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GIFtS

PFKFB4 Gene

protein-coding   GIFtS: 63
GCID: GC03M048555

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
 Explore 5 diseases affiliated with
PFKFB4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PFKFB4    

Aliases
for PFKFB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 41 2     6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-41
6PF-2-K/Fru-2,6-P2ase 42 3     6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 42
6PF-2-K/Fru-2,6-P2ase Testis-Type Isozyme2 3     Bifunctional Enzyme With Kinase And Biphosphatase Activities2
PFK/FBPase 42 3     

External Ids:    HGNC: 88751   Entrez Gene: 52102   Ensembl: ENSG000001142687   OMIM: 6053205   UniProtKB: Q168773   

Export aliases for PFKFB4 gene to outside databases

Previous GC identifers: GC03M048349 GC03M047841 GC03M048516 GC03M048517 GC03M048530


Summaries
for PFKFB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: F264_HUMAN, Q16877
Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB4


Genomic Views
for PFKFB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PFKFB4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PFKFB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PFKFB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p22-p21

PFKFB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048555:  view genomic region     (about GC identifiers)

Start:
 48,555,117 bp from pter      End:
 48,599,448 bp from pter
Size:
 44,332 bases      Orientation:
 minus strand

Proteins
for PFKFB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F264_HUMAN, Q16877 (See protein sequence)
Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4  
Size: 469 amino acids; 54040 Da
Subunit: Homodimer (By similarity)
Secondary accessions: Q5S3G5

Explore the universe of human proteins at neXtProt for PFKFB4: NX_Q16877

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16877

    • PFKFB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004558.1  
    ENSEMBL proteins: 
     ENSP00000232375   ENSP00000388394   ENSP00000389169   ENSP00000400772   ENSP00000373240  
     ENSP00000407657   ENSP00000393047   ENSP00000415764   ENSP00000438908   ENSP00000437446  
     ENSP00000437844  
    Reactome Protein details: Q16877
    Human Recombinant Protein Products: 
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    Novus Biologicals PFKFB4 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PFKFB4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    PFKFB4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PFKFB4

    Protein Domains /
    Families
    for PFKFB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PFKFB4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016260 Bifunct_6PFK/fruc_bisP_Ptase
     IPR001345 PG/BPGM_mutase_AS
     IPR003094 6Pfruct_kin
     IPR013079 6Phosfructo_kin
     IPR013078 His_Pase_superF_clade-1

    Graphical View of Domain Structure for InterPro Entry Q16877

    ProtoNet protein and cluster: Q16877

    2 Blocks protein families:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB013079 6-phosphofructo-2-kinase


    UniProtKB/Swiss-Prot: F264_HUMAN, Q16877
    Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family


    Function
    for PFKFB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: F264_HUMAN, Q16877
    Function: Synthesis and degradation of fructose 2,6-bisphosphate
    Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
    Enzyme regulation: The most important regulatory mechanism of these opposing activities is by phosphorylation and
    dephosphorylation of the enzyme (By similarity)

         Genatlas biochemistry entry for PFKFB4:
    6-phosphofructo-2-kinase-fructose-2,6-biphosphatase bifunctional enzyme responsible for the synthesis and breakdown of
    fructose 2,6 biphosphate,key metabolite in the regulation of glycolysis,expressed in testis

    miRNA
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    hsa-miR-330-5p hsa-miR-15a hsa-miR-25 hsa-miR-128 hsa-miR-3138 hsa-miR-548l hsa-miR-424 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: PFKFB4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00038736-phosphofructo-2-kinase activity NAS10095107
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0042802identical protein binding ----


    PFKFB4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PFKFB4:
     Decreased focal adhesion (FA)  


    Pathways & Interactions
    for PFKFB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucose metabolism
    		Glucose metabolism1.00
    		Glycolysis0.44
    2AMPK Enzyme Complex Pathway
    		AMPK Enzyme Complex Pathway1.00
    3Akt Signaling
    		Akt Signaling1.00
    4Fructose and mannose metabolism
    		Fructose and mannose metabolism1.00
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB4
        AMPK Enzyme Complex Pathway
    Akt Signaling

    4        Reactome Pathways for PFKFB4
        Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    1         Kegg Pathway  (Kegg details for PFKFB4):
        Fructose and mannose metabolism


