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PDE3A Gene

protein-coding GIFtS: 60

GC12P020413

phosphodiesterase 3A, cGMP-inhibited
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CGI-PDE ^¹, ²
EC 3.1.4.17 ^³

Descriptions
CGI-PDE A ^³
Cyclic GMP-inhibited phosphodiesterase A ^³
cGMP-inhibited 3',5'-cyclic phosphodiesterase A ^²
cyclic GMP inhibited phosphodiesterase A ^²
phosphodiesterase 3A ^²
phosphodiesterase 3A, cGMP-inhibited ^²

External Ids
HGNC: 8778¹
Entrez Gene: 5139²
UniProtKB: Q14432³
Ensembl: ENSG00000172572⁷

Search outside databases for aliases for PDE3A gene

Previous GC identifers: GC12P020791 GC12P020523 GC12P020422

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432

Function: Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDE3A gene

Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p12.2 HGNC cytogenetic band: 12p12

PDE3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P020413: (about GC identifiers)

Start:	20,413,464 bp from pter
End:	20,725,148 bp from pter
Size:	311,685 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009714.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432 (See protein sequence)

Recommended Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Size: 1141 amino acids; 124979 Da

Subcellular location: Membrane; Peripheral membrane protein (Potential)

PDB structures from and Proteopedia :

1LRC (3D)

Secondary accessions: O60865 Q13348 Q17RD1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000912.3

ENSEMBL proteins:

ENSP00000351957

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for PDE3A
	Recombinant Proteins from Abcam (PDE3A)
	Human Recombinant Proteins from Abnova (PDE3A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	IEA	--
GO:0005626	insoluble fraction	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for PDE3A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PDE3A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PDE3A), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDE3A)
	Novus Biologicals Antibodies for PDE3A

Assays for PDE3A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for PDE3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14432

ProtoNet protein and cluster: Q14432

1 Blocks protein family: IPB001917 Aminotransferase

UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432

Similarity: Belongs to the cyclic nucleotide phosphodiesterase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE3A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDE3A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000921

Applied Biosystems Silencer® siRNAs for PDE3A

Sigma-Aldrich siRNA and siRNA Panels for PDE3A

Sigma-Aldrich shRNA for PDE3A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000921
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000921
untagged cDNA clone in CMV expression vector: NM_000921

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000921

UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432

Function: Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP) (By similarity)

Catalytic activity: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate

Enzyme regulation: Inhibited by cGMP

Enzyme Number (IUBMB): EC 3.1.4.17

Genatlas biochemistry entry for PDE3A:

cAMP,cGMP inhibited nucleotide phosphodiesterase 3A homolog,involved in fat metabolism

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pde3a):

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IEA	--
GO:0004119	cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	TAS	9173884
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for PDE3A (Your Favorite Gene powered by Ingenuity) (see all 7 )

Purine Metabolism
Aminosugars Metabolism
Cellular Effects of Sildenafil (Viagra)
Cardiac &beta
Relaxin Signaling

GeneDecks PDE3A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for PDE3A

5/18 Interacting proteins for PDE3A (ENSP00000351957³ Q14432²) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²	MINT-3295899
PRKACA	ENSP00000309591³	STRING (score=.943)
PRKACB	ENSP00000359719³	STRING (score=.943)
PRKACG	ENSP00000366488³	STRING (score=.943)
PRKAR1A	ENSP00000351410³	STRING (score=.943)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001556	oocyte maturation	IEA	--
GO:0006629	lipid metabolic process	TAS	8921398
GO:0007165	signal transduction	IEA	--
GO:0040020	regulation of meiosis	IEA	--
GO:0042493	response to drug	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for PDE3A

Sigma-Aldrich Small Molecules for PDE3A:

Inhibitor

Compounds for PDE3A available from Tocris Bioscience

Compound	Action	CAS number
Milrinone	PDE3 inhibitor	[78415-72-2]
Cilostazol	PDE3A inhibitor. Also adenosine uptake inhibitor	[73963-72-1]
Cilostamide	PDE3 inhibitor	[68550-75-4]
Zardaverine	PDE3/4 inhibitor	[101975-10-4]
Anagrelide hydrochloride	Potent PDE3 inhibitor	[58579-51-4]

