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PGR Gene

protein-coding GIFtS: 75

GC11M100414

progesterone receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
NR3C3 ^¹, ², ³
PR ^¹, ², ³

Descriptions
Nuclear receptor subfamily 3 group C member 3 ^³
progesterone receptor ^²

External Ids
HGNC: 8910¹
Entrez Gene: 5241²
UniProtKB: P06401³
Ensembl: ENSG00000082175⁷

Search outside databases for aliases for PGR gene

Previous GC identifers: GC11M103103 GC11M102266 GC11M100943 GC11M100446

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PGR:

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the

physiological effects of progesterone, which plays a central role in reproductive events

associated with the establishment and maintenance of pregnancy. This gene uses two distinct

promotors and translation start sites in the first exon to produce two isoforms, A and B. The two

isoforms are identical except for the additional 165 amino acids found in the N-terminus of

isoform A only, and mediate their own response genes and physiologic effects with little overlap.

The location of transcription initiation for isoform B has not been clearly determined. [provided

by RefSeq]

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401

Function: Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation

Gene Wiki entry for PGR (Progesterone_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PGR gene

Entrez Gene cytogenetic band: 11q22-q23 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q22-q23

PGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M100414: (about GC identifiers)

Start:	100,414,313 bp from pter
End:	100,506,465 bp from pter
Size:	92,153 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401 (See protein sequence)

Recommended Name: Progesterone receptor

Size: 933 amino acids; 98981 Da

Subunit: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes

ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with

PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits

DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires

ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK

Subcellular location: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell

cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases

Subcellular location: Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear

PDB structures from and Proteopedia :

1A28 (3D)

1E3K (3D)

1SQN (3D)

1SR7 (3D)

1ZUC (3D)

2C7A (3D)

2OVH (3D)

2OVM (3D)

2W8Y (3D)

Secondary accessions: A7X8B0 Q9UPF7

Alternative splicing: 2 isoforms: P06401-1 P06401-2

Post-translational modifications:

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent.

Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and

modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also

requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is

increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex.

Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA

and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear

translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at

Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by

ERK1/2 MAPK is required for interaction with SP1¹

Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three

sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of

sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at

Ser-294¹

Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by

MAPK-mediated phosphorylation on Ser-294¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000917.3

ENSEMBL proteins:

ENSP00000263463 ENSP00000325120

Human Recombinant Proteins

	Invitrogen human recombinant proteins for PGR
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Progesterone receptor B, Progesterone Receptor)
	Human Recombinant Proteins from Abnova (PGR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for PGR:

	Invitrogen Antibodies for PGR
	Millipore Mono- and Polyclonal Antibodies for the study of PGR
	Sigma-Aldrich Antibodies for PGR
	R&D Systems Antibodies for PGR (Progesterone R/NR3C3)
	Cell Signaling Technology (CST) Antibodies for PGR (PGR, PR, Progesterone Receptor A/B)
	Antibodies from Abcam (Progesterone receptor B, Progesterone Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PGR)
	Novus Biologicals Antibodies for PGR

Assays for PGR:

	Invitrogen Assays for PGR
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06401

ProtoNet protein and cluster: P06401

2 Blocks protein families:

IPB000128 Progesterone receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PGR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PGR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000926

Applied Biosystems Silencer® siRNAs for PGR

Sigma-Aldrich siRNA and siRNA Panels for PGR

Sigma-Aldrich shRNA Panels and shRNA for PGR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000926
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000926
untagged cDNA clone in CMV expression vector: NM_000926

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000926

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401

Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic

gene expression and affect cellular proliferation and differentiation in target tissues.

Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone

stimulation

Function: Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation

Genatlas biochemistry entry for PGR:

progesterone receptor with two distinct forms PR-A (94kDa),PR-B (114kDa) transcribed from distinct

promoters of PRG,with PR-A acting as a transcriptional repressor and PR-B as an

activator,steroid/thyroid hormone receptor superfamily,required for normal mammary development in

the puberty

8 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Pgr):

behavior/neurological	embryogenesis	endocrine/exocrine gland	immune system	life span-post-weaning/aging
normal	reproductive system	tumorigenesis

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003707	steroid hormone receptor activity	TAS	10840043
GO:0005496	steroid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for PGR (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling
Glucocorticoid Receptor Signaling

