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Aliases for PGGT1B Gene

Aliases for PGGT1B Gene

  • Protein Geranylgeranyltransferase Type I Subunit Beta 2 3
  • Protein Geranylgeranyltransferase Type I, Beta Subunit 2 3 5
  • Type I Protein Geranyl-Geranyltransferase Subunit Beta 3 4
  • Geranylgeranyl Transferase Type I Subunit Beta 3 4
  • GGTase-I-Beta 3 4
  • EC 2.5.1.59 4 63
  • Geranylgeranyltransferase Type I Beta Subunit 3
  • CTC-428G20.3 3
  • EC 2.5.1 63
  • BGGI 3
  • GGTI 3

External Ids for PGGT1B Gene

Previous GeneCards Identifiers for PGGT1B Gene

  • GC05M114151
  • GC05M114950
  • GC05M114578
  • GC05M114623
  • GC05M114575
  • GC05M109728
  • GC05M114546

Summaries for PGGT1B Gene

Entrez Gene Summary for PGGT1B Gene

  • Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

GeneCards Summary for PGGT1B Gene

PGGT1B (Protein Geranylgeranyltransferase Type I Subunit Beta) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of RAC1 activity and G-protein signaling_Rac2 regulation pathway. GO annotations related to this gene include drug binding and protein geranylgeranyltransferase activity. An important paralog of this gene is RABGGTB.

UniProtKB/Swiss-Prot for PGGT1B Gene

  • Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Tocris Summary for PGGT1B Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGGT1B Gene

Genomics for PGGT1B Gene

Regulatory Elements for PGGT1B Gene

Promoters for PGGT1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGGT1B on UCSC Golden Path with GeneCards custom track

Genomic Location for PGGT1B Gene

Chromosome:
5
Start:
115,200,241 bp from pter
End:
115,262,887 bp from pter
Size:
62,647 bases
Orientation:
Minus strand

Genomic View for PGGT1B Gene

Genes around PGGT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGGT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGGT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGGT1B Gene

Proteins for PGGT1B Gene

  • Protein details for PGGT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53609-PGTB1_HUMAN
    Recommended name:
    Geranylgeranyl transferase type-1 subunit beta
    Protein Accession:
    P53609
    Secondary Accessions:
    • Q5MJP9

    Protein attributes for PGGT1B Gene

    Size:
    377 amino acids
    Molecular mass:
    42368 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.

    Alternative splice isoforms for PGGT1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGGT1B Gene

Proteomics data for PGGT1B Gene at MOPED

Selected DME Specific Peptides for PGGT1B Gene

Post-translational modifications for PGGT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGGT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PGGT1B Gene

Protein Domains for PGGT1B Gene

Suggested Antigen Peptide Sequences for PGGT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53609

UniProtKB/Swiss-Prot:

PGTB1_HUMAN :
  • Belongs to the protein prenyltransferase subunit beta family.
  • Contains 4 PFTB repeats.
Family:
  • Belongs to the protein prenyltransferase subunit beta family.
Similarity:
  • Contains 4 PFTB repeats.
genes like me logo Genes that share domains with PGGT1B: view

No data available for Gene Families for PGGT1B Gene

Function for PGGT1B Gene

Molecular function for PGGT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Enzyme Numbers (IUBMB) for PGGT1B Gene

Gene Ontology (GO) - Molecular Function for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004661 protein geranylgeranyltransferase activity IDA 16893176
GO:0005515 protein binding IEA --
GO:0019840 isoprenoid binding IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with PGGT1B: view
genes like me logo Genes that share phenotypes with PGGT1B: view

Animal Models for PGGT1B Gene

MGI Knock Outs for PGGT1B:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PGGT1B Gene

Localization for PGGT1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGGT1B Gene COMPARTMENTS Subcellular localization image for PGGT1B gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PGGT1B Gene

Pathways & Interactions for PGGT1B Gene

genes like me logo Genes that share pathways with PGGT1B: view

Gene Ontology (GO) - Biological Process for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018344 protein geranylgeranylation IDA 16893176
genes like me logo Genes that share ontologies with PGGT1B: view

No data available for SIGNOR curated interactions for PGGT1B Gene

Drugs & Compounds for PGGT1B Gene

(7) Drugs for PGGT1B Gene - From: HMDB, Tocris, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma Competitive, Inhibitor 144
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE Experimental Pharma Target 0
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE Experimental Pharma Target 0
GERANYLGERANYL DIPHOSPHATE Experimental Pharma Feedback inhibition, Inhibitor, Target 0
Diphosphate Experimental Pharma 0

(5) Additional Compounds for PGGT1B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Geranylgeranyl-PP
  • 2-trans,6-trans,10-trans-Geranylgeranyl diphosphate
  • 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl diphosphate
  • All-trans-geranyl-geranyl-pp
  • Geranylgeranyl-diphosphate
  • Geranylgeranyl-PP
FTI 277
1217447-06-7
GGTI 297
GGTI 298
1217457-86-7
gliotoxin
67-99-2

