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OPRM1 Gene

protein-coding GIFtS: 72

GC06P154452

opioid receptor, mu 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA0403 ^²
LMOR ^²
MOR ^²
MOR-1 ^³
MOR1 ^¹, ², ³
OPRM ^²

Descriptions
mu opiate receptor ^²
opioid receptor, mu 1 ^²

External Ids
HGNC: 8156¹
Entrez Gene: 4988²
UniProtKB: P35372³
Ensembl: ENSG00000112038⁷

Search outside databases for aliases for OPRM1 gene

Previous GC identifers: GC06P153921 GC06P154255 GC06P154391

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372

Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing

potassium ion conductance. Receptor for beta-endorphin

Gene Wiki entry for OPRM1 (Mu_Opioid_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OPRM1 gene

Entrez Gene cytogenetic band: 6q24-q25 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 6q24-q25

OPRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P154452: (about GC identifiers)

Start:	154,402,136 bp from pter
End:	154,609,693 bp from pter
Size:	207,558 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372 (See protein sequence)

Recommended Name: Mu-type opioid receptor

Size: 400 amino acids; 44779 Da

Subunit: Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The

formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and

RGSZ20 (By similarity)

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q12930 Q7Z2D8 Q9UCZ4 Q9UN57

Alternative splicing: 2 isoforms: P35372-1 P35372-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (13 alternative transcripts):

NP_000905.3 NP_001008503.2 NP_001008504.2 NP_001008505.2 NP_001138751.1 NP_001138752.1 NP_001138753.1 NP_001138754.1

NP_001138755.1 NP_001138756.1 NP_001138757.1 NP_001138758.1 NP_001138759.1

ENSEMBL proteins:

ENSP00000328264 ENSP00000353598 ENSP00000338381 ENSP00000229768

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant OPRM1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Mu Opioid Receptor)
	Human Recombinant Proteins from Abnova (OPRM1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	TAS	9242668
GO:0005794	Golgi apparatus	TAS	9242668
GO:0005886	plasma membrane	TAS	9242668
GO:0005887	integral to plasma membrane	TAS	7905839

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Antibodies for OPRM1:

	Invitrogen Antibodies for OPRM1
	Millipore Mono- and Polyclonal Antibodies for the study of OPRM1
	Sigma-Aldrich Antibodies for OPRM1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Mu Opioid Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for OPRM1

Assays for OPRM1:

	Invitrogen Assays for OPRM1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35372

ProtoNet protein and cluster: P35372

2 Blocks protein families:

IPB000105 Mu opioid receptor signature

IPB001418 Opioid receptor signature

UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OPRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OPRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 13): NM_000914

Applied Biosystems Silencer® siRNAs for OPRM1

Sigma-Aldrich siRNA and siRNA Panels for OPRM1

Sigma-Aldrich shRNA Panels and shRNA for OPRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OPRM1
		Millipore Clones for the Expression of OPRM1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 13): NM_000914
Myc/DDK tagged cDNA clones in CMV expression vector (see all 13): NM_000914
untagged cDNA clones in CMV expression vector (see all 13): NM_000914

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001145279

UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372

Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing

potassium ion conductance. Receptor for beta-endorphin

Genatlas biochemistry entry for OPRM1:

opioid receptor,mu 1,G protein coupled receptor superfamily,with three alternatively spliced

isoforms,mu1,mu2,expressed in pinealocytes,principal sites of action of several endogenous opioid

peptides,also major target for opioid analgesic agents and heroin and a third splice varient

acting as a morphine-6 beta-glucuronide receptor,depressing cAMP levels,opening a G

protein-modulated K+ channel

11 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Oprm1):

behavior/neurological	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
life span-post-weaning/aging	nervous system	no phenotypic analysis	normal	reproductive system
touch/vibrissae

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004988	mu-opioid receptor activity	TAS	9689128

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for OPRM1 (Your Favorite Gene powered by Ingenuity)

cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling

GeneDecks OPRM1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for OPRM1

5/52 Interacting proteins for OPRM1 (ENSP00000229768³) via UniProtKB, MINT, and/or STRING (see all 52 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDYN	ENSP00000217305³	STRING (score=.997)
PENK	ENSP00000324248³	STRING (score=.989)
PNOC	ENSP00000301908³	STRING (score=.981)
GNAO1	ENSP00000262493³	STRING (score=.97)
OPRD1	ENSP00000234961³	STRING (score=.962)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS	7905839
GO:0007600	sensory perception	TAS	9689128
GO:0007610	behavior	TAS	9689128
GO:0008285	negative regulation of cell proliferation	TAS	2159143

