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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1M Gene

protein-coding   GIFtS: 47
GCID: GC16P056666

metallothionein 1M

(Previous name: metallothionein 1K )
(Previous symbols: MT1, MT1K)
 Explore 5 diseases affiliated with
MT1M via our new
 Human Malady Compendium 
Biological research products
for MT1M
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Metallothionein 1M1 2     MT-IM2 3
MT1K1 2 3 5     Metallothionein 1Y2
MT11 2     Metallothionein-1M1
Metallothionein 1K1 2     Metallothionein-IM3
MT-1M2 3     

External Ids:    HGNC: 142961   Entrez Gene: 44992   Ensembl: ENSG000002053647   OMIM: 1563575   UniProtKB: Q8N3393   

Export aliases for MT1M gene to outside databases

Previous GC identifers: GC16P055225 GC16P042535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MT1M:
This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of
cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and
glucocorticoids. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1M


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1M gene promoter:
         TBP   p53   Sp1   Zic1   TFIID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MT1M

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1M gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056666:  view genomic region     (about GC identifiers)

Start:
56,666,145 bp from pter      End:
56,667,898 bp from pter
Size:
1,754 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339 (See protein sequence)
Recommended Name: Metallothionein-1M  
Size: 61 amino acids; 6110 Da
Subunit: Monomer (By similarity)
Secondary accessions: Q8TDN3

Explore the universe of human proteins at neXtProt for MT1M: NX_Q8N339

MT1M Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_789846.1  
ENSEMBL proteins: 
 ENSP00000369146   ENSP00000457575  

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Uscn Proteins for MT1M

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ISS--
GO:0005737cytoplasm ISS--
GO:0048471perinuclear region of cytoplasm ISS--


MT1M for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MT1M for domains           About GeneDecksing

5 InterPro domains/families:
 IPR000006 Metalthion_vert
 IPR018064 Metalthion_vert_metal_BS
 IPR003019 Metalthion_sfam_euk
 IPR023587 Metalthion_dom_vert
 IPR017854 Metalthion_dom

Graphical View of Domain Structure for InterPro Entry Q8N339

ProtoNet protein and cluster: Q8N339

1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339
Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Similarity: Belongs to the metallothionein superfamily. Type 1 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

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Inhib. RNA
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding ISS--
GO:0046872metal ion binding ----


MT1M for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Mineral absorption
Mineral absorption1.00

Pathway sources
See GeneCards unified pathways
Show all pathways



1         Kegg Pathway  (Kegg details for MT1M):
    Mineral absorption


MT1M for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1M

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for MT1M (ENSP000003691464) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
RELBENSP000002214524STRING: ENSP00000221452
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0045926negative regulation of growth ISS--
GO:0071294cellular response to zinc ion ISS--


MT1M for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT1M

1 HMDB Compound for MT1M    About this table
CompoundSynonyms CAS #PubMed Ids
CadmiumCd (see all 6)7440-43-9--
Search CenterWatch for drugs/clinical trials and news about MT1M 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MT1M gene: 
NM_176870.2  

Unigene Cluster for MT1M:

Metallothionein 1M
Hs.647370  [show with all ESTs]
Unigene Representative Sequence: BI488702
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000379818(uc010vhe.2 uc002ejn.3) ENST00000570233

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidMT1M 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene shRNA RFP: MT1M
OriGene siRNA: MT1M
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Clone
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1M

Additional cDNA sequence: 

AF136177.1 BC028280.1 BC103841.1 

7 DOTS entries:

DT.87013327  DT.100746942  DT.219306  DT.120684849  DT.92419270  DT.85103340  DT.95167555 

21 AceView cDNA sequences:

BC069421 BX118979 H72723 AA370427 BC028280 BF973961 NM_005947 NM_176870 
AY168638 AI719425 R99207 H72722 AF349000 BG217075 BU663337 R99208 
BG183187 BG221550 BG192094 BG220590 BG195149 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MT1M expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

