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PDE4A Gene

protein-coding GIFtS: 60

GC19P010392

phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
(Previous names: phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DPDE2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DPDE2 ^², ³, ⁵
EC 3.1.4.17 ^³
PDE4 ^²
PDE46 ^², ³

Descriptions
cAMP-specific phosphodiesterase ^²
phosphodiesterase 4A ^²
phosphodiesterase 4A, cAMP-specific (dunce ^²
phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2) ^¹
phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) ^²
phosphodiesterase E2 dunce homolog, Drosophila ^²
phosphodiesterase isozyme 4 ^²

External Ids
HGNC: 8780¹
Entrez Gene: 5141²
UniProtKB: P27815³
Ensembl: ENSG00000065989⁷

Search outside databases for aliases for PDE4A gene

Previous GC identifers: GC19P010663 GC19P010376

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for PDE4A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDE4A gene

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

PDE4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P010392: (about GC identifiers)

Start:	10,388,449 bp from pter
End:	10,441,306 bp from pter
Size:	52,858 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815 (See protein sequence)

Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Size: 886 amino acids; 98143 Da

Subcellular location: Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has

propensity for association with membranes

PDB structures from and Proteopedia :

2QYK (3D)

Secondary accessions: O75522 O76092 Q16255 Q16691 Q8WUQ3

Alternative splicing: 5 isoforms: P27815-1 P27815-2 P27815-3 P27815-4 P27815-5 (Additional isoforms seem to exist)

Post-translational modifications:

Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001104777.1 NP_001104778.1 NP_001104779.1 NP_006193.1

ENSEMBL proteins:

ENSP00000370061 ENSP00000341007 ENSP00000293683 ENSP00000270474 ENSP00000370078

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for PDE4A
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PDE4A
	Recombinant Proteins from Abcam (PDE4A8, PDE4A4 , PDE4A5, PDE4, PDE4A)
	Human Recombinant Proteins from Abnova (PDE4A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	9677330
GO:0005625	soluble fraction	TAS	8940140
GO:0016020	membrane	IEA	--

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Antibodies for PDE4A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PDE4A8, PDE4A4 , PDE4A5, PDE4, PDE4A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDE4A)
	Novus Biologicals Antibodies for PDE4A

Assays for PDE4A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for PDE4A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27815

ProtoNet protein and cluster: P27815

UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE4A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_006202

Applied Biosystems Silencer® siRNAs for PDE4A

Sigma-Aldrich siRNA and siRNA Panels for PDE4A

Sigma-Aldrich shRNA for PDE4A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PDE4A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111307
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111307
untagged cDNA clones in CMV expression vector (see all 4): NM_001111307

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001111307

UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815

Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate

Enzyme regulation: Inhibited by rolipram

Enzyme Number (IUBMB): EC 3.1.4.17

Genatlas biochemistry entry for PDE4A:

cAMP specific nucleotide phosphodiesterase class IV,A,with homology to Drosophila dunce

gene,involved in signal transduction

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pde4a):

immune system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	TAS	9677330
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for PDE4A (Your Favorite Gene powered by Ingenuity) (see all 7 )

Aminosugars Metabolism
Cellular Effects of Sildenafil (Viagra)
cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling
Purine Metabolism

GeneDecks PDE4A for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815

Pathway: Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for PDE4A

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8940140

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for PDE4A

Sigma-Aldrich Small Molecules for PDE4A:

Activator Antagonist Inhibitor

Compounds for PDE4A available from Tocris Bioscience

Compound	Action	CAS number
CP 80633	Selective PDE4 inhibitor	[135637-46-6]
YM 976	PDE4 inhibitor	[191219-80-4]
Etazolate hydrochloride	PDE4 inhibitor	[51022-77-6]
Mesopram	Orally active PDE4 inhibitor	[189940-24-7]
Rolipram	PDE4 inhibitor	[61413-54-5]

