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Aliases for IMPA2 Gene

Aliases for IMPA2 Gene

  • Inositol Monophosphatase 2 2 3
  • Inositol(Myo)-1(Or 4)-Monophosphatase 2 2 5
  • EC 3.1.3.25 4 63
  • Inositol-1(Or 4)-Monophosphatase 2 4
  • Myo-Inositol Monophosphatase A2 4
  • Myo-Inositol Monophosphatase 2 2
  • IMPase 2 4
  • IMP.18P 4
  • IMP 2 4

External Ids for IMPA2 Gene

Previous GeneCards Identifiers for IMPA2 Gene

  • GC18P012247
  • GC18P012038
  • GC18P011971

Summaries for IMPA2 Gene

Entrez Gene Summary for IMPA2 Gene

  • This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

GeneCards Summary for IMPA2 Gene

IMPA2 (Inositol Monophosphatase 2) is a Protein Coding gene. Diseases associated with IMPA2 include Bipolar Disorder and Febrile Seizures. Among its related pathways are Inositol phosphate metabolism (REACTOME) and Metabolism. GO annotations related to this gene include protein homodimerization activity and inositol monophosphate 3-phosphatase activity. An important paralog of this gene is IMPA1.

UniProtKB/Swiss-Prot for IMPA2 Gene

  • Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.

Gene Wiki entry for IMPA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPA2 Gene

Genomics for IMPA2 Gene

Regulatory Elements for IMPA2 Gene

Enhancers for IMPA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IMPA2 on UCSC Golden Path with GeneCards custom track

Promoters for IMPA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IMPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IMPA2 Gene

Chromosome:
18
Start:
11,981,025 bp from pter
End:
12,030,886 bp from pter
Size:
49,862 bases
Orientation:
Plus strand

Genomic View for IMPA2 Gene

Genes around IMPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPA2 Gene

Proteins for IMPA2 Gene

  • Protein details for IMPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14732-IMPA2_HUMAN
    Recommended name:
    Inositol monophosphatase 2
    Protein Accession:
    O14732
    Secondary Accessions:
    • B0YJ29
    • Q9UJT3

    Protein attributes for IMPA2 Gene

    Size:
    288 amino acids
    Molecular mass:
    31321 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IMPA2 Gene

    Alternative splice isoforms for IMPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IMPA2 Gene

Proteomics data for IMPA2 Gene at MOPED

Selected DME Specific Peptides for IMPA2 Gene

Post-translational modifications for IMPA2 Gene

  • Ubiquitination at Lys 184
  • Modification sites at PhosphoSitePlus

Domains & Families for IMPA2 Gene

Gene Families for IMPA2 Gene

Graphical View of Domain Structure for InterPro Entry

O14732

UniProtKB/Swiss-Prot:

IMPA2_HUMAN :
  • Belongs to the inositol monophosphatase family.
Family:
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with IMPA2: view

Function for IMPA2 Gene

Molecular function for IMPA2 Gene

GENATLAS Biochemistry:
inositol(myo)-1(or 4)-monophosphatase 2,widely expressed in adult and fetal tissues but minimally in brain
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate {ECO:0000269 PubMed:17068342}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17068342};
UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by high Li(+) and restricted Mg(2+) concentrations.
UniProtKB/Swiss-Prot Function:
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
UniProtKB/Swiss-Prot Induction:
Repressed by Li(+).

Enzyme Numbers (IUBMB) for IMPA2 Gene

Gene Ontology (GO) - Molecular Function for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 17068342
GO:0052832 inositol monophosphate 3-phosphatase activity IEA,TAS --
GO:0052833 inositol monophosphate 4-phosphatase activity IEA,TAS --
genes like me logo Genes that share ontologies with IMPA2: view
genes like me logo Genes that share phenotypes with IMPA2: view

Animal Models for IMPA2 Gene

MGI Knock Outs for IMPA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IMPA2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IMPA2 Gene

Localization for IMPA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IMPA2 Gene COMPARTMENTS Subcellular localization image for IMPA2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IMPA2 Gene

Pathways & Interactions for IMPA2 Gene

genes like me logo Genes that share pathways with IMPA2: view

UniProtKB/Swiss-Prot O14732-IMPA2_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 9322233
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for SIGNOR curated interactions for IMPA2 Gene

Drugs & Compounds for IMPA2 Gene

(4) Drugs for IMPA2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
Magnesium Nutra 0

(9) Additional Compounds for IMPA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
2831-74-5
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
  • 1D-Myo-inositol 4-phosphate
  • D-Myo-inositol-4-phosphate
  • D-Myoinositol 4-phosphate
  • Inositol 4-phosphate
46495-39-0
Inositol phosphate
  • 1D-Myo-Inositol 1-monophosphate
  • 1D-Myo-Inositol 1-phosphate
  • D-Myo-Inositol-1-Phosphate
  • Inositol 1-monophosphate
15421-51-9
Myoinositol
  • cis-1,2,3,5-trans-4,6-Cyclohexanehexol
  • i-Inositol
  • Iso-Inositol
  • Meat sugar
  • Meso-Inositol
87-89-8
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
573-35-3
genes like me logo Genes that share compounds with IMPA2: view

