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Aliases & Descriptions for OXT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC126890 2 | | MGC126892 2 | | OT 2, 3 | | OT-NPI 2, 3 | | OTTHUMP00000030079 2 |
| | | Descriptions |
|---|
| neurophysin I 2 | | oxytocin, prepro- (neurophysin I) 1, 2 | | oxytocin, prepropeptide 2 | | oxytocin-neurophysin I 2 | | oxytocin-neurophysin I, preproprotein 2 |
|
| | Search outside databases for aliases for OXT genePrevious GC identifers: GC20P003040 GC20P003047 |
Summaries for OXT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OXT: There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq] UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland |
Genomic Location for OXT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OXT gene 
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13OXT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P003000:
(about GC identifiers)
Start:
|
3,000,266 bp from pter |
End:
|
3,001,162 bp from pter |
Size:
|
897 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000020.9 NT_011387.8
| Proteins for OXT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178 (See
protein sequence)Recommended Name: Oxytocin-neurophysin 1 precursor Size: 125 amino acids; 12722 Da
Subcellular location: Secreted
Secondary accessions: Q3MIG0REFSEQ proteins: NP_000906.1
ENSEMBL proteins: ENSP00000217386
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | About this table
Antibodies for OXT: Assays for OXT: | Protein
Domains/ Families for OXT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01178
ProtoNet protein and cluster: P01178 1 Blocks protein family: IPB000981 Neurohypophysial hormone
UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178Similarity: Belongs to the vasopressin/oxytocin family | Gene Function for OXT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000915
Applied Biosystems Silencer® siRNAs for OXT
Sigma-Aldrich siRNA for OXT  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000915                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000915                                  untagged cDNA clone in CMV expression vector: NM_000915 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000915
UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178Function: Neurophysin 1 specifically binds oxytocinFunction: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary glandGenatlas biochemistry entry for OXT:oxytocin,prepro- (neurophysin 1)8 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Oxt):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for OXT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for OXT 
5/36 Interacting proteins for OXT (ENSP000002173863 P011781) via UniProtKB, MINT, and/or STRING (see all 36
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for OXT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  | Sigma-Aldrich Small Molecules for OXT: Ligand |
Compounds for OXT available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| L-368,899 hydrochloride | Potent, non-peptide oxytocin receptor antagonist | [148927-60-0] | | Capsazepine | Vanilloid receptor antagonist. Also activator of ENaCdelta | [138977-28-3] | | L-371,257 | Potent and selective oxytocin receptor antagonist | [162042-44-6] | About this table
UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor 10/32 Novoseek chemical compound relationships for OXT gene (see all 32
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carbetocin |
86.05 |
69 |
16769107 (6), 17636798 (6), 9659650 (5), 10076146 (5) (see all 20) |
| 13,14-dihydro-15-ketoprostaglandin f2alpha |
83.33 |
33 |
1475375 (2), 9437586 (2), 7616495 (2), 9640273 (2) (see all 25) |
| prostaglandin |
78.80 |
208 |
10860251 (5), 10735096 (4), 10230581 (4), 8315315 (3) (see all 99) |
| tocinoic acid |
72.69 |
7 |
9062067 (1), 15791394 (1), 17723478 (1), 8275925 (1) (see all 5) |
| progesterone |
70.80 |
375 |
8377978 (7), 1730809 (6), 9640267 (6), 8886706 (6) (see all 99) |
| pressinoic acid |
69.38 |
4 |
8589250 (1), 8275925 (1), 9546658 (1), 8256869 (1) |
| barusiban |
68.74 |
8 |
15740719 (3), 16914691 (2), 15350251 (2) |
| (+-)-pgf2-alpha |
65.06 |
56 |
9348208 (6), 11566737 (3), 17459165 (3), 17491148 (3) (see all 25) |
| ovta |
64.48 |
4 |
12183418 (3), 15613460 (1) |
| sodium prasterone sulfate |
59.92 |
2 |
9772437 (1), 7664601 (1) |
About this table
|
Transcripts for OXT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000915