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6 Novoseek chemical compound relationships for PDE3A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
8-((4-bromo-2,3-dioxobutyl)thio)-adenosine 3',5'-cyclic monophosphate	93.18	2	11955000 (1), 11863434 (1)
cgmp	76.97	55	11468344 (4), 8713077 (3), 17704206 (3), 18394675 (3) (see all 18)
forskolin	56.19	5	9031467 (2), 11832336 (1), 16153182 (1)
cyclic amp	44.93	1	17392505 (5), 18467075 (1)
histidine	6.80	4	8713077 (3), 9826434 (1)
nitric oxide	0.00	1	15265792 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDE3A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PDE3A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000921

Sigma-Aldrich siRNA and siRNA Panels for PDE3A

Sigma-Aldrich shRNA for PDE3A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000921

REFSEQ mRNAs for PDE3A gene:

NM_000921.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000921

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000921
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000921
                                 untagged cDNA clone in CMV expression vector: NM_000921

Additional cDNA sequence:

AJ005036.1 AK308317.1 BC117369.1 BC117371.1 M91667.2 U36798.1

1 DOTS entry:

DT.109816

24/84 AceView cDNA sequences (see all 84 ):

AI597722 BF435350 CK300107 BF593925 AI628567 BU632064 BQ187047 AI961922

BM726612 NM_000921 AI289578 BX483871 BM930781 AJ005036 AL600736 AW195207

BX507268 AI683378 AI742043 BU752871 BM681258 AK095203 AI249381 BX507232

highest scoring ESTs for PDE3A:

AJ005036 AL600188 AL600736 AL600910 AL700955 AW195207 BE931135 BE933967 BM930781 BQ187047

Unigene Cluster for PDE3A:

Phosphodiesterase 3A, cGMP-inhibited

Hs.591150 [show with all ESTs]

Unigene Representative Sequence: U36798

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000359062

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PDE3A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDE3A

¹ / ² / ³

5 probe-sets matching PDE3A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34650_at²^{, 3}	U95-A	1	0.69	1.00	1.00	1.00	AJ005036	1.00	0.90	0.95	1
206389_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000921	0.60	1.00	0.82	1
206388_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U36798	0.80	0.88	0.84	1
206389_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206388_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PDE3A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTGCATA

SOURCE GeneReport for Unigene cluster: Hs.591150
Expression variation in blood from EXPOLDB for PDE3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDE3A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PDE3A¹	--	phosphodiesterase 3A, cGMP-inhibited	99.62(n) 99.65(a)	465329 XM_520783.2 XP_520783.2
cow (Bos taurus)	PDE3A¹	--	phosphodiesterase 3A, cGMP-inhibited	90.65(n) 92.01(a)	536636 XM_616776.3 XP_616776.3
rat (Rattus norvegicus)	Pde3a¹	--	phosphodiesterase 3A, cGMP inhibited	83.35(n) 85.11(a)	50678 NM_017337.1 NP_059033.1
mouse (Mus musculus)	Pde3a^{1, 5}	6⁵	phosphodiesterase 3A, cGMP inhibited^{1, 5}	83.85(n)¹ 84.49(a)¹	54611¹ NM_018779.1¹ NP_061249.1¹ AA212102⁵ AF099187⁵ (see all 19)
chicken (Gallus gallus)	PDE3A¹	--	phosphodiesterase 3A, cGMP-inhibited	76.86(n) 82.92(a)	418185 XM_416416.2 XP_416416.2

About this table Species with no ortholog for PDE3A

ENSEMBL Gene Tree for PDE3A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PDE3A gene

PDE3B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1916 NCBI SNPs in PDE3A are shown (see all 1916 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 589)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs954865^1,2	A,C,F,H,O	20725429(-)	`AGTTCC/TTATAC`	1	--	ng3¹		17		NS MN EA NA EU WA	1206
	rs6487131^1,2	A,C,F,H	20725509(+)	`AAACAC/TCTAAG`	1	--	ng3¹		7		EU EA WA NA	536
	rs6487132^1,2	A,C,F,H	20725556(+)	`AAATGA/GTGCCA`	1	--	ng3¹		7		EU EA WA NA	548
	rs1515775^1,2	C,F,H	20725103(-)	`AAGCAC/ACCTCT`	1	--	ut3¹ ese³		7		EU EA WA NA	542
	rs954866^1,2	A,C	20725286(-)	`CTCCAC/TCAGCA`	1	--	ng3¹ ese³		0	--	--	--	--
	rs7133764^1,2	F,H	20725435(+)	`GAACTG/CTCTAT`	1	--	ng3¹		4		EU EA WA	408
	rs10743380^1,2	A,C,F,H	20657826(+)	`CCCGTT/CACTTC`	1	V/V	syn¹ ese³		8		EU EA WA	840
--	rs2229192^1,2	F	20691130(+)	`TTTCTA/GGTGGC`	1	L/L	syn¹		1		MN	58
	rs1348581^1,2	A,C,F,H,O	20422908(+)	`GTCATT/CGTAAC`	1	--	int¹		16		EA NA EU WA	1472
	rs978349^1,2	A,C,F,H,O	20454401(-)	`AAGGAC/TAGCCC`	1	--	int¹		12		EU EA WA NA	1052

