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Aliases for PGGT1B Gene

Aliases for PGGT1B Gene

  • Protein Geranylgeranyltransferase Type I, Beta Subunit 2 3
  • Type I Protein Geranyl-Geranyltransferase Subunit Beta 3 4
  • Geranylgeranyl Transferase Type I Subunit Beta 3 4
  • GGTase-I-Beta 3 4
  • EC 2.5.1.59 4 63
  • Geranylgeranyl Transferase Type-1 Subunit Beta 3
  • Geranylgeranyltransferase Type I Beta Subunit 3
  • CTC-428G20.3 3
  • EC 2.5.1 63
  • BGGI 3
  • GGTI 3

External Ids for PGGT1B Gene

Previous GeneCards Identifiers for PGGT1B Gene

  • GC05M114151
  • GC05M114950
  • GC05M114578
  • GC05M114623
  • GC05M114575
  • GC05M109728
  • GC05M114546

Summaries for PGGT1B Gene

Entrez Gene Summary for PGGT1B Gene

  • Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

GeneCards Summary for PGGT1B Gene

PGGT1B (Protein Geranylgeranyltransferase Type I, Beta Subunit) is a Protein Coding gene. Among its related pathways are G-protein signaling_RhoA regulation pathway and G-protein signaling_Regulation of RAC1 activity. GO annotations related to this gene include CAAX-protein geranylgeranyltransferase activity. An important paralog of this gene is RABGGTB.

UniProtKB/Swiss-Prot for PGGT1B Gene

  • Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Tocris Summary for PGGT1B Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGGT1B Gene

Genomics for PGGT1B Gene

Regulatory Elements for PGGT1B Gene

Genomic Location for PGGT1B Gene

Start:
115,210,830 bp from pter
End:
115,263,426 bp from pter
Size:
52,597 bases
Orientation:
Minus strand

Genomic View for PGGT1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGGT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGGT1B Gene

Proteins for PGGT1B Gene

  • Protein details for PGGT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53609-PGTB1_HUMAN
    Recommended name:
    Geranylgeranyl transferase type-1 subunit beta
    Protein Accession:
    P53609
    Secondary Accessions:
    • Q5MJP9

    Protein attributes for PGGT1B Gene

    Size:
    377 amino acids
    Molecular mass:
    42368 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.

    Alternative splice isoforms for PGGT1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGGT1B Gene

Proteomics data for PGGT1B Gene at MOPED

Selected DME Specific Peptides for PGGT1B Gene

Post-translational modifications for PGGT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGGT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PGGT1B Gene

Protein Domains for PGGT1B Gene

Suggested Antigen Peptide Sequences for PGGT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53609

UniProtKB/Swiss-Prot:

PGTB1_HUMAN :
  • P53609
Family:
  • Belongs to the protein prenyltransferase subunit beta family.
Similarity:
  • Contains 4 PFTB repeats.
genes like me logo Genes that share domains with PGGT1B: view

No data available for Gene Families for PGGT1B Gene

Function for PGGT1B Gene

Molecular function for PGGT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.

Enzyme Numbers (IUBMB) for PGGT1B Gene

Gene Ontology (GO) - Molecular Function for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004661 protein geranylgeranyltransferase activity IDA 16893176
GO:0004662 CAAX-protein geranylgeranyltransferase activity ISS --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with PGGT1B: view
genes like me logo Genes that share phenotypes with PGGT1B: view

Animal Models for PGGT1B Gene

MGI Knock Outs for PGGT1B:

Animal Model Products

CRISPR Products

miRNA for PGGT1B Gene

miRTarBase miRNAs that target PGGT1B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGGT1B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PGGT1B Gene

Localization for PGGT1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGGT1B Gene COMPARTMENTS Subcellular localization image for PGGT1B gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005953 CAAX-protein geranylgeranyltransferase complex IDA 16893176
genes like me logo Genes that share ontologies with PGGT1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PGGT1B Gene

Pathways for PGGT1B Gene

genes like me logo Genes that share pathways with PGGT1B: view

Gene Ontology (GO) - Biological Process for PGGT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0018344 protein geranylgeranylation IDA 16893176
GO:0034097 response to cytokine IEA --
GO:0045787 positive regulation of cell cycle IEA --
GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA --
genes like me logo Genes that share ontologies with PGGT1B: view

Compounds for PGGT1B Gene

(3) Tocris Compounds for PGGT1B Gene

Compound Action Cas Number
FTI 276 Farnesyltransferase (FTase) inhibitor; antitumor [1217471-51-6]
GGTI 297 Geranylgeranyltransferase I (GGTase I) inhibitor
LB 42708 Selective farnesyltransferase (FTase) inhibitor [226929-39-1]

