V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

MAOB Gene

protein-coding GIFtS: 66

GC0XM043510

monoamine oxidase B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.4.3.4 ^³
MAO-B ^³
MGC26382 ^²

Descriptions
MAO, brain ^²
MAO, platelet ^²
Monoamine oxidase type B ^³
adrenalin oxidase ^²
monoamine oxidase B ^²
tyramine oxidase ^²

External Ids
HGNC: 6834¹
Entrez Gene: 4129²
UniProtKB: P27338³
Ensembl: ENSG00000069535⁷

Search outside databases for aliases for MAOB gene

Previous GC identifers: GC0XM041637 GC0XM041886 GC0XM042452 GC0XM042671 GC0XM043383

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAOB:

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme

located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic

and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive

amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades

benzylamine and phenylethylamine. [provided by RefSeq]

UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338

Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important

functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and

peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAOB gene

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.4-p11.3

MAOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM043510: (about GC identifiers)

Start:	43,510,801 bp from pter
End:	43,626,665 bp from pter
Size:	115,865 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338 (See protein sequence)

Recommended Name: Amine oxidase [flavin-containing] B

Size: 520 amino acids; 58763 Da

Cofactor: FAD

Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit

contains a covalently bound flavin. Enzymatically active as monomer (By similarity)

Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein;

Cytoplasmic side

Mass spectrometry: Mass=59474; Mass_error=14.0; Method=Electrospray; Range=2-520;

Source=PubMed:11049757;

PDB structures from and Proteopedia :

1GOS (3D)

1H8R (3D)

1OJ9 (3D)

1OJA (3D)

1OJB (3D)

1OJC (3D)

1OJD (3D)

1S2Q (3D)

1S2Y (3D)

1S3B (3D)

1S3E (3D)

2BK3 (3D)

2BK4 (3D)

2BK5 (3D)

2BYB (3D)

2C64 (3D)

2C65 (3D)

2C66 (3D)

2C67 (3D)

2C70 (3D)

2C72 (3D)

2C73 (3D)

2C75 (3D)

2C76 (3D)

2V5Z (3D)

2V60 (3D)

2V61 (3D)

2VRL (3D)

2VRM (3D)

2VZ2 (3D)

Secondary accessions: Q7Z6S2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000889.3

ENSEMBL proteins:

ENSP00000380428 ENSP00000367309

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for MAOB
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Monoamine Oxidase, Monoamine oxidase A+B, Monoamine Oxidase B)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005740	mitochondrial envelope	TAS	7063850
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for MAOB:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAOB
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Monoamine Oxidase, Monoamine oxidase A+B, Monoamine Oxidase B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAOB)
	Novus Biologicals Antibodies for MAOB

Assays for MAOB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27338

ProtoNet protein and cluster: P27338

1 Blocks protein family: IPB001613 Flavin-containing amine oxidase signature

UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338

Similarity: Belongs to the flavin monoamine oxidase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAOB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAOB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000898

Applied Biosystems Silencer® siRNAs for MAOB

Sigma-Aldrich siRNA and siRNA Panels for MAOB

Sigma-Aldrich shRNA for MAOB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAOB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000898
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000898
untagged cDNA clone in CMV expression vector: NM_000898

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000898

UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338

Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important

functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and

peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine

Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

Enzyme Number (IUBMB): EC 1.4.3.4

Genatlas biochemistry entry for MAOB:

monoamine oxidase B

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Maob):

behavior/neurological

homeostasis/metabolism

nervous system

renal/urinary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008131	amine oxidase activity	IEA	--
GO:0009055	electron carrier activity	TAS	8602220
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for MAOB (Your Favorite Gene powered by Ingenuity) (see all 11 )

Xenobiotic Metabolism Signaling
Glycine, Serine and Threonine Metabolism
Histidine Metabolism
LPS/IL-1 Mediated Inhibition of RXR Function
Mitochondrial Dysfunction

