Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MT1G Gene

Aliases for MT1G Gene

  • Metallothionein 1G 2 3 5
  • Metallothionein-1K 3 4
  • Metallothionein-IG 3 4
  • MT-1G 3 4
  • MT-1K 3 4
  • MT-IG 3 4
  • MT1K 3 4
  • Metallothionein 1K 2
  • Metallothionein-1G 3
  • MT1M 4
  • MT1 3

External Ids for MT1G Gene

Previous HGNC Symbols for MT1G Gene

  • MT1

Previous GeneCards Identifiers for MT1G Gene

  • GC16M047084
  • GC16M056752
  • GC16M056435
  • GC16M056476
  • GC16M055258
  • GC16M042570
  • GC16M056700

Summaries for MT1G Gene

GeneCards Summary for MT1G Gene

MT1G (Metallothionein 1G) is a Protein Coding gene. Among its related pathways are Metabolism and Metal ion SLC transporters. An important paralog of this gene is MT2A.

UniProtKB/Swiss-Prot for MT1G Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Wiki entry for MT1G Gene

Additional gene information for MT1G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1G Gene

Genomics for MT1G Gene

GeneHancer (GH) Regulatory Elements for MT1G Gene

Promoters and enhancers for MT1G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I056667 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 555.5 -0.8 -797 3.2 DRAP1 TFAP4 USF1 TAF1 ZNF792 SAP130 SUZ12 ARID4B MAX DMAP1 MT1G MT1H MT1X MT1L
GH16I056604 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.5 +57.9 57909 10.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MT2A ENSG00000260823 GC16P056608 GC16P056609 RSPRY1 POLR2C BBS2 MT1A MT1F MT1G
GH16I056518 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 +148.5 148513 2.9 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B GLIS2 ZNF207 ZNF143 BBS2 OGFOD1 MT3 MT1G MT1H MT1A NUDT21 MT4 ENSG00000274031
GH16I056624 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.6 +41.8 41811 3 ARID4B FEZF1 DMAP1 ZNF2 ZNF48 YY1 ZNF213 ZNF143 FOS RXRA MT1E MT3 MT1G MT1H MT1B MT1F MT1X MT1A BBS2 NUP93
GH16I056908 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -243.3 -243305 5.5 HDGF FOXA2 RB1 BMI1 BATF KLF5 IRF4 EGR1 SCRT2 ATF7 HERPUD1 MIR138-2 MT1G MT1H ENSG00000261270 NLRC5 RPS24P17 SLC12A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MT1G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MT1G gene promoter:

Genomic Locations for MT1G Gene

Genomic Locations for MT1G Gene
chr16:56,666,731-56,668,065
(GRCh38/hg38)
Size:
1,335 bases
Orientation:
Minus strand
chr16:56,700,643-56,701,977
(GRCh37/hg19)

Genomic View for MT1G Gene

Genes around MT1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MT1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MT1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1G Gene

Proteins for MT1G Gene

  • Protein details for MT1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13640-MT1G_HUMAN
    Recommended name:
    Metallothionein-1G
    Protein Accession:
    P13640
    Secondary Accessions:
    • P80296

    Protein attributes for MT1G Gene

    Size:
    62 amino acids
    Molecular mass:
    6141 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for MT1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MT1G Gene

Post-translational modifications for MT1G Gene

No Post-translational modifications

Other Protein References for MT1G Gene

No data available for DME Specific Peptides for MT1G Gene

Domains & Families for MT1G Gene

Gene Families for MT1G Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MT1G Gene

Graphical View of Domain Structure for InterPro Entry

P13640

UniProtKB/Swiss-Prot:

MT1G_HUMAN :
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
  • Belongs to the metallothionein superfamily. Type 1 family.
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1G: view

Function for MT1G Gene

Molecular function for MT1G Gene

GENATLAS Biochemistry:
metallothionein 1G cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Gene Ontology (GO) - Molecular Function for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12646258
GO:0008270 zinc ion binding IDA 8119276
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MT1G: view

Phenotypes for MT1G Gene

GenomeRNAi human phenotypes for MT1G:
genes like me logo Genes that share phenotypes with MT1G: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT1G Gene

Localization for MT1G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT1G gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 7559655
GO:0005737 cytoplasm IDA 3403543
GO:0048471 perinuclear region of cytoplasm IDA 15735762
genes like me logo Genes that share ontologies with MT1G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MT1G Gene

