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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIGM Gene

protein-coding   GIFtS: 53
GCID: GC01M159997

Phosphatidylinositol Glycan Anchor Biosynthesis, Class M

(Previous names: phosphatidylinositol glycan, class M)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol Glycan Anchor Biosynthesis, Class M1 2     GPI Mannosyltransferase I2 3
Dol-P-Man Dependent GPI Mannosyltransferase1 2     Phosphatidylinositol Glycan, Class M1
DPM:GlcN-(Acyl-)PI Mannosyltransferase1 2     PIG-M Mannosyltransferase2
GPI Mannosyltransferase 11 2     EC 2.4.1.-3
Phosphatidylinositol-Glycan Biosynthesis Class M Protein2 3     PIG-M3
GPI-MT-I2 3     EC 2.4.18

External Ids:    HGNC: 188581   Entrez Gene: 931832   Ensembl: ENSG000001433157   OMIM: 6102735   UniProtKB: Q9H3S53   

Export aliases for PIGM gene to outside databases

Previous GC identifers: GC01M157791 GC01M155731 GC01M156777 GC01M157216 GC01M156812 GC01M158261 GC01M131354


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIGM Gene:
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in
GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three
mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins
to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI
on the lumenal side of the endoplasmic reticulum. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIGM Gene: 
PIGM (phosphatidylinositol glycan anchor biosynthesis, class M) is a protein-coding gene. Diseases associated with PIGM include glycosylphosphatidylinositol deficiency, and babesiosis, and among its related super-pathways are Post-translational modification: synthesis of GPI-anchored proteins and Post-translational protein modification. GO annotations related to this gene include mannosyltransferase activity.

UniProtKB/Swiss-Prot: PIGM_HUMAN, Q9H3S5
Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first
alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIGM gene promoter:
         HOXA9B   HOXA9   NRSF form 1   Nkx2-5   NRSF form 2   c-Rel   Nkx6-1   Ik-2   Cart-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIGM promoter sequence
   Search SABiosciences Chromatin IP Primers for PIGM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIGM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

PIGM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIGM gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159997:  view genomic region     (about GC identifiers)

Start:
159,997,462 bp from pter      End:
160,001,783 bp from pter
Size:
4,322 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIGM_HUMAN, Q9H3S5 (See protein sequence)
Recommended Name: GPI mannosyltransferase 1  
Size: 423 amino acids; 49460 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for PIGM: NX_Q9H3S5

Explore proteomics data for PIGM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H3S5

  • 4/13 DME Specific Peptides for PIGM (Q9H3S5) (see all 13)
     FVTFNKV  FCCFLHT  VCTSQYF  VHMKIYP 

    PIGM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIGM Protein Expression
    REFSEQ proteins: NP_660150.1  
    ENSEMBL proteins: 
     ENSP00000357069  
    Reactome Protein details: Q9H3S5
    Human Recombinant Protein Products for PIGM: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    PIGM for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DOLPM: Dolichyl D-mannosyl phosphate dependent mannosyltransferases
    PIG: Phosphatidylinositol glycan anchor biosynthesis

    1 InterPro protein domain:
     IPR007704 Mannosyltransferase_DXD

    Graphical View of Domain Structure for InterPro Entry Q9H3S5

    ProtoNet protein and cluster: Q9H3S5

    UniProtKB/Swiss-Prot: PIGM_HUMAN, Q9H3S5
    Similarity: Belongs to the PIGM family


    PIGM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIGM_HUMAN, Q9H3S5
    Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first
    alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000030mannosyltransferase activity IEA--
    GO:0016758transferase activity, transferring hexosyl groups ----
         
    PIGM for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidPIGM 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIGM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational modification: synthesis of GPI-anchored proteins0.79
    Synthesis of glycosylphosphatidylinositol (GPI)0.64
    Glycosylphosphatidylinositol(GPI)-anchor biosynthesis0.79
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for PIGM
        Metabolism of proteins
    Post-translational modification: synthesis of GPI-anchored proteins
    Post-translational protein modification
    Synthesis of glycosylphosphatidylinositol (GPI)


