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PDE5A Gene

protein-coding GIFtS: 63

GC04M120698

phosphodiesterase 5A, cGMP-specific
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CGB-PDE ^², ³
CN5A ^²
EC 3.1.4.35 ^³
PDE5 ^², ³
PDE5A1 ^²

Descriptions
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase ^²
cGMP-binding cGMP-specific phosphodiesterase ^³
phosphodiesterase 5A ^²
phosphodiesterase 5A, cGMP-specific ^²

External Ids
HGNC: 8784¹
Entrez Gene: 8654²
UniProtKB: O76074³
Ensembl: ENSG00000138735⁷

Search outside databases for aliases for PDE5A gene

Previous GC identifers: GC04M121176 GC04M120811 GC04M120877 GC04M120878 GC04M120776

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PDE5A:

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic

nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to

5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic

nucleotides and is important for smooth muscle relaxation in the cardiovascular system.

Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Function: Plays a role in signal transduction by regulating the intracellular concentration of

cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP

Gene Wiki entry for PDE5A (CGMP_specific_phosphodiesterase_type_5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDE5A gene

Entrez Gene cytogenetic band: 4q25-q27 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q27

PDE5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M120698: (about GC identifiers)

Start:	120,634,998 bp from pter
End:	120,769,429 bp from pter
Size:	134,432 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074 (See protein sequence)

Recommended Name: cGMP-specific 3',5'-cyclic phosphodiesterase

Size: 875 amino acids; 100013 Da

Cofactor: Divalent cations. Zinc ions yields maximum activity. Manganese, magnesium and cobalt also

support catalysis but at much higher concentrations

PDB structures from and Proteopedia :

1RKP (3D)

1T9R (3D)

1T9S (3D)

1TBF (3D)

1UDT (3D)

1UDU (3D)

1UHO (3D)

1XOZ (3D)

1XP0 (3D)

2CHM (3D)

2H40 (3D)

2H42 (3D)

2H44 (3D)

3B2R (3D)

3BJC (3D)

Secondary accessions: A0AV69 A8K2C4 O75026 O75887 Q86UI0 Q86V66 Q9Y6Z6

Alternative splicing: 2 isoforms: O76074-1 O76074-2

Post-translational modifications:

Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001074.2 NP_236914.2 NP_246273.2

ENSEMBL proteins:

ENSP00000348623 ENSP00000377957 ENSP00000347046 ENSP00000264805

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PDE5A
	Recombinant Proteins from Abcam (PDE5A)
	Human Recombinant Proteins from Abnova (PDE5A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IDA	18029348

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Antibodies for PDE5A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PDE5A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PDE5A (PDE5)
	Antibodies from Abcam (PDE5A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDE5A)
	Novus Biologicals Antibodies for PDE5A

Assays for PDE5A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for PDE5A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O76074

ProtoNet protein and cluster: O76074

1 Blocks protein family: IPB003018 GAF domain

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Domain: Composed of a C-terminal catalytic domain containing two putative divalent metal sites and

an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A

and B

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family

Similarity: Contains 2 GAF domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDE5A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033430

Applied Biosystems Silencer® siRNAs for PDE5A

Sigma-Aldrich siRNA and siRNA Panels for PDE5A

Sigma-Aldrich shRNA for PDE5A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001083
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001083
untagged cDNA clones in CMV expression vector (see all 4): NM_001083

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001083

UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Function: Plays a role in signal transduction by regulating the intracellular concentration of

cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP

Catalytic activity: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate

Enzyme regulation: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is

effective in the treatment of penile erectile dysfunction. Also inhibited by zaprinast

Enzyme Number (IUBMB): EC 3.1.4.35

Genatlas biochemistry entry for PDE5A:

cGMP specific nucleotide phosphodiesterase,class V,alpha subunit,two alternatively spliced forms

A1,A2,100kDa,highly expressed in tissues,aortic smooth muscle cells,heart,placenta,skeletal

muscle,pancreas,brain,liver and lung

1 MGI phenotypic allele

for Pde5a (no phenotypes)

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0008270	zinc ion binding	NAS	--
GO:0016787	hydrolase activity	IEA	--
GO:0030553	cGMP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for PDE5A (Your Favorite Gene powered by Ingenuity)

Purine Metabolism
Cellular Effects of Sildenafil (Viagra)