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for OPRM1

Sigma-Aldrich Small Molecules for OPRM1:

Mixed Agonist/Antagonist Antagonist Agonist Ligand

Compounds for OPRM1 available from Tocris Bioscience

Compound	Action	CAS number
Cyprodime hydrochloride	Selective mu antagonist	[118111-54-9]
Naloxonazine dihydrochloride	Selective mu1 antagonist	[82824-01-9]
Fentanyl citrate	Potent and selective mu agonist	[990-73-8]
BRL 52537 hydrochloride	Potent and selective mu agonist	130497-33-5
beta-Funaltrexamine hydrochloride	Irreversible mu-selective antagonist	[72786-10-8]

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10/30 Novoseek chemical compound relationships for OPRM1 gene (see all 30 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
damgo	93.76	122	16682505 (7), 10617147 (4), 9544801 (4), 14743438 (2) (see all 74)
dpdpe	78.82	10	7925596 (1), 11165441 (1), 8386968 (1), 8947072 (1) (see all 10)
2,6-dimethyltyrosine	77.42	4	18468445 (1), 14534366 (1), 15026001 (1), 12606628 (1)
morphine 6-glucuronide	76.66	19	15731588 (2), 16415919 (2), 8026550 (2), 16434406 (1) (see all 9)
naloxonazine	76.08	9	7805771 (4), 15114518 (1), 7773532 (1), 11033087 (1) (see all 6)
443c81	74.50	3	8187029 (2), 1659440 (1)
bw 373u86	73.41	5	8246161 (1), 9223564 (1), 9862398 (1)
6beta-naltrexol	69.79	1	19220294 (1)
salvinorin a	67.45	1	17060492 (1)
snc 80	66.27	3	8667189 (2)

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3 PharmGKB drug compound relationships for OPRM1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
morphine-6-glucoronide	CO	11773859
nicotine	CO PD GN	15007373
opiates	FA	9689128

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OPRM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OPRM1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 13): NM_000914

Sigma-Aldrich siRNA and siRNA Panels for OPRM1

Sigma-Aldrich shRNA Panels and shRNA for OPRM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000914 NM_001008503 NM_001008504 NM_001008505

REFSEQ mRNAs for OPRM1 gene (13 alternative transcripts):

NM_000914.3 NM_001008503.1 NM_001008504.2 NM_001008505.1 NM_001145279.1 NM_001145280.1 NM_001145281.1 NM_001145282.1

NM_001145283.1 NM_001145284.1 NM_001145285.1 NM_001145286.1 NM_001145287.1

NM_000914 NM_001008503 NM_001008504 NM_001008505

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 13): NM_000914
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 13): NM_000914
                                 untagged cDNA clones in CMV expression vector (see all 13): NM_000914

Additional cDNA sequence:

AK309655.1 AK313901.1 AY036622.1 AY036623.1 AY195733.2 AY225404.1 AY309001.1 AY309005.1

AY309006.1 AY309007.1 AY309008.1 AY364230.1 AY364890.1 AY521028.1 BC074927.2 DQ680044.1

EF666090.1 EU340241.1 EU340242.1 EU340243.1 EU360599.2 EU362990.2 L25119.1 L29301.1

U12569.1

4 DOTS entries:

DT.306401 DT.100690305 DT.92414497 DT.102820783

12 AceView cDNA sequences:

AY364890 BC074927 AY521028 AY036623 AY364230 L29301 L25119 AY036622

AY195733 U12569 BP346782 NM_000914

highest scoring ESTs for OPRM1:

AY036623 L25119 U12569 AY036622 AY195733 AY364230 AY521028 L29301 NM_000914 AY225404

Unigene Cluster for OPRM1:

Opioid receptor, mu 1

Hs.2353 [show with all ESTs]

Unigene Representative Sequence: NM_001145287

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for OPRM1 (see all 14 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13
SP1:													-		-						-		-		-		-				-		-		-		-		-
SP2:													-		-						-		-		-		-				-		-
SP3:													-		-						-		-		-		-		-		-		-		-		-		-
SP4:													-		-						-		-		-		-		-		-		-		-		-
SP5:													-		-						-		-		-		-		-		-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for OPRM1

4 Ensembl transcripts including schematic representations:

ENST00000330432 ENST00000360422 ENST00000337049 ENST00000229768

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OPRM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OPRM1

