MT1M Gene
protein-coding GIFtS : 47
GCID: GC16 P056666
metallothionein 1M (Previous name: metallothionein 1K ) (Previous symbols: MT1, MT1K )
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Aliasesfor MT1M gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Metallothionein 1M 1 2 MT-IM2 3 MT1K1 2 3 5 Metallothionein 1Y2 MT11 2 Metallothionein-1M1 Metallothionein 1K1 2 Metallothionein-IM3 MT-1M2 3
Export aliases for MT1M gene to outside databases Previous GC identifers: GC16P055225 GC16P042535
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Summariesfor MT1M gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MT1M : This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. (provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids Gene Wiki entry for MT1M
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Genomic Viewsfor MT1M gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010498.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MT1M gene promoter: TBP p53 Sp1 Zic1 TFIID Other transcription factors Search SABiosciences Chromatin IP Primers for MT1M Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MT1M
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13 MT1M Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P056666: view genomic region
(about GC identifiers )
Start:
56,666,145 bp from pter
End:
56,667,898 bp from pter
Size:
1,754 bases
Orientation:
plus strand
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Proteinsfor MT1M gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339 (See
protein sequence )Recommended Name: Metallothionein-1M Size : 61 amino acids; 6110 Da
Subunit : Monomer (By similarity)
Secondary accessions : Q8TDN3Explore the universe of human proteins at neXtProt for MT1M: NX_Q8N339 MT1M Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_789846.1 ENSEMBL proteins: ENSP00000369146 ENSP00000457575 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
MT1M for ontologies About GeneDecksing MT1M Antibody Products: Assay Products for MT1M:
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Protein
Domains / Familiesfor MT1M gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MT1M for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N339 ProtoNet protein and cluster: Q8N339
1 Blocks protein family : IPB002400 Growth factor cystine knot superfamily signature UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339 Domain : Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A ofthe alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines Similarity : Belongs to the metallothionein superfamily. Type 1 family
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Functionfor MT1M gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MT1M_HUMAN, Q8N339 Function : Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins aretranscriptionally regulated by both heavy metals and glucocorticoids
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1M OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1MOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MT1M (NM_176870 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1M Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1M
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008270 zinc ion binding
ISS -- GO:0046872 metal ion binding
-- --
MT1M for ontologies About GeneDecksing
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Pathways & Interactionsfor MT1M gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Mineral absorption
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for MT1M) :
MT1M for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1M STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for MT1M (ENSP00000369146 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0045926 negative regulation of growth
ISS -- GO:0071294 cellular response to zinc ion
ISS --
MT1M for ontologies About GeneDecksing
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Drugs & Compoundsfor MT1M gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MT1M 1 HMDB Compound for MT1M About this table Search CenterWatch for drugs/clinical trials and news about MT1M
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Transcriptsfor MT1M gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MT1M gene: NM_176870.2 Unigene Cluster for MT1M:
Metallothionein 1M Hs.647370 [show with all ESTs ] Unigene Representative Sequence: BI488702 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000379818 (uc010vhe.2 uc002ejn.3 ) ENST00000570233 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1M OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1MOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MT1M (NM_176870 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MT1M Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1M
Additional cDNA sequence: AF136177.1 BC028280.1 BC103841.1
7 DOTS entries : DT.87013327 DT.100746942
DT.219306 DT.120684849 DT.92419270 DT.85103340 DT.95167555 21 AceView cDNA sequences :
BC069421 BX118979 H72723 AA370427 BC028280 BF973961 NM_005947 NM_176870 AY168638 AI719425 R99207 H72722 AF349000 BG217075 BU663337 R99208 BG183187 BG221550 BG192094 BG220590 BG195149 GeneLoc Exon Structure
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Expression for MT1M gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MT1M expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image MT1M expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 2 LifeMap Cells Name Category PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney Mesendoderm-like cells (Generation of mesend... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MT1M Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MT1M SOURCE GeneReport for Unigene cluster: Hs.647370 SABiosciences Custom PCR Arrays for MT1M Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat MT1M QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MT1M QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1M
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Orthologsfor MT1M gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for MT1M gene from 2/6 species (see all 6 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
MT36
--
66(a)
1 → many
GL343675.1(182526-186438)
zebrafish (Danio rerio)
Actinopterygii
mt26
metallothionein 2
60(a)
1 → many
18(17193795-17195147)
ENSEMBL Gene Tree for MT1M (if available)TreeFam Gene Tree for MT1M (if available)
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Paralogsfor MT1M gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MT1M gene MT1G 2 MT1E 2 MT1X 2 MT1F 2 MT1B 2 MT2A 2 MT4 2 MT3 2 MT1H 2 MT1A 2 12 SIMAP similar genes for MT1M using alignment to 2 protein entries: MT1M_HUMAN (see all proteins ):MT1A MT1L MT1G MT1H MT1B MT1DP MT1X MTP MT1F MTE MT2A MT1E
MT1M for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for MT1M PGOHUM00000243912 PGOHUM00000243964 PGOHUM00000262507
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Genomic Variantsfor MT1M gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MT1M (56666145 - 56667898 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MT1M: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MT1M
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Disorders
/ Diseasesfor MT1M gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MT1M for disorders About GeneDecksing
OMIM gene information: 156357
OMIM disorders : --5 diseases for MT1M : About MalaCards amyotrophic lateral sclerosis lateral sclerosis esophageal cancer esophagitis neuronitis Export disorders for MT1M gene to outside databases
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Publicationsfor MT1M gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MT1M gene, integrated from 9 sources (see all 15 ): (articles sorted by number of sources associating them with MT1M) Utopia : connect your pdf to the dynamic world of online information
Characterisation of six additional human metallothionein genes. (PubMed id 8049263) 1 , 3, 9 Stennard F.A....West A.K. (1994) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373) 1 , 3 West A.K....Richards R.I. (1990) Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. (PubMed id 17244347) 1 Lederer C.W....Cavallaro S. (2007) HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042) 1 Izmailova E....Aldovini A. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes. (PubMed id 10774930) 1 Vandeghinste N....De Ley M. (2000) Metallothioneins in human kidneys and associated tumors. (PubMed id 10575295) 1 Hellemans G....De Ley M. (1999) Smoking specifically induces metallothionein-2 isoform in human placenta at term. (PubMed id 16621216) 9 Ronco A.M....Llanos M.N. (2006)
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External Searches for MT1M gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MT1M gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MT1M gene
(According to HUGE )
About This Section --
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Specialized Databases showing MT1M gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MT1M Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MT1M gene: Search GeneIP for patents involving MT1M GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MT1M gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MT1M OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MT1M Browse OriGene genome-wide validated SYBR primer pairs OriGene Protein Over-expression Lysate for MT1M Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MT1M OriGene 3'-UTR Clone for MT1M OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MT1M OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MT1M Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MT1M OriGene Custom Protein Services for MT1M OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MT1M QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MT1M QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MT1M QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MT1M QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MT1M QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MT1M
Search Tocris compounds for MT1M
MT1M Proteins, Antibodies, CLIAs, and ELISAs
Search ThermoFisher Antibodies for MT1M
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MT1M
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