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PDE4B Gene

protein-coding GIFtS: 65

GC01P065970

phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
(Previous names: phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DPDE4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp686F2182 ^²
DPDE4 ^², ³, ⁵
EC 3.1.4.17 ^³
MGC126529 ^²
OTTHUMP00000010652 ^²
OTTHUMP00000010656 ^²
OTTHUMP00000046896 ^²
PDE32 ^³
PDE4B5 ^²
PDEIVB ^²

Descriptions
cAMP-specific 3',5'-cyclic phosphodiesterase 4B ^²
cAMP-specific phosphodiesterase-4 B isoform ^²
dunce-like phosphodiesterase E4 ^²
phosphodiesterase 4B ^²
phosphodiesterase 4B, cAMP-specific (dunce ^²
phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4) ^¹
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) ^²

External Ids
HGNC: 8781¹
Entrez Gene: 5142²
UniProtKB: Q07343³
Ensembl: ENSG00000184588⁷

Search outside databases for aliases for PDE4B gene

Previous GC identifers: GC01P066339 GC01P065729 GC01P065615 GC01P065628

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PDE4B:

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide

phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate

and mediate a number of cellular responses to extracellular signals, such as hormones, light, and

neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular

concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene

encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been

associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice

variants, encoding different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343

Function: May be involved in mediating central nervous system effects of therapeutic agents ranging

from antidepressants to antiasthmatic and anti-inflammatory agents

Gene Wiki entry for PDE4B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDE4B gene

Entrez Gene cytogenetic band: 1p31 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31

PDE4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P065970: (about GC identifiers)

Start:	66,030,781 bp from pter
End:	66,612,850 bp from pter
Size:	582,070 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343 (See protein sequence)

Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Size: 736 amino acids; 83343 Da

PDB structures from and Proteopedia :

1F0J (3D)

1JP1 (3D)

1JP2 (3D)

1RO6 (3D)

1RO9 (3D)

1ROR (3D)

1TB5 (3D)

1XLX (3D)

1XLZ (3D)

1XM4 (3D)

1XM6 (3D)

1XMU (3D)

1XMY (3D)

1XN0 (3D)

1XOS (3D)

1XOT (3D)

1Y2H (3D)

1Y2J (3D)

2CHM (3D)

2QYL (3D)

Secondary accessions: O15443

Alternative splicing: 3 isoforms: Q07343-1 Q07343-2 Q07343-3 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001032416.1 NP_001032417.1 NP_001032418.1 NP_002591.2

ENSEMBL proteins:

ENSP00000360087 ENSP00000342637 ENSP00000332116 ENSP00000360088 ENSP00000360084

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PDE4B
	Recombinant Proteins from Abcam (PDE4B3, PDE4B, PDE4B4, PDE4)
	Human Recombinant Proteins from Abnova (PDE4B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	9371714
GO:0005626	insoluble fraction	TAS	9371714
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348

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Antibodies for PDE4B:

	Invitrogen Antibodies for PDE4B
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PDE4B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PDE4B3, PDE4B, PDE4B4, PDE4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDE4B)
	Novus Biologicals Antibodies for PDE4B

Assays for PDE4B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for PDE4B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q07343

ProtoNet protein and cluster: Q07343

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE4B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002600

Applied Biosystems Silencer® siRNAs for PDE4B

Sigma-Aldrich siRNA and siRNA Panels for PDE4B

Sigma-Aldrich shRNA for PDE4B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001037339
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001037339
untagged cDNA clones in CMV expression vector (see all 5): AK000989

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002600

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343

Function: May be involved in mediating central nervous system effects of therapeutic agents ranging

from antidepressants to antiasthmatic and anti-inflammatory agents

Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

Enzyme regulation: Inhibited by rolipram

Enzyme Number (IUBMB): EC 3.1.4.17

Genatlas biochemistry entry for PDE4B:

cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce

gene,involved in signal transduction

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pde4b):

immune system

lethality-postnatal

life span-post-weaning/aging

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	TAS	9371714
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for PDE4B (Your Favorite Gene powered by Ingenuity) (see all 7 )

