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P4HA1 Gene

protein-coding GIFtS: 60

GC10M074436

prolyl 4-hydroxylase, alpha polypeptide I
(Previous names: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: P4HA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C-P4Halpha(I) ^¹, ²
EC 1.14.11.2 ^³
P4HA ^², ³, ⁵

Descriptions
4-PH alpha-1 ^³
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 ^³
collagen prolyl 4-hydroxylase alpha(I) ^²
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I ^¹, ²
prolyl 4-hydroxylase, alpha I subunit ^²
prolyl 4-hydroxylase, alpha polypeptide I ^²

External Ids
HGNC: 8546¹
Entrez Gene: 5033²
UniProtKB: P13674³
Ensembl: ENSG00000122884⁷

Search outside databases for aliases for P4HA1 gene

Previous GC identifers: GC10M073545 GC10M073870 GC10M074660 GC10M074111

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P4HA1:

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed

of two identical alpha subunits and two beta subunits. The encoded protein is one of several

different types of alpha subunits and provides the major part of the catalytic site of the active

enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of

4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized

procollagen chains. Alternatively spliced transcript variants encoding different isoforms have

been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: P4HA1_HUMAN, P13674

Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences

in collagens and other proteins

Gene Wiki entry for P4HA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P4HA1 gene

Entrez Gene cytogenetic band: 10q21.3-q23.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q21.3-q23.1

P4HA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M074436: (about GC identifiers)

Start:	74,436,981 bp from pter
End:	74,526,630 bp from pter
Size:	89,650 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P4HA1_HUMAN, P13674 (See protein sequence)

Recommended Name: Prolyl 4-hydroxylase subunit alpha-1 precursor

Size: 534 amino acids; 61049 Da

Cofactor: Binds 1 Fe(2+) ion per subunit

Cofactor: Ascorbate

Subunit: Heterotetramer of two alpha-1 chains and two beta chains (the beta chain is the

multi-functional PDI)

Subcellular location: Endoplasmic reticulum lumen

PDB structures from and Proteopedia :

1TJC (3D)

Secondary accessions: Q15082 Q15083 Q5VSQ5

Alternative splicing: 2 isoforms: P13674-1 P13674-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000908.2 NP_001017962.1 NP_001136067.1 NP_001136068.1

ENSEMBL proteins:

ENSP00000378353 ENSP00000307318 ENSP00000362099 ENSP00000263556

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P4HA1)
	Human Recombinant Proteins from Abnova (P4HA1)

OriGene Purified Recombinant Human Proteins (see all 2): P4HA1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	18029348
GO:0005783	endoplasmic reticulum	TAS	2543975
GO:0005788	endoplasmic reticulum lumen	IEA	--

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Antibodies for P4HA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P4HA1
	Sigma-Aldrich Antibodies for P4HA1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P4HA1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (P4HA1)
	Novus Biologicals Antibodies for P4HA1

Assays for P4HA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13674

ProtoNet protein and cluster: P13674

2 Blocks protein families:

IPB006620 Prolyl 4-hydroxylase

IPB013547 Prolyl 4-hydroxylase alpha-subunit

UniProtKB/Swiss-Prot: P4HA1_HUMAN, P13674

Similarity: Belongs to the P4HA family

Similarity: Contains 1 PKHD (prolyl/lysyl hydroxylase) domain

Similarity: Contains 1 TPR repeat

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P4HA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000917

Applied Biosystems Silencer® siRNAs for P4HA1

Sigma-Aldrich siRNA and siRNA Panels for P4HA1

Sigma-Aldrich shRNA for P4HA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P4HA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000917
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000917
untagged cDNA clones in CMV expression vector (see all 5): NM_000917

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001017962

UniProtKB/Swiss-Prot: P4HA1_HUMAN, P13674

Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences

in collagens and other proteins

Catalytic activity: Procollagen L-proline + 2-oxoglutarate + O(2) = procollagen

trans-4-hydroxy-L-proline + succinate + CO(2)

Enzyme Number (IUBMB): EC 1.14.11.2

Genatlas biochemistry entry for P4HA1:

procollagen-proline,2-oxoglutarate 4-dioxygenase (prolyl-4-hydroxylase),alpha polypeptide,isoform

1,component of the heterodimer (alpha 1) 2,beta 2,type I,enzyme inhibited by poly (L-proline)