    2         Kegg Pathways  (Kegg details for PIGM):
        Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: PIGM_HUMAN, Q9H3S5
    Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis


    PIGM for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIGM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/22 Interacting proteins for PIGM (Q9H3S53 ENSP000003570694) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIGXQ8TBF53, ENSP000003173014I2D: score=1 STRING: ENSP00000317301
    ALDH3A1P308383I2D: score=2 
    GIPC1O149083I2D: score=2 
    ACTBP607093I2D: score=1 
    ACTG1P632613I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006501C-terminal protein lipidation TAS--
    GO:0006506GPI anchor biosynthetic process ----
    GO:0016254preassembly of GPI anchor in ER membrane TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    PIGM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIGM

    10/898 HMDB Compounds for PIGM (see all 898)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Dehydrosphinganine1-Hydroxy-2-amino-3-oxo-octadecane (see all 9)16105-69-4--
    3-O-Sulfogalactosylceramide (d18:1/12:0)Sulfatide (d18:1/12:0) (see all 13)852100-88-0--
    3-O-Sulfogalactosylceramide (d18:1/14:0)Sulfatide (d18:1/14:0) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/16:0)Sulfatide (d18:1/16:0) (see all 13)862509-48-6--
    3-O-Sulfogalactosylceramide (d18:1/18:0)Sulfatide (d18:1/18:0) (see all 13)244215-65-4--
    3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))Sulfatide (d18:1/18:1(9Z)) (see all 13)----
    3-O-Sulfogalactosylceramide (d18:1/20:0)Sulfatide (d18:1/20:0) (see all 13)265096-81-9--
    3-O-Sulfogalactosylceramide (d18:1/22:0)Sulfatide (d18:1/22:0) (see all 13)265096-83-1--
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    3-O-Sulfogalactosylceramide (d18:1/24:1(15Z))Sulfatide (d18:1/24:1(15Z)) (see all 13)151057-28-2--

    Search CenterWatch for drugs/clinical trials and news about PIGM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIGM gene: 
    NM_145167.2  

    Unigene Cluster for PIGM:

    Phosphatidylinositol glycan anchor biosynthesis, class M
    Hs.552810  [show with all ESTs]
    Unigene Representative Sequence: NM_145167
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000368090(uc001fuv.1)
    miRNA
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    hsa-miR-548am hsa-miR-576-5p hsa-miR-892b hsa-miR-7-2* hsa-miR-3133 hsa-miR-500a hsa-miR-9 hsa-miR-501-5p
    SwitchGear 3'UTR luciferase reporter plasmidPIGM 3' UTR sequence
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    Additional mRNA sequence: 

    AB028127.1 AK074655.1 BC001803.1 BC011395.1 BC019865.1 

    5 DOTS entries:

    DT.109042  DT.108723  DT.100779967  DT.97781362  DT.100667066 

    24/125 AceView cDNA sequences (see all 125):

    BC001803 H88189 BQ018479 BM684777 AI720413 W32308 CD519160 BM692305 
    CR621612 NM_145167 BX471158 AI761712 BQ639200 Z40760 AK074655 CR602111 
    BU076247 AI262873 AB028127 BQ434884 CR606417 AA161444 BI760251 CR624318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIGM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIGM Expression
    About this image


