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KCNN4 Gene

protein-coding GIFtS: 59

GC19M048962

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
IK1 ^², ³
IKCA1 ^², ³
IKCa1 ^³
KCA4 ^², ³, ⁵
KCa3.1 ^¹, ²
KCa4 ^³
SK4 ^², ³, ⁵
hIKCa1 ^¹, ²
hKCa4 ^¹, ²
hSK4 ^¹, ²

Descriptions
Putative Gardos channel ^³
intermediate conductance calcium-activated potassium channel protein 1 ^²
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 ^²
putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel ^²

External Ids
HGNC: 6293¹
Entrez Gene: 3783²
UniProtKB: O15554³
Ensembl: ENSG00000104783⁷

Search outside databases for aliases for KCNN4 gene

Previous GC identifers: GC19M044916 GC19M044662 GC19M048946

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for KCNN4:

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent

potassium channel that is activated by intracellular calcium. Activation is followed by membrane

hyperpolarization, which promotes calcium influx. The encoded protein may be part of the

predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other

KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a

new subfamily. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554

Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium.

Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is

blocked by clotrimazole and charybdotoxin but is insensitive to apamin

Gene Wiki entry for KCNN4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the KCNN4 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.2

KCNN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M048962: (about GC identifiers)

Start:	48,962,525 bp from pter
End:	48,977,249 bp from pter
Size:	14,725 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554 (See protein sequence)

Recommended Name: Intermediate conductance calcium-activated potassium channel protein 4

Size: 427 amino acids; 47696 Da

Subunit: Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6

Subcellular location: Membrane; Multi-pass membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002241.1

ENSEMBL proteins:

ENSP00000384427 ENSP00000262888

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KCNN4)
	Human Recombinant Proteins from Abnova (KCNN4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008076	voltage-gated potassium channel complex	TAS	9380751
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for KCNN4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of KCNN4
	Sigma-Aldrich Antibodies for KCNN4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KCNN4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KCNN4)
	Search Novus for antibodies for KCNN4

Assays for KCNN4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O15554

ProtoNet protein and cluster: O15554

3 Blocks protein families:

IPB004178 Calmodulin binding domain

IPB011996 SK channel region

IPB013099 Ion transport 2

UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554

Similarity: Belongs to the potassium channel KCNN family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNN4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNN4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002250

Applied Biosystems Silencer® siRNAs for KCNN4

Sigma-Aldrich siRNA and siRNA Panels for KCNN4

Sigma-Aldrich shRNA Panels and shRNA for KCNN4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KCNN4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002250
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002250
untagged cDNA clones in CMV expression vector (see all 3): NM_002250

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002250

UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554

Function: Forms a voltage-independent potassium channel that is activated by intracellular calcium.

Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is

blocked by clotrimazole and charybdotoxin but is insensitive to apamin

Induction: Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells

Genatlas biochemistry entry for KCNN4:

potassium intermediate/small conductance calcium-activated channel,subfamily N,member 4,expressed

in T lymphocytes and red cells,also expressed in placenta,prostate,fetal,liver and spleen,pancreas

and ovarian tumors

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Kcnn4):

digestive/alimentary

endocrine/exocrine gland

hematopoietic system

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0015269	calcium-activated potassium channel activity	TAS	9380751

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for KCNN4 (Your Favorite Gene powered by Ingenuity)

Cellular Effects of Sildenafil (Viagra)
Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks KCNN4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for KCNN4

5/51 Interacting proteins for KCNN4 (ENSP00000262888³) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KCNMB4	ENSP00000258111³	STRING (score=.982)
KCND3	ENSP00000319591³	STRING (score=.951)
KCNC1	ENSP00000265969³	STRING (score=.949)
KCNMB3	ENSP00000319370³	STRING (score=.943)
KCNE2	ENSP00000290310³	STRING (score=.94)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	9380751
GO:0006884	cell volume homeostasis	IEA	--
GO:0006952	defense response	TAS	9407042
GO:0045332	phospholipid translocation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for KCNN4:

Ligand

Compounds for KCNN4 available from Tocris Bioscience

Compound	Action	CAS number
DCEBIO	Activates Cl- conductance and hIK1 K+ channels	[60563-36-2]
SG 209	K+ channel opener	[83440-03-3]
Doxazosin mesylate	alpha1 antagonist	[77883-43-3]
Apamin	K+ channel blocker (small conductance, Ca2+-dependent)	[24345-16-2]
4-Aminopyridine	K+ channel blocker	[504-24-5]

