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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDXP Gene

protein-coding   GIFtS: 54
GCID: GC22P038054

pyridoxal (pyridoxine, vitamin B6) phosphatase
 Explore 12 diseases affiliated with
PDXP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDXP    

Aliases
for PDXP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pyridoxal (Pyridoxine, Vitamin B6) Phosphatase1 2     Chronophin3
DJ37E16.51     Pyridoxal Phosphate Phosphatase2
CIN2 3     Chronophin3
PLP2 3     EC 3.1.3.33
PLP Phosphatase2 3     PLPP3
EC 3.1.3.743 8     EC 3.1.38
FLJ327031     

External Ids:    HGNC: 302591   Entrez Gene: 570262   Ensembl: ENSG000002413607   OMIM: 6092465   UniProtKB: Q96GD03   

Export aliases for PDXP gene to outside databases

Previous GC identifers: GC00U914367 GC22P036299 GC22P036379 GC22P021021


Summaries
for PDXP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDXP:
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical
homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by
PDXP (Jang et al., 2003 (PubMed 14522954)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: PLPP_HUMAN, Q96GD0
Function: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates
phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal
progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not
dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards
pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity
with PLP followed by PNP




Genomic Views
for PDXP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDXP gene promoter:
         NF-1   NF-1/L   AP-1   p53   ATF-2   GATA-2   YY1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDXP promoter sequence
   Search SABiosciences Chromatin IP Primers for PDXP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDXP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12.3

PDXP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDXP gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038054:  view genomic region     (about GC identifiers)

Start:
 38,054,734 bp from pter      End:
 38,062,941 bp from pter
Size:
 8,208 bases      Orientation:
 plus strand

Proteins
for PDXP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PLPP_HUMAN, Q96GD0 (See protein sequence)
Recommended Name: Pyridoxal phosphate phosphatase  
Size: 296 amino acids; 31698 Da
Cofactor: Divalent ions. Magnesium is the most effective
Subunit: Homodimer
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral
membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic
side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in
membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase.
Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during
cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody
6 PDB 3D structures from and Proteopedia for PDXP:
2CFR (3D)        2CFS (3D)        2CFT (3D)        2OYC (3D)        2P27 (3D)        2P69 (3D)    
Secondary accessions: Q9UGY2

Explore the universe of human proteins at neXtProt for PDXP: NX_Q96GD0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96GD0

    • 3 DME Specific Peptides for PDXP (Q96GD0)
     LTLTGVS  EACAHLRDP  LFDCDGVLW 

    PDXP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064711.1  
    ENSEMBL proteins: 
     ENSP00000215904   ENSP00000385336  

    Human Recombinant Protein Products: 
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    Uscn Proteins for PDXP

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA15580268
    GO:0005886colocalizes with plasma membrane IDA15580268
    GO:0015629colocalizes with actin cytoskeleton IDA15580268
    GO:0030027colocalizes with lamellipodium IDA15580268
    GO:0030496colocalizes with midbody IDA15580268


    PDXP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PDXP

    Protein Domains /
    Families
    for PDXP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDXP for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR023214 HAD-like_dom
     IPR006357 HAD-SF_hydro_IIA
     IPR006349 PGP_euk
     IPR023215 NPhePase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96GD0

    ProtoNet protein and cluster: Q96GD0

    UniProtKB/Swiss-Prot: PLPP_HUMAN, Q96GD0
    Similarity: Belongs to the HAD-like hydrolase superfamily


    Function
    for PDXP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PLPP_HUMAN, Q96GD0
    Function: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates
    phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal
    progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not
    dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards
    pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity
    with PLP followed by PNP
    Catalytic activity: Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate
    Catalytic activity: O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate
    Enzyme regulation: Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA

    Enzyme Numbers (IUBMB): EC 3.1.3.741 2 EC 3.1.32 EC 3.1.3.31

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PDXP:
    hsa-miR-141 hsa-miR-1281 hsa-miR-3121-3p hsa-miR-200a hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: PDXP 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004647phosphoserine phosphatase activity IEA--
    GO:0004721phosphoprotein phosphatase activity IDA19000834
    GO:0005515protein binding IPI17500066
    GO:0031072heat shock protein binding IDA19000834
    GO:0033883pyridoxal phosphatase activity IEA--


    PDXP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PDXP:
     Increased G2M DNA content  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for PDXP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    2Phosphatases
    		Phosphatases1.00
    3Metabolism
    		Metabolic pathways0.38
    4Vitamins B6 activation to pyridoxal phosphate
    		Vitamin B6 metabolism0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PDXP
        Phosphatases
    Cytoskeletal Signaling