Pathways & Interactions for MT1G Gene

genes like me logo Genes that share pathways with MT1G: view

Pathways by source for MT1G Gene

2 BioSystems pathways for MT1G Gene
1 KEGG pathway for MT1G Gene

Interacting Proteins for MT1G Gene

Gene Ontology (GO) - Biological Process for MT1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030224 monocyte differentiation NAS 8119276
GO:0035924 cellular response to vascular endothelial growth factor stimulus IEP 15735762
GO:0042117 monocyte activation NAS 8119276
GO:0045926 negative regulation of growth IDA 18332874
GO:0071276 cellular response to cadmium ion IEP 3403543
genes like me logo Genes that share ontologies with MT1G: view

No data available for SIGNOR curated interactions for MT1G Gene

Drugs & Compounds for MT1G Gene

(3) Drugs for MT1G Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Carrier, binder 202

(1) Additional Compounds for MT1G Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
genes like me logo Genes that share compounds with MT1G: view

Transcripts for MT1G Gene

mRNA/cDNA for MT1G Gene

Unigene Clusters for MT1G Gene

Metallothionein 1G:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1G Gene

No ASD Table

Relevant External Links for MT1G Gene

GeneLoc Exon Structure for
MT1G
ECgene alternative splicing isoforms for
MT1G

Expression for MT1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT1G Gene

mRNA differential expression in normal tissues according to GTEx for MT1G Gene

This gene is overexpressed in Liver (x24.3), Kidney - Cortex (x7.1), and Pancreas (x5.3).

Protein differential expression in normal tissues from HIPED for MT1G Gene

This gene is overexpressed in Fetal Liver (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT1G Gene



Protein tissue co-expression partners for MT1G Gene

NURSA nuclear receptor signaling pathways regulating expression of MT1G Gene:

MT1G

SOURCE GeneReport for Unigene cluster for MT1G Gene:

Hs.433391

Evidence on tissue expression from TISSUES for MT1G Gene

  • Liver(4.6)
  • Thyroid gland(3)
  • Kidney(2.9)
  • Pancreas(2.4)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with MT1G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MT1G Gene

Orthologs for MT1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
OneToMany
MT1G 34
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MT2A 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MT2 34
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mt1 34
  • 82 (a)
ManyToMany
Species where no ortholog for MT1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1G Gene

ENSEMBL:
Gene Tree for MT1G (if available)
TreeFam:
Gene Tree for MT1G (if available)

Paralogs for MT1G Gene

Paralogs for MT1G Gene

(12) SIMAP similar genes for MT1G Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1G: view

Variants for MT1G Gene

Sequence variations from dbSNP and Humsavar for MT1G Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000057034 -- 56,666,979(-) G/C intron_variant
rs1000231292 -- 56,669,234(-) G/A upstream_transcript_variant
rs1000260807 -- 56,669,429(-) T/C upstream_transcript_variant
rs1001898498 -- 56,666,669(-) A/G downstream_transcript_variant
rs1004767919 -- 56,668,896(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MT1G Gene

Variant ID Type Subtype PubMed ID
dgv2988n100 CNV gain 25217958
dgv2989n100 CNV gain 25217958
dgv480n67 CNV loss 20364138
dgv481n67 CNV loss 20364138
dgv524e214 CNV gain 21293372
nsv1058153 CNV gain 25217958
nsv827679 CNV loss 20364138
nsv827682 CNV gain 20364138
nsv974819 CNV duplication 23825009

Variation tolerance for MT1G Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MT1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1G Gene

Disorders for MT1G Gene

Additional Disease Information for MT1G

No disorders were found for MT1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MT1G Gene

Publications for MT1G Gene

  1. Induction by zinc of specific metallothionein isoforms in human monocytes. (PMID: 8119276) Pauwels M … De Ley M (European journal of biochemistry 1994) 3 4 22 58
  2. Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. (PMID: 3403543) Foster R … Gedamu L (The Journal of biological chemistry 1988) 2 3 4 58
  3. Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis. (PMID: 19639168) Kanda M … Nakao A (International journal of oncology 2009) 3 22 58
  4. Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. (PMID: 16827180) Chang XL … Zhou YF (Biomedical and environmental sciences : BES 2006) 3 22 58
  5. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. (PMID: 15735762) Joshi B … Chellappan S (Oncogene 2005) 3 22 58

Products for MT1G Gene

Sources for MT1G Gene

Content
Loading form....