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10 Novoseek chemical compound relationships for KCNN4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1-[(2-chlorophenyl)diphenylmethyl]-1h-pyrazole	87.60	1	15662023 (1)
charybdotoxin	82.25	7	15662023 (1), 17310992 (1), 15208030 (1), 11425865 (1) (see all 5)
phosphatidylinositol 3-phosphate	65.34	16	16251351 (4), 15831468 (2)
potassium	61.68	18	9407042 (3), 11425865 (3), 19270724 (2), 9380751 (2) (see all 11)
iberiotoxin	51.50	1	15662023 (1)
ionomycin	43.46	1	14600080 (1)
chloride	38.19	1	16251351 (1)
calcium	30.30	20	19270724 (3), 9407042 (3), 15241346 (3), 16847315 (2) (see all 7)
atp	19.69	1	14659794 (1)
thymidine	19.12	1	10884437 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KCNN4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KCNN4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002250

Sigma-Aldrich siRNA and siRNA Panels for KCNN4

Sigma-Aldrich shRNA Panels and shRNA for KCNN4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002250

REFSEQ mRNAs for KCNN4 gene:

NM_002250.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002250

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002250
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002250
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002250

Additional cDNA sequence:

AF000972.1 AF022150.1 AF022797.1 AF033021.1 AF053403.1 AF395661.1 BC015337.1 BT007426.1

CR598085.1 CR617778.1 CR626849.1

7 DOTS entries:

DT.441715 DT.97842628 DT.121463297 DT.100801472 DT.40133113 DT.97833328 DT.100801466

24/148 AceView cDNA sequences (see all 148 ):

AF000972 CB959502 BM767320 BX364995 AI467982 BG284696 BM825707 CA309592

BM707162 BT007426 BM716240 BP350966 NM_002250 BQ679375 AF053403 CA432594

BX340406 BX339013 BX417280 BC015337 CR617778 BM673192 CR626849 AA603035

highest scoring ESTs for KCNN4:

AF022797 AF000972 AF022150 AF033021 AF395661 BC015337 BE770390 BG178210 BG829947 BI907306

Unigene Cluster for KCNN4:

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Hs.10082 [show with all ESTs]

Unigene Representative Sequence: NM_002250

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN4 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b
SP1:																											-		-								-
SP2:																											-		-								-
SP3:
SP4:									-		-		-		-		-										-		-
SP5:																													-

About this scheme

ECgene alternative splicing isoforms for KCNN4

2 Ensembl transcripts including schematic representations:

ENST00000407385 ENST00000262888

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KCNN4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KCNN4

¹ / ² / ³

3 probe-sets matching KCNN4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41106_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF022797	1.00	1.00	1.00	1
204401_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002250	0.60	1.00	0.82	1
204401_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KCNN4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCACCCCCA

SOURCE GeneReport for Unigene cluster: Hs.10082
Expression variation in blood from EXPOLDB for KCNN4
UniProtKB/Swiss-Prot: KCNN4_HUMAN, O15554
Tissue specificity: Widely expressed in non-excitable tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for KCNN4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNN4¹	--	potassium intermediate/small conductance calcium-activated more	89.12(n) 90.85(a)	484464 XM_541579.2 XP_541579.2
chimpanzee (Pan troglodytes)	KCNN4¹	--	potassium intermediate/small conductance calcium-activated more	99.64(n) 99.46(a)	456098 XM_512722.2 XP_512722.2
rat (Rattus norvegicus)	Kcnn4¹	--	potassium intermediate/small conductance calcium-activated more	84.32(n) 85.82(a)	65206 NM_023021.1 NP_075410.1
mouse (Mus musculus)	Kcnn4^{1, 5}	7⁵	potassium intermediate/small conductance calcium-activated more^{1, 5}	86.08(n)¹ 87.5(a)¹	16534¹ NM_008433.3¹ NP_032459.2¹ AA033013⁵ AA042002⁵ (see all 24)
zebrafish (Danio rerio)	LOC568363¹	--	similar to small conductance calcium-activated potassium more	56.01(n) 50.36(a)	568363 XM_691690.3 XP_696782.3

About this table Species with no ortholog for KCNN4

ENSEMBL Gene Tree for KCNN4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for KCNN4 gene

KCNN2² KCNN1² KCNN3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/121 NCBI SNPs in KCNN4 are shown (see all 121 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11665924^1,2	A,C,F,H	48978822(+)	`AACTGA/GTGACA`	1	--	ng3¹		7		NA EU EA WA	540
	rs3760983^1,2	A,C,F,H	48978500(+)	`TCCTCC/TGACAC`	1	--	ng3¹ tfbs³		8		EU EA WA	836
	rs12427^1,2	A,C,F,H	48962659(-)	`GGGGCT/CGGAGG`	1	--	ut3¹ ese³		5		MN EU EA WA	596
	rs3760982^1,2	A,C,F,H	48978353(+)	`ACATAG/AACACA`	1	--	ng3¹ tfbs³		13		EA EU WA NA	1944
	rs3760984^1,2	A,C,F	48978602(+)	`AGGGAT/CATGGA`	1	--	ng3¹		1		EA	1484
	rs10422551^1,2	C,F,H	48978313(+)	`CATACA/GCGGAG`	1	--	ng3¹		7		NA EU EA WA	524
	rs11351^1,2	A,C,F	48962906(+)	`GGCCTA/CCCCAC`	1	--	ut3¹ ese³		8		EA NA MN	472
	rs3786956^1,2	C,F,H	48978669(+)	`CAACAC/TACAAC`	1	--	ng3¹		17		EA EU WA NA	2966
--	rs10853767^1,2	A,C	48962407(+)	`CCTACA/TGAGTT`	1	--	ng5¹		0	--	--	--	--
	rs7181^1,2	A,F	48962765(-)	`GACTCC/TTGGGT`	1	--	ut3¹ ese³		1		MN	184

