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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PFKFB4 Gene

protein-coding   GIFtS: 65
GCID: GC03M048555

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 41 2     6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-42
6PF-2-K/Fru-2,6-P2ase 42 3     6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 42
6PF-2-K/Fru-2,6-P2ase Testis-Type Isozyme2 3     Bifunctional Enzyme With Kinase And Biphosphatase Activities2
PFK/FBPase 42 3     

External Ids:    HGNC: 88751   Entrez Gene: 52102   Ensembl: ENSG000001142687   OMIM: 6053205   UniProtKB: Q168773   

Export aliases for PFKFB4 gene to outside databases

Previous GC identifers: GC03M048349 GC03M047841 GC03M048516 GC03M048517 GC03M048530


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PFKFB4 Gene: 
PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4) is a protein-coding gene. Diseases associated with PFKFB4 include hypoxia, and pancreatic cancer, and among its related super-pathways are Gluconeogenesis and p38 Signaling. GO annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB3.

UniProtKB/Swiss-Prot: F264_HUMAN, Q16877
Function: Synthesis and degradation of fructose 2,6-bisphosphate

Gene Wiki entry for PFKFB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PFKFB4 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPFKFB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PFKFB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PFKFB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22-p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p22-p21

PFKFB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PFKFB4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048555:  view genomic region     (about GC identifiers)

Start:
48,555,117 bp from pter      End:
48,599,448 bp from pter
Size:
44,332 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F264_HUMAN, Q16877 (See protein sequence)
Recommended Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4  
Size: 469 amino acids; 54040 Da
Subunit: Homodimer (By similarity)
Secondary accessions: Q5S3G5

Explore the universe of human proteins at neXtProt for PFKFB4: NX_Q16877

Explore proteomics data for PFKFB4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16877

  • PFKFB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PFKFB4 Protein Expression
    REFSEQ proteins: NP_004558.1  
    ENSEMBL proteins: 
     ENSP00000232375   ENSP00000388394   ENSP00000389169   ENSP00000400772   ENSP00000373240  
     ENSP00000407657   ENSP00000393047   ENSP00000415764   ENSP00000438908   ENSP00000437446  
     ENSP00000437844  
    Reactome Protein details: Q16877
    Human Recombinant Protein Products for PFKFB4: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PFKFB4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    PFKFB4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016260 Bifunct_6PFK/fruc_bisP_Ptase
     IPR001345 PG/BPGM_mutase_AS
     IPR003094 6Pfruct_kin
     IPR013079 6Phosfructo_kin
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q16877

    ProtoNet protein and cluster: Q16877

    2 Blocks protein domains:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB013079 6-phosphofructo-2-kinase


    UniProtKB/Swiss-Prot: F264_HUMAN, Q16877
    Similarity: In the C-terminal section; belongs to the phosphoglycerate mutase family


    PFKFB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F264_HUMAN, Q16877
    Function: Synthesis and degradation of fructose 2,6-bisphosphate
    Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Catalytic activity: ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
    Enzyme regulation: The most important regulatory mechanism of these opposing activities is by phosphorylation and
    dephosphorylation of the enzyme (By similarity)

         Genatlas biochemistry entry for PFKFB4:
    6-phosphofructo-2-kinase-fructose-2,6-biphosphatase bifunctional enzyme responsible for the synthesis and
    breakdown of fructose 2,6 biphosphate,key metabolite in the regulation of glycolysis,expressed in testis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00038736-phosphofructo-2-kinase activity NAS10095107
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity IEA--
    GO:0005524ATP binding IEA--
         
    PFKFB4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PFKFB4:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PFKFB4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PFKFB4 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    2Akt Signaling
    Akt Signaling0.60
    3MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    4Metabolism
    Metabolism0.40
    5HIF-1 signaling pathway
    HIF-1 signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PFKFB4
        AMPK Enzyme Complex Pathway
    Akt Signaling