Cellular Effects of Sildenafil (Viagra)
Purine Metabolism
Cardiac &beta
Relaxin Signaling
cAMP-mediated Signaling

GeneDecks PDE4B for the pathways selected above

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UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343

Pathway: Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for PDE4B

5/74 Interacting proteins for PDE4B (ENSP00000332116³) via UniProtKB, MINT, and/or STRING (see all 74 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	ENSP00000355598³	STRING (score=.994)
PRKACA	ENSP00000309591³	STRING (score=.977)
ADCY2	ENSP00000371971³	STRING (score=.952)
ADCY1	ENSP00000297323³	STRING (score=.913)
ADCY3	ENSP00000260600³	STRING (score=.913)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDE4B

Sigma-Aldrich Small Molecules for PDE4B:

Inhibitor

Compounds for PDE4B available from Tocris Bioscience

Compound	Action	CAS number
CP 80633	Selective PDE4 inhibitor	[135637-46-6]
YM 976	PDE4 inhibitor	[191219-80-4]
Etazolate hydrochloride	PDE4 inhibitor	[51022-77-6]
Mesopram	Orally active PDE4 inhibitor	[189940-24-7]
Rolipram	PDE4 inhibitor	[61413-54-5]

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2 Novoseek chemical compound relationships for PDE4B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	52.91	6	15331441 (4)
forskolin	42.62	2	9003416 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE4B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002600

Sigma-Aldrich siRNA and siRNA Panels for PDE4B

Sigma-Aldrich shRNA for PDE4B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001037339 NM_001037340 NM_001037341 NM_002600

REFSEQ mRNAs for PDE4B gene (4 alternative transcripts):

NM_001037339.1 NM_001037340.1 NM_001037341.1 NM_002600.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001037339 NM_001037340 NM_001037341 NM_002600

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001037339
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001037339
                                 untagged cDNA clones in CMV expression vector (see all 5): AK000989

Additional cDNA sequence:

AB209081.1 AK289969.1 AK290006.1 AK290206.1 AK294441.1 BC036108.1 BC046161.1 BC071607.1

BC101480.1 BC105040.1 CR749667.1 EF595686.1 L12685.1 L12686.1 L20966.1 M97515.1

U85048.1

23 DOTS entries:

DT.100741919 DT.100741918 DT.121644658 DT.40259510 DT.442607 DT.100804857 DT.121331236 DT.95371539

DT.92037235 DT.121331177 DT.92025734 DT.100691054 DT.121331222 DT.91986363 DT.121331184 DT.121331223

DT.121331224 DT.121331225 DT.121331230 DT.121331245 DT.97825163 DT.99955375 DT.40118505

24/144 AceView cDNA sequences (see all 144 ):

AI684715 BF957513 AL133915 AA206316 AA769288 AI830034 BF934703 CD721828

BU616750 AU118147 AA582841 BU170024 BM760114 AW571513 CR749667 BX951946

AW086078 AA805258 AA453293 AK000989 BP344045 BM759232 U85048 BG218299

highest scoring ESTs for PDE4B:

AA056218 AA056219 AA206316 AA206317 AA226393 AA279642 AA280008 AA280532 AA291939 AA320556

Unigene Cluster for PDE4B:

Phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)

Hs.198072 [show with all ESTs]

Unigene Representative Sequence: NM_001037341

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B (see all 10 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18a	·
SP1:					-		-		-		-		-														-		-				-		-																-
SP2:											-		-														-		-				-		-																-
SP3:																																	-		-																-
SP4:
SP5:																																			-

ExUns:	18b	^	19a	·	19b	^	20	^	21a	·	21b	·	21c
SP1:					-
SP2:					-
SP3:					-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PDE4B

5 Ensembl transcripts including schematic representations:

ENST00000371048 ENST00000341517 ENST00000329654 ENST00000371049 ENST00000371045

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PDE4B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDE4B