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for P4ha1):

	cellular	embryogenesis	growth/size	lethality-prenatal/perinatal
other	skin/coat/nails

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004656	procollagen-proline 4-dioxygenase activity	TAS	2543975
GO:0005488	binding	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for P4HA1 (Your Favorite Gene powered by Ingenuity)

Arginine and Proline Metabolism

GeneDecks P4HA1 for the pathways selected above

About GeneDecksing

5/14 Interacting proteins for P4HA1 (ENSP00000362099³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARS2	ENSP00000360327³	STRING (score=.912)
ALDH4A1	ENSP00000290597³	STRING (score=.899)
EPRS	ENSP00000355890³	STRING (score=.899)
LAP3	ENSP00000226299³	STRING (score=.899)
PRODH	ENSP00000334726³	STRING (score=.899)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019538	protein metabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for P4HA1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P4HA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000917

Sigma-Aldrich siRNA and siRNA Panels for P4HA1

Sigma-Aldrich shRNA for P4HA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000917 NM_001017962 NM_001142595 NM_001142596

REFSEQ mRNAs for P4HA1 gene (4 alternative transcripts):

NM_000917.3 NM_001017962.2 NM_001142595.1 NM_001142596.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000917 NM_001017962 NM_001142595 NM_001142596

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000917
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000917
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000917

Additional cDNA sequence:

AK123653.1 AK222960.1 AK312593.1 BC034998.1 BX648829.1 CR590114.1 M24486.1 M24487.1

17 DOTS entries:

DT.101983410 DT.99944438 DT.100793094 DT.452516 DT.91867531 DT.97793771 DT.121301381 DT.100782196

DT.100793096 DT.121301410 DT.121301432 DT.121301453 DT.40226814 DT.97803495 DT.121301418 DT.95171545

DT.92432123

24/230 AceView cDNA sequences (see all 230 ):

AI128777 BX489858 AI858630 AU121350 AL701971 AL701340 BU743221 BU167243

BM710650 AU279754 BG230763 CD013930 CD013931 AL550156 BP337008 BM930020

CB156311 N88160 AI139319 AA336955 CD013928 AI061083 BQ217818 BM691656

highest scoring ESTs for P4HA1:

M24486 AA279041 AL598620 AL701971 AL702003 AL702270 BQ421908 BX496553 AA083833 AA165549

Unigene Cluster for P4HA1:

Prolyl 4-hydroxylase, alpha polypeptide I

Hs.500047 [show with all ESTs]

Unigene Representative Sequence: BX648829

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000394890 ENST00000307116 ENST00000373008 ENST00000263556

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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P4HA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P4HA1

¹ / ² / ³

6 probe-sets matching P4HA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37037_at²^{, 3}	U95-A	1	1.00	1.00	0.52	1.49	M24486	1.00	0.87	0.94	1
88134_at*²^{, 3}	U95-D	1	1.00	1.00	0.91	0.55	AA581869	0.60	1.00	0.82	1
207543_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000917	0.60	1.00	0.82	1
243335_at*²	U133-B	NULL	0.00	0.00	--	--	--	--	--	--	--
207543_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
243335_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGACATTAGT

SOURCE GeneReport for Unigene cluster: Hs.500047
Expression variation in blood from EXPOLDB for P4HA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P4HA1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P4HA1¹	--	prolyl 4-hydroxylase, alpha polypeptide I	94.32(n) 98.31(a)	479242 XM_857164.1 XP_862257.1
chimpanzee (Pan troglodytes)	P4HA1¹	--	prolyl 4-hydroxylase, alpha polypeptide I	99.94(n) 100(a)	450891 XM_001141043.1 XP_001141043.1
cow (Bos taurus)	P4HA1¹	--	prolyl 4-hydroxylase, alpha polypeptide I	94.82(n) 97.75(a)	518288 NM_001075770.1 NP_001069238.1
rat (Rattus norvegicus)	P4ha1¹	--	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline more	88.2(n) 94.01(a)	64475 NM_172062.2 NP_742059.2
mouse (Mus musculus)	P4ha1^{1, 5}	10⁵	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline more^{1, 5}	89.26(n)¹ 95.32(a)¹	18451¹ NM_011030.1¹ NP_035160.1¹ AI314028⁵ AK030574⁵ (see all 23)

About this table Species with no ortholog for P4HA1

ENSEMBL Gene Tree for P4HA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P4HA1 gene