¹ / ² / ³

9 probe-sets matching OPRM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34535_at²^{, 3}	U95-A	1	1.00	1.00	-0.20	0.59	U12569	0.80	1.00	0.91	1
34534_at²^{, 3}	U95-A	1	1.00	1.00	0.53	0.98	L25119	0.80	1.00	0.91	1
34536_g_at²^{, 3}	U95-A	2	1.00	0.97	0.84	1.09	U12569	0.80	1.00	0.91	1
207989_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000914	0.60	1.00	0.82	1
207994_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L29301	0.60	1.00	0.82	1
211359_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U12569	0.80	1.00	0.91	1
207989_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207994_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211359_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACCCTAAAA

SOURCE GeneReport for Unigene cluster: Hs.2353
Expression variation in blood from EXPOLDB for OPRM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OPRM1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OPRM1¹	--	opioid receptor, mu 1	93.04(n) 96.39(a)	484041 XM_541158.2 XP_541158.2
chimpanzee (Pan troglodytes)	OPRM1¹	--	opioid receptor, mu 1	99.23(n) 99.23(a)	472165 NM_001033915.1 NP_001029087.1
cow (Bos taurus)	OPRM1¹	--	opioid receptor, mu 1	91.67(n) 94.85(a)	281958 NM_174408.2 NP_776833.1
rat (Rattus norvegicus)	Oprm1¹	--	opioid receptor, mu 1	87.05(n) 94.3(a)	25601 NM_013071.1 NP_037203.1
mouse (Mus musculus)	Oprm1^{1, 5}	10 (8.00 cM)⁵	opioid receptor, mu 1^{1, 5}	86.86(n)¹ 92.31(a)¹	18390¹ NM_001039652.1¹ NP_001034741.1¹ AB047546⁵ AB441734⁵ (see all 72)

About this table Species with no ortholog for OPRM1

ENSEMBL Gene Tree for OPRM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OPRM1 gene

OPRL1² NPBWR1² OPRK1² OPRD1² NPBWR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: OPRM_HUMAN, P35372

Polymorphism: Variant Asp-40 does not show altered binding affinities for most opioid peptides and

alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid

receptor, approximately 3 times more tightly than the most common allelic form

10/862 NCBI SNPs in OPRM1 are shown (see all 862 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 473)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1799971^1,2	A,C,F,H,O	154402490(+)	`ATGGCA/GACCTG`	4	N/D	mis¹		24	EA MN CSAM NS NA EU WA	3654
	rs540825^1,2	A,C,F,H	154456139(-)	`CAGCCA/TTGCTC`	3	Q/H	mis¹ int¹		13	MN CSAM EA EU WA	1218
	rs671531^1,2	A,C,F,H	154482434(+)	`TCCCCG/ACATAT`	2	--	int¹ ng3¹		6	MN NS EU EA WA	782
--	rs9282819^1,2	C,F,H	154402569(+)	`TCCCTC/TCATGA`	4	S/F	mis¹		9	MN CSAM EA EU WA	800
	rs7759974^1,2	C,F,H	154454667(+)	`GCTGCA/CATACC`	4	--	int¹ ng3¹		5	NS EU EA WA	572
	rs6912029^1,2	C,F,H	154402201(+)	`GCTCAG/TCTCGG`	4	--	ut5¹		6	NS EU EA WA	746
	rs12205732^1,2	C,F,H	154400626(+)	`AACATG/ATCCAA`	4	--	ng5¹		5	EU EA WA NS	596
--	rs9282815^1,2	C,F	154402335(+)	`CCTGGC/ATACCT`	4	--	ut5¹ ese³		6	MN CSAM EA NS	580
	rs17174794^1,2	C,F	154452803(+)	`GATCTC/GCATAG`	4	S/C	mis¹ ese³		2	NS NA	240
	rs11575858^1,2	C,F	154481557(+)	`GGTCTC/TATGCC`	2	--	int¹ ut3¹		1	NS	178

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HapMap Linkage Disequilibrium images for OPRM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600018

10/56 Novoseek disease relationships for OPRM1 gene (see all 56 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
opioid dependence	74.93	25	12960749 (5), 17416470 (5), 15558714 (3), 12648891 (2) (see all 11)
heroin addiction	67.06	6	18518925 (1), 10911931 (1), 16682632 (1), 17416470 (1) (see all 6)
respiratory depression	61.11	6	15731588 (2), 17922561 (1), 16029065 (1), 15112443 (1)
substance dependence	59.74	17	12815747 (4), 16476706 (2), 10982041 (1), 9790747 (1) (see all 10)
hyperalgesia	58.45	2	14504663 (1), 12750434 (1)
alcoholism	53.91	43	17979515 (4), 15902904 (3), 9884158 (3), 16476706 (2) (see all 25)
drug dependence	52.72	9	9756053 (2), 16476706 (1), 9399694 (1), 15925706 (1) (see all 6)
dependence psychological	49.10	1	11316510 (1)
drug addiction	39.32	3	11067846 (1), 16046395 (1), 11506703 (1)
acute alcohol withdrawal	39.01	2	8234933 (1), 10399772 (1)