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HapMap Linkage Disequilibrium images for KCNN4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602754

5 Novoseek disease relationships for KCNN4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sickle cell disease	61.17	2	11425865 (1), 10884437 (1)
erythroleukemia	40.88	1	14600080 (1)
hyperplasia	3.52	2	17310992 (1), 16209944 (1)
tumors	0.00	1	15662023 (1)
rheumatoid arthritis	0.00	1	10884437 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/75 PubMed articles for KCNN4 gene (see all 75 ):

hSK4, a member of a novel subfamily of calcium-activated potassium channels. (PubMed id 9380751)^{1, 2, 3, 4} Joiner W.J.... Kaczmarek L.K. (1997)
A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. (PubMed id 9407042)^{1, 2, 3, 4} Logsdon N.J....Aiyar J. (1997)
Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. (PubMed id 11425865)^{1, 3, 4} Wulff H.... Chandy K.G. (2001)
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. (PubMed id 10961988)^{1, 3, 4} Ghanshani S.... Chandy K.G. (2000)
Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. (PubMed id 10026195)^{1, 3, 4} Fanger C.M.... Aiyar J. (1999)
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. (PubMed id 16382103)^{2, 3} Wei A.D....Wulff H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. (PubMed id 9693050)^{3, 4} Ghanshani S.... Chandy K.G. (1998)
A human intermediate conductance calcium-activated potassium channel. (PubMed id 9326665)^{3, 4} Ishii T.M....Maylie J. (1997)
The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. (PubMed id 12773623)^{1, 3} Hoffman J.F....Wickrema A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3783	HGNC: 6293	AceView: KCNN4	Ensembl:ENSG00000104783	euGenes: HUgn3783
ECgene: KCNN4	H-InvDB: KCNN4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KCNN4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KCNN4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KCNN4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNN4		Antibodies for KCNN4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNN4		Small molecules for KCNN4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KCNN4)
	Antibodies (KCNN4)
	Chimera RNAi (KCNN4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (KCNN4)
	Antibodies (KCNN4)

Search OriGene for KCNN4

Tocris compounds for KCNN4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KCNN4

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KCNN4 Gene at Home site.
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KCNN4 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for KCNN4

Summaries
for KCNN4

Genomic Location
for KCNN4

Proteins
for KCNN4

Protein Domains/
Families
for KCNN4

Gene Function
for KCNN4

Pathways & Interactions
for KCNN4

Drugs & Compounds
for KCNN4

Transcripts
for KCNN4

Expression
for KCNN4

Orthologs
for KCNN4

Paralogs
for KCNN4

SNPs/Variants
for KCNN4

Disorders & Mutations
for KCNN4

Medical News
for KCNN4

Publications
for KCNN4

Search for KCNN4

Genome Databases showing KCNN4

Other Databases showing KCNN4

Specialized Databases showing KCNN4

Licensable Technologies
for KCNN4

Services
for KCNN4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KCNN4 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor KCNN4

Summariesfor KCNN4

Genomic Locationfor KCNN4

Proteinsfor KCNN4

Protein Domains/Familiesfor KCNN4

Gene Functionfor KCNN4

Pathways & Interactionsfor KCNN4

Drugs & Compoundsfor KCNN4

Transcriptsfor KCNN4

Expression for KCNN4

Orthologsfor KCNN4

Paralogsfor KCNN4

SNPs/Variantsfor KCNN4

Disorders & Mutationsfor KCNN4

Medical Newsfor KCNN4

Publicationsfor KCNN4

Search for KCNN4

Genome Databases showing KCNN4

Other Databases showing KCNN4

Specialized Databases showing KCNN4

Licensable Technologiesfor KCNN4

Servicesfor KCNN4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KCNN4

Summaries
for KCNN4

Genomic Location
for KCNN4

Proteins
for KCNN4

Protein Domains/
Families
for KCNN4

Gene Function
for KCNN4

Pathways & Interactions
for KCNN4

Drugs & Compounds
for KCNN4

Transcripts
for KCNN4

Expression
for KCNN4

Orthologs
for KCNN4

Paralogs
for KCNN4

SNPs/Variants
for KCNN4

Disorders & Mutations
for KCNN4

Medical News
for KCNN4

Publications
for KCNN4

Licensable Technologies
for KCNN4

Services
for KCNN4