GeneDecks MAOB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MAOB

5/60 Interacting proteins for MAOB (ENSP00000367309³) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COMT	ENSP00000207636³	STRING (score=.985)
DDC	ENSP00000339928³	STRING (score=.969)
DBH	ENSP00000263611³	STRING (score=.95)
PNMT	ENSP00000269582³	STRING (score=.937)
ADH1B	ENSP00000306606³	STRING (score=.922)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MAOB

Sigma-Aldrich Small Molecules for MAOB:

Antagonist Inhibitor

Compounds for MAOB available from Tocris Bioscience

Compound	Action	CAS number
8-(3-Chlorostyryl)caffeine	Selective A2A antagonist. Also MAO-B inhibitor	[147700-11-6]
Harmane	Putative endogenous imidazoline ligand. Also MAO inhibitor	[486-84-0]
(R)-(-)-Deprenyl hydrochloride	MAO-B inhibitor	[14611-52-0]
Bifemelane hydrochloride	MAO-A and MAO-B inhibitor	[90293-01-9]
Lazabemide hydrochloride	Selective MAO-B inhibitor	[103878-83-7]

About this table

10/41 Novoseek chemical compound relationships for MAOB gene (see all 41 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
propargylamine	89.09	11	16027398 (2), 14696044 (1), 7931256 (1), 18035186 (1) (see all 7)
1,4-diphenyl-2-butene	88.72	8	15710600 (2), 14501143 (1), 12913124 (1), 17030739 (1) (see all 5)
safinamide	88.45	23	17824599 (5), 15082032 (2), 17915852 (2), 18041937 (2) (see all 9)
n-(2-aminoethyl)-p-chlorobenzamide	86.17	4	7931243 (1), 9131670 (1), 15279562 (1)
ladostigil	83.09	1	18751929 (1)
1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine	81.01	2	7696527 (1), 8605171 (1)
kynuramine	79.65	3	12482210 (1), 12672993 (1), 15694196 (1)
n-propargyl-1(s)-aminoindan	77.81	1	15027868 (1)
1 methyl 4 phenylpyridinium	76.14	51	10863544 (4), 9131670 (4), 7832430 (1), 8627546 (1) (see all 20)
benzylamine	75.48	18	1741773 (2), 1413647 (2), 16807522 (1), 9503561 (1) (see all 13)

About this table

1 PharmGKB drug compound relationship for MAOB gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
citalopram	FA	11840311

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAOB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAOB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000898

Sigma-Aldrich siRNA and siRNA Panels for MAOB

Sigma-Aldrich shRNA for MAOB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000898

REFSEQ mRNAs for MAOB gene:

NM_000898.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000898

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000898
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000898
                                 untagged cDNA clone in CMV expression vector: NM_000898

Additional cDNA sequence:

AF088019.1 AK294306.1 AK298942.1 AK310458.1 AK312679.1 BC022494.1 M69177.1 S62734.1

7 DOTS entries:

DT.95267653 DT.40112738 DT.95267654 DT.121287446 DT.75103384 DT.92427362 DT.40131695

24/114 AceView cDNA sequences (see all 114 ):

BM726427 AI127508 CA975968 CF552692 H23118 AI769484 CF552693 AL133791

BM666549 AI081909 AA363929 AI199665 BF970035 H23119 F31900 CB216420

BQ956448 NM_000898 AA635647 BF939986 BM680285 AI095601 S62734 BU681213

highest scoring ESTs for MAOB:

M69177 AU127841 BC022494 BM544639 S62734 AA363929 AA826412 AI696860 AI933377 AL118671

Unigene Cluster for MAOB:

Monoamine oxidase B

Hs.654473 [show with all ESTs]

Unigene Representative Sequence: NM_000898

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000397257 ENST00000378069

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAOB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAOB

¹ / ² / ³

3 probe-sets matching MAOB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37628_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M69177	1.00	1.00	1.00	1
204041_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000898	0.60	1.00	0.82	1
204041_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAOB for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACAAGGAAT

SOURCE GeneReport for Unigene cluster: Hs.654473
Expression variation in blood from EXPOLDB for MAOB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAOB gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAOB¹	--	monoamine oxidase B	91.73(n) 94.81(a)	403451 XM_850456.1 XP_855549.1
cow (Bos taurus)	MAOB¹	--	monoamine oxidase B	90.64(n) 91.35(a)	338445 NM_177944.2 NP_808813.2
rat (Rattus norvegicus)	Maob¹	--	monoamine oxidase B	86.64(n) 88.44(a)	25750 NM_013198.1 NP_037330.1
mouse (Mus musculus)	Maob^{1, 5}	X (5.20 cM)⁵	monoamine oxidase B^{1, 5}	87.52(n)¹ 88.8(a)¹	109731¹ NM_172778.1¹ NP_766366.1¹ AI265558⁵ AK031833⁵ (see all 10)
chicken (Gallus gallus)	MAOB¹	--	monoamine oxidase B	74.57(n) 75.34(a)	418561 XM_416766.2 XP_416766.2

About this table Species with no ortholog for MAOB

ENSEMBL Gene Tree for MAOB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAOB gene

IL4I1² MAOA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/363 NCBI SNPs in MAOB are shown (see all 363 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 165)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1040398^1,2	A,C,F,H	43510375(-)	`TTAAAT/CGGTAT`	1	--	ng5¹		7	EA NA EU WA	434
	rs2072745^1,2	C,F,H,O	43511273(-)	`TTCCCT/AAGTTC`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs3027440^1,2	C,F,H	43511425(+)	`AGGGCA/GATAAA`	1	--	ut3¹ ese³		7	NA EU EA WA	560
	rs1040399^1,2	C,F,H	43510343(-)	`CCTCTC/TGACTC`	1	--	ng5¹		12	NA EA MN EU WA	1052
	rs17462^1,2	C,F,H	43511440(-)	`TCACCA/GGTTTC`	1	--	ut3¹ ese³		8	MN NA EU EA WA	724
	rs1181252^1,2	C,F,H	43627603(+)	`ATAGAG/ATGGCT`	1	--	ng3¹		7	EA NA EU WA	464
	rs3027439^1,2	F,H	43511080(+)	`TCCAAA/GGAGGT`	1	--	ut3¹		4	EU EA WA	408
	rs7066677^1,2	F,H	43511453(+)	`CAGAAC/TGCTAA`	1	--	ut3¹		4	EU EA WA	416
	rs12845783^1,2	C,H	43541343(+)	`ATGATT/GCTTGT`	1	S/R	mis¹		4	EU EA WA	412
--	rs12850496^1,2	H	43541335(+)	`TTGTCG/TAGATG`	1	S/X	non¹ ese³		4	EU EA WA	402

About this table

HapMap Linkage Disequilibrium images for MAOB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 309860

10/56 Novoseek disease relationships for MAOB gene (see all 56 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	86.96	235	10990520 (4), 11160474 (4), 8413955 (3), 18937611 (3) (see all 99)
parkinsonism	67.33	29	2266365 (1), 1801542 (1), 10047935 (1), 11008487 (1) (see all 20)
neurodegenerative diseases	60.33	19	10619718 (2), 8405291 (1), 9489486 (1), 17168653 (1) (see all 11)
alzheimers disease	51.99	30	7816197 (3), 8815165 (2), 10867219 (2), 2222781 (1) (see all 21)
neurodegeneration	50.33	12	16252076 (1), 17347320 (1), 12165403 (1), 12963742 (1) (see all 7)
lewy body disease	41.48	1	18751929 (1)
alcoholism	40.31	34	17592478 (3), 8154672 (2), 9622437 (2), 15918154 (1) (see all 16)
akinesia	34.64	1	7593732 (1)
gliosis	32.74	5	7931234 (1), 17624626 (1), 11586414 (1)
neurological disorders	29.36	9	15247489 (3), 15111100 (1), 11072748 (1), 11753429 (1) (see all 5)

About this table

Genatlas disease: MAOB

monoamine oxidase deficiency

Human Gene Mutation Database: MAOB
Genetic Association Database: MAOB
Human Genome Epidemiology Navigator: MAOB (49 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/573 PubMed articles for MAOB gene (see all 573 ):