P4HA3² P4HA2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/360 NCBI SNPs in P4HA1 are shown (see all 360 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 120)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs8380^1,2	A,C,F,H,O	74437341(-)	`TTTAAT/CGGAAA`	4	--	ut3¹ ese³		8		MN NA EU EA WA	740
	rs7918396^1,2	A,C,F,H	74527553(+)	`TTTTTT/CCCTTG`	2	--	ng3¹ trp³		13		EU EA WA NA MN	2212
--	rs10306^1,2	C,F,H	74437408(-)	`TTTCTT/CTTAGC`	4	--	ut3¹ trp³		5		MN EU EA WA	576
	rs16930262^1,2	F,H	74437701(+)	`TTATCC/TAACCA`	4	--	ut3¹		7		NA EU EA WA	558
--	rs7908374^1,2	F,H	74436875(+)	`AAGAGT/CATAAA`	2	--	ng5¹		4		EU EA WA	420
	rs7901481^1,2	F,H	74527190(+)	`taagaG/Actcca`	2	--	ng3¹		4		EU EA WA	418
--	rs4405231^1,2	A,C	74504657(+)	`GAAGAC/TTTAAT`	4	--	ut5¹ ese³		0	--	--	--	--
	rs12263220^1,2	H	74526734(+)	`CCAGCG/TCCCCG`	4	--	ut5¹		3		EU EA	300
	rs28384495^1,2	F	74526582(-)	`TCCGAG/CTGGAG`	4	--	ut5¹ ese³		2		MN EA	1252
--	rs12971^1,2	C	74437400(-)	`AGCTCC/TTCTGT`	4	--	ut3¹ ese³		1		MN	184

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HapMap Linkage Disequilibrium images for P4HA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176710

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/22 PubMed articles for P4HA1 gene (see all 22 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Structure and expression of the human gene for the alpha subunit of prolyl 4-hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues. (PubMed id 7961714)^{3, 4} Helaakoski T.... Pihlajaniemi T. (1994)
Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1. (PubMed id 2556027)^{2, 3} Pajunen L....Kivirikko K.I. (1989)
Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts. (PubMed id 2543975)^{3, 4} Helaakoski T.... Pihlajaniemi T. (1989)
The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH. (PubMed id 9417920)^{1, 3} Horelli-Kuitunen N....Palotie A. (1997)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)⁴ Chen R.... Zou H. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. (PubMed id 16488890)³ Chen L....Wang X.L. (2006)
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. (PubMed id 16877351)³ Grimmer C....Pfander D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5033	HGNC: 8546	AceView: P4HA1	Ensembl:ENSG00000122884	euGenes: HUgn5033
ECgene: P4HA1	H-InvDB: P4HA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for P4HA1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P4HA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P4HA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P4HA1		Antibodies for P4HA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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P4HA1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for P4HA1

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Genomic Location
for P4HA1

Proteins
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for P4HA1

Services
for P4HA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P4HA1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor P4HA1

Summariesfor P4HA1

Genomic Locationfor P4HA1

Proteinsfor P4HA1

Protein Domains/Familiesfor P4HA1

Gene Functionfor P4HA1

Pathways & Interactionsfor P4HA1

Drugs & Compoundsfor P4HA1

Transcriptsfor P4HA1

Expression for P4HA1

Orthologsfor P4HA1

Paralogsfor P4HA1

SNPs/Variantsfor P4HA1

Disorders & Mutationsfor P4HA1

Medical Newsfor P4HA1

Publicationsfor P4HA1

Search for P4HA1

Genome Databases showing P4HA1

Other Databases showing P4HA1

Specialized Databases showing P4HA1

Licensable Technologiesfor P4HA1

Servicesfor P4HA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P4HA1

Summaries
for P4HA1

Genomic Location
for P4HA1

Proteins
for P4HA1

Protein Domains/
Families
for P4HA1

Gene Function
for P4HA1

Pathways & Interactions
for P4HA1

Drugs & Compounds
for P4HA1

Transcripts
for P4HA1

Expression
for P4HA1

Orthologs
for P4HA1

Paralogs
for P4HA1

SNPs/Variants
for P4HA1

Disorders & Mutations
for P4HA1

Medical News
for P4HA1

Publications
for P4HA1

Licensable Technologies
for P4HA1

Services
for P4HA1