GeneDecks PGR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PGR

5/112 Interacting proteins for PGR (ENSP00000325120³ P06401^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 112 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUEDC2	Q9H467¹^,²	STRING (score=.767) EBI-78539, EBI-1248228 MINT-4787932 MINT-4787991 MINT-4787971 MINT-4788009 MINT-4787894 MINT-4787873 MINT-4787953 EBI-78539, EBI-1248228 MINT-4787932 MINT-4787991 MINT-4787971 MINT-4788009 MINT-4787894 MINT-4787873 MINT-4787953
JDP2	Q8WYK2¹^,²	STRING (score=.924) EBI-78539, EBI-1248415 MINT-4788079 EBI-78539, EBI-1248415 MINT-4788079
NCOR2	Q9Y618¹^,²	STRING (score=.999) EBI-78539, EBI-80830 MINT-4788120 EBI-78539, EBI-80830 MINT-4788120
PRMT2	P55345¹	EBI-78539, EBI-78458
SMARCD1	Q96GM5¹	EBI-78539, EBI-358489

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001542	ovulation from ovarian follicle	IEA	--
GO:0002070	epithelial cell maturation	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	TAS	1557371

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PGR

Sigma-Aldrich Small Molecules for PGR:

Mixed Agonist/Antagonist Metabolite Activator Antagonist Inhibitor Ligand

Compounds for PGR available from Tocris Bioscience

Compound	Action	CAS number
Mifepristone	Progesterone and glucocorticoid antagonist	[84371-65-3]
Progesterone	Endogenous progesterone receptor agonist	[57-83-0]

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10/21 Novoseek chemical compound relationships for PGR gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	98.85	12510	16236516 (10), 11389093 (9), 14595509 (8), 12416559 (8) (see all 99)
progestins	89.04	164	8049131 (2), 18467956 (2), 8398308 (2), 2373707 (2) (see all 99)
steroid	89.03	443	10499535 (3), 15072922 (3), 11355082 (3), 18566116 (3) (see all 99)
estradiol	81.61	288	11165037 (5), 2004610 (5), 1351839 (4), 8486312 (4) (see all 99)
asoprisnil	78.15	14	18765509 (2), 17339234 (2), 18281245 (2), 17652152 (2) (see all 9)
promegestone	76.62	10	11355082 (2), 8721984 (1), 1451096 (1), 8587697 (1) (see all 7)
zk112993	74.79	4	7626494 (1), 1384159 (1)
tanaproget	72.93	18	15937332 (5), 16418212 (2), 16078826 (2), 17046384 (2) (see all 5)
org2058	69.36	4	8049131 (1), 12432283 (1), 9863567 (1)
trimegestone	68.58	10	11108870 (5), 10599548 (1), 11772282 (1), 15937332 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PGR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PGR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000926

Sigma-Aldrich siRNA and siRNA Panels for PGR

Sigma-Aldrich shRNA Panels and shRNA for PGR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000926

REFSEQ mRNAs for PGR gene:

NM_000926.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000926

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000926
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000926
                                 untagged cDNA clone in CMV expression vector: NM_000926

Additional cDNA sequence:

AB084248.1 AF016381.1 AK304853.1 AL137566.1 AY212933.1 AY382151.1 AY382152.1 BX537881.1

M15716.1 X51730.1

9 DOTS entries:

DT.403831 DT.302605 DT.437770 DT.433385 DT.100019113 DT.120729880 DT.97824326 DT.95364504

DT.100019112

20 AceView cDNA sequences:

AB085844 M15716 AB084248 AY382152 AF016381 AL709143 AB085683 AB085843

AB085845 NM_000926 BI461125 AY212933 AY382151 BU570792 BV173553 X51730

AL708996 BI832037 BI827058 AI498426

highest scoring ESTs for PGR:

X51730 AB084248 AF016381 AY382152 BI827058 BI832037 M15716 AB085683 AB085843 AB085845

Unigene Cluster for PGR:

Progesterone receptor

Hs.32405 [show with all ESTs]

Unigene Representative Sequence: NM_000926

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PGR (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c
SP1:									-		-
SP2:									-		-								-
SP3:									-		-		-
SP4:							-		-		-								-
SP5:									-		-		-						-		-

About this scheme

ECgene alternative splicing isoforms for PGR

2 Ensembl transcripts including schematic representations:

ENST00000263463 ENST00000325455

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PGR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PGR

¹ / ² / ³

8 probe-sets matching PGR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
81847_at²	U95-D	1	1.00	1.00	0.92	0.88	--	--	--	--	--
160021_r_at²^{, 3}	U95-A	1	1.00	1.00	-0.40	0.56	X51730	1.00	1.00	1.00	1
44598_at²	U95-B	1	1.00	1.00	0.86	1.68	--	--	--	--	--
83526_at²	U95-E	1	0.94	1.00	0.82	0.50	--	--	--	--	--
208305_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000926	0.60	1.00	0.82	1
228554_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
208305_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228554_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACTCACGCCC

SOURCE GeneReport for Unigene cluster: Hs.32405
Expression variation in blood from EXPOLDB for PGR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PGR gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PGR¹	--	progesterone receptor	82.67(n) 77.57(a)	403621 NM_001003074.1 NP_001003074.1
rat (Rattus norvegicus)	Pgr¹	--	progesterone receptor	80.69(n) 82.1(a)	25154 NM_022847.1 NP_074038.1
mouse (Mus musculus)	Pgr^{1, 5}	9⁵	progesterone receptor^{1, 5}	80.11(n)¹ 80.97(a)¹	18667¹ NM_008829.2¹ NP_032855.2¹ AK036862⁵ AK054117⁵ (see all 14)
chicken (Gallus gallus)	PGR¹	--	progesterone receptor	69.47(n) 67.31(a)	396198 NM_205262.1 NP_990593.1
African clawed frog (Xenopus laevis)	pgr-A²	--	progesterone receptor	75.16(n)	AF279335.1

About this table Species with no ortholog for PGR

ENSEMBL Gene Tree for PGR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PGR gene

NR3C2² NR3C1² AR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/848 NCBI SNPs in PGR are shown (see all 848 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 313)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1545611^1,2	A,C,F,H,O	100405976(-)	`CTGAGT/CGGGAA`	1	--	ut3¹		18	NA EA MN EU WA CSAM	1578
	rs502465^1,2	A,C,F,H,O	100413208(+)	`GTATAT/CGTTGA`	1	--	ut3¹		8	NS NA EU EA WA	732
	rs1046982^1,2	A,C,F,H,O	100405926(-)	`TTGCCA/GAGAAG`	1	--	ut3¹		18	MN EU EA WA NA CSAM	1646
	rs507141^1,2	A,C,F,H,O	100508322(-)	`TAGCCC/TCATCA`	1	--	ng3¹		6	MN EU EA WA NS	730
	rs561610^1,2	A,C,F,H,O	100408204(+)	`TATGaC/Tcatca`	1	--	ut3¹		12	EU EA WA NA	1056
	rs2008112^1,2	A,C,F,H	100505580(-)	`AGTACG/AGAGCC`	1	--	ut5¹ ese³		6	MN EU EA WA NS	774
	rs1042838^1,2	C,F,H,O	100438622(-)	`AGCCAG/TTGGGC`	1	V/L	mis¹ ese³		29	NS MN NA CSAM EA EU WA	2882
	rs1870019^1,2	C,F,H,O	100406683(-)	`CCATGT/CTTTTC`	1	--	ut3¹		7	EU EA WA NA	558
	rs518162^1,2	A,C,F,H	100505711(+)	`CACGCG/ACAAAT`	1	--	ut5¹ ese³		6	MN NS EU EA WA	782
	rs471767^1,2	A,C,F,H	100410507(+)	`AAACTA/GTTCTT`	1	--	ut3¹		8	EA NA MN EU WA	660

About this table

HapMap Linkage Disequilibrium images for PGR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607311 disorders: 264080

10/93 Novoseek disease relationships for PGR gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	93.56	1712	18466613 (6), 9591211 (6), 19419938 (5), 8722747 (4) (see all 99)
breast carcinoma	91.30	349	15301464 (4), 7914767 (4), 8751328 (4), 1734234 (3) (see all 99)
carcinoma ductal	87.68	89	17522367 (2), 18296077 (2), 12014222 (2), 15375487 (2) (see all 63)
endometrial carcinoma	84.69	209	12501628 (5), 10053107 (4), 16831363 (4), 9639729 (4) (see all 99)
tumors	84.39	2406	9392336 (9), 8095853 (6), 8251648 (5), 12657124 (5) (see all 99)
carcinoma lobular	79.04	29	10672061 (5), 1916439 (2), 8328824 (1), 15329896 (1) (see all 19)
endometrial cancer	78.35	141	8467457 (4), 17556066 (4), 15001645 (4), 14519645 (4) (see all 81)
carcinoma	77.18	288	17591366 (6), 10338073 (5), 1661896 (4), 8834526 (4) (see all 99)
progesterone resistance	75.42	7	10946900 (2), 16406281 (1), 19001520 (1)
metastasis	74.96	269	10053107 (5), 15360050 (4), 10206068 (3), 10338073 (2) (see all 99)

