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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MT1G Gene

protein-coding   GIFtS: 50
GCID: GC16M056700

metallothionein 1G


(Previous symbol: MT1)
 Explore 25 diseases affiliated with
MT1G via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MT1G    

Aliases
for MT1G gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Metallothionein 1G1 2     Metallothionein-1G1
MT1K1 2 3     Metallothionein-1K3
MT11 2     Metallothionein-IG3
MT-1G2 3     MT1M3
MT-1K2 3     Metallothionein-1K3
MT-IG2 3     Metallothionein-IG3
Metallothionein 1K2     

External Ids:    HGNC: 73991   Entrez Gene: 44952   Ensembl: ENSG000001251447   OMIM: 1563535   UniProtKB: P136403   

Export aliases for MT1G gene to outside databases

Previous GC identifers: GC16M047084 GC16M056752 GC16M056435 GC16M056476 GC16M055258 GC16M042570


Summaries
for MT1G gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1G (Metallothionein 1G)


Genomic Views
for MT1G gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1G gene promoter:
         STAT5B   STAT1   Sp1   STAT4   STAT1beta   STAT1alpha   STAT2   STAT3   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MT1G promoter sequence
   Search SABiosciences Chromatin IP Primers for MT1G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MT1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

MT1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1G gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M056700:  view genomic region     (about GC identifiers)

Start:
 56,700,643 bp from pter      End:
 56,701,977 bp from pter
Size:
 1,335 bases      Orientation:
 minus strand

Proteins
for MT1G gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640 (See protein sequence)
Recommended Name: Metallothionein-1G  
Size: 62 amino acids; 6141 Da
Subunit: Monomer
Secondary accessions: P80296
Alternative splicing: 2 isoforms:  P13640-1   P13640-2   

Explore the universe of human proteins at neXtProt for MT1G: NX_P13640

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13640

    • MT1G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005941.1  
    ENSEMBL proteins: 
     ENSP00000391397   ENSP00000456675   ENSP00000369139   ENSP00000456835  

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    Novus Biologicals MT1G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MT1G

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15735762
    GO:0005737cytoplasm IDA3403543
    GO:0048471perinuclear region of cytoplasm IDA15735762


    MT1G for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MT1G

    Protein Domains /
    Families
    for MT1G gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MT1G for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000006 Metalthion_vert
     IPR018064 Metalthion_vert_metal_BS
     IPR003019 Metalthion_sfam_euk
     IPR023587 Metalthion_dom_vert
     IPR017854 Metalthion_dom

    Graphical View of Domain Structure for InterPro Entry P13640

    ProtoNet protein and cluster: P13640

    UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    Function
    for MT1G gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MT1G_HUMAN, P13640
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

         Genatlas biochemistry entry for MT1G:
    metallothionein 1G cluster

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MT1G

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MT1G

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12970870
    GO:0008270zinc ion binding IDA8119276
    GO:0046872metal ion binding ----


    MT1G for ontologies           About GeneDecksing



    Pathways & Interactions
    for MT1G gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    		Mineral absorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for MT1G):
        Mineral absorption


    MT1G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT1G

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MT1G (P136401, 3 ENSP000003913974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK7P580621, 3, ENSP000002745654EBI-1182473,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030224monocyte differentiation NAS8119276
    GO:0035924cellular response to vascular endothelial growth factor stimulus IEP15735762
    GO:0042117monocyte activation NAS8119276
    GO:0045926negative regulation of growth IDA18332874
    GO:0071276cellular response to cadmium ion IEP16827180


    MT1G for ontologies           About GeneDecksing



    Drugs & Compounds
    for MT1G gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MT1G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1G

    1 HMDB Compound for MT1G    About this table
    CompoundSynonyms CAS #PubMed Ids
    CadmiumCd (see all 6)7440-43-9--
    4 Novoseek chemical compound relationships for MT1G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 67.6 10 19330122 (3), 8171441 (1), 16827180 (1), 17485079 (1) (see all 7)
    zinc 51.7 11 14998373 (2), 10774930 (1), 1690731 (1), 15894685 (1)
    copper 11.5 2 1690731 (1)
    calcium 0 1 19356627 (1)

    Search CenterWatch for drugs/clinical trials and news about MT1G 

    Transcripts
    for MT1G gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MT1G gene: 
    NM_005950.1  

    Unigene Cluster for MT1G:

    Metallothionein 1G
    Hs.433391  [show with all ESTs]
    Unigene Representative Sequence: BC048334
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444837(uc002eju.1) ENST00000569500 ENST00000379811(uc002ejv.1)
    ENST00000568675

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MT1G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MT1G

    Additional cDNA sequence: 

    BC020757.1 BC048334.1 

    13 DOTS entries:

    DT.218152  DT.85102569  DT.416087  DT.85103384  DT.100794889  DT.95131272  DT.120684773  DT.120684946 
    DT.120684906  DT.100794887  DT.87014110  DT.87014218  DT.100059597 

    24/162 AceView cDNA sequences (see all 162):

    BC048334 AW953868 BM923855 BM817643 R29068 BI760266 BX092376 AI126783 
    S68954 CF456768 AW963354 BC035287 CA309973 AA075656 BI765780 BI761514 
    W03216 AI367453 BM702890 AI110774 BE122696 BX422558 BC005311 BC020757 