Transcripts for IMPA2 Gene

Unigene Clusters for IMPA2 Gene

Inositol(myo)-1(or 4)-monophosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IMPA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for IMPA2 Gene

GeneLoc Exon Structure for
IMPA2
ECgene alternative splicing isoforms for
IMPA2

Expression for IMPA2 Gene

mRNA expression in normal human tissues for IMPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMPA2 Gene

This gene is overexpressed in Pancreas (x7.0), Muscle - Skeletal (x5.8), and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for IMPA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Tonsil (11.3), Oral epithelium (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IMPA2 Gene



SOURCE GeneReport for Unigene cluster for IMPA2 Gene Hs.743311

genes like me logo Genes that share expression patterns with IMPA2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IMPA2 Gene

Orthologs for IMPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IMPA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IMPA2 35
  • 82.75 (n)
  • 90.28 (a)
IMPA2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IMPA2 35
  • 88.98 (n)
  • 94.16 (a)
IMPA2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Impa2 35
  • 87.38 (n)
  • 90.97 (a)
Impa2 16
Impa2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IMPA2 35
  • 99.42 (n)
  • 99.65 (a)
IMPA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Impa2 35
  • 88.08 (n)
  • 90.28 (a)
oppossum
(Monodelphis domestica)
Mammalia IMPA2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IMPA2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves IMPA2 35
  • 77.2 (n)
  • 84.03 (a)
IMPA2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia impa2 35
  • 71.48 (n)
  • 78.34 (a)
Str.15017 35
zebrafish
(Danio rerio)
Actinopterygii impa2 35
  • 65.93 (n)
  • 69.74 (a)
impa2 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17026 37
  • 35 (a)
CG17027 37
  • 34 (a)
CG17029 37
  • 36 (a)
CG9389 37
  • 38 (a)
CG9391 37
  • 46 (a)
CG9389 35
  • 51.44 (n)
  • 47.24 (a)
CG17026 36
  • 31 (a)
ManyToMany
CG17027 36
  • 32 (a)
ManyToMany
CG17028 36
  • 34 (a)
ManyToMany
CG17029 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F13G3.5 37
  • 43 (a)
ttx-7 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INM1 36
  • 27 (a)
ManyToMany
INM2 36
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06022 35
  • 49.22 (n)
  • 39.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for IMPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMPA2 Gene

ENSEMBL:
Gene Tree for IMPA2 (if available)
TreeFam:
Gene Tree for IMPA2 (if available)

Paralogs for IMPA2 Gene

Paralogs for IMPA2 Gene

genes like me logo Genes that share paralogs with IMPA2: view

Variants for IMPA2 Gene

Sequence variations from dbSNP and Humsavar for IMPA2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs16976948 - 12,009,914(+) CTGGG(A/G)CCAAG reference, missense, utr-variant-5-prime
rs7231196 -- 11,989,824(+) CGCTG(C/T)CCAGG intron-variant
rs7231315 -- 11,998,431(+) CTGAG(A/T)CAGCT intron-variant
rs8086120 -- 12,017,792(+) tcacc(A/G)tgttg intron-variant
rs8086581 -- 11,989,363(+) GCCTC(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IMPA2 Gene

Variant ID Type Subtype PubMed ID
dgv1011e1 CNV Complex 17122850
nsv909384 CNV Gain 21882294
nsv909385 CNV Loss 21882294
nsv909386 CNV Loss 21882294
nsv909387 CNV Loss 21882294
dgv3385n71 CNV Gain 21882294
nsv528699 CNV Loss 19592680
esv2663207 CNV Deletion 23128226
esv9600 CNV Gain 19470904

Variation tolerance for IMPA2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IMPA2 Gene

Human Gene Mutation Database (HGMD)
IMPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA2 Gene

Disorders for IMPA2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IMPA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
febrile seizures
  • seizures febrile
whipple disease
  • intestinal lipodystrophy
mood disorder
  • episodic mood disorder
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search IMPA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IMPA2

Genetic Association Database (GAD)
IMPA2
Human Genome Epidemiology (HuGE) Navigator
IMPA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IMPA2
genes like me logo Genes that share disorders with IMPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPA2 Gene

Publications for IMPA2 Gene

  1. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (PMID: 9322233) Yoshikawa T. … Detera-Wadleigh S.D. (Mol. Psychiatry 1997) 2 3 4 23 67
  2. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T. … Yoshikawa T. (J. Biol. Chem. 2007) 3 23 25 26