Aliases for PIGM Gene
External Ids for PIGM Gene
Previous GeneCards Identifiers for PIGM Gene
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIGM Gene
PIGM (Phosphatidylinositol Glycan Anchor Biosynthesis, Class M) is a Protein Coding gene. Diseases associated with PIGM include glycosylphosphatidylinositol deficiency and hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include transferase activity, transferring hexosyl groups and mannosyltransferase activity.
UniProtKB/Swiss-Prot for PIGM Gene
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.