MT1M expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
Mesendoderm-like cells (Generation of mesend...)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See MT1M Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MT1M

SOURCE GeneReport for Unigene cluster: Hs.647370
    SABiosciences Custom PCR Arrays for MT1M
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1M
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1M

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MT1M gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia MT36
--
66(a)
1 → many
GL343675.1(182526-186438)
zebrafish
(Danio rerio)
Actinopterygii mt26
metallothionein 2
60(a)
1 → many
18(17193795-17195147)


ENSEMBL Gene Tree for MT1M (if available)
TreeFam Gene Tree for MT1M (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MT1M gene
MT1G2  MT1E2  MT1X2  MT1F2  MT1B2  MT2A2  MT42  MT32  
MT1H2  MT1A2  
12 SIMAP similar genes for MT1M using alignment to 2 protein entries:     MT1M_HUMAN (see all proteins):
MT1A    MT1L    MT1G    MT1H    MT1B    MT1DP
MT1X    MTP    MT1F    MTE    MT2A    MT1E

MT1M for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for MT1M
PGOHUM00000243912 PGOHUM00000243964 PGOHUM00000262507


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/61 NCBI SNPs in MT1M are shown (see all 61    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs47839471,2
C,F,--42534969(+) ACTAGT/CATTTC 1 -- us2k12Minor allele frequency- C:0.08WA NA 238
rs585620341,2
C,--42534997(+) AGGATT/ACAAAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs560653001,2
C--42535495(+) GGACAA/GGCAAG 1 -- us2k10--------
rs779384671,2
--42535882(+) CGCCCG/TGCACT 1 -- us2k10--------
rs80607851,2
C,--42536007(+) CAGCCG/TCAGGC 1 -- ut510--------
rs560960041,2
C,--42536301(+) CTCTGG/AGTCAG 1 -- int13Minor allele frequency- A:0.09CSA WA NA 240
rs735516311,2
C,--42536824(+) GAGGGA/CACCCA 1 -- int12Minor allele frequency- C:0.04WA 120
rs1117501181,2
C,--56664581(+) GGGGATATT/-  
        
ATATT
1 -- us2k11Minor allele frequency- -:0.50CSA 2
rs559192751,2
C--56664594(+) TATTTATTT/-  
        
GCACA
1 -- us2k11Minor allele frequency- -:0.00NA 2
rs1890045641,2
--56664595(+) TATTTA/GCACAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MT1M (56666145 - 56667898 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MT1M: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MT1M for disorders           About GeneDecksing

OMIM gene information: 156357    OMIM disorders: --

5 diseases for MT1M:    About MalaCards
amyotrophic lateral sclerosis    lateral sclerosis    esophageal cancer    esophagitis
neuronitis


Export disorders for MT1M gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MT1M gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MT1M)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterisation of six additional human metallothionein genes. (PubMed id 8049263)1, 3, 9 Stennard F.A....West A.K. (1994)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1, 3 West A.K....Richards R.I. (1990)
  4. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. (PubMed id 17244347)1 Lederer C.W....Cavallaro S. (2007)
  5. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  8. Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930)1 Vandeghinste N....De Ley M. (2000)
  9. Metallothioneins in human kidneys and associated tumors. (PubMed id 10575295)1 Hellemans G....De Ley M. (1999)
  10. Smoking specifically induces metallothionein-2 isoform in human placenta at term. (PubMed id 16621216)9 Ronco A.M....Llanos M.N. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 4499 HGNC: 14296 AceView: MT1BandMT1K Ensembl:ENSG00000205364 euGenes: HUgn4499
ECgene: MT1M Kegg: 4499 H-InvDB: MT1M

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MT1M Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MT1M gene:
Search GeneIP for patents involving MT1M

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1M
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 GenScript Custom Purified and Recombinant Proteins Services for MT1M GenScript cDNA clones with any tag delivered in your preferred vector for MT1M
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 Regulatory tfbs in MT1M promoter
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 Novus Tissue Slides
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MT1M
       
GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
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von Willebrand factor
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