(1) HMDB Compounds for PGGT1B Gene

Compound Synonyms Cas Number PubMed IDs
Pravastatin
  • 3beta-Hydroxycompactin
81093-37-0
genes like me logo Genes that share compounds with PGGT1B: view

Transcripts for PGGT1B Gene

Unigene Clusters for PGGT1B Gene

Protein geranylgeranyltransferase type I, beta subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGGT1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PGGT1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGGT1B Gene

No ASD Table

Relevant External Links for PGGT1B Gene

GeneLoc Exon Structure for
PGGT1B
ECgene alternative splicing isoforms for
PGGT1B

Expression for PGGT1B Gene

mRNA expression in normal human tissues for PGGT1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGGT1B Gene

SOURCE GeneReport for Unigene cluster for PGGT1B Gene Hs.254006

genes like me logo Genes that share expressions with PGGT1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGGT1B Gene

Orthologs for PGGT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGGT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGGT1B 35
  • 99.65 (n)
  • 99.73 (a)
PGGT1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PGGT1B 35
  • 92.48 (n)
  • 98.67 (a)
PGGT1B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGGT1B 35
  • 94.08 (n)
  • 97.88 (a)
PGGT1B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pggt1b 35
  • 87.18 (n)
  • 96.82 (a)
Pggt1b 16
Pggt1b 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PGGT1B 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGGT1B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pggt1b 35
  • 89.92 (n)
  • 97.61 (a)
chicken
(Gallus gallus)
Aves PGGT1B 35
  • 82.01 (n)
  • 91.21 (a)
PGGT1B 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGGT1B 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4454 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pggt1b 35
  • 74.84 (n)
  • 81.4 (a)
Str.1329 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10651 35
pggt1b 35
  • 65.71 (n)
  • 75.22 (a)
pggt1b 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008406 35
  • 51.46 (n)
  • 50.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta betaggt-I 35
  • 51.55 (n)
  • 45.93 (a)
betaggt-I 36
  • 40 (a)
OneToOne
bgrggt-I 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48E1B.3 35
  • 51.13 (n)
  • 44.25 (a)
Y48E1B.3 36
  • 14 (a)
OneToOne
csp-1 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET2 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PGGT-I 35
  • 51.04 (n)
  • 41.93 (a)
rice
(Oryza sativa)
Liliopsida Os01g0150100 35
  • 52.67 (n)
  • 43.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3753 36
  • 51 (a)
OneToOne
Species with no ortholog for PGGT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGGT1B Gene

ENSEMBL:
Gene Tree for PGGT1B (if available)
TreeFam:
Gene Tree for PGGT1B (if available)

Paralogs for PGGT1B Gene

Paralogs for PGGT1B Gene

Pseudogenes.org Pseudogenes for PGGT1B Gene

genes like me logo Genes that share paralogs with PGGT1B: view

Variants for PGGT1B Gene

Sequence variations from dbSNP and Humsavar for PGGT1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs155414 -- 115,218,862(+) catct(A/G)aaatg intron-variant
rs155573 -- 115,249,663(+) GCAGG(C/T)GATTG intron-variant
rs169088 -- 115,222,431(+) AATAA(C/G)ATAAA intron-variant
rs187852 -- 115,224,128(+) TTATT(A/G)CAACC intron-variant
rs190561 -- 115,260,213(+) AAACA(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGGT1B Gene

Variant ID Type Subtype PubMed ID
nsv830453 CNV Gain 17160897
nsv830454 CNV Gain+Loss 17160897

Relevant External Links for PGGT1B Gene

HapMap Linkage Disequilibrium report
PGGT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGGT1B Gene

Disorders for PGGT1B Gene

Relevant External Links for PGGT1B

Genetic Association Database (GAD)
PGGT1B
Human Genome Epidemiology (HuGE) Navigator
PGGT1B
genes like me logo Genes that share disorders with PGGT1B: view

No data available for UniProtKB/Swiss-Prot for PGGT1B Gene

Publications for PGGT1B Gene

  1. cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I. (PMID: 8106351) Zhang F.L. … Omer C.A. (J. Biol. Chem. 1994) 2 3 4
  2. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PMID: 19667218) Comabella M. … Montalban X. (Arch. Neurol. 2009) 3 48
  3. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. (PMID: 20403997) Lipkin S.M. … Gruber S.B. (Cancer Prev Res (Phila) 2010) 3
  4. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. (PMID: 20446922) Virtanen S.S. … HAorkAPnen P.L. (Cell Biol. Int. 2010) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for PGGT1B Gene

Sources for PGGT1B Gene

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