About this table

10/49 Novoseek chemical compound relationships for PDE4A gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
roflumilast	95.17	80	17573446 (3), 16257550 (3), 16735669 (3), 17428447 (3) (see all 47)
cdp 840	90.53	8	9218122 (1), 9163639 (1), 9405253 (1), 11044563 (1) (see all 8)
8-((4-bromo-2,3-dioxobutyl)thio)-adenosine 3',5'-cyclic monophosphate	87.95	2	2160272 (1), 11863434 (1)
motapizone	81.94	4	9154331 (2), 9559883 (1), 11834608 (1)
cyclic amp	79.62	127	9559883 (4), 7998974 (4), 15021978 (3), 19442182 (3) (see all 55)
7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine	78.49	2	11992633 (2)
quazinone	76.81	1	10856433 (1)
forskolin	74.70	38	9003416 (4), 7931278 (1), 10373535 (1), 14561639 (1) (see all 31)
cipamfylline	73.64	3	12709818 (2), 12174103 (1)
cgmp	73.49	59	8730511 (3), 8869231 (2), 1313303 (2), 1315035 (2) (see all 32)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE4A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_006202

Sigma-Aldrich siRNA and siRNA Panels for PDE4A

Sigma-Aldrich shRNA for PDE4A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111307 NM_001111308 NM_001111309 NM_006202

REFSEQ mRNAs for PDE4A gene (4 alternative transcripts):

NM_001111307.1 NM_001111308.1 NM_001111309.1 NM_006202.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111307 NM_001111308 NM_001111309 NM_006202

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111307
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111307
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001111307

Additional cDNA sequence:

AF073745.2 AY266362.1 AY593872.1 AY618547.1 BC019864.1 BC038234.1 CR604925.1 L20965.1

M37744.1 S75213.1 U18087.1 U18088.1 U68532.1 U97584.1

9 DOTS entries:

DT.208282 DT.75134232 DT.97812911 DT.100691695 DT.91866715 DT.121480536 DT.92427218 DT.86844360

DT.121480539

24/108 AceView cDNA sequences (see all 108 ):

AW138155 BM462182 BC038234 BQ446409 BU169201 BQ928991 BQ672933 AF073745

AY593872 BM021314 AW296744 BQ711857 F37034 U97584 S75213 BC019864

F31164 BQ052490 BQ009232 BQ961810 BF116176 CR604925 BM021079 NM_006202

highest scoring ESTs for PDE4A:

AA523395 L20965 U18088 AA205223 AA326506 AA402738 AA613574 AA962029 AA975441 AA994528

Unigene Cluster for PDE4A:

Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)

Hs.89901 [show with all ESTs]

Unigene Representative Sequence: NM_001111307

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4A (see all 10 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17a	·	17b	·	17c	^	18a	·	18b	^	19a	·
SP1:			-		-		-												-		-								-												-								-
SP2:																			-		-								-												-								-
SP3:					-		-												-		-								-												-								-
SP4:																													-												-								-
SP5:							-												-		-

ExUns:	19b	·	19c	·	19d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PDE4A

5 Ensembl transcripts including schematic representations:

ENST00000380686 ENST00000344979 ENST00000293683 ENST00000352831 ENST00000380702

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PDE4A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDE4A

¹ / ² / ³

13 probe-sets matching PDE4A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
666_at²^{, 3}	U95-A	1	1.00	1.00	0.23	0.85	L20965	1.00	1.00	1.00	1
47611_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.16	AA523395	1.00	1.00	1.00	1
40750_at²^{, 3}	U95-A	1	1.00	1.00	0.34	0.17	U18088	1.00	1.00	1.00	1
63678_g_at²^{, 3}	U95-C	1	1.00	1.00	0.48	0.61	AI352523	0.80	1.00	0.91	1
63677_at²^{, 3}	U95-C	1	0.94	1.00	0.95	1.39	AI352523	0.80	1.00	0.91	1
211901_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF073745	0.80	1.00	0.91	1
211591_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L20965	1.00	1.00	1.00	1
204735_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006202	0.60	1.00	0.82	1
211447_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U18088	1.00	1.00	1.00	1
211901_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211591_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204735_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211447_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PDE4A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCACTGTG

SOURCE GeneReport for Unigene cluster: Hs.89901
Expression variation in blood from EXPOLDB for PDE4A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDE4A gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Pde4a⁵	9 (8.00 cM)	phosphodiesterase 4A, cAMP specific	--	U97586
fruit fly (Drosophila melanogaster)	dnc³	1A1--3C10	behavior cAMP-specific phosphodiesterase	60(a)	--
worm (Caenorhabditis elegans)	R153.1a³	II(7627989-7634156)	cyclic nucleotide phosphodiesterase	54(a)	--

About this table Species with no ortholog for PDE4A

ENSEMBL Gene Tree for PDE4A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDE4A gene

PDE4D² PDE4B² PDE4C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/127 NCBI SNPs in PDE4A are shown (see all 127 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7256672^1,2	A,C,F,H	10440474(+)	`TTGCCG/TAGCCT`	4	--	ut3¹ ese³		4		EU EA WA	420
	rs1051738^1,2	C,F,H,O	10438843(+)	`GACTGC/AGCAGG`	4	E/A	mis¹ ese³		15		MN EA NA EU WA	1400
	rs3745258^1,2	C,F,H	10440834(-)	`AATGAA/GCAAAA`	4	--	ut3¹		8		NA EU EA WA	630
	rs2230190^1,2	C,H	10439058(+)	`TAAGCC/TACAGC`	4	H/Y	mis¹ ese³		6		MN EU EA WA	528
--	rs28395786^1,2	F	10426553(+)	`TGAGCC/TGGTCC`	8	R/R R/W	syn¹ mis¹		1		--	48
	rs2569766^1,2	H	10422726(-)	`AATGGC/GTGGCT`	1	--	ng5¹		4		EU EA WA	396
	rs3745260^1,2	H	10440023(-)	`GTGAAC/TGCTCC`	4	--	ut3¹		4		EU EA WA	408
	rs28395790^1,2	F	10439375(+)	`TGCCTC/AAAAGA`	4	--	ut3¹ ese³		1		--	56
--	rs2569757^1,2	C	10424006(-)	`CCTCCA/CGAGTA`	1	--	ng5¹		0	--	--	--	--
	rs2569763^1,2	H	10422777(-)	`CTGCCC/GTAATC`	1	--	ng5¹		4		EU EA WA	416

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HapMap Linkage Disequilibrium images for PDE4A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600126

10/62 Novoseek disease relationships for PDE4A gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pulmonary disease chronic obstructive	75.45	71	11964752 (3), 18341675 (2), 19213793 (2), 16267357 (2) (see all 51)
chronic obstructive asthma	67.87	9	15912967 (1), 16257373 (1), 10419856 (1), 17428447 (1) (see all 7)
asthma	62.31	106	19135348 (4), 15639300 (3), 11964752 (3), 14636078 (2) (see all 63)
inflammation	49.47	37	15607122 (2), 16469485 (2), 14580925 (2), 10372831 (2) (see all 27)
airways disease	48.73	2	16861399 (1), 15765929 (1)
dermatitis atopic	40.43	10	17355425 (2), 8752839 (2), 9338548 (1), 12824943 (1) (see all 7)
necrosis	39.41	31	10193778 (2), 19256507 (2), 11996895 (2), 14561639 (1) (see all 20)
leydig cell tumor	34.56	1	1713581 (1)
asthma allergic	32.77	7	15665325 (3), 11590377 (2)
leukemia lymphocytic chronic	31.68	10	12531792 (2), 11839681 (2), 15652238 (2), 17699872 (1) (see all 5)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/534 PubMed articles for PDE4A gene (see all 534 ):