    PFKFB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PFKFB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for PFKFB4 (Q168772, 3 ENSP000002323754) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253517 I2D: score=2 
    GADD45AP245222, 3MINT-8255978 I2D: score=2 
    GSK3BP498412, 3MINT-8257559 I2D: score=2 
    FBP1ENSP000003644754STRING: ENSP00000364475
    FBP2ENSP000003644864STRING: ENSP00000364486
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process IEA--
    GO:0006003fructose 2,6-bisphosphate metabolic process NAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006096glycolysis TAS--


    PFKFB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PFKFB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PFKFB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PFKFB4

    7 HMDB Compounds for PFKFB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    D-Fructose 2,6-bisphosphateD-Fructose 2,6-bisphosphate (see all 6)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PFKFB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fructose-6-Phosphate-- --target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235

    3 Novoseek chemical compound relationships for PFKFB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cobalt chloride 75.4 1 15474002 (1)
    deferoxamine 56.5 1 15474002 (1)
    vegf 51 4 17143338 (1), 15925437 (1), 16311927 (1), 16025159 (1)

    Search CenterWatch for drugs/clinical trials and news about PFKFB4 / F264 

    Transcripts
    for PFKFB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PFKFB4 gene: 
    NM_004567.2  

    Unigene Cluster for PFKFB4:

    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
    Hs.476217  [show with all ESTs]
    Unigene Representative Sequence: NM_004567
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232375(uc003ctv.3 uc003ctw.3 uc010hkc.3 uc003ctx.3 uc010hkb.3 uc011bbm.2)
    ENST00000416568 ENST00000417753 ENST00000445633 ENST00000383734 ENST00000490115
    ENST00000478516 ENST00000452531 ENST00000468162 ENST00000412035 ENST00000471890
    ENST00000496767 ENST00000422701 ENST00000490404 ENST00000467176 ENST00000536104
    ENST00000541519 ENST00000545984(uc011bbn.1)

    miRNA
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    hsa-miR-330-5p hsa-miR-15a hsa-miR-25 hsa-miR-128 hsa-miR-3138 hsa-miR-548l hsa-miR-424 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: PFKFB4 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF108765.1 AK298732.1 AK299097.1 AK312623.1 AY707863.1 AY714243.1 AY756062.1 AY756063.1 
    AY756064.1 BC010269.1 D49818.1 

    10 DOTS entries:

    DT.209790  DT.120868602  DT.120868607  DT.92003590  DT.100734924  DT.91706860  DT.100733991  DT.120868611 
    DT.91679723  DT.91679727 

    24/80 AceView cDNA sequences (see all 80):

    CD370053 BQ894396 AW589829 AI220522 BG681134 AI123746 BF062291 BI826350 
    NM_004567 AI336996 F05856 BE408167 CD366049 BC010269 BE279356 AY707863 
    BX442369 BU150821 AA399574 AW193821 Z45155 BQ926967 BG056306 BU848741 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB4 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                            -     -                 -                                                                     
    SP2:                          -                       -                 -                                                                     
    SP3:                          -                 -     -                 -                             -                                       
    SP4:                          -                 -     -                 -                                                                     
    SP5:                          -                 -     -                 -                                   -                                 


    ECgene alternative splicing isoforms for PFKFB4

    Expression
    for PFKFB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PFKFB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAACACTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PFKFB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PFKFB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PFKFB4

    SOURCE GeneReport for Unigene cluster: Hs.476217
        SABiosciences Expression via Pathway-Focused PCR Array including PFKFB4: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
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    Orthologs
    for PFKFB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PFKFB4 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008596531 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 76.42(n)
    90.78(a)    		   100859653  XM_003641962.1  XP_003642010.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PFKFB46
    		 --
    		 90(a)
    		 1 ↔ 1
    		 2(155763846-155803610)
    zebrafish
    (Danio rerio)    		 Actinopterygii pfkfb42 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 77.59(n)   386663  BC060931.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pfrx6
    		 6-phosphofructo-2-kinase
    		 36(a)
    		 1 → many
    		 X(19389538-19403390)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y110A7A.6b3   -- 56(a)
    (best of 3)    		   I(5131526-5133910)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons F2KP6
    		 fructose-2,6-bisphosphatase
    		 25(a)
    		 possible ortholog
    		 1(2178104-2184148)
    rice
    (Oryza sativa)    		 Liliopsida Os03g02942001 hypothetical protein 52.8(n)
    47.73(a)    		   4332523  NM_001056350.1  NP_001049815.1 


