	Synthesis of PA
	Metabolism
	Acyl chain remodelling of PC
	Acyl chain remodelling of PG

5/16 Kegg Pathways (Kegg details for PLA2G2E) (see all 16):

	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism

PLA2G2E for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PLA2G2E

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for PLA2G2E (ENSP00000364257⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALOX12B	ENSP00000315167⁴	STRING: ENSP00000315167
CYP4F2	ENSP00000221700⁴	STRING: ENSP00000221700
PTDSS2	ENSP00000308258⁴	STRING: ENSP00000308258
PTGS1	ENSP00000354612⁴	STRING: ENSP00000354612
PTGS2	ENSP00000356438⁴	STRING: ENSP00000356438

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006654	phosphatidic acid biosynthetic process	TAS	--
GO:0006954	inflammatory response	TAS	10681567
GO:0016042	lipid catabolic process	IEA	--
GO:0036148	phosphatidylglycerol acyl-chain remodeling	TAS	--

PLA2G2E for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PLA2G2E:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PLA2G2E available from Tocris Bioscience About this table

Compound	Action	CAS #
RHC 80267	Diacylglycerol lipase inhibitor	[83654-05-1]
AACOCF3	Phospholipase A2 inhibitor	[149301-79-1]
OBAA	Phospholipase A2 inhibitor	[221632-26-4]
PACOCF3	Phospholipase A2 inhibitor	[141022-99-3]

10/2140 HMDB Compounds for PLA2G2E (see all 2140) About this table

Compound	Synonyms	CAS #	PubMed Ids
PC(O-16:0/18:2(9Z,12Z))	1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)	88542-95-4	12486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)	--	12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))	1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)	103597-60-0	12486725
Alpha-Linolenic acid	(9,12,15)-linolenate (see all 23)	463-40-1	--
Arachidic acid	Arachate (see all 10)	506-30-9	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Calcium	Ca (see all 2)	7440-70-2	--
Heptadecanoic acid	Heptadecanoate (see all 16)	506-12-7	--
Heptadecanoyl CoA	Heptadecanoyl coenzyme A (see all 19)	3546-17-6	--
Linoleic acid	(9Z,12Z)-9,12-Octadecadienoate (see all 26)	60-33-3	--

10/14 DrugBank Compounds for PLA2G2E (see all 14) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,4-Butanediol	--	110-63-4	target	--	17139284 17016423 10592235
Glycerol	--	--	target	--	17139284 17016423 10592235
Oxyphenbutazone	1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione (see all 21)	129-20-4	target	--	17139284 17016423 10592235
P-Anisic Acid	--	100-09-4	target	--	17139284 17016423 10592235
(2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID	--	--	target	--	10592235
(2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one	--	--	target	--	10592235
1H-INDOL-3-YLACETIC ACID	--	--	target	--	10592235
2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE	--	--	target	--	10592235
3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL	--	--	target	--	10592235
9-Hydroxy-8-Methoxy-6-Nitro-Phenanthrol[3,4-D][1,3]Dioxole-5-Carboxylic Acid	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about PLA2G2E / PA2GE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLA2G2E gene:

NM_014589.2

Unigene Cluster for PLA2G2E:

Phospholipase A2, group IIE

Hs.272372

Unigene Representative Sequence: AF189279

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000375116(uc001bct.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLA2G2E

Additional cDNA sequence:

AF189279.1 BC069116.1

1 DOTS entry:

DT.92024965

3 AceView cDNA sequences:

BC069116 NM_014589 AF189279

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLA2G2E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PLA2G2E expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PLA2G2E Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLA2G2E

SOURCE GeneReport for Unigene cluster: Hs.272372

UniProtKB/Swiss-Prot: PA2GE_HUMAN, Q9NZK7

Tissue specificity: Restricted to the brain, heart, lung, and placenta

SABiosciences Expression via Pathway-Focused PCR Array including PLA2G2E:

VEGF Signaling in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PLA2G2E

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLA2G2E gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PLA2G2E¹	phospholipase A2, group IIE	60.1(n) 54.01(a)		426747 NM_001184949.1 NP_001171878.1
fruit fly (Drosophila melanogaster)	Insecta	CG14507⁶	--	10(a)	possible ortholog	3R(25051926-25053447)
worm (Caenorhabditis elegans)	Secernentea	C07E3.9⁶ Y69A2AL.2⁶	--	25(a) 19(a)	possible ortholog possible ortholog	II(10350700-10351557) IV(2482256-2484111)

ENSEMBL Gene Tree for PLA2G2E (if available)
TreeFam Gene Tree for PLA2G2E (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PLA2G2E gene

ENSG00000258417² PLA2G2F² PLA2G1B² PLA2G2A² PLA2G2D² OC90² PLA2G10² PLA2G5²

PLA2G2C²

8 SIMAP similar genes for PLA2G2E using alignment to 1 protein entry: PA2GE_HUMAN:

PLA2G10 PLA2G2F PLA2G2A PLA2G2D PLA2G5 PLA2G1B

PLA2G2C OC90

PLA2G2E for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114089384^1,2	C,F,	--	20246312(+)	`TTACTG/ATCATG`	1	--	ds500¹		1		WA	118
rs182540805^1,2		--	20246507(+)	`TTATGA/GGAAAA`	1	--	ds500¹		0	--	--	--	--
rs186672757^1,2		--	20246703(+)	`ATTTTC/TCAAAG`	1	--	ds500¹		0	--	--	--	--
rs192084901^1,2	C,	--	20246762(+)	`CGAGGC/TGGGAC`	1	--	ds500¹		0	--	--	--	--
rs142945210^1,2	C,	--	20246777(+)	`GGGAC-/GGGGGG`	1	--	ds500¹		0	--	--	--	--
rs78889206^1,2	C,F,	--	20246852(+)	`CATATT/CTGCGG`	2	/K /R	mis¹		2		WA NA	4670
rs61729970^1,2	C,F,	--	20246876(+)	`GGTTGC/TGGCGA`	2	H R	mis¹		7		NS CSA WA NA EA EU	6051
rs201523720^1,2	F	--	20246898(+)	`AGCCCT/GCTTGT`	2	/R	syn¹		1		EU	1207
rs199821584^1,2	C,	--	20246944(+)	`CCGGCT/CGGATG`	1	--	spa¹		1		EU	1207
rs202119329^1,2		--	20246964(+)	`GAGTCA/CGGGAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PLA2G2E (20246502 - 20250110 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PLA2G2E: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PLA2G2E for disorders About GeneDecksing

5 diseases for PLA2G2E: About MalaCards

common cold ulcerative colitis toxoplasmosis pancreatitis

neuronitis

Human Genome Epidemiology (HuGE) Navigator: PLA2G2E (2 documents)

Export disorders for PLA2G2E gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PLA2G2E gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with PLA2G2E)

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Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. (PubMed id 10681567)^{1, 2, 3} Suzuki N.... Hanasaki K. (2000)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Arachidonate release and eicosanoid generation by gro up IIE phospholipase A(2). (PubMed id 11922621)^{1, 3} Murakami M....Kudo I. (2002)
Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)¹ Segat L....Crovella S. (2010)
Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)¹ McGovern D.P....Weersma R.K. (2010)
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)¹ Silverberg M.S....Duerr R.H. (2009)
Genome-wide association study of ulcerative colitis i dentifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)¹ .... D.P. (2009)
Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)⁶ Kurz M....Kramer W. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 30814	HGNC: 13414	AceView: PLA2G2E	Ensembl:ENSG00000188784	euGenes: HUgn30814
ECgene: PLA2G2E	Kegg: 30814	H-InvDB: PLA2G2E

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PLA2G2E	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PLA2G2E	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PLA2G2E gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PLA2G2E gene:
Search GeneIP for patents involving PLA2G2E

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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phospholipase A2, group IIE

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PLA2G2E Gene

phospholipase A2, group IIE

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