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HapMap Linkage Disequilibrium images for PDE3A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 123805

3 Novoseek disease relationships for PDE3A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	33.66	2	8695850 (1), 9031467 (1)
erectile dysfunction	17.21	3	10421499 (2), 10859452 (1)
heart failure	6.48	3	15867171 (2), 17332439 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/85 PubMed articles for PDE3A gene (see all 85 ):

Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase. (PubMed id 1315035)^{1, 2, 3, 4} Meacci E.... Manganiello V. (1992)
Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase. (PubMed id 8155697)^{1, 3, 4} Degerman E.... Manganiello V. (1994)
Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum. (PubMed id 10421499)^{1, 3, 4} Kuthe A....Maegert H.-J. (1999)
Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis. (PubMed id 8695850)^{1, 3, 4} Cheung P.P....Colman R.W. (1996)
Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene. (PubMed id 10679291)^{1, 2, 3} Kasuya J....Fujita-Yamaguchi Y. (2000)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428. (PubMed id 16153182)^{1, 3} Pozuelo Rubio M....Mackintosh C. (2005)
Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. (PubMed id 17392505)^{1, 3} Zhang W. and Colman R.W. (2007)
Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A) -- a gene involved in fat metabolism located at 11p15.1. (PubMed id 8921398)^{1, 3} Loebbert R.W.... Zabel B.U. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5139	HGNC: 8778	AceView: PDE3A	Ensembl:ENSG00000172572	euGenes: HUgn5139
ECgene: PDE3A	H-InvDB: PDE3A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/PDE3

Licensable Technologies for PDE3A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PDE3A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDE3A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDE3A		Antibodies for PDE3A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PDE3A		Small molecules for PDE3A
	"Your Favorite Gene" Pathways		feedback

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PDE3A

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PDE3A Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for PDE3A

Summaries
for PDE3A

Genomic Location
for PDE3A

Proteins
for PDE3A

Protein Domains/
Families
for PDE3A

Gene Function
for PDE3A

Pathways & Interactions
for PDE3A

Drugs & Compounds
for PDE3A

Transcripts
for PDE3A

Expression
for PDE3A

Orthologs
for PDE3A

Paralogs
for PDE3A

SNPs/Variants
for PDE3A

Disorders & Mutations
for PDE3A

Medical News
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Publications
for PDE3A

Search for PDE3A

Genome Databases showing PDE3A

Other Databases showing PDE3A

Specialized Databases showing PDE3A

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDE3A Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor PDE3A

Summariesfor PDE3A

Genomic Locationfor PDE3A

Proteinsfor PDE3A

Protein Domains/Familiesfor PDE3A

Gene Functionfor PDE3A

Pathways & Interactionsfor PDE3A

Drugs & Compoundsfor PDE3A

Transcriptsfor PDE3A

Expression for PDE3A

Orthologsfor PDE3A

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SNPs/Variantsfor PDE3A

Disorders & Mutationsfor PDE3A

Medical Newsfor PDE3A

Publicationsfor PDE3A

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Genome Databases showing PDE3A

Other Databases showing PDE3A

Specialized Databases showing PDE3A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDE3A

Summaries
for PDE3A

Genomic Location
for PDE3A

Proteins
for PDE3A

Protein Domains/
Families
for PDE3A

Gene Function
for PDE3A

Pathways & Interactions
for PDE3A

Drugs & Compounds
for PDE3A

Transcripts
for PDE3A

Expression
for PDE3A

Orthologs
for PDE3A

Paralogs
for PDE3A

SNPs/Variants
for PDE3A

Disorders & Mutations
for PDE3A

Medical News
for PDE3A

Publications
for PDE3A

Licensable Technologies
for PDE3A

Services
for PDE3A