    See PIGM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIGM

    SOURCE GeneReport for Unigene cluster: Hs.552810
        SABiosciences Custom PCR Arrays for PIGM
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIGM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIGM gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pigm1 , 5 phosphatidylinositol glycan anchor biosynthesis, class more1, 5 85.66(n)1
    89.83(a)1
      1 (79.73 cM)5
    675561  NM_026234.41  NP_080510.11 
     1723765315 
    chicken
    (Gallus gallus)
    Aves PIGM1 phosphatidylinositol glycan anchor biosynthesis, class more 65.58(n)
    62.72(a)
      428583  NM_001031522.2  NP_001026693.2 
    lizard
    (Anolis carolinensis)
    Reptilia PIGM6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    1(216582886-216584154)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.170512 Transcribed sequence with weak similarity to protein more 75.81(n)    BX741733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641772 hypothetical protein MGC64177 72.73(n)   393361  BC053299.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423791 CG42379 48.88(n)
    42.63(a)
      7354410  NM_137756.3  NP_611600.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0491.11 Protein B0491.1 51.11(n)
    44.8(a)
      174736  NM_064025.2  NP_496426.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GPI14(YJR013W)4
    GPI141
    Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase more4
    Gpi14p1
    50.09(n)1
    40.91(a)1
      10(460382-461593)4
    8534701, 4  NP_012547.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PNT11 GPI mannosyltransferase 1 47.46(n)
    42.89(a)
      832274  NM_001203432.1  NP_001190361.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06702001 hypothetical protein 49.91(n)
    42.56(a)
      4333686  NM_001057404.1  NP_001050869.1 


    ENSEMBL Gene Tree for PIGM (if available)
    TreeFam Gene Tree for PIGM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 SNPs in PIGM are shown (see all 157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114140391,2
    C--159999185(+) TTTTT-/T/TT  
            
    GATAT
    2 -- ut31 trp30--------
    rs666691031,2
    C--160003289(+) TTCAA-/CTTTAT 1 -- us2k10--------
    rs801707361,2
    F--166492665(+) CCTAGG/CTATAA 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs13190861,2
    C,F,A,H--166492693(-) TGAATG/AGAAAA 1 -- ds5001 ese3 trp321Minor allele frequency- A:0.18NA EA NS WA 2569
    rs1424671851,2
    --166492757(+) AGAAGC/TAACAG 1 -- ds50010--------
    rs64275031,2
    C,F,A,H--166492898(+) AAGCAC/GTGGGT 1 -- ds5001 ese311Minor allele frequency- G:0.23NS EA NA WA 782
    rs1898569271,2
    --166493036(+) ACACAC/TAATCT 1 -- ds50010--------
    rs19340851,2
    C,F,O,A--166493052(+) ATCATA/CCCTCT 1 -- ds5001 ese311Minor allele frequency- N:0.00EA NA WA 582
    rs1486382301,2
    C--166493214(+) GAAGC-/AAAAAA 1 -- ut310--------
    rs1807670701,2
    C--166493314(+) CTAAAC/TGTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIGM (159997462 - 160001783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PIGM:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669935CNV Deletion23128226


    Human Gene Mutation Database (HGMD): PIGM
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIGM
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610273   
    OMIM disorders: 610293  
    UniProtKB/Swiss-Prot: PIGM_HUMAN, Q9H3S5
  • Glycosylphosphatidylinositol deficiency (GPID) [MIM:610293]: Autosomal recessive trait that results in a
    propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences
    of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong
    reduction of expression. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for PIGM:    About MalaCards
    glycosylphosphatidylinositol deficiency    babesiosis    thrombosis


    PIGM for disorders           About GeneDecksing


    Export disorders for PIGM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIGM gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with PIGM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. (PubMed id 11226175)1, 2, 3 Maeda Y....Kinoshita T. (2001)
    2. Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. (PubMed id 16767100)1, 2 Almeida A.M.... Karadimitris A. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Understanding human glycosylation disorders: biochemis try leads the charge. (PubMed id 23329837)1 Freeze H.H. (2013)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. (PubMed id 15635094)1 Ashida H.... Kinoshita T. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93183 HGNC: 18858 AceView: PIGM Ensembl:ENSG00000143315 euGenes: HUgn93183
    ECgene: PIGM Kegg: 93183 H-InvDB: PIGM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIGM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIGM gene:
    Search GeneIP for patents involving PIGM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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