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OXT Gene

protein-coding   GIFtS: 53

GC20P003000
oxytocin, prepropeptide
(Previous names: oxytocin, prepro- (neurophysin I) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OT)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC126890 2
MGC126892 2
OT 2, 3
OT-NPI 2, 3
OTTHUMP00000030079 2
Descriptions
neurophysin I 2
oxytocin, prepro- (neurophysin I) 1, 2
oxytocin, prepropeptide 2
oxytocin-neurophysin I 2
oxytocin-neurophysin I, preproprotein 2
External Ids
HGNC: 85281
Entrez Gene: 50202
UniProtKB: P011783
Ensembl: ENSG000001014057
Search outside databases for aliases for OXT gene

Previous GC identifers: GC20P003040 GC20P003047

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for OXT:
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior
pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its
carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory
vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either
stored or secreted into the bloodstream. The precursor seems to be activated while it is being
transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during
parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex
sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular
functions. [provided by RefSeq]

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OXT gene  

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

OXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003000:     (about GC identifiers)

Start:
3,000,266 bp from pter
End:
3,001,162 bp from pter
Size:
897 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011387.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178 (See protein sequence)
Recommended Name: Oxytocin-neurophysin 1 precursor  
Size: 125 amino acids; 12722 Da
Subcellular location: Secreted
Secondary accessions: Q3MIG0

REFSEQ proteins: NP_000906.1  

ENSEMBL proteins: 
ENSP00000217386 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for OXT  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Oxytocin)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
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Antibodies for OXT: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of OXT
Sigma-Aldrich Antibodies for OXT
Browse R&D Systems for Antibodies
Antibodies from Abcam (Oxytocin), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for OXT

Assays for OXT: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR000981 Neurhyp_horm
 IPR016321 Nonapeptide_hormone_prcur


   GeneDecks  OXT for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P01178

ProtoNet protein and cluster: P01178

1 Blocks protein family: IPB000981 Neurohypophysial hormone

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Similarity: Belongs to the vasopressin/oxytocin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000915

              Applied Biosystems Silencer® siRNAs for OXT

              Sigma-Aldrich siRNA for OXT  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000915
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000915
                                 untagged cDNA clone in CMV expression vector: NM_000915 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000915

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Function: Neurophysin 1 specifically binds oxytocin
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Genatlas biochemistry entry for OXT:
oxytocin,prepro- (neurophysin 1)

8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Oxt):

behavior/neurologicaldigestive/alimentaryendocrine/exocrine glandlife span-post-weaning/aging
nervous systemrenal/urinary systemreproductive system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005179 hormone activity IEA--
GO:0005185 neurohypophyseal hormone activity IEA--
GO:0005515 protein binding IPI17474147
GO:0031855 oxytocin receptor binding IEA--
GO:0031894 V1A vasopressin receptor binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  OXT 


5/36 Interacting proteins for OXT (ENSP000002173863 P011781) via UniProtKB, MINT, and/or STRING (see all 36 )
InteractantInteraction Details
GeneCardExternal ID(s)
NCK1P163331EBI-1762651, EBI-389883
OXTRENSP000003242703STRING (score=.999)
CRHENSP000002765713STRING (score=.967)
FOSENSP000003062453STRING (score=.953)
ESR2ENSP000003439253STRING (score=.952)
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3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006950 response to stress IEA--
GO:0007165 signal transduction TAS10218979
GO:0050891 multicellular organismal water homeostasis IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for OXT:
Ligand

Compounds for OXT available from Tocris Bioscience
CompoundAction CAS number
L-368,899 hydrochloridePotent, non-peptide oxytocin receptor antagonist[148927-60-0]
CapsazepineVanilloid receptor antagonist. Also activator of ENaCdelta[138977-28-3]
L-371,257Potent and selective oxytocin receptor antagonist[162042-44-6]
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UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon
(Sandoz). Used to artificially speed or induce labor

10/32 Novoseek chemical compound relationships for OXT gene (see all 32 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
carbetocin 86.05 69 16769107 (6), 17636798 (6), 9659650 (5), 10076146 (5) (see all 20)
13,14-dihydro-15-ketoprostaglandin f2alpha 83.33 33 1475375 (2), 9437586 (2), 7616495 (2), 9640273 (2) (see all 25)
prostaglandin 78.80 208 10860251 (5), 10735096 (4), 10230581 (4), 8315315 (3) (see all 99)
tocinoic acid 72.69 7 9062067 (1), 15791394 (1), 17723478 (1), 8275925 (1) (see all 5)
progesterone 70.80 375 8377978 (7), 1730809 (6), 9640267 (6), 8886706 (6) (see all 99)
pressinoic acid 69.38 4 8589250 (1), 8275925 (1), 9546658 (1), 8256869 (1)
barusiban 68.74 8 15740719 (3), 16914691 (2), 15350251 (2)
(+-)-pgf2-alpha 65.06 56 9348208 (6), 11566737 (3), 17459165 (3), 17491148 (3) (see all 25)
ovta 64.48 4 12183418 (3), 15613460 (1)
sodium prasterone sulfate 59.92 2 9772437 (1), 7664601 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000915

              Sigma-Aldrich siRNA for OXT  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000915  

REFSEQ mRNAs for OXT gene: 

NM_000915.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000915  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000915
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000915
                                 untagged cDNA clone in CMV expression vector: NM_000915 

Additional cDNA sequence: 

