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OPRK1 Gene

protein-coding GIFtS: 71

GC08M054304

opioid receptor, kappa 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KOR ^¹, ²
KOR-1 ^³
OPRK ^², ³

Descriptions
Opiate receptor, kappa-1 ^²
kappa opioid receptor ^²
opioid receptor, kappa 1 ^²

External Ids
HGNC: 8154¹
Entrez Gene: 4986²
UniProtKB: P41145³
Ensembl: ENSG00000082556⁷

Search outside databases for aliases for OPRK1 gene

Previous GC identifers: GC08M053424 GC08M054146 GC08M053864 GC08M054191

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145

Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing

potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of

autonomic and neuroendocrine functions

Gene Wiki entry for OPRK1 (Kappa_Opioid_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OPRK1 gene

Entrez Gene cytogenetic band: 8q11.2 Ensembl cytogenetic band: 8q11.23 HGNC cytogenetic band: 8q11.2

OPRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M054304: (about GC identifiers)

Start:	54,300,829 bp from pter
End:	54,326,747 bp from pter
Size:	25,919 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145 (See protein sequence)

Recommended Name: Kappa-type opioid receptor

Size: 380 amino acids; 42645 Da

Subunit: Interacts with SLC9A3R1. Interacts with GABARAPL1

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

2A0D (3D)

2IQN (3D)

Secondary accessions: Q499G4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000903.2

ENSEMBL proteins:

ENSP00000265572 ENSP00000380016

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant OPRK1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Kappa Opioid Receptor)
	Human Recombinant Proteins from Abnova (OPRK1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	7624359

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Antibodies for OPRK1:

	Invitrogen Antibodies for OPRK1
	Millipore Mono- and Polyclonal Antibodies for the study of OPRK1
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for OPRK1 (KOR)
	Antibodies from Abcam (Kappa Opioid Receptor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OPRK1)
	Novus Biologicals Antibodies for OPRK1

Assays for OPRK1:

	Invitrogen Assays for OPRK1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P41145

ProtoNet protein and cluster: P41145

2 Blocks protein families:

IPB000452 Kappa opioid receptor signature

IPB001418 Opioid receptor signature

UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OPRK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OPRK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000912

Applied Biosystems Silencer® siRNAs for OPRK1

Sigma-Aldrich siRNA and siRNA Panels for OPRK1

Sigma-Aldrich shRNA Panels and shRNA for OPRK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of OPRK1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000912
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000912
untagged cDNA clone in CMV expression vector: NM_000912

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000912

UniProtKB/Swiss-Prot: OPRK_HUMAN, P41145

Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing

potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of

autonomic and neuroendocrine functions

Genatlas biochemistry entry for OPRK1:

opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G

protein-modulated K+ channel

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Oprk1):

behavior/neurological

digestive/alimentary

endocrine/exocrine gland

reproductive system

touch/vibrissae

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004987	kappa-opioid receptor activity	TAS	8755601
GO:0005515	protein binding	IPI	16431922

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for OPRK1 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
cAMP-mediated Signaling

GeneDecks OPRK1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for OPRK1

5/18 Interacting proteins for OPRK1 (ENSP00000265572³ P41145^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²	STRING (score=.985) MINT-58245
GABARAPL1	Q9H0R8¹	EBI-925028, EBI-746969
PDYN	ENSP00000217305³	STRING (score=.989)
PENK	ENSP00000324248³	STRING (score=.988)
GABARAPL3	ENSP00000266458³	STRING (score=.971)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	8755601
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling	TAS	7624359
GO:0007268	synaptic transmission	TAS	7624359

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for OPRK1

Sigma-Aldrich Small Molecules for OPRK1:

Mixed Agonist/Antagonist Antagonist Agonist

Compounds for OPRK1 available from Tocris Bioscience

Compound	Action	CAS number
(�)-U-50488 hydrochloride	Standard selective kappa agonist	[67198-13-4]
Salvinorin A	Highly potent and selective kappa-opioid agonist	[83729-01-5]
N-MPPP Hydrochloride	Selective kappa agonist
BRL 52537 hydrochloride	Potent and selective kappa agonist	130497-33-5
ICI 199,441 hydrochloride	Potent kappa agonist	[115199-84-3]

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10/49 Novoseek chemical compound relationships for OPRK1 gene (see all 49 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
salvinorin a	92.56	60	14718611 (5), 17951511 (5), 12628350 (4), 15383632 (3) (see all 23)
cyclorphan	86.23	2	17433695 (1), 17276685 (1)
morphinan	84.06	3	15542743 (1), 16076937 (1)
asimadoline	83.03	4	18715494 (1), 10971307 (1), 10369454 (1), 10381799 (1)
damgo	82.60	27	9696421 (6), 14534366 (2), 11834622 (2), 8387137 (1) (see all 14)
dpdpe	81.66	8	8387137 (1), 16032459 (1), 8947072 (1), 12676881 (1) (see all 8)
nalfurafine	75.65	7	16919318 (2), 16251241 (1), 18842704 (1)
niravoline	69.37	3	10706433 (2), 10673065 (1)
fedotozine	67.24	1	11116283 (1)
cys(2)-tyr(3)-orn(5)-pen(7)-amide	66.61	1	8093687 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OPRK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OPRK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000912

