Aliases for PIGM Gene
External Ids for PIGM Gene
Previous GeneCards Identifiers for PIGM Gene
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIGM Gene
PIGM (Phosphatidylinositol Glycan Anchor Biosynthesis Class M) is a Protein Coding gene. Diseases associated with PIGM include Glycosylphosphatidylinositol Deficiency and Hypercoagulability Syndrome Due To Glycosylphosphatidylinositol Deficiency. Among its related pathways are Glycosylphosphatidylinositol (GPI)-anchor biosynthesis and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include transferase activity, transferring hexosyl groups and mannosyltransferase activity.
UniProtKB/Swiss-Prot for PIGM Gene
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.