(5) Tocris Compounds for PGGT1B Gene

Compound Action Cas Number
FTI 276 Farnesyltransferase (FTase) inhibitor; antitumor 1217471-51-6
FTI 277 Prodrug form of FTI 276 (Cat. No. 2406) 1217447-06-7
GGTI 297 Geranylgeranyltransferase I (GGTase I) inhibitor
GGTI 298 Geranylgeranyltransferase I (GGTase I) inhibitor 1217457-86-7
Gliotoxin Inhibitor of 20S proteasome; immunosuppressant 67-99-2
genes like me logo Genes that share compounds with PGGT1B: view

Transcripts for PGGT1B Gene

Unigene Clusters for PGGT1B Gene

Protein geranylgeranyltransferase type I, beta subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGGT1B Gene

No ASD Table

Relevant External Links for PGGT1B Gene

GeneLoc Exon Structure for
PGGT1B
ECgene alternative splicing isoforms for
PGGT1B

Expression for PGGT1B Gene

mRNA expression in normal human tissues for PGGT1B Gene

Protein differential expression in normal tissues from HIPED for PGGT1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.6) and Spleen (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGGT1B Gene



SOURCE GeneReport for Unigene cluster for PGGT1B Gene Hs.254006

genes like me logo Genes that share expression patterns with PGGT1B: view

Protein tissue co-expression partners for PGGT1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGGT1B Gene

Orthologs for PGGT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGGT1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGGT1B 35
  • 92.48 (n)
  • 98.67 (a)
PGGT1B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGGT1B 35
  • 94.08 (n)
  • 97.88 (a)
PGGT1B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pggt1b 35
  • 87.18 (n)
  • 96.82 (a)
Pggt1b 16
Pggt1b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGGT1B 35
  • 99.65 (n)
  • 99.73 (a)
PGGT1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pggt1b 35
  • 89.92 (n)
  • 97.61 (a)
oppossum
(Monodelphis domestica)
Mammalia PGGT1B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGGT1B 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGGT1B 35
  • 82.01 (n)
  • 91.21 (a)
PGGT1B 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGGT1B 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pggt1b 35
  • 74.84 (n)
  • 81.4 (a)
Str.1329 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4454 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10651 35
pggt1b 35
  • 65.71 (n)
  • 75.22 (a)
pggt1b 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bgrggt-I 37
  • 44 (a)
betaggt-I 35
  • 51.55 (n)
  • 45.93 (a)
betaggt-I 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008406 35
  • 51.46 (n)
  • 50.99 (a)
worm
(Caenorhabditis elegans)
Secernentea csp-1 37
  • 40 (a)
Y48E1B.3 35
  • 51.13 (n)
  • 44.25 (a)
Y48E1B.3 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET2 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGGT-I 35
  • 51.04 (n)
  • 41.93 (a)
rice
(Oryza sativa)
Liliopsida Os01g0150100 35
  • 52.67 (n)
  • 43.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3753 36
  • 51 (a)
OneToOne
Species with no ortholog for PGGT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGGT1B Gene

ENSEMBL:
Gene Tree for PGGT1B (if available)
TreeFam:
Gene Tree for PGGT1B (if available)

Paralogs for PGGT1B Gene

Paralogs for PGGT1B Gene

Pseudogenes.org Pseudogenes for PGGT1B Gene

genes like me logo Genes that share paralogs with PGGT1B: view

Variants for PGGT1B Gene

Sequence variations from dbSNP and Humsavar for PGGT1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34918686 - 115,241,559(-) TGGGT(A/G)TTCCG reference, missense, utr-variant-5-prime
rs166459 -- 115,203,709(+) GGCCA(C/T)AGAAT intron-variant, downstream-variant-500B
rs187852 -- 115,224,128(+) TTATT(A/G)CAACC intron-variant
rs155413 -- 115,203,833(+) CCATG(C/G)CCCAC intron-variant, downstream-variant-500B
rs155414 -- 115,218,862(+) catct(A/G)aaatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGGT1B Gene

Variant ID Type Subtype PubMed ID
nsv830453 CNV Gain 17160897
nsv830454 CNV Gain+Loss 17160897

Variation tolerance for PGGT1B Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGGT1B Gene

HapMap Linkage Disequilibrium report
PGGT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGGT1B Gene

Disorders for PGGT1B Gene

Relevant External Links for PGGT1B

Genetic Association Database (GAD)
PGGT1B
Human Genome Epidemiology (HuGE) Navigator
PGGT1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGGT1B

No disorders were found for PGGT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGGT1B Gene

Publications for PGGT1B Gene

  1. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. (PMID: 8106351) Zhang F.L. … Omer C.A. (J. Biol. Chem. 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Geranylgeranyltransferase I regulates HIF-1I+ promoting glioblastoma cell migration and invasion. (PMID: 23475391) Zhou X. … Yu R. (J. Neurooncol. 2013) 3
  4. Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle. (PMID: 22160308) Ghavami S. … Halayko A.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2012) 3
  5. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 3

Products for PGGT1B Gene

Sources for PGGT1B Gene

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