BC069144.1 BC101841.1 BC101843.1 M25650.1 M62611.1 X03173.1 

1 DOTS entry:

DT.306364 

7 AceView cDNA sequences:

X03173 AW242780 BC069144 NM_000915 AW270827 M25650 M62611 

highest scoring ESTs for OXT:

AW242780 AW270827 BC069144 M25650 M62611 NM_000915 X03173 BC101841 BC101843 DB506474 

Unigene Cluster for OXT:

Oxytocin, prepropeptide
Hs.113216  [show with all ESTs]
Unigene Representative Sequence: NM_000915


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000217386  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OXT expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OXT

1 / 2 / 3

3 probe-sets matching OXT gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
32472_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M11186 0.20 1.00 0.72 1

207576_x_at2, 3 U133-A 2 1.00 0.82 -- -- NM_000915 0.60 1.00 0.82 1

207576_x_at2 U133Plus2 2 1.00 0.82 -- -- -- -- -- -- --
GeneDecks  OXT for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCCGGCCCCA

SOURCE GeneReport for Unigene cluster: Hs.113216

Expression variation in blood from EXPOLDB for OXT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OXT gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OXT1   -- oxytocin, prepropeptide 91.2(n)
86.4(a)
609301  XM_846540.1  XP_851633.1 
chimpanzee
(Pan troglodytes)
OXT1   -- oxytocin, prepropeptide 98.92(n)
99.19(a)
746851  XM_001160221.1  XP_001160221.1 
cow
(Bos taurus)
OXT1   -- oxytocin, prepropeptide 89.78(n)
88.71(a)
280888  NM_176855.1  NP_789825.1 
rat
(Rattus norvegicus)
Oxt1   -- oxytocin, prepropeptide 87.47(n)
88(a)
25504  NM_012996.1  NP_037128.1 
mouse
(Mus musculus)
Oxt1, 5 2 (73.50 cM)5
oxytocin1, 5 86.93(n)1
87.2(a)1
184291  NM_011025.31  NP_035155.11 
 AF4835085  AF4835095  (see all 11)
About this table        Species with no ortholog for OXT

ENSEMBL Gene Tree for OXT
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OXT gene
AVP2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/34 NCBI SNPs in OXT are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs61330101,2
A,C,F,H2998301(+) CCCTGA/GGCCAG 1 -- ng518Minor allele frequency- N:0.02EU EA WA NA 636
rs27402101,2
A,C,F,H3001255(-) TCTGAG/TCGCAA 1 -- ng314Minor allele frequency- T:0.21EU EA WA 412
rs27703781,2
A,C,F,H3001514(+) AGGAAG/ACGGGC 1 -- ng318Minor allele frequency- A:0.32EU EA WA NA 774
rs27402081,2
C,F,H3001634(-) ACATGG/TTGGCC 1 -- ng313Minor allele frequency- T:0.02EA WA 266
rs119084231,2
C,H2999645(+) ccacaG/Agtatt 1 -- ng514Minor allele frequency- A:0.00EU EA WA 420
--
rs48136261,2
A,C2999291(+) tcccaA/Ggcagc 1 -- ng510--------
rs37612481,2
C,F2998393(+) GCAGGT/CGCTTT 1 -- ng514Minor allele frequency- C:0.15EU EA WA 420
--
rs9135541,2
A,C2998566(+) ctatcA/Gcctag 1 -- ng510--------
rs37612461,2
C,F2998335(+) GCTCTC/AGAGGA 1 -- ng514Minor allele frequency- A:0.14EU EA WA 418
--
rs61390021,2
A2998537(+) tttttA/Tttttt 1 -- ng510--------
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HapMap Linkage Disequilibrium images for OXT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 167050

10/93 Novoseek disease relationships for OXT gene (see all 93 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
postpartum hemorrhage 88.58 84 11802188 (4), 15103233 (4), 17578351 (4), 12179676 (4) (see all 54)
uterine atony 83.79 29 10076146 (3), 11530117 (2), 19177043 (2), 10789257 (1) (see all 21)
fetal distress 77.80 24 8233251 (3), 9141942 (1), 11730496 (1), 8262291 (1) (see all 21)
pregnancy prolonged 74.82 10 1892182 (2), 1398272 (2), 11928554 (1), 11883268 (1) (see all 8)
cephalopelvic disproportion 73.68 7 1445129 (1), 11080926 (1), 15770303 (1), 2145531 (1) (see all 7)
chorioamnionitis 72.61 36 1579312 (3), 9170488 (3), 10796160 (2), 10796161 (2) (see all 23)
labor prolonged 72.10 13 16949410 (2), 11883027 (1), 10368493 (1), 11120525 (1) (see all 12)
endometritis 63.49 10 8841214 (3), 9170488 (2), 17636608 (1), 1897091 (1) (see all 6)
shoulder dystocia 61.59 11 2082887 (1), 8813305 (1), 9396889 (1), 15970854 (1) (see all 10)
fetal macrosomia 61.28 3 11958242 (1), 10190670 (1), 12596626 (1)
About this table

Human Genome Epidemiology Navigator: OXT (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/1228 PubMed articles for OXT gene (see all 1228 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5020 HGNC: 8528 AceView: OXT Ensembl:ENSG00000101405 euGenes: HUgn5020
ECgene: OXT H-InvDB: OXT
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
Wikipedia http://en.wikipedia.org/wiki/Oxytocin
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OXT:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OXT-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
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 Predesigned and custom siRNAs for OXT Antibodies for OXT
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 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(Oxytocin)
 Antibodies (Oxytocin)
 Search OriGene for OXT
 Tocris compounds for OXT




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for OXT

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