GeneDecks PDE5A for the pathways selected above

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UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074

Pathway: Purine metabolism; cGMP degradation; GMP from cGMP: step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for PDE5A

5/72 Interacting proteins for PDE5A (ENSP00000347046³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY2	ENSP00000371971³	STRING (score=.959)
PRKG1	ENSP00000363092³	STRING (score=.954)
NPR1	ENSP00000357669³	STRING (score=.934)
GUCY1A2	ENSP00000282249³	STRING (score=.918)
GUCY1A3	ENSP00000296518³	STRING (score=.918)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	--
GO:0009187	cyclic nucleotide metabolic process	NAS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDE5A

Sigma-Aldrich Small Molecules for PDE5A:

Inhibitor

Compounds for PDE5A available from Tocris Bioscience

Compound	Action	CAS number
Dipyridamole	Adenosine transport inhibitor	[58-32-2]
Zaprinast	PDE5/6/9/11 inhibitor	[37762-06-4]
T 0156 hydrochloride	Highly potent, selective PDE5 inhibitor	[324572-92-1]
MY-5445	PDE5 inhibitor	[78351-75-4]

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10/21 Novoseek chemical compound relationships for PDE5A gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cgmp	89.95	587	12554648 (6), 9445376 (5), 12761347 (5), 10679826 (5) (see all 99)
nitric oxide	69.63	163	17275845 (5), 15295092 (5), 12604588 (5), 15640438 (3) (see all 71)
motapizone	65.08	1	11834608 (1)
guanylate	63.39	5	12437503 (2), 18761597 (1), 15312978 (1), 15475488 (1)
roflumilast	46.24	2	15576036 (1), 11834608 (1)
cyclic amp	44.32	5	11162575 (1), 18467075 (1), 11358813 (1), 15045518 (1)
8-bromo cgmp	44.20	6	16751794 (1), 17929303 (1), 9486247 (1)
nitrate	40.86	16	18302448 (4), 14642699 (1), 16387566 (1), 11351772 (1) (see all 8)
erythro-9-(2 hydroxy 3-nonyl)adenine	40.24	2	17308037 (1), 15265792 (1)
forskolin	21.06	1	7476903 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDE5A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_033430

Sigma-Aldrich siRNA and siRNA Panels for PDE5A

Sigma-Aldrich shRNA for PDE5A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001083 NM_033430 NM_033437

REFSEQ mRNAs for PDE5A gene (3 alternative transcripts):

NM_001083.3 NM_033430.2 NM_033437.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001083 NM_033430 NM_033437

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001083
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001083
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001083

Additional cDNA sequence:

AB015656.1 AF043731.1 AF043732.1 AF155193.1 AJ004865.1 AK290189.1 AY264918.1 AY266363.1

BC126233.1

10 DOTS entries:

DT.100754842 DT.315121 DT.97786450 DT.97791706 DT.40224319 DT.205491 DT.404201 DT.95176543

DT.97813364 DT.99957235

24/142 AceView cDNA sequences (see all 142 ):

BX099915 AI814041 NM_033437 BU683142 AL701932 AA653566 BU146143 CA437264

AL701305 BM978332 AA461399 BM711448 AW130701 CF541229 CA443303 AW152010

H90636 BU616900 AY264918 BF222313 AA861242 AF155192 BF221547 AA382741

highest scoring ESTs for PDE5A:

AF043731 AJ004865 BF821833 AA317061 AA332394 AA447619 AB015656 AF043732 AF155192 AI313117

Unigene Clusters for PDE5A:

Phosphodiesterase 5A, cGMP-specific

Hs.587281 [show with all ESTs], Hs.647971 [show with all ESTs]

Unigene Representative Sequences: XM_001724855, NM_001083

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000356278 ENST00000394439 ENST00000354960 ENST00000264805

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PDE5A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDE5A

¹ / ² / ³

12 probe-sets matching PDE5A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
84162_at²^{, 3}	U95-E	1	1.00	1.00	0.87	1.11	AI457626	0.60	1.00	0.82	1
70665_at²^{, 3}	U95-E	1	1.00	1.00	0.94	1.08	AI796210	0.60	1.00	0.82	1
54668_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.37	W88427	0.60	1.00	0.82	1
34954_r_at²^{, 3}	U95-A	1	0.94	1.00	0.70	0.28	D89094	0.80	0.79	0.80	1
34953_i_at²^{, 3}	U95-A	1	0.73	1.00	0.91	0.47	D89094	0.80	0.79	0.80	1
227088_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF221547	0.40	1.00	0.76	1
206757_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_001083	0.60	1.00	0.82	1
1562228_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1562227_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227088_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553175_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206757_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks PDE5A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTGTAAAA

SOURCE GeneReport for Unigene clusters: Hs.587281 Hs.647971
Expression variation in blood from EXPOLDB for PDE5A
UniProtKB/Swiss-Prot: PDE5A_HUMAN, O76074
Tissue specificity: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and
pancreas and, to a much lesser extent, in brain, liver and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDE5A gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDE5A¹	--	phosphodiesterase 5A, cGMP-specific	94.55(n) 97.94(a)	403825 NM_001003188.1 NP_001003188.1
chimpanzee (Pan troglodytes)	PDE5A¹	--	phosphodiesterase 5A, cGMP-specific	99.81(n) 99.77(a)	461461 XM_001150967.1 XP_001150967.1
cow (Bos taurus)	PDE5A¹	--	phosphodiesterase 5A, cGMP-specific	92.91(n) 96.18(a)	281972 NM_174417.2 NP_776842.1
rat (Rattus norvegicus)	Pde5a¹	--	phosphodiesterase 5A, cGMP-specific	89.39(n) 93.46(a)	171115 NM_133584.1 NP_598268.1
mouse (Mus musculus)	Pde5a^{1, 5}	3⁵	phosphodiesterase 5A, cGMP-specific^{1, 5}	88.75(n)¹ 93.41(a)¹	242202¹ NM_153422.1¹ NP_700471.1¹ AF541937⁵ AK031275⁵ (see all 8)

About this table Species with no ortholog for PDE5A

ENSEMBL Gene Tree for PDE5A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PDE5A gene

PDE11A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/647 NCBI SNPs in PDE5A are shown (see all 647 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 288)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3733526^1,2	A,C,F,H	120747775(+)	`CAGGGA/GCACTG`	3	A/V	mis¹ ese³		15	EA NA EU WA	2726
	rs17051276^1,2	C,F,H	120747512(+)	`AGCAGA/CTATCA`	3	S/A	mis¹ ese³		11	NA EU EA WA	970
	rs11947234^1,2	A,C,F,H	120694307(+)	`TTGACA/GTACTG`	3	Y/Y	syn¹ ese³		10	EA NA EU WA	814
	rs1010740^1,2	A,C,F,H,O	120682857(-)	`ATGTCA/GTATAA`	3	--	int¹		11	EU EA WA NA	980
	rs2389866^1,2	A,C,F,H,O	120734711(+)	`gtacgT/Cgaatt`	3	--	int¹		9	NS EU EA WA	526
	rs2715021^1,2	A,C,F,H,O	120698413(-)	`TCAGAC/TTGATT`	3	--	int¹		4	EU NA	260
	rs2291185^1,2	A,C,F,H,O	120654281(+)	`TTCAAC/ACCATC`	3	--	int¹		7	NA EU EA WA	546
	rs1987179^1,2	A,C,F,H,O	120739382(+)	`CAGAAC/TTGAAT`	3	--	int¹		13	MN EA NA EU WA	2606
	rs1552095^1,2	A,C,F,H,O	120679754(-)	`ACAGCA/GAACAA`	3	--	int¹		19	NS MN EU EA WA NA	1347
	rs1480940^1,2	A,C,F,H,O	120677130(+)	`AACTGT/CTCATC`	3	--	int¹		8	MN EU EA WA NA	744

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HapMap Linkage Disequilibrium images for PDE5A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603310

10/49 Novoseek disease relationships for PDE5A gene (see all 49 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erectile dysfunction	95.64	239	17253475 (5), 17948826 (3), 17076943 (3), 18674473 (3) (see all 99)
hypertension pulmonary	69.70	37	17305584 (2), 19416631 (2), 15907910 (2), 15817798 (2) (see all 29)
priapism	64.04	25	17100941 (5), 12853767 (3), 16698365 (3), 19267844 (2) (see all 8)
benign prostatic hyperplasia	63.47	9	16387566 (1), 16956354 (1), 17329019 (1), 18761597 (1) (see all 7)
naion	62.48	30	17076943 (4), 18528398 (4), 17947271 (3), 17969789 (1) (see all 7)
hypogonadism	61.83	8	16939550 (2), 17309554 (2), 16422803 (1), 18641415 (1)
hypertension arterial	59.56	25	17606845 (2), 15907910 (2), 18689467 (2), 15466636 (1) (see all 19)
female sexual arousal disorder	53.53	1	16247643 (1)
peyronie disease	52.34	2	17942972 (1), 16885993 (1)
impotence	51.70	4	10541153 (1), 18778098 (1), 12789393 (1), 17017938 (1) (see all 5)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/417 PubMed articles for PDE5A gene (see all 417 ):

