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SIGMAR1 Gene

protein-coding   GIFtS: 49

GC09M034625
sigma non-opioid intracellular receptor 1
(Previous names: opioid receptor, sigma 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OPRS1)
Services    

Aliases &
Descriptions
for SIGMAR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ25585 2
MGC3851 2
OPRS1 2
OTTHUMP00000000515 2
OTTHUMP00000000516 2
OTTHUMP00000000517 2
OTTHUMP00000021286 2
SIG-1R 3
SR-BP 3
SR-BP1 1, 2
SRBP 3
Sigma1-receptor 3
Sigma1R 3
hSigmaR1 3
Descriptions
Aging-associated gene 8 protein 2, 3
SR31747 binding protein 1 2
SR31747-binding protein 3
opioid receptor, sigma 1 1, 2
sigma non-opioid intracellular receptor 1 2
sigma1 receptor 2
type I sigma receptor 2
External Ids
HGNC: 81571
Entrez Gene: 102802
UniProtKB: Q997203
Ensembl: ENSG000001479557
Search outside databases for aliases for SIGMAR1 gene

Summaries
for SIGMAR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for SIGMAR1:
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs,
including cocaine and amphetamines. The receptor is believed to play an important role in the
cellular functions of various tissues associated with the endocrine, immune, and nervous systems.
As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was
erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid
receptor. Alternative splicing of this gene results in transcript variants encoding distinct
isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: OPRS1_HUMAN, Q99720
Function: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide
array of cellular functions probably through regulation of the biogenesis of lipid microdomains at
the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF
signaling and EGF signaling. Also regulates ion channels like the potassium channel and could
modulate neurotransmitter release. Plays a role in calcium signaling through modulation together
with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in
several other cell functions including proliferation, survival and death. Originally identified
for its ability to bind various psychoactive drugs it is involved in learning processes, memory
and mood alteration

Genomic Location
for SIGMAR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

SIGMAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034625:     (about GC identifiers)

Start:
 34,624,719 bp from pter
End:
 34,627,768 bp from pter
Size:
 3,050 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  

Proteins
for SIGMAR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: OPRS1_HUMAN, Q99720 (See protein sequence)
Recommended Name: Sigma 1-type opioid receptor  
Size: 223 amino acids; 25128 Da
Subcellular location: Nucleus inner membrane. Nucleus outer membrane. Endoplasmic reticulum
membrane. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Note=Targeted
to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic
reticulum. Enriched at cell-cell communication regions, growth cone and postsynaptic structures.
Localization is modulated by ligand-binding
Miscellaneous: Depletion of OPRS1 by RNAi inhibits growth and survival signaling cascades and
induces cell death. The OSPR1 antagonist rimcazole produces the same effect
Secondary accessions: O00673 O00725 Q0Z9W6 Q153Z1 Q2TSD1 Q53GN2 Q7Z653 Q8N7H3 Q9NYX0
Alternative splicing: 5 isoforms:  Q99720-1   Q99720-2   Q99720-3   Q99720-4   Q99720-5   

REFSEQ proteins (2 alternative transcripts): 
NP_005857.1  NP_671513.1  


ENSEMBL proteins: 
ENSP00000368170 ENSP00000277010 ENSP00000277009 ENSP00000353935 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (OPRS1 )
Human Recombinant Proteins from Abnova (OPRS1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005637 nuclear inner membrane IEA--
GO:0005640 nuclear outer membrane IEA--
GO:0005783 endoplasmic reticulum IEA--
GO:0005789 endoplasmic reticulum membrane IEA--
About this table

Antibodies for SIGMAR1: 
Invitrogen Antibodies for SIGMAR1
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for SIGMAR1
Browse R&D Systems for Antibodies
Antibodies from Abcam (OPRS1 ), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OPRS1)
Search Novus for antibodies for SIGMAR1

Assays for SIGMAR1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for SIGMAR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR006716 ERG2_sigma1_rcpt-like


   GeneDecks  SIGMAR1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q99720

ProtoNet protein and cluster: Q99720

1 Blocks protein family: IPB006716 ERG2 and sigma1 receptor-like protein

UniProtKB/Swiss-Prot: OPRS1_HUMAN, Q99720
Similarity: Belongs to the ERG2 family

Gene Function
for SIGMAR1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SIGMAR1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OPRS1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_147158

              Applied Biosystems Silencer® siRNAs for SIGMAR1

              Sigma-Aldrich siRNA and siRNA Panels for SIGMAR1  
                     Sigma-Aldrich shRNA for SIGMAR1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for SIGMAR1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005866
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005866
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005866 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005866