The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson's disease. (PubMed id 15355491)^{1, 3, 6} Bial/ecka M....Stankiewicz J. (2004)
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. (PubMed id 15710600)^{1, 3, 4} Hubalek F....Edmondson D.E. (2005)
High-level expression of human liver monoamine oxidase B in Pichia pastoris. (PubMed id 11049757)^{1, 3, 4} Newton-Vinson P.... Edmondson D.E. (2000)
The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. (PubMed id 8515265)^{1, 3, 4} Chen K.... Shih J.C. (1993)
Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men. (PubMed id 15955630)^{1, 3, 6} Costa-Mallen P....Checkoway H. (2005)
Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. (PubMed id 8665924)^{1, 3, 4} Cesura A.M.... Da Prada M. (1996)
Human monoamine oxidase A and B genes exhibit identical exon-intron organization. (PubMed id 2023912)^{1, 3, 4} Grimsby J.... Shih J.C. (1991)
Monoamine oxidases A and B gene polymorphisms in migraine patients. (PubMed id 15694196)^{1, 3, 6} Filic V....Jernej B. (2005)
Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. (PubMed id 15211623)^{1, 3, 6} Zammit S....Owen M.J. (2004)
Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia. (PubMed id 15261699)^{1, 3, 6} Matsumoto C....Nakamura J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4129	HGNC: 6834	AceView: MAOB	Ensembl:ENSG00000069535	euGenes: HUgn4129
ECgene: MAOB	H-InvDB: MAOB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB
Wikipedia	http://en.wikipedia.org/wiki/Monoamine_oxidase

Licensable Technologies for MAOB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAOB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAOB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAOB		Antibodies for MAOB
	Explore super-pooled esiRNAs		Proteins for MAOB
	Lentivirus-delivered shRNAs for MAOB		Small molecules for MAOB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (MAOB)
	Chimera RNAi (MAOB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Monoamine Oxidase, Monoamine oxidase A+B, Monoamine Oxidase B)
	Antibodies (Monoamine Oxidase, Monoamine oxidase A+B, Monoamine Oxidase B)

Search OriGene for MAOB

Tocris compounds for MAOB

	Drugs for MAOB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MAOB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
MAOB Gene at Home site.
Version 2.41.1
server5.xennexinc.com

MAOB Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for MAOB

Summaries
for MAOB

Genomic Location
for MAOB

Proteins
for MAOB

Protein Domains/
Families
for MAOB

Gene Function
for MAOB

Pathways & Interactions
for MAOB

Drugs & Compounds
for MAOB

Transcripts
for MAOB

Expression
for MAOB

Orthologs
for MAOB

Paralogs
for MAOB

SNPs/Variants
for MAOB

Disorders & Mutations
for MAOB

Medical News
for MAOB

Publications
for MAOB

Search for MAOB

Genome Databases showing MAOB

Other Databases showing MAOB

Specialized Databases showing MAOB

Licensable Technologies
for MAOB

Services
for MAOB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAOB Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor MAOB

Summariesfor MAOB

Genomic Locationfor MAOB

Proteinsfor MAOB

Protein Domains/Familiesfor MAOB

Gene Functionfor MAOB

Pathways & Interactionsfor MAOB

Drugs & Compoundsfor MAOB

Transcriptsfor MAOB

Expression for MAOB

Orthologsfor MAOB

Paralogsfor MAOB

SNPs/Variantsfor MAOB

Disorders & Mutationsfor MAOB

Medical Newsfor MAOB

Publicationsfor MAOB

Search for MAOB

Genome Databases showing MAOB

Other Databases showing MAOB

Specialized Databases showing MAOB

Licensable Technologiesfor MAOB

Servicesfor MAOB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAOB

Summaries
for MAOB

Genomic Location
for MAOB

Proteins
for MAOB

Protein Domains/
Families
for MAOB

Gene Function
for MAOB

Pathways & Interactions
for MAOB

Drugs & Compounds
for MAOB

Transcripts
for MAOB

Expression
for MAOB

Orthologs
for MAOB

Paralogs
for MAOB

SNPs/Variants
for MAOB

Disorders & Mutations
for MAOB

Medical News
for MAOB

Publications
for MAOB

Licensable Technologies
for MAOB

Services
for MAOB