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (PubMed id 9714779)^{1, 2, 3, 4} Loughney K.... Ferguson K. (1998)
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase. (PubMed id 9642111)^{2, 3, 4} Stacey P.... Phillips S.C. (1998)
Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene. (PubMed id 9716380)^{1, 3, 4} Yanaka N.... Omori K. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (PubMed id 12955149)^{3, 4} Sung B.-J.... Cho J.M. (2003)
Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells. (PubMed id 10393044)^{3, 4} Zhou L.... Potter D.E. (1999)
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. (PubMed id 12554648)^{1, 3} Rybalkin S.D....Beavo J.A. (2003)
Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases. (PubMed id 10411650)^{1, 3} Kotera J....Omori K. (1999)
Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions. (PubMed id 18757735)^{1, 3} Wilson L.S....Maurice D.H. (2008)
The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3. (PubMed id 11602184)^{1, 3} Frame M....Pyne N.J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8654	HGNC: 8784	AceView: PDE5A	Ensembl:ENSG00000138735	euGenes: HUgn8654
ECgene: PDE5A	H-InvDB: PDE5A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PDE5A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDE5A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDE5A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDE5A		Antibodies for PDE5A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PDE5A		Small molecules for PDE5A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PDE5A)
	Antibodies (PDE5A)
	Chimera RNAi (PDE5A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PDE5A (PDE5)

	Recombinant Proteins (PDE5A)
	Antibodies (PDE5A)

Search OriGene for PDE5A

Tocris compounds for PDE5A

	Assays/Drugs/Proteins for PDE5A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PDE5A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PDE5A Gene at Home site.
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PDE5A Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PDE5A

Summaries
for PDE5A

Genomic Location
for PDE5A

Proteins
for PDE5A

Protein Domains/
Families
for PDE5A

Gene Function
for PDE5A

Pathways & Interactions
for PDE5A

Drugs & Compounds
for PDE5A

Transcripts
for PDE5A

Expression
for PDE5A

Orthologs
for PDE5A

Paralogs
for PDE5A

SNPs/Variants
for PDE5A

Disorders & Mutations
for PDE5A

Medical News
for PDE5A

Publications
for PDE5A

Search for PDE5A

Genome Databases showing PDE5A

Other Databases showing PDE5A

Specialized Databases showing PDE5A

Licensable Technologies
for PDE5A

Services
for PDE5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDE5A Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PDE5A

Summariesfor PDE5A

Genomic Locationfor PDE5A

Proteinsfor PDE5A

Protein Domains/Familiesfor PDE5A

Gene Functionfor PDE5A

Pathways & Interactionsfor PDE5A

Drugs & Compoundsfor PDE5A

Transcriptsfor PDE5A

Expression for PDE5A

Orthologsfor PDE5A

Paralogsfor PDE5A

SNPs/Variantsfor PDE5A

Disorders & Mutationsfor PDE5A

Medical Newsfor PDE5A

Publicationsfor PDE5A

Search for PDE5A

Genome Databases showing PDE5A

Other Databases showing PDE5A

Specialized Databases showing PDE5A

Licensable Technologiesfor PDE5A

Servicesfor PDE5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDE5A

Summaries
for PDE5A

Genomic Location
for PDE5A

Proteins
for PDE5A

Protein Domains/
Families
for PDE5A

Gene Function
for PDE5A

Pathways & Interactions
for PDE5A

Drugs & Compounds
for PDE5A

Transcripts
for PDE5A

Expression
for PDE5A

Orthologs
for PDE5A

Paralogs
for PDE5A

SNPs/Variants
for PDE5A

Disorders & Mutations
for PDE5A

Medical News
for PDE5A

Publications
for PDE5A

Licensable Technologies
for PDE5A

Services
for PDE5A