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1 PharmGKB disease relationship for OPRM1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Substance-Related Disorders	FA	9689128

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Human Gene Mutation Database: OPRM1
Genetic Association Database: OPRM1
Human Genome Epidemiology Navigator: OPRM1 (99 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/564 PubMed articles for OPRM1 gene (see all 564 ):

Mu opioid receptor gene variants: lack of association with alcohol dependence. (PubMed id 9399694)^{1, 3, 4, 6} Bergen A.W.... Goldman D. (1997)
The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. (PubMed id 15007373)^{3, 6, 7} Lerman C....Berrettini W.H. (2004)
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. (PubMed id 9689128)^{3, 4, 7} Bond C....Yu L. (1998)
Polymorphism of mu-opioid receptor gene (OPRM1:c.118A>G) does not protect against opioid-induced respiratory depression despite reduced analgesic response. (PubMed id 15731588)^{1, 3, 6} Romberg R.R....Dahan A. (2005)
A genetic association study of the mu opioid receptor and severe opioid dependence. (PubMed id 12960749)^{1, 3, 6} Crowley J.J....Grice D.E. (2003)
The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. (PubMed id 15772909)^{1, 3, 6} Fillingim R.B....Wallace M.R. (2005)
Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. (PubMed id 15558714)^{1, 3, 6} Smith R.J....Berrettini W.H. (2005)
Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. (PubMed id 15542732)^{1, 3, 6} Ide S....Sora I. (2004)
The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. (PubMed id 15504181)^{1, 3, 6} Klepstad P....Skorpen F. (2004)
Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. (PubMed id 15902904)^{1, 3, 6} Kim S.A....Chung J.H. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4988	HGNC: 8156	AceView: OPRM1	Ensembl:ENSG00000112038	euGenes: HUgn4988
ECgene: OPRM1	H-InvDB: OPRM1

(According to HUGE)
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HUGE: KIAA0403

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Mu_opioid_receptor
NIEHS-SNPs	http://egp.gs.washington.edu/data/oprm1/

Licensable Technologies for OPRM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OPRM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OPRM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for OPRM1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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OPRM1 Gene at Home site.
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OPRM1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for OPRM1

Summaries
for OPRM1

Genomic Location
for OPRM1

Proteins
for OPRM1

Protein Domains/
Families
for OPRM1

Gene Function
for OPRM1

Pathways & Interactions
for OPRM1

Drugs & Compounds
for OPRM1

Transcripts
for OPRM1

Expression
for OPRM1

Orthologs
for OPRM1

Paralogs
for OPRM1

SNPs/Variants
for OPRM1

Disorders & Mutations
for OPRM1

Medical News
for OPRM1

Publications
for OPRM1

Search for OPRM1

Genome Databases showing OPRM1

Other Databases showing OPRM1

Specialized Databases showing OPRM1

Licensable Technologies
for OPRM1

Services
for OPRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OPRM1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor OPRM1

Summariesfor OPRM1

Genomic Locationfor OPRM1

Proteinsfor OPRM1

Protein Domains/Familiesfor OPRM1

Gene Functionfor OPRM1

Pathways & Interactionsfor OPRM1

Drugs & Compoundsfor OPRM1

Transcriptsfor OPRM1

Expression for OPRM1

Orthologsfor OPRM1

Paralogsfor OPRM1

SNPs/Variantsfor OPRM1

Disorders & Mutationsfor OPRM1

Medical Newsfor OPRM1

Publicationsfor OPRM1

Search for OPRM1

Genome Databases showing OPRM1

Other Databases showing OPRM1

Specialized Databases showing OPRM1

Licensable Technologiesfor OPRM1

Servicesfor OPRM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OPRM1

Summaries
for OPRM1

Genomic Location
for OPRM1

Proteins
for OPRM1

Protein Domains/
Families
for OPRM1

Gene Function
for OPRM1

Pathways & Interactions
for OPRM1

Drugs & Compounds
for OPRM1

Transcripts
for OPRM1

Expression
for OPRM1

Orthologs
for OPRM1

Paralogs
for OPRM1

SNPs/Variants
for OPRM1

Disorders & Mutations
for OPRM1

Medical News
for OPRM1

Publications
for OPRM1

Licensable Technologies
for OPRM1

Services
for OPRM1