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PubMed id 8009369)^{1, 2, 3} Milatovich A....Francke U. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells. (PubMed id 11566027)^{3, 4} Lario P.I....Huang Z. (2001)
Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2. (PubMed id 9677330)^{3, 4} Sullivan M.... Houslay M.D. (1998)
Molecular cloning of a novel splice variant of human type IVA (PDE- IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19. (PubMed id 7772058)^{3, 4} Horton Y.M.... Houslay M.D. (1995)
Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1). (PubMed id 7888306)^{3, 4} Sullivan M.... Houslay M.D. (1994)
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (PubMed id 8413254)^{3, 4} Bolger G.... Ferguson K. (1993)
Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase. (PubMed id 2160582)^{3, 4} Livi G.P.... Balcarek J.M. (1990)
Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils. (PubMed id 12764607)^{1, 3} Pryzwansky K.B. and Madden V.J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5141	HGNC: 8780	AceView: PDE4A	Ensembl:ENSG00000065989	euGenes: HUgn5141
ECgene: PDE4A	H-InvDB: PDE4A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PDE4A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PDE4A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDE4A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDE4A		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for PDE4A
	Lentivirus-delivered shRNAs for PDE4A		Small molecules for PDE4A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PDE4A)
	Antibodies (PDE4A)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PDE4A8, PDE4A4 , PDE4A5, PDE4, PDE4A)
	Antibodies (PDE4A8, PDE4A4 , PDE4A5, PDE4, PDE4A)

Search OriGene for PDE4A

Tocris compounds for PDE4A

	Assays/Drugs/Proteins for PDE4A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PDE4A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PDE4A Gene at Home site.
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PDE4A Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for PDE4A

Summaries
for PDE4A

Genomic Location
for PDE4A

Proteins
for PDE4A

Protein Domains/
Families
for PDE4A

Gene Function
for PDE4A

Pathways & Interactions
for PDE4A

Drugs & Compounds
for PDE4A

Transcripts
for PDE4A

Expression
for PDE4A

Orthologs
for PDE4A

Paralogs
for PDE4A

SNPs/Variants
for PDE4A

Disorders & Mutations
for PDE4A

Medical News
for PDE4A

Publications
for PDE4A

Search for PDE4A

Genome Databases showing PDE4A

Other Databases showing PDE4A

Specialized Databases showing PDE4A

Licensable Technologies
for PDE4A

Services
for PDE4A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDE4A Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor PDE4A

Summariesfor PDE4A

Genomic Locationfor PDE4A

Proteinsfor PDE4A

Protein Domains/Familiesfor PDE4A

Gene Functionfor PDE4A

Pathways & Interactionsfor PDE4A

Drugs & Compoundsfor PDE4A

Transcriptsfor PDE4A

Expression for PDE4A

Orthologsfor PDE4A

Paralogsfor PDE4A

SNPs/Variantsfor PDE4A

Disorders & Mutationsfor PDE4A

Medical Newsfor PDE4A

Publicationsfor PDE4A

Search for PDE4A

Genome Databases showing PDE4A

Other Databases showing PDE4A

Specialized Databases showing PDE4A

Licensable Technologiesfor PDE4A

Servicesfor PDE4A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDE4A

Summaries
for PDE4A

Genomic Location
for PDE4A

Proteins
for PDE4A

Protein Domains/
Families
for PDE4A

Gene Function
for PDE4A

Pathways & Interactions
for PDE4A

Drugs & Compounds
for PDE4A

Transcripts
for PDE4A

Expression
for PDE4A

Orthologs
for PDE4A

Paralogs
for PDE4A

SNPs/Variants
for PDE4A

Disorders & Mutations
for PDE4A

Medical News
for PDE4A

Publications
for PDE4A

Licensable Technologies
for PDE4A

Services
for PDE4A