Sigma-Aldrich siRNA for OXT  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000915 REFSEQ mRNAs for OXT gene: NM_000915.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000915               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000915                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000915                                  untagged cDNA clone in CMV expression vector: NM_000915  Additional cDNA sequence: BC069144.1 BC101841.1 BC101843.1 M25650.1 M62611.1 X03173.1 1 DOTS entry: DT.306364 7 AceView cDNA sequences:X03173 AW242780 BC069144 NM_000915 AW270827 M25650 M62611
highest scoring ESTs for OXT:AW242780 AW270827 BC069144 M25650 M62611 NM_000915 X03173 BC101841 BC101843 DB506474 Unigene Cluster for OXT: Oxytocin, prepropeptide Hs.113216 [show with all ESTs]Unigene Representative Sequence: NM_000915
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000217386
|
Expression for OXT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OXT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OXT
1 / 2 / 3 3 probe-sets matching OXT gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCGGCCCCA
SOURCE GeneReport for Unigene cluster: Hs.113216
Expression variation in blood from EXPOLDB for OXT |
Orthologs for OXT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OXT gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OXT
ENSEMBL Gene Tree for OXT | Paralogs for OXT(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OXT gene
- AVP2
|
SNPs/Variants for OXT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OXT (up to first 250kb)
|
Disorders & Mutations for OXT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 167050
10/93 Novoseek disease relationships for OXT gene (see all 93
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| postpartum hemorrhage |
88.58 |
84 |
11802188 (4), 15103233 (4), 17578351 (4), 12179676 (4) (see all 54) |
| uterine atony |
83.79 |
29 |
10076146 (3), 11530117 (2), 19177043 (2), 10789257 (1) (see all 21) |
| fetal distress |
77.80 |
24 |
8233251 (3), 9141942 (1), 11730496 (1), 8262291 (1) (see all 21) |
| pregnancy prolonged |
74.82 |
10 |
1892182 (2), 1398272 (2), 11928554 (1), 11883268 (1) (see all 8) |
| cephalopelvic disproportion |
73.68 |
7 |
1445129 (1), 11080926 (1), 15770303 (1), 2145531 (1) (see all 7) |
| chorioamnionitis |
72.61 |
36 |
1579312 (3), 9170488 (3), 10796160 (2), 10796161 (2) (see all 23) |
| labor prolonged |
72.10 |
13 |
16949410 (2), 11883027 (1), 10368493 (1), 11120525 (1) (see all 12) |
| endometritis |
63.49 |
10 |
8841214 (3), 9170488 (2), 17636608 (1), 1897091 (1) (see all 6) |
| shoulder dystocia |
61.59 |
11 |
2082887 (1), 8813305 (1), 9396889 (1), 15970854 (1) (see all 10) |
| fetal macrosomia |
61.28 |
3 |
11958242 (1), 10190670 (1), 12596626 (1) |
About this table
Human Genome Epidemiology Navigator: OXT (6 documents)
|
Medical News for OXT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OXT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1228 PubMed articles for OXT gene (see all 1228
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)3, 4 Deloukas P....Rogers J. (2001)
- Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues. (PubMed id 2249637)3, 4 Ivell R.... Khan-Dawood F. (1990)
- The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation. (PubMed id 3768139)3, 4 Rehbein M....Richter D. (1986)
- The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. (PubMed id 2991279)3, 4 Sausville E.... Battey J. (1985)
- Expression of the vasopressin and oxytocin genes in human hypothalami. (PubMed id 4065330)3, 4 Mohr E.... Richter D. (1985)
- Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins. (PubMed id 6574452)3, 4 Chauvet M.-T.... Acher R. (1983)
- A comparative study of mammalian neurophysin protein sequences. (PubMed id 7262323)3, 4 Schlesinger D.H. and Audhya T.K. (1981)
- On the nature of oxytocin and vasopressin from human pituitary. (PubMed id 13591312)3, 4 Light A. and du Vigneaud V. (1958)
- The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. (PubMed id 17492653)1, 3 Whittington K....Nicholson H. (2007)
|
Search for OXT
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OXT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OXT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OXT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Oxytocin |
|
| | | About This Section
| --
| Services for OXT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OXT:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|