    GeneLoc Exon Structure


    Expression
    for MT1G gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MT1G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MT1G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesendoderm-like cells (Generation of mesend...)
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MT1G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MT1G

    SOURCE GeneReport for Unigene cluster: Hs.433391
        SABiosciences Custom PCR Arrays for MT1G
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    In Situ
    Assay Products:     
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    Orthologs
    for MT1G gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MT1G gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MT36
    		 --
    		 69(a)
    		 1 → many
    		 GL343675.1(182526-186438)
    zebrafish
    (Danio rerio)    		 Actinopterygii mt26
    		 metallothionein 2
    		 63(a)
    		 1 → many
    		 18(17193795-17195147)


    ENSEMBL Gene Tree for MT1G (if available)
    TreeFam Gene Tree for MT1G (if available) 

    Paralogs
    for MT1G gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MT1G gene
    MT1E2  MT1X2  MT1F2  MT1B2  MT2A2  MT42  MT1M2  MT32  
    MT1H2  MT1A2  
    12 SIMAP similar genes for MT1G using alignment to 3 protein entries:     MT1G_HUMAN (see all proteins):
    MT1X    MTE    MT1M    MT1F    MT1E    MT2A
    MT4    MT1A    MT1L    MT1H    MT1B    MTP

    MT1G for paralogs           About GeneDecksing



    Genomic Variants
    for MT1G gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/40 NCBI SNPs in MT1G are shown (see all 40)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1833275191,2
    		--56701758(+) ACTGGA/GCCAAT 1 -- us2k10--------
    rs727847371,2
    		C,F,--56701798(+) AATACG/CACCTC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1499803631,2
    		--56701820(+) GGACA-/CTCT  
                CTATG     		1 -- us2k10--------
    rs124486541,2
    		C,F,H,--56701827(+) CTCTAT/CGGTGT 1 -- us2k116Minor allele frequency- C:0.08NS EA NA EU 2276
    rs1996331941,2
    		--56701901(+) TGGGGC/TCCATT 1 -- us2k10--------
    rs1393845331,2
    		C,--56701913(+) CAACCC/TGAGGC 1 -- us2k10--------
    rs1927187321,2
    		--56701973(+) AAGGCG/TGAGTG 1 -- us2k10--------
    rs787809441,2
    		C,F,--56701977(+) CGGAGT/AGGAGC 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs9047701,2
    		C,A,H,--56702000(+) GGCTGC/TTTTTA 1 -- us2k1 tfbs312Minor allele frequency- T:0.14NA WA CSA EA 374
    rs2019003831,2
    		--56702033(+) GCAGA-/CGCC  
      CCGCCC    CGCCC     		1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MT1G (56700643 - 56701977 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT1G: --

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    Disorders / Diseases
    for MT1G gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MT1G for disorders           About GeneDecksing

    OMIM gene information: 156353    OMIM disorders: --

    20/25 diseases for MT1G (see all 25):    About MalaCards
    clear cell renal cell carcinoma    esophageal squamous cell carcinoma    renal cell carcinoma    squamous cell carcinoma
    papillary thyroid carcinoma    acute lymphoblastic leukemia    lymphoblastic leukemia    thyroid carcinoma
    hepatocellular carcinoma    keloids    carcinoma    thyroiditis
    esophagitis    hepatoblastoma    esophageal carcinoma    osteoporosis
    thyroid cancer    gastric cancer    pancreatic cancer    leukemia

    2 Novoseek disease relationships for MT1G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 22.1 2 19639168 (1), 1690731 (1)
    tumors 0 5 19639168 (2), 15894685 (2)


    Export disorders for MT1G gene to outside databases

    Publications
    for MT1G gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MT1G gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with MT1G)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. (PubMed id 3403543)1, 2, 3 Foster R.... Gedamu L. (1988)
    2. Induction by zinc of specific metallothionein isoforms in human monocytes. (PubMed id 8119276)1, 2, 9 Pauwels M.... Ley M. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structure and expression of the human metallothionein genes. (PubMed id 2444457)1, 2 Gedamu L.... Shworak N.W. (1987)
    5. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
    6. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of doub le combination array analysis. (PubMed id 19639168)1, 9 Kanda M....Nakao A. (2009)
    7. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. (PubMed id 15735762)1, 9 Joshi B....Chellappan S. (2005)
    8. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PubMed id 16827180)1, 9 Chang X.L....Zhou Y.F. (2006)
    9. Genome-wide association study of a quantitative disord ered gambling trait. (PubMed id 22780124)1 Lind P.A....Slutske W.S. (2012)
    10. MT1G hypermethylation: a potential prognostic marker for hepatoblastoma. (PubMed id 20032811)1 Sakamoto L.H....Vettore A.L. (2010)

    External Searches for MT1G gene

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    Genome Databases showing MT1G gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4495 HGNC: 7399 AceView: MT1G Ensembl:ENSG00000125144 euGenes: HUgn4495
    ECgene: MT1G Kegg: 4495 H-InvDB: MT1G

    Other Databases showing MT1G gene

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    Specialized Databases showing MT1G gene

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    PharmGKB entry for MT1G Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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