    2         Kegg Pathways  (Kegg details for PDXP):
        Vitamin B6 metabolism
    Metabolic pathways


    PDXP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDXP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for PDXP (Q96GD01, 3 ENSP000002159044) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDA1Q9BW613I2D: score=1 
    PNPOENSP000002255734STRING: ENSP00000225573
    AOX1ENSP000003638324STRING: ENSP00000363832
    PDXKENSP000002915654STRING: ENSP00000291565
    PHOSPHO2ENSP000003527824STRING: ENSP00000352782
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA15580268
    GO:0007088regulation of mitosis IMP15580268
    GO:0030836positive regulation of actin filament depolymerization IMP15580268
    GO:0031247actin rod assembly IDA19000834
    GO:0032465regulation of cytokinesis IMP15580268


    PDXP for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDXP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDXP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDXP

    9 HMDB Compounds for PDXP    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Pyridoxal3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde (see all 3)66-72-8--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Pyridoxamine2-methyl-4-aminomethyl-5-hydroxymethyl-3-Pyridinol (see all 5)85-87-0--
    Pyridoxamine 5'-phosphatePyridoxamine 5'-phosphate (see all 2)529-96-4--
    Pyridoxine2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine (see all 16)65-23-6--
    Pyridoxine 5'-phosphate5-Hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridylmethyl dihydrogen phosphate (see all 11)447-05-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PDXP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor17531224 16336786 14522954 16336194 11000053
    PyridoxinePyridoxol (see all 2)65-23-6targetcofactor17531224 16336786 16941173

    10/15 Novoseek chemical compound relationships for PDXP gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridoxine 5-phosphate 93 3 14522954 (1), 7625842 (1), 8053678 (1)
    pyridoxal 91 24 15452547 (6), 14522954 (2), 8053678 (2), 11000053 (2) (see all 11)
    pyridoxal 5-phosphate 90.4 82 9166745 (7), 10052942 (6), 14522954 (5), 17116355 (5) (see all 18)
    dehydroalanine 79.1 1 10052942 (1)
    vitamin b6 76.9 4 17482557 (2), 7814235 (1), 14522954 (1)
    cystathionine 54.7 1 11000053 (1)
    hydroxylamine 39.9 2 10052942 (2)
    pyridine 36.4 2 12460116 (1)
    serine 35.5 3 10052942 (1), 15580268 (1), 8679597 (1)
    aspartate 34.2 4 7814235 (1), 12460116 (1)

    Search CenterWatch for drugs/clinical trials and news about PDXP / PLPP 

    Transcripts
    for PDXP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDXP gene: 
    NM_020315.4  

    Unigene Cluster for PDXP:

    Pyridoxal (pyridoxine, vitamin B6) phosphatase
    Hs.632762  [show with all ESTs]
    Unigene Representative Sequence: BC064922
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215904(uc003atm.1) ENST00000403251

    miRNA
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    hsa-miR-141 hsa-miR-1281 hsa-miR-3121-3p hsa-miR-200a hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: PDXP 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK057265.1 AY125047.1 BC000320.2 BC009756.2 BC012832.2 BC018844.2 BC064922.1 

    12 DOTS entries:

    DT.448479  DT.100766554  DT.100856284  DT.100870723  DT.86821142  DT.100865256  DT.100768181  DT.100856666 
    DT.100867924  DT.120664730  DT.100645371  DT.100757530 

    24/335 AceView cDNA sequences (see all 335):

    BQ717808 BQ923764 BX456404 CA436893 BP350008 CR620574 BX387308 BC000320 
    BE675264 BM703623 BF512253 CR615489 BG683314 AL157480 CR601934 CR617653 
    BQ018954 CR617992 CR600890 BQ431762 T34990 BQ689646 BE552177 BM552170 

    GeneLoc Exon Structure


    Expression
    for PDXP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDXP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACCCGTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PDXP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDXP

    SOURCE GeneReport for Unigene cluster: Hs.632762

    UniProtKB/Swiss-Prot: PLPP_HUMAN, Q96GD0
    Tissue specificity: Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord.
    Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain

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    In Situ
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    Orthologs
    for PDXP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for PDXP gene from 8/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7712071 pyridoxal phosphate phosphatase-like 76(n)
    74.06(a)    		   771207  XM_003640384.1  XP_003640432.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1944091 zgc:194409 64.58(n)
    56.1(a)    		   561030  NM_001128705.1  NP_001122177.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG55676
    CG55776
    (see all 8)    		 --
    		 32(a)
    30(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 3L(17834640-17836644)
    3L(17832891-17834527)
    worm
    (Caenorhabditis elegans)    		 Secernentea K09H11.76
    F44E7.26
    (see all 5)    		 --
    		 29(a)
    28(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 V(5752447-5753516)
    V(5770438-5771750)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes PHO131 Pho13p 40.47(n)
    33.58(a)    		   851362   NP_010045.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G367901 haloacid dehalogenase-like hydrolase domain-containing more 44.92(n)
    39(a)    		   833646  NM_123037.4  NP_198495.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04908001 hypothetical protein 48.78(n)
    39(a)    		   4336245  NM_001059702.1  NP_001053167.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria nagD6
    		 UMP phosphatase
    		 31(a)
    		 1 → many
    		 Chromosome(698797-699549)


    ENSEMBL Gene Tree for PDXP (if available)
    TreeFam Gene Tree for PDXP (if available) 

    Paralogs
    for PDXP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDXP gene
    PGP2  
    2 SIMAP similar genes for PDXP using alignment to 2 protein entries:     PLPP_HUMAN (see all proteins):
    SH3BP1    PGP

    PDXP for paralogs           About GeneDecksing



    Genomic Variants
    for PDXP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 NCBI SNPs in PDXP are shown (see all 201)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1169486471,2
    		F,--38052839(+) AAAAAA/TAATTT 1 -- us2k11Minor allele frequency- T:0.22NA 120
    rs763286031,2
    		--38052840(+) AAAAAA/TATTTT 1 -- us2k12Minor allele frequency- T:0.22NA 122
    rs104276361,2
    		C,A--38052841(+) aaaaaA/AAA   
          /T/TTT    tttta     		1 -- us2k10--------
    rs781151761,2
    		C,--38052841(+) AAAAAA/TTTTTA 1 -- us2k14Minor allele frequency- T:0.21WA NA EA 244
    rs2019235061,2
    		--38053002(+) AAAAC-/AAAAAA 1 -- us2k10--------
    rs1151040361,2
    		--38053062(+) GCCATA/GTAACC 1 -- us2k10--------
    rs1389551981,2
    		--38053071(+) CCTAGA/GCTCAT 1 -- us2k10--------
    rs597832861,2
    		--38053154(+) CTGAAC/GGTGAA 1 -- us2k10--------
    rs1131189341,2
    		--38053205(+) TGTTTT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs2004710461,2
    		--38053205(+) TGTTT-/ATTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDXP (38054734 - 38062941 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PDXP
         1 CNV: 4128
         1 Indel: 73824

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PDXP

    Disorders / Diseases
    for PDXP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDXP for disorders           About GeneDecksing

    OMIM gene information: 609246    OMIM disorders: --

    12 diseases for PDXP:    About MalaCards
    laurence-moon syndrome    hypopyon    hypopyon ulcer    autoimmune hepatitis
    down syndrome    homocysteine    hepatitis    pneumonia
    tuberculosis    malaria    neuronitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for PDXP:
    Laurence-Moon syndrome     Kidney failure

    3 Novoseek disease relationships for PDXP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurological disorders 42.6 1 15452547 (1)
    inflammation 0 1 11000053 (1)
    cancer 0 3 15452547 (3)


    Export disorders for PDXP gene to outside databases

    Publications
    for PDXP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDXP gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with PDXP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution. (PubMed id 14522954)1, 2, 3, 7, 9 Jang Y.M.... Kwon O.-S. (2003)
    2. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. (PubMed id 15580268)1, 2, 9 Gohla A....Bokoch G.M. (2005)
    3. Identification of an essential cysteine residue in pyridoxal phosphatase from human erythrocytes. (PubMed id 8132548)1, 2, 9 Gao G.-J. and Fonda M.L. (1994)
    4. Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies. (PubMed id 16336786)1, 7, 9 Kim D.W....Choi S.Y. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    7. Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. (PubMed id 19000834)1, 9 Huang T.Y....Bokoch G.M. (2008)
    8. Human brain pyridoxal-5'-phosphate phosphatase (PLPP) :protein transduction of PEP-1-PLPP into PC12 cells. (PubMed id 18510874)1, 9 Lee Y.P....Choi S.Y. (2008)
    9. Increased homocyst(e)ine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity. (PubMed id 11000053)7, 9 McCarty M.F. (2000)
    10. Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. (PubMed id 17531224)7, 9 Hwang I.K....Won M.H. (2007)

    External Searches for PDXP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDXP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57026 HGNC: 30259 AceView: SH3BP1 Ensembl:ENSG00000241360 euGenes: HUgn57026
    ECgene: PDXP Kegg: 57026 H-InvDB: PDXP

    Other Databases showing PDXP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDXP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDXP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDXP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDXP gene:
    Search GeneIP for patents involving PDXP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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