    ENSEMBL Gene Tree for PFKFB4 (if available)
    TreeFam Gene Tree for PFKFB4 (if available) 

    Paralogs
    for PFKFB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PFKFB4 gene
    PFKFB32  PFKFB12  PFKFB22  
    4 SIMAP similar genes for PFKFB4 using alignment to 11 protein entries:     F264_HUMAN (see all proteins):
    PFKFB3    DKFZp781D2217    PFKFB2    PFKFB1

    PFKFB4 for paralogs           About GeneDecksing



    Genomic Variants
    for PFKFB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/560 NCBI SNPs in PFKFB4 are shown (see all 560)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1497723871,2
    		--48554673(+) AAAGAA/TAAAGA 1 -- int10--------
    rs792383371,2
    		--48554739(+) TCCTTG/AACCCA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1456847131,2
    		--48554773(+) AATGCC/TGCATT 1 -- int10--------
    rs1407245501,2
    		--48554978(+) GTGAGA/GGTGAA 1 -- int10--------
    rs1834947011,2
    		--48555068(+) CCAGAA/GAAAAA 1 -- int10--------
    rs40750821,2
    		C,F,A,H,--48555082(+) CTTCAG/CAAATG 1 -- int139Minor allele frequency- C:0.28NS EA NA WA CSA 3682
    rs1859916521,2
    		--48555205(+) AACTCA/GGGAAA 1 -- ut310--------
    rs1148205751,2
    		C,F,--48555246(+) TGGCCG/AAAATG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1904011101,2
    		--48555369(+) GTCCTC/TGTAAT 1 -- ut310--------
    rs1156718871,2
    		--48555447(+) CAGATG/AACATC 1 -- ut311Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for PFKFB4 (48555117 - 48599448 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PFKFB4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PFKFB4
    DNA2.0 Custom Variant and Variant Library Synthesis for PFKFB4

    Disorders / Diseases
    for PFKFB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PFKFB4 for disorders           About GeneDecksing

    OMIM gene information: 605320    OMIM disorders: --

    5 diseases for PFKFB4:    About MalaCards
    gastric cancer    pancreatic cancer    pancreatitis    hypoxia
    hepatitis

    1 Novoseek disease relationship for PFKFB4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 25.6 10 15925437 (3), 16025159 (3), 17143338 (2), 15474002 (2)


    Export disorders for PFKFB4 gene to outside databases

    Publications
    for PFKFB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PFKFB4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PFKFB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (PubMed id 10095107)1, 2, 3, 9 Manzano A....Bartrons R. (1999)
    2. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PubMed id 8830046)1, 2, 3 Sakai A.... Sakakibara R. (1996)
    3. Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. (PubMed id 15642344)1, 2, 9 Gomez M.... Bartrons R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. (PubMed id 17143338)1, 9 Bobarykina A.Y....Minchenko O.H. (2006)
    6. Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose- 2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. (PubMed id 15474002)1, 9 Minchenko O.... Esumi H. (2004)
    7. Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors. (PubMed id 15925437)1, 9 Minchenko O.H....Esumi H. (2005)
    8. Sertoli-secreted FGF-2 induces PFKFB4 isozyme expressi on in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway. (PubMed id 22811469)1 Gomez M....Navarro-Sabate A. (2012)
    9. RNAi screening in glioma stem-like cells identifies PF KFB4 as a key molecule important for cancer cell survival. (PubMed id 22056879)1 Goidts V....Radlwimmer B. (2012)
    10. Sulforaphane induces apoptosis in human hepatic cance r cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphata se4, mediated by hypoxia inducible factor-1-dependent pathway. (PubMed id 21640852)1 Jeon Y.K....Nam M.J. (2011)

    External Searches for PFKFB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PFKFB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5210 HGNC: 8875 AceView: SCOTIN Ensembl:ENSG00000114268 euGenes: HUgn5210
    ECgene: PFKFB4 Kegg: 5210 H-InvDB: PFKFB4

    Other Databases showing PFKFB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PFKFB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PFKFB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PFKFB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PFKFB4 gene:
    Search GeneIP for patents involving PFKFB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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