UniProtKB/Swiss-Prot: OPRS1_HUMAN, Q99720
Function: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide
array of cellular functions probably through regulation of the biogenesis of lipid microdomains at
the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF
signaling and EGF signaling. Also regulates ion channels like the potassium channel and could
modulate neurotransmitter release. Plays a role in calcium signaling through modulation together
with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in
several other cell functions including proliferation, survival and death. Originally identified
for its ability to bind various psychoactive drugs it is involved in learning processes, memory
and mood alteration

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sigmar1):

behavior/neurologicalnormal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000247 C-8 sterol isomerase activity IEA--
GO:0004872 receptor activity IEA--
GO:0008144 drug binding TAS8954936
About this table

Pathways & Interactions
for SIGMAR1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/6 Interacting proteins for SIGMAR1 (ENSP000002770103) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
NPYENSP000002421523STRING (score=.951)
FOSENSP000003062453STRING (score=.861)
DRD2ENSP000003474743STRING (score=.771)
PNOCENSP000003019083STRING (score=.701)
HTR1AENSP000003162443STRING (score=.7)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006696 ergosterol biosynthetic process IEA--
GO:0006869 lipid transport IEA--
About this table

Drugs & Compounds
for SIGMAR1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for SIGMAR1:
Antagonist Agonist Ligand

Browse Tocris compounds for SIGMAR1
5 Novoseek chemical compound relationships for SIGMAR1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
phenylacetamide 85.02 2 11728186 (2)
dhea 58.99 3 16512622 (1), 15225127 (1)
dehydroepiandrosterone sulfate 53.52 3 16012349 (2), 10562964 (1)
indole 33.09 2 16288878 (1), 11728186 (1)
sterol 24.16 1 10406945 (1)
About this table


Transcripts
for SIGMAR1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (SIGMAR1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OPRS1)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_147158

              Sigma-Aldrich siRNA and siRNA Panels for SIGMAR1  
                     Sigma-Aldrich shRNA for SIGMAR1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005866  NM_147157  

REFSEQ mRNAs for SIGMAR1 gene (2 alternative transcripts): 

NM_005866.2   NM_147157.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005866  NM_147157  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005866
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005866
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_005866 

Additional cDNA sequence: 

AF226604.1 AK098451.1 AK130502.1 AK222899.1 AK291092.1 AK299130.1 AY633611.1 BC004899.2 
BC007839.2 CR457075.1 CR590434.1 CR591652.1 CR592515.1 CR592762.1 CR593685.1 CR593849.1 
CR594423.1 CR595153.1 CR596218.1 CR598930.1 CR602297.1 CR603042.1 CR604206.1 CR604448.1 
CR606455.1 CR606713.1 CR608230.1 CR608948.1 CR609235.1 CR611273.1 CR611989.1 CR619527.1 
CR622156.1 CR624845.1 CR625524.1 DQ644568.1 DQ647702.1 DQ656583.1 U75283.1 U79528.1 

22 DOTS entries:

DT.100884984  DT.216839  DT.92455053  DT.99985706  DT.101985446  DT.100884994  DT.100045181  DT.75154631 
DT.121165570  DT.95270500  DT.100884998  DT.100885001  DT.100885009  DT.92455046  DT.100884989  DT.100885004 
DT.100885007  DT.100885011  DT.121165534  DT.100885010  DT.40123046  DT.95270523 

24/574 AceView cDNA sequences (see all 574 ):

CR594423 BQ679437 BU620056 CR604206 BQ070845 BQ064293 BE276415 BM849552 
CR619527 NM_147158 AA316259 CR604448 CR622156 CR593849 BI822247 CR592762 
BX427615 AF226604 CR591652 CR606713 BE255885 BM745065 AL532097 BU557093 

Unigene Cluster for SIGMAR1:

Sigma non-opioid intracellular receptor 1
Hs.522087  [show with all ESTs]
Unigene Representative Sequence: AK130502


GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SIGMAR1 (see all 11 )

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
SP1:                                                        -           -                                             
SP2:                                                        -           -     -     -     -                           
SP3:                                                  -     -           -                                             
SP4:                                                                    -                                             
SP5:                                            -     -     -           -                                             

About this scheme

ECgene alternative splicing isoforms for SIGMAR1

4 Ensembl transcripts including schematic representations:
ENST00000378892  ENST00000277010  ENST00000353468  ENST00000360710  

Expression
for SIGMAR1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SIGMAR1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for SIGMAR1

1 / 2

6 probe-sets matching SIGMAR1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