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3 PharmGKB disease relationships for PGR gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Endometrial Neoplasms	CO GN	15598772
Endometriosis	CO GN	15272913
Ovarian Neoplasms	CO GN	15579801

About this table

Human Gene Mutation Database: PGR
Genetic Association Database: PGR
Human Genome Epidemiology Navigator: PGR (120 documents)
Tumor Gene Database: PGR
Breast Cancer Gene Database: PGR

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2687 PubMed articles for PGR gene (see all 2687 ):

Genetics of endometriosis: a role for the progesterone receptor gene polymorphism PROGINS? (PubMed id 15272913)^{1, 3, 6, 7} Lattuada D....Di Blasio A.M. (2004)
A germline variation in the progesterone receptor gene increases transcriptional activity and may modify ovarian cancer risk. (PubMed id 15579801)^{1, 3, 7} Agoulnik I.U....Kieback D.G. (2004)
Progesterone receptor promoter +331A polymorphism is associated with a reduced risk of endometrioid and clear cell ovarian cancers. (PubMed id 15598772)^{3, 6, 7} Berchuck A....Chenevix-Trench G. (2004)
Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. (PubMed id 15937332)^{1, 3, 4} Zhang Z.... Winneker R.C. (2005)
The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. (PubMed id 18375150)^{1, 3, 4} Chen C.... Wildman D.E. (2008)
Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women. (PubMed id 15272917)^{1, 3, 6} Westberg L....Eriksson E. (2004)
A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk. (PubMed id 12218173)^{1, 3, 6} De Vivo I....Hunter D.J. (2002)
No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer. (PubMed id 11323389)^{1, 3, 6} Spurdle A.B....Chenevix-Trench G. (2001)
Analysis of the human progesterone receptor gene polymorphism progins in Austrian ovarian carcinoma patients. (PubMed id 11668524)^{1, 3, 6} Tong D....Zeillinger R. (2001)
Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity. (PubMed id 15798179)^{1, 3, 4} Narayanan R....Weigel N.L. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5241	HGNC: 8910	AceView: PGR	Ensembl:ENSG00000082175	euGenes: HUgn5241
ECgene: PGR	H-InvDB: PGR

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PGR	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pgr/
Wikipedia	http://en.wikipedia.org/wiki/Progesterone_receptor

Licensable Technologies for PGR
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PGR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PGR-related products

	Millipore Custom Antibody & Bulk Services
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Antibodies & Assays for PGR (PGR, PR, Progesterone Receptor A/B)

	Recombinant Proteins (Progesterone receptor B, Progesterone Receptor)
	Antibodies (Progesterone receptor B, Progesterone Receptor)

Search OriGene for PGR

Tocris compounds for PGR

	Drugs for PGR
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PGR

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PGR Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for PGR

Summaries
for PGR

Genomic Location
for PGR

Proteins
for PGR

Protein Domains/
Families
for PGR

Gene Function
for PGR

Pathways & Interactions
for PGR

Drugs & Compounds
for PGR

Transcripts
for PGR

Expression
for PGR

Orthologs
for PGR

Paralogs
for PGR

SNPs/Variants
for PGR

Disorders & Mutations
for PGR

Medical News
for PGR

Publications
for PGR

Search for PGR

Genome Databases showing PGR

Other Databases showing PGR

Specialized Databases showing PGR

Licensable Technologies
for PGR

Services
for PGR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PGR Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor PGR

Summariesfor PGR

Genomic Locationfor PGR

Proteinsfor PGR

Protein Domains/Familiesfor PGR

Gene Functionfor PGR

Pathways & Interactionsfor PGR

Drugs & Compoundsfor PGR

Transcriptsfor PGR

Expression for PGR

Orthologsfor PGR

Paralogsfor PGR

SNPs/Variantsfor PGR

Disorders & Mutationsfor PGR

Medical Newsfor PGR

Publicationsfor PGR

Search for PGR

Genome Databases showing PGR

Other Databases showing PGR

Specialized Databases showing PGR

Licensable Technologiesfor PGR

Servicesfor PGR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PGR

Summaries
for PGR

Genomic Location
for PGR

Proteins
for PGR

Protein Domains/
Families
for PGR

Gene Function
for PGR

Pathways & Interactions
for PGR

Drugs & Compounds
for PGR

Transcripts
for PGR

Expression
for PGR

Orthologs
for PGR

Paralogs
for PGR

SNPs/Variants
for PGR

Disorders & Mutations
for PGR

Medical News
for PGR

Publications
for PGR

Licensable Technologies
for PGR

Services
for PGR