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Aliases for NNMT Gene

Aliases for NNMT Gene

  • Nicotinamide N-Methyltransferase 2 3
  • EC 2.1.1.1 4

External Ids for NNMT Gene

Summaries for NNMT Gene

Entrez Gene Summary for NNMT Gene

  • N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NNMT Gene

NNMT (Nicotinamide N-Methyltransferase) is a Protein Coding gene. Diseases associated with NNMT include thyroid cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include nicotinamide N-methyltransferase activity. An important paralog of this gene is PNMT.

UniProtKB/Swiss-Prot for NNMT Gene

  • Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds

Gene Wiki entry for NNMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NNMT Gene

Genomics for NNMT Gene

Genomic Location for NNMT Gene

Start:
114,257,787 bp from pter
End:
114,313,285 bp from pter
Size:
55,499 bases
Orientation:
Plus strand

Genomic View for NNMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NNMT Gene

Regulatory Elements for NNMT Gene

Proteins for NNMT Gene

  • Protein details for NNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40261-NNMT_HUMAN
    Recommended name:
    Nicotinamide N-methyltransferase
    Protein Accession:
    P40261
    Secondary Accessions:

    Protein attributes for NNMT Gene

    Size:
    264 amino acids
    Molecular mass:
    29574 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NNMT Gene

neXtProt entry for NNMT Gene

Proteomics data for NNMT Gene at MOPED

Post-translational modifications for NNMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NNMT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NNMT Gene

Domains for NNMT Gene

Suggested Antigen Peptide Sequences for NNMT Gene

Graphical View of Domain Structure for InterPro Entry

P40261

UniProtKB/Swiss-Prot:

NNMT_HUMAN
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.:
    • P40261
genes like me logo Genes that share domains with NNMT: view

No data available for Gene Families for NNMT Gene

Function for NNMT Gene

Molecular function for NNMT Gene

GENATLAS Biochemistry: nicotinamide N-methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide
UniProtKB/Swiss-Prot Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds

Enzyme Numbers (IUBMB) for NNMT Gene

Gene Ontology (GO) - Molecular Function for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008112 nicotinamide N-methyltransferase activity IEA --
GO:0008168 methyltransferase activity --
genes like me logo Genes that share ontologies with NNMT: view

Phenotypes for NNMT Gene

genes like me logo Genes that share phenotypes with NNMT: view

miRNA for NNMT Gene

miRTarBase miRNAs that target NNMT

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NNMT Gene

Localization for NNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NNMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NNMT Gene COMPARTMENTS Subcellular localization image for NNMT gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NNMT: view

Pathways for NNMT Gene

genes like me logo Genes that share pathways with NNMT: view

Pathways by source for NNMT Gene

1 GeneGo (Thomson Reuters) pathway for NNMT Gene
1 BioSystems pathway for NNMT Gene

Interacting Proteins for NNMT Gene

Gene Ontology (GO) - Biological Process for NNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0031100 organ regeneration IEA --
GO:0032259 methylation TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with NNMT: view

Compounds for NNMT Gene

(4) HMDB Compounds for NNMT Gene

Compound Synonyms Cas Number PubMed IDs
1-Methylnicotinamide
  • 1-Methyl-3-carbamoylpyridinium
3106-60-3
Niacinamide
  • 3-Carbamoylpyridine
98-92-0
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(1) Drugbank Compounds for NNMT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Niacin
  • 3-Pyridinecarboxylic acid
59-67-6 target binder

(10) Novoseek inferred chemical compound relationships for NNMT Gene

Compound -log(P) Hits PubMed IDs
nnmt 99.7 212
nicotinamide 93.1 78
n(1)-methylnicotinamide 87.3 9
4-phenylpyridine 85 2
mptp 44.4 1
genes like me logo Genes that share compounds with NNMT: view

Transcripts for NNMT Gene

Unigene Clusters for NNMT Gene

Nicotinamide N-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NNMT Gene

No ASD Table

Relevant External Links for NNMT Gene

GeneLoc Exon Structure for
NNMT
ECgene alternative splicing isoforms for
NNMT

Expression for NNMT Gene

mRNA expression in normal human tissues for NNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NNMT Gene

This gene is overexpressed in Liver (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NNMT Gene

SOURCE GeneReport for Unigene cluster for NNMT Gene Hs.503911

mRNA Expression by UniProt/SwissProt for NNMT Gene

P40261-NNMT_HUMAN
Tissue specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas
genes like me logo Genes that share expressions with NNMT: view

Orthologs for NNMT Gene

This gene was present in the common ancestor of animals.

