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Aliases & Descriptions for OPRD1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DOR-1 3 | | OPRD 2, 3 | | OTTHUMP00000003778 2 |
| | | Descriptions |
|---|
| opioid receptor, delta 1 2 |
|
| | Search outside databases for aliases for OPRD1 genePrevious GC identifers: GC01P029144 GC01P028304 GC01P028643 GC01P028826 |
Summaries for OPRD1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalinsGene Wiki entry for OPRD1 (Delta_Opioid_receptor) |
Genomic Location for OPRD1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OPRD1 gene 
Entrez Gene cytogenetic band: 1p36.1-p34.3 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p36.1-p34.3OPRD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P028959:
(about GC identifiers)
Start:
|
29,011,241 bp from pter |
End:
|
29,062,795 bp from pter |
Size:
|
51,555 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for OPRD1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143 (See
protein sequence)Recommended Name: Delta-type opioid receptor Size: 372 amino acids; 40413 Da
Subunit: Interacts with GPRASP1
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structure from and Proteopedia :1OZC (3D)
 2IQM (3D)
 
Secondary accessions: B5B0B8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000902.3
ENSEMBL proteins: ENSP00000234961
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OPRD1: Assays for OPRD1: | Protein
Domains/ Families for OPRD1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P41143
ProtoNet protein and cluster: P41143 2 Blocks protein families: IPB000321 Delta opioid receptor signature IPB001418 Opioid receptor signature
UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for OPRD1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000911
Applied Biosystems Silencer® siRNAs for OPRD1
Sigma-Aldrich siRNA and siRNA Panels for OPRD1  Sigma-Aldrich shRNA Panels and shRNA for OPRD1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000911                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000911                                  untagged cDNA clone in CMV expression vector: NM_000911 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000911
UniProtKB/Swiss-Prot: OPRD_HUMAN, P41143Function: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalinsGenatlas biochemistry entry for OPRD1:opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G protein-modulated K+ channel,regulating G protein expression in pineal gland5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Oprd1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OPRD1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for OPRD1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for OPRD1 
5/23 Interacting proteins for OPRD1 (ENSP000002349613) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
TAS | 9548483 | | GO:0007165 | signal transduction |
IEA | -- | | GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger |
TAS | 7808419 | | GO:0007193 | inhibition of adenylate cyclase activity by G-protein signaling |
IEA | -- | | GO:0007218 | neuropeptide signaling pathway |
IEA | -- | About this table
|
Drugs & Compounds for OPRD1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for OPRD1 |
Compounds for OPRD1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| SNC 162 | Potent, selective non-peptide delta agonist | [178803-51-5] | | SB 205607 dihydrobromide | delta1 selective, high affinity non-peptide agonist | [148545-09-9] | | SNC 80 | Highly selective non-peptide delta agonist | [156727-74-1] | | FIT | Irreversible delta agonist | [85951-63-9] | | SNC 121 | Potent analog of Cat. No. 0764 | [159860-31-8] | About this table
10/49 Novoseek chemical compound relationships for OPRD1 gene (see all 49
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dpdpe |
94.19 |
69 |
9822547 (3), 7925596 (2), 10650167 (2), 7952866 (2) (see all 51) |
| bw 373u86 |
90.65 |
6 |
8246161 (2), 11324539 (1), 8876019 (1), 9655881 (1) |
| deltorphin |
90.27 |
36 |
8157070 (4), 10893226 (3), 1369601 (3), 1656944 (3) (see all 15) |
| snc 80 |
89.77 |
13 |
10650167 (2), 12505529 (2), 9655881 (2), 11786497 (1) (see all 10) |
| deltorphin ii |
87.52 |
5 |
14999000 (3), 17373766 (1), 15632119 (1) |
| damgo |
87.44 |
25 |
10789829 (2), 11834622 (2), 7925596 (1), 8001688 (1) (see all 20) |
| tipp-psi |
84.23 |
4 |
11408548 (3), 9606725 (1) |
| siom |
83.57 |
2 |
9651172 (2) |
| oxymorphindole |
81.53 |
1 |
2172675 (1) |
| 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid |
68.73 |
7 |
19062273 (1) |
About this table
1 PharmGKB drug compound relationship for OPRD1 gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| heroin | PD   | 9261824 | About this table
|
Transcripts for OPRD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000911
Sigma-Aldrich siRNA and siRNA Panels for OPRD1  Sigma-Aldrich shRNA Panels and shRNA for OPRD1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000911 REFSEQ mRNAs for OPRD1 gene: NM_000911.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000911               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000911                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000911                                  untagged cDNA clone in CMV expression vector: NM_000911  Additional cDNA sequence: EU883570.1 U07882.2 U10504.1 1 DOTS entry: DT.106072 4 AceView cDNA sequences:U10504 BF434068 NM_000911 U07882
highest scoring ESTs for OPRD1:U07882 U10504 NM_000911 BF434068 BP213719 BP214141 CR747003 DA179390 Unigene Cluster for OPRD1: Opioid receptor, delta 1 Hs.372 [show with all ESTs]Unigene Representative Sequence: NM_000911
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000234961
|
Expression for OPRD1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OPRD1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OPRD1
1 / 2 / 3 3 probe-sets matching OPRD1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGTGGGCCT
SOURCE GeneReport for Unigene cluster: Hs.372
Expression variation in blood from EXPOLDB for OPRD1 |
Orthologs for OPRD1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OPRD1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for OPRD1
ENSEMBL Gene Tree for OPRD1 | Paralogs for OPRD1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OPRD1 gene
- OPRL12 NPBWR12 OPRK12 OPRM12 NPBWR22
|
SNPs/Variants for OPRD1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OPRD1 (up to first 250kb)
|
Disorders & Mutations for OPRD1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 165195
10/24 Novoseek disease relationships for OPRD1 gene (see all 24
)
About this table
1 PharmGKB disease relationship for OPRD1 geneAbout this table
Genetic Association Database: OPRD1 Human Genome Epidemiology Navigator: OPRD1 (15 documents)
|
Medical News for OPRD1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OPRD1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/387 PubMed articles for OPRD1 gene (see all 387
):- Modulation of postendocytic sorting of G protein-coupled receptors. (PubMed id 12142540)1, 3, 4 Whistler J.L.... Von Zastrow M. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han. (PubMed id 14745298)3, 6 Loh e.l. . . . . . . . . . . .W....Cheng A.T. (2004)
- Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PubMed id 15086532)3, 4 Simonin F....Kieffer B.L. (2004)
- Opioid receptor random mutagenesis reveals a mechanism for G protein- coupled receptor activation. (PubMed id 12847517)3, 4 Decaillot F.M....Kieffer B.L. (2003)
- Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. (PubMed id 12116270)3, 6 Xu K....Goldman D. (2002)
- Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. (PubMed id 10982041)3, 4 Gelernter J. and Kranzler H.R. (2000)
- Association between a delta opioid receptor gene polymorphism and heroin dependence in man. (PubMed id 9261824)6, 7 Mayer P....Hollt V. (1997)
- The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. (PubMed id 7808419)3, 4 Simonin F.... Kieffer B. (1994)
- Identification of a human delta opioid receptor: cloning and expression. (PubMed id 8201839)3, 4 Knapp R.J.... Yamamura H.I. (1994)
|
Search for OPRD1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OPRD1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OPRD1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OPRD1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Delta_opioid_receptor |
|
| | | About This Section
| --
| Services for OPRD1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OPRD1:

 | |
 | | | | |
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 |  |  |
| | | | Tocris compounds for OPRD1 |
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Incremental update: 13 Oct 2009
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