Sigma-Aldrich siRNA and siRNA Panels for OPRK1

Sigma-Aldrich shRNA Panels and shRNA for OPRK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000912

REFSEQ mRNAs for OPRK1 gene:

NM_000912.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000912

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000912
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000912
                                 untagged cDNA clone in CMV expression vector: NM_000912

Additional cDNA sequence:

AF498922.1 AK023198.1 AK310233.1 AK310407.1 AK313058.1 AY168006.1 AY466378.1 BC099912.1

L36130.1 L37362.1 U11053.1 U17298.1

4 DOTS entries:

DT.100016314 DT.108243 DT.121472989 DT.101962844

15 AceView cDNA sequences:

NM_000912 BX092912 U17298 L37362 AY466378 L36130 U11053 AF498922

CF593603 CB565888 AY168006 R81583 R81332 R31984 R31938

highest scoring ESTs for OPRK1:

AY466378 L37362 AF498922 AI952898 AY168006 BC099912 BX092912 CB565888 CF593603 L36130

Unigene Cluster for OPRK1:

Opioid receptor, kappa 1

Hs.106795 [show with all ESTs]

Unigene Representative Sequence: NM_000912

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000265572 ENST00000396798

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OPRK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OPRK1

¹ / ² / ³

7 probe-sets matching OPRK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89039_at²^{, 3}	U95-D	1	1.00	1.00	0.59	1.09	R31938	0.60	1.00	0.82	1
58176_at²^{, 3}	U95-B	1	1.00	1.00	0.94	0.92	AI952898	0.60	1.00	0.82	1
35024_at²^{, 3}	U95-A	2	1.00	0.97	-0.16	0.19	L37362	0.80	1.00	0.91	1
229944_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU153412	0.40	1.00	0.76	1
207553_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000912	0.60	1.00	0.82	1
229944_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207553_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OPRK1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAAATTCAGG

SOURCE GeneReport for Unigene cluster: Hs.106795
Expression variation in blood from EXPOLDB for OPRK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OPRK1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OPRK1¹	--	opioid receptor, kappa 1	90.26(n) 92.89(a)	486951 XM_544080.2 XP_544080.2
cow (Bos taurus)	OPRK1¹	--	opioid receptor, kappa 1	89.04(n) 93.68(a)	540519 NM_001046480.1 NP_001039945.1
rat (Rattus norvegicus)	Oprk1¹	--	opioid receptor, kappa 1	86.84(n) 94.21(a)	29335 NM_017167.1 NP_058863.1
mouse (Mus musculus)	Oprk1^{1, 5}	1 (5.50 cM)⁵	opioid receptor, kappa 1^{1, 5}	86.67(n)¹ 93.68(a)¹	18387¹ NM_011011.1¹ NP_035141.1¹ AK136866⁵ AK138198⁵ (see all 16)
chicken (Gallus gallus)	OPRK1¹	--	opioid receptor, kappa 1	77.02(n) 85.79(a)	428533 XM_426087.2 XP_426087.2

About this table Species with no ortholog for OPRK1

ENSEMBL Gene Tree for OPRK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OPRK1 gene

OPRL1² NPBWR1² OPRD1² OPRM1² NPBWR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/206 NCBI SNPs in OPRK1 are shown (see all 206 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 113)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs963549^1,2	A,C,F,H,O	54304377(+)	`CTTCCC/TGAAGA`	1	--	ut3¹ trp³		27	EA NA NS MN CSAM EU WA	3268
	rs7839445^1,2	A,C,F,H	54303000(+)	`ATAGGC/TTTGGA`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs7820807^1,2	A,C,F,H	54301414(+)	`TGAGAT/CACTAA`	1	--	ut3¹		6	NA EA WA	440
	rs3802281^1,2	A,C,F,H	54303716(+)	`ACTGTT/CTACCT`	1	--	ut3¹		7	EA NA WA	1186
	rs10090337^1,2	A,C,F,H	54301602(+)	`ACATGC/GAGTTC`	1	--	ut3¹ ese³		1	WA	104
--	rs11992022^1,2	A,C,F	54300844(+)	`ATTTTC/TAGCAG`	1	--	ut3¹		4	EA NA	216
	rs3808628^1,2	C,F,H	54328157(+)	`TTTGAG/ACACTC`	1	--	ng3¹		4	EU EA WA	416
	rs3808627^1,2	C,F,H	54327355(+)	`AAACAC/TTCTCC`	1	--	ng3¹		12	NA EU EA WA	1032
--	rs9282808^1,2	C,F,H	54304433(-)	`ACATCG/AATGGG`	1	N/D	mis¹ ese³		13	MN CSAM EA EU WA	1234
	rs3802280^1,2	C,F,H	54303552(+)	`CAGGGG/AATATC`	1	--	ut3¹ ese³		7	EA NA WA	1744

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HapMap Linkage Disequilibrium images for OPRK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 165196