Orthologs for NNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NNMT 35
  • 99.62 (n)
  • 99.62 (a)
NNMT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia NNMT 35
  • 85.98 (n)
  • 85.61 (a)
NNMT 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nnmt 35
  • 82.95 (n)
  • 85.5 (a)
Nnmt 16
Nnmt 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NNMT 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NNMT 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nnmt 35
  • 83.91 (n)
  • 87.26 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC69005 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127789 35
  • 52.9 (n)
  • 46.33 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 36
  • 39 (a)
ManyToMany
zgc:64002 36
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea anmt-1 36
  • 23 (a)
ManyToMany
anmt-2 36
  • 23 (a)
ManyToMany
anmt-3 36
  • 22 (a)
ManyToMany
Species with no ortholog for NNMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NNMT Gene

ENSEMBL:
Gene Tree for NNMT (if available)
TreeFam:
Gene Tree for NNMT (if available)

Paralogs for NNMT Gene

Paralogs for NNMT Gene

Selected SIMAP similar genes for NNMT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for NNMT Gene

genes like me logo Genes that share paralogs with NNMT: view

Variants for NNMT Gene

Sequence variations from dbSNP and Humsavar for NNMT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs949372 -- 114,298,738(+) ATACT(C/T)ACAAC intron-variant
rs949374 -- 114,302,647(-) TATAC(G/T)TAACA intron-variant
rs1050207 -- 114,312,415(+) CTTCC(A/C)CCATG reference, missense
rs1802605 -- 114,296,622(+) CTAGA(A/G)AAATA reference, synonymous-codon
rs1802606 -- 114,296,662(+) AAAGC(A/C)AGATT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for NNMT Gene

Variant ID Type Subtype PubMed ID
nsv898395 CNV Gain 21882294

Relevant External Links for NNMT Gene

HapMap Linkage Disequilibrium report
NNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NNMT Gene

Disorders for NNMT Gene

(1) MalaCards Diseases for NNMT Gene

Search for NNMT Gene in MalaCards »

(8) Novoseek inferred disease relationships for NNMT Gene

Disease -log(P) Hits PubMed IDs
papillary thyroid cancer 49.8 5
parkinson disease 41.6 5
thyroid cancer 22.7 1
carcinoma renal cell 20.8 5
colorectal cancer 16.6 6

Relevant External Links for NNMT

Genetic Association Database (GAD)
NNMT
Human Genome Epidemiology (HuGE) Navigator
NNMT
genes like me logo Genes that share disorders with NNMT: view

No data available for UniProtKB/Swiss-Prot for NNMT Gene

Publications for NNMT Gene

  1. Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization. (PMID: 8575745) Aksoy S. … Weinshilboum R.M. (Genomics 1995) 2 3 4 23
  2. Genetic and environmental influences on plasma homocysteine: results from a Danish twin study. (PMID: 17412799) Bathum L. … Kyvik K.O. (Clin. Chem. 2007) 3 23 48
  3. Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida. (PMID: 18553462) Lu W. … Finnell R.H. (Birth Defects Res. Part A Clin. Mol. Teratol. 2008) 3 23 48
  4. Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (PMID: 18635682) Giusti B. … Abbate R. (J. Med. Genet. 2008) 3 23 48
  5. High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism. (PMID: 18427977) Giusti B. … Abbate R. (Biochem. Genet. 2008) 3 23 48

Products for NNMT Gene

  • Addgene plasmids for NNMT

Sources for NNMT Gene

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