33879_at2 U95-A 1 1.00 1.00 0.95 0.96 -- -- -- -- --

75103_at2 U95-D 1 0.88 1.00 0.94 1.04 -- -- -- -- --

214484_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

201692_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

214484_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

201692_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CACTCACACC

SOURCE GeneReport for Unigene cluster: Hs.522087

UniProtKB/Swiss-Prot: OPRS1_HUMAN, Q99720
Tissue specificity: Widely expressed with higher expression in liver, colon, prostate, placenta,
small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells

Orthologs
for SIGMAR1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for SIGMAR1 gene from 5/13 species (see all 13 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 SIGMAR11   -- sigma non-opioid intracellular receptor 1 93.72(n)
97.76(a)		 481587  XM_847451.1  XP_852544.1 
chimpanzee
(Pan troglodytes)		 SIGMAR11   -- sigma non-opioid intracellular receptor 1 99.55(n)
100(a)		 465062  XM_001163924.1  XP_001163924.1 
cow
(Bos taurus)		 SIGMAR11   -- sigma non-opioid intracellular receptor 1 92.64(n)
96.85(a)		 538903  NM_001034655.1  NP_001029827.1 
rat
(Rattus norvegicus)		 Oprs11   -- opioid receptor, sigma 1 88.04(n)
93.27(a)		 29336  NM_030996.1  NP_112258.1 
mouse
(Mus musculus)		 Sigmar11, 5 45
 sigma non-opioid intracellular receptor 11, 5 86.19(n)1
90.54(a)1		 183911  NM_011014.21  NP_035144.11 
 AF0049275  AF0301985  (see all 19)
About this table        Species with no ortholog for SIGMAR1

ENSEMBL Gene Tree for SIGMAR1

Paralogs
for SIGMAR1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for SIGMAR1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/41 NCBI SNPs in SIGMAR1 are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 15)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs108141301,2
A,C,F,H34627991(+) GCTARC/AGCCAC 2 -- ng316Minor allele frequency- A:0.23MN EA EU WA 1670
--
rs48798091,2
C,F,H34625598(+) CTGTCC/TATCCG 2 -- ut31 ese38Minor allele frequency- T:0.01EU EA WA 836
rs18008661,2
A,C,F34627690(-) GATGCA/CGTGGG 2 Q/P mis1 ese33Minor allele frequency- C:0.11NA 120
--
rs17997291,2
C,F34627990(-) TGGCKC/GC    
   /T/TTTAGCT 		2 -- ng312MN EA 1252
--
rs48798111,2
A34629474(+) GAGGCC/TGAAGT 2 -- ng310--------
--
rs48785831,2
A34624422(+) CAAGAC/TCCCAT 2 -- ng510--------
--
rs78651001,2
A,C34626594(+) GCCACC/TGCACG 2 -- int10--------
rs121156731,2
H34626112(+) GTCTGC/TACTCC 2 -- int14Minor allele frequency- T:0.00EU EA WA 408
--
rs576970251,2
--34624629(+) AAAAA-/ATCTAC 2 -- ng510--------
rs617395881,2
--34625749(+) AGCGCC/TAAGGC 4 F/L mis10--------
About this table

HapMap Linkage Disequilibrium images for SIGMAR1 (up to first 250kb)

Disorders & Mutations
for SIGMAR1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 601978

2 Novoseek disease relationships for SIGMAR1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
neurodegenerative diseases 18.32 1 18076369 (1)
cancer 0.00 5 16388898 (3), 17534441 (1)
About this table

Human Genome Epidemiology Navigator: SIGMAR1 (8 documents)

Medical News
for SIGMAR1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for SIGMAR1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/81 PubMed articles for SIGMAR1 gene (see all 81 ):

Search for SIGMAR1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing SIGMAR1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 10280 HGNC: 8157 AceView: OPRS1 Ensembl:ENSG00000147955 euGenes: HUgn10280
ECgene: SIGMAR1 H-InvDB: SIGMAR1

Other Databases showing SIGMAR1

(According to HUGE)
About This Section

   --

Specialized Databases showing SIGMAR1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
Wikipedia http://en.wikipedia.org/wiki/Sigma_1_Receptor

Licensable Technologies
for SIGMAR1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for SIGMAR1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for SIGMAR1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for SIGMAR1 Antibodies for SIGMAR1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for SIGMAR1 Small molecules for SIGMAR1
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search OriGene for SIGMAR1
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 Search Novus for antibodies for SIGMAR1

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Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SIGMAR1 Gene at Home site.
Version 2.41.1
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