¹ / ² / ³

7 probe-sets matching PDE4B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33705_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L20971	0.80	1.00	0.91	1
215671_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU144792	0.40	1.00	0.76	1
211302_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L20966	0.80	1.00	0.91	1
203708_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_002600	0.60	1.00	0.82	1
215671_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211302_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203708_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks PDE4B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.198072
Expression variation in blood from EXPOLDB for PDE4B
UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
Tissue specificity: Expressed in brain, heart, lung and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDE4B gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDE4B¹	--	phosphodiesterase 4B, cAMP-specific (phosphodiesterase more	92.06(n) 96.88(a)	479540 XM_536678.2 XP_536678.2
chimpanzee (Pan troglodytes)	PDE4B¹	--	phosphodiesterase 4B, cAMP-specific (phosphodiesterase more	99.49(n) 99.45(a)	456921 XM_001162777.1 XP_001162777.1
rat (Rattus norvegicus)	Pde4b¹	--	phosphodiesterase 4B, cAMP specific	89(n) 96.39(a)	24626 NM_017031.2 NP_058727.2
mouse (Mus musculus)	Pde4b^{1, 5}	4 (46.80 cM)⁵	phosphodiesterase 4B, cAMP specific^{1, 5}	89.74(n)¹ 96.81(a)¹	18578¹ NM_019840.2¹ NP_062814.2¹ AF208023⁵ AF326555⁵ (see all 32)
chicken (Gallus gallus)	PDE4B¹	--	phosphodiesterase 4B, cAMP-specific (phosphodiesterase more	79.12(n) 91.03(a)	424700 NM_001031291.1 NP_001026462.1

About this table Species with no ortholog for PDE4B

ENSEMBL Gene Tree for PDE4B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDE4B gene

PDE4D² PDE4C² PDE4A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2972 NCBI SNPs in PDE4B are shown (see all 2972 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1124)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs910693^1,2	A,C,F,H,O	66568836(-)	`AATATC/TGGACA`	4	--	ng5¹ int¹		17	NA NS EU EA WA	1098
	rs910694^1,2	A,C,F,H,O	66568814(-)	`GGTGGA/GGAGAA`	4	--	int¹ ng5¹ trp³		6	EA NA EU WA	462
	rs2253745^1,2	A,C,F,H,O	66229832(+)	`TGACAG/ATCATT`	3	--	ng5¹ int¹		11	EU EA WA NA	978
	rs9326069^1,2	A,C,F,H	66030004(+)	`CAGGCA/GAATGT`	2	--	ng5¹		4	EU EA WA	418
--	rs2186118^1,2	A,C,F,H	66229053(-)	`ACAGAG/TCTAGA`	3	--	int¹ ng5¹		4	EU EA WA	420
	rs783067^1,2	A,C,F,H	66611321(-)	`ACAAGT/GGAGAA`	4	--	ut3¹ ese³		9	MN EU EA WA NA	964
	rs3767309^1,2	C,F,H	66570257(+)	`CCTAGA/GCTTTG`	4	--	int¹ ng5¹		9	EA EU WA	2330
	rs1890195^1,2	C,F,H	66568966(-)	`TCTGAA/GGAGAC`	4	--	ng5¹ int¹		4	EU EA WA	420
	rs12040309^1,2	C,F,H	66230374(+)	`TTTTTT/ATATTG`	3	--	ng5¹ int¹		7	EU EA WA NA	558
	rs10127702^1,2	A,F,H	66229025(+)	`tatgaT/Ctttag`	3	--	int¹ ng5¹		4	EU EA WA	392

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HapMap Linkage Disequilibrium images for PDE4B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600127

4 Novoseek disease relationships for PDE4B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	57.88	25	17417055 (5), 18394866 (5), 17823207 (2), 16293762 (2) (see all 8)
bipolar disorder	48.56	4	17417055 (2), 18394866 (2)
psychiatric disorder	35.75	2	17417055 (1), 16293762 (1)
asthma	0.00	1	18348140 (1)

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1 PharmGKB disease relationship for PDE4B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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Human Gene Mutation Database: PDE4B
Human Genome Epidemiology Navigator: PDE4B (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/73 PubMed articles for PDE4B gene (see all 73 ):