10/34 Novoseek disease relationships for OPRK1 gene (see all 34 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
opioid dependence	55.98	3	9365966 (1), 9517399 (1)
cocaine abuse	39.16	1	19253970 (1)
cocaine dependence	34.56	1	15988468 (1)
morphine dependence	25.74	1	8544279 (1)
brain diseases	22.74	6	9030693 (2), 9874464 (1), 12473373 (1), 7746504 (1) (see all 5)
drug dependence	22.50	3	15542743 (2)
drug addiction	18.67	1	9729284 (1)
hyperalgesia	11.21	1	15037816 (1)
glioma	5.45	6	10646507 (3), 9918595 (2), 9874464 (1)
adenocarcinoma	4.94	1	1971702 (1)

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1 PharmGKB disease relationship for OPRK1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Heroin Dependence	CO FA GN	15608558

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Human Gene Mutation Database: OPRK1
Genetic Association Database: OPRK1
Human Genome Epidemiology Navigator: OPRK1 (14 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/362 PubMed articles for OPRK1 gene (see all 362 ):

Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (PubMed id 15608558)^{1, 3, 6, 7} Yuferov V....Kreek M.J. (2004)
Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. (PubMed id 7624359)^{1, 3, 4} Simonin F.... Kieffer B. (1995)
N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. (PubMed id 17711303)^{3, 4} Li J.G....Liu-Chen L.Y. (2007)
GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. (PubMed id 16431922)^{3, 4} Chen C....Liu-Chen L.Y. (2006)
Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. (PubMed id 14745298)^{3, 6} Loh e.l. . . . . . . . . . . .W....Cheng A.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down- regulation of the human kappa opioid receptor by enhancing its recycling rate. (PubMed id 12004055)^{3, 4} Li J.-G.... Liu-Chen L.-Y. (2002)
Cloning of a human kappa opioid receptor from the brain. (PubMed id 7869844)^{3, 4} Zhu J.... Liu-Chen L.-Y. (1995)
Isolation of a human kappa opioid receptor cDNA from placenta. (PubMed id 8060324)^{3, 4} Mansson E.... Yang D. (1994)
Localization of the kappa opioid receptor gene to human chromosome band 8q11.2. (PubMed id 8188308)^{2, 3} Yasuda K....Bell G.I. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4986	HGNC: 8154	AceView: OPRK1	Ensembl:ENSG00000082556	euGenes: HUgn4986
ECgene: OPRK1	H-InvDB: OPRK1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Kappa_opioid_receptor

Licensable Technologies for OPRK1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OPRK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OPRK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OPRK1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OPRK1		Small molecules for OPRK1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OPRK1)
	Antibodies (OPRK1)
	Chimera RNAi (OPRK1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Kappa Opioid Receptor)
	Antibodies (Kappa Opioid Receptor)

Search OriGene for OPRK1

Tocris compounds for OPRK1

	Drugs for OPRK1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for OPRK1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OPRK1 Gene at Home site.
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OPRK1 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for OPRK1

Summaries
for OPRK1

Genomic Location
for OPRK1

Proteins
for OPRK1

Protein Domains/
Families
for OPRK1

Gene Function
for OPRK1

Pathways & Interactions
for OPRK1

Drugs & Compounds
for OPRK1

Transcripts
for OPRK1

Expression
for OPRK1

Orthologs
for OPRK1

Paralogs
for OPRK1

SNPs/Variants
for OPRK1

Disorders & Mutations
for OPRK1

Medical News
for OPRK1

Publications
for OPRK1

Search for OPRK1

Genome Databases showing OPRK1

Other Databases showing OPRK1

Specialized Databases showing OPRK1

Licensable Technologies
for OPRK1

Services
for OPRK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OPRK1 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor OPRK1

Summariesfor OPRK1

Genomic Locationfor OPRK1

Proteinsfor OPRK1

Protein Domains/Familiesfor OPRK1

Gene Functionfor OPRK1

Pathways & Interactionsfor OPRK1

Drugs & Compoundsfor OPRK1

Transcriptsfor OPRK1

Expression for OPRK1

Orthologsfor OPRK1

Paralogsfor OPRK1

SNPs/Variantsfor OPRK1

Disorders & Mutationsfor OPRK1

Medical Newsfor OPRK1

Publicationsfor OPRK1

Search for OPRK1

Genome Databases showing OPRK1

Other Databases showing OPRK1

Specialized Databases showing OPRK1

Licensable Technologiesfor OPRK1

Servicesfor OPRK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OPRK1

Summaries
for OPRK1

Genomic Location
for OPRK1

Proteins
for OPRK1

Protein Domains/
Families
for OPRK1

Gene Function
for OPRK1

Pathways & Interactions
for OPRK1

Drugs & Compounds
for OPRK1

Transcripts
for OPRK1

Expression
for OPRK1

Orthologs
for OPRK1

Paralogs
for OPRK1

SNPs/Variants
for OPRK1

Disorders & Mutations
for OPRK1

Medical News
for OPRK1

Publications
for OPRK1

Licensable Technologies
for OPRK1

Services
for OPRK1