    4        Reactome Pathways for PFKFB4
        Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    2         Kegg Pathways  (Kegg details for PFKFB4):
        Fructose and mannose metabolism
    HIF-1 signaling pathway


    PFKFB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PFKFB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/24 Interacting proteins for PFKFB4 (Q168772, 3 ENSP000002323754) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253517 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253517 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253517 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253517 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253517 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process IEA--
    GO:0006003fructose 2,6-bisphosphate metabolic process NAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006096glycolysis TAS--

    PFKFB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PFKFB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PFKFB4 (F264)

    7 HMDB Compounds for PFKFB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Phosphoglyceric acid2-(dihydrogen phosphate)Glycerate (see all 16)2553-59-5--
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    D-Fructose 2,6-bisphosphateD-Fructose 2,6-bisphosphate (see all 6)----
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PFKFB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fructose-6-Phosphate-- --target--17139284 17016423 10592235
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for PFKFB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cobalt chloride 75.4 1 15474002 (1)
    deferoxamine 56.5 1 15474002 (1)
    vegf 51 4 17143338 (1), 15925437 (1), 16311927 (1), 16025159 (1)

    Search CenterWatch for drugs/clinical trials and news about PFKFB4 / F264

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PFKFB4 gene: 
    NM_004567.2  

    Unigene Cluster for PFKFB4:

    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
    Hs.476217  [show with all ESTs]
    Unigene Representative Sequence: NM_004567
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000232375(uc003ctv.3 uc003ctw.3 uc010hkc.3 uc003ctx.3 uc010hkb.3 uc011bbm.2)
    ENST00000416568 ENST00000417753 ENST00000445633 ENST00000383734 ENST00000490115
    ENST00000478516 ENST00000452531 ENST00000468162 ENST00000412035 ENST00000471890
    ENST00000496767 ENST00000422701 ENST00000490404 ENST00000467176 ENST00000536104
    ENST00000541519 ENST00000545984(uc011bbn.1)
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    Additional mRNA sequence: 

    AF108765.1 AK298732.1 AK299097.1 AK312623.1 AY707863.1 AY714243.1 AY756062.1 AY756063.1 
    AY756064.1 BC010269.1 D49818.1 

    10 DOTS entries:

    DT.209790  DT.120868602  DT.120868607  DT.92003590  DT.100734924  DT.91706860  DT.100733991  DT.120868611 
    DT.91679723  DT.91679727 

    24/80 AceView cDNA sequences (see all 80):

    BG056306 BU848741 AI633801 AI961045 F02099 AI699924 BM673013 Z45155 
    BQ926967 AL038786 CD370053 AW589829 BG681134 BQ894396 AI123746 BI826350 
    BF062291 AI220522 NM_004567 AI336996 F05856 BE279356 BE408167 AY707863 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PFKFB4 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                            -     -                 -                                                                     
    SP2:                          -                       -                 -                                                                     
    SP3:                          -                 -     -                 -                             -                                       
    SP4:                          -                 -     -                 -                                                                     
    SP5:                          -                 -     -                 -                                   -                                 


    ECgene alternative splicing isoforms for PFKFB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PFKFB4 expression in normal human tissues (normalized intensities)      PFKFB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACACTGTG
    PFKFB4 Expression
    About this image


    PFKFB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             Human Brain Vascular Pericyte (HBVP)   
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Eye (Sensory Organs)
             Retina
     
     Spinal Cord (Nervous System)