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. (PubMed id 9371714)^{1, 3, 4} Huston E.... Houslay M.D. (1997)
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (PubMed id 8413254)^{3, 4} Bolger G.... Ferguson K. (1993)
A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. (PubMed id 8384210)^{3, 4} McLaughlin M.M.... Livi G.P. (1993)
Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PubMed id 18785206)^{1, 3} Numata S....Ohmori T. (2008)
PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (PubMed id 18394866)^{1, 3} Fatemi S.H....Menniti F.S. (2008)
Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. (PubMed id 18329668)^{1, 3} Numata S....Ohmori T. (2008)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. (PubMed id 16293762)^{1, 3} Millar J.K....Porteous D.J. (2005)
The PDE4B gene confers sex-specific protection against schizophrenia. (PubMed id 17417055)^{1, 3} Pickard B.S....Muir W.J. (2007)
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness. (PubMed id 17823207)^{1, 3} Millar J.K....Porteous D.J. (2007)
DISC1, PDE4B, and NDE1 at the centrosome and synapse. (PubMed id 18983980)^{1, 3} Bradshaw N.J....Millar J.K. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5142	HGNC: 8781	AceView: PDE4B	Ensembl:ENSG00000184588	euGenes: HUgn5142
ECgene: PDE4B	H-InvDB: PDE4B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PDE4B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDE4B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDE4B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDE4B		Antibodies for PDE4B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PDE4B		Small molecules for PDE4B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PDE4B)
	Antibodies (PDE4B)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PDE4B3, PDE4B, PDE4B4, PDE4)
	Antibodies (PDE4B3, PDE4B, PDE4B4, PDE4)

Search OriGene for PDE4B

Tocris compounds for PDE4B

	Assays/Drugs/Proteins for PDE4B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PDE4B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PDE4B Gene at Home site.
Version 2.41.1
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PDE4B Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PDE4B

Summaries
for PDE4B

Genomic Location
for PDE4B

Proteins
for PDE4B

Protein Domains/
Families
for PDE4B

Gene Function
for PDE4B

Pathways & Interactions
for PDE4B

Drugs & Compounds
for PDE4B

Transcripts
for PDE4B

Expression
for PDE4B

Orthologs
for PDE4B

Paralogs
for PDE4B

SNPs/Variants
for PDE4B

Disorders & Mutations
for PDE4B

Medical News
for PDE4B

Publications
for PDE4B

Search for PDE4B

Genome Databases showing PDE4B

Other Databases showing PDE4B

Specialized Databases showing PDE4B

Licensable Technologies
for PDE4B

Services
for PDE4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDE4B Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PDE4B

Summariesfor PDE4B

Genomic Locationfor PDE4B

Proteinsfor PDE4B

Protein Domains/Familiesfor PDE4B

Gene Functionfor PDE4B

Pathways & Interactionsfor PDE4B

Drugs & Compoundsfor PDE4B

Transcriptsfor PDE4B

Expression for PDE4B

Orthologsfor PDE4B

Paralogsfor PDE4B

SNPs/Variantsfor PDE4B

Disorders & Mutationsfor PDE4B

Medical Newsfor PDE4B

Publicationsfor PDE4B

Search for PDE4B

Genome Databases showing PDE4B

Other Databases showing PDE4B

Specialized Databases showing PDE4B

Licensable Technologiesfor PDE4B

Servicesfor PDE4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDE4B

Summaries
for PDE4B

Genomic Location
for PDE4B

Proteins
for PDE4B

Protein Domains/
Families
for PDE4B

Gene Function
for PDE4B

Pathways & Interactions
for PDE4B

Drugs & Compounds
for PDE4B

Transcripts
for PDE4B

Expression
for PDE4B

Orthologs
for PDE4B

Paralogs
for PDE4B

SNPs/Variants
for PDE4B

Disorders & Mutations
for PDE4B

Medical News
for PDE4B

Publications
for PDE4B

Licensable Technologies
for PDE4B

Services
for PDE4B