    See PFKFB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PFKFB4

    SOURCE GeneReport for Unigene cluster: Hs.476217
        SABiosciences Expression via Pathway-Focused PCR Array including PFKFB4: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PFKFB4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pfkfb41 , 5 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more1, 5 89.2(n)1
    97.44(a)1
      9 (59.63 cM)5
    2701981  NM_173019.51  NP_766607.31 
     1089919025 
    chicken
    (Gallus gallus)
    Aves LOC1008596531 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 76.42(n)
    90.78(a)
      100859653  XM_003641962.1  XP_003642010.1 
    lizard
    (Anolis carolinensis)
    Reptilia PFKFB46
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatas...
    88(a)
    1 ↔ 1
    2(155763814-155838804)
    zebrafish
    (Danio rerio)
    Actinopterygii pfkfb42 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase more 77.59(n)   386663  BC060931.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pfrx6
    6-phosphofructo-2-kinase
    37(a)
    1 → many
    X(19389538-19403390)
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A7A.6b3   -- 56(a)
    (best of 3)
      I(5131526-5133910)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YLR345W)4 Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase more   --   12(820511-822040) 851059  NP_013449.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02942001 hypothetical protein 52.8(n)
    47.73(a)
      4332523  NM_001056350.1  NP_001049815.1 


    ENSEMBL Gene Tree for PFKFB4 (if available)
    TreeFam Gene Tree for PFKFB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PFKFB4 gene
    PFKFB32  PFKFB12  PFKFB22  
    4 SIMAP similar genes for PFKFB4 using alignment to 11 protein entries:     F264_HUMAN (see all proteins):
    PFKFB3    DKFZp781D2217    PFKFB2    PFKFB1

    PFKFB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/737 SNPs in PFKFB4 are shown (see all 737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360754
    A breast cancer sample4--see VAR_0360752 N K mis40--------
    rs1497723871,2
    --48554673(+) AAAGAA/TAAAGA 1 -- int10--------
    rs792383371,2
    C,F--48554739(+) TCCTTG/AACCCA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1456847131,2
    --48554773(+) AATGCC/TGCATT 1 -- int10--------
    rs1407245501,2
    --48554978(+) GTGAGA/GGTGAA 1 -- int10--------
    rs1834947011,2
    --48555068(+) CCAGAA/GAAAAA 1 -- int10--------
    rs40750821,2
    C,F,A,H--48555082(+) CTTCAG/CAAATG 1 -- int139Minor allele frequency- C:0.28NS EA NA WA CSA 3682
    rs1859916521,2
    --48555205(+) AACTCA/GGGAAA 1 -- ut310--------
    rs1148205751,2
    C,F--48555246(+) TGGCCG/AAAATG 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1904011101,2
    --48555369(+) GTCCTC/TGTAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PFKFB4 (48555117 - 48599448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PFKFB4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv523981CNV Loss19592680
    nsv834684CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PFKFB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605320    OMIM disorders: --

    5 diseases for PFKFB4:    About MalaCards
    hypoxia    pancreatic cancer    gastric cancer    pancreatitis
    hepatitis


    PFKFB4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PFKFB4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 25.6 10 15925437 (3), 16025159 (3), 17143338 (2), 15474002 (2)


    Export disorders for PFKFB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PFKFB4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with PFKFB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. (PubMed id 10095107)1, 2, 3, 9 Manzano A....Bartrons R. (1999)
    2. Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta. (PubMed id 8830046)1, 2, 3 Sakai A.... Sakakibara R. (1996)
    3. Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. (PubMed id 15642344)1, 2, 9 Gomez M.... Bartrons R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. (PubMed id 17143338)1, 9 Bobarykina A.Y....Minchenko O.H. (2006)
    6. Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose- 2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. (PubMed id 15474002)1, 9 Minchenko O.... Esumi H. (2004)
    7. Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors. (PubMed id 15925437)1, 9 Minchenko O.H....Esumi H. (2005)
    8. PFKFB4 as a prognostic marker in non-muscle-invasive b ladder cancer. (PubMed id 21396842)1 Yun S.J....Kim W.J. (2012)
    9. Coordinated expression of 6-phosphofructo-2-kinase/fru ctose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism. (PubMed id 22892400)1 Li B....Furuyama K. (2012)
    10. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5210 HGNC: 8875 AceView: SCOTIN Ensembl:ENSG00000114268 euGenes: HUgn5210
    ECgene: PFKFB4 Kegg: 5210 H-InvDB: PFKFB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PFKFB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PFKFB4 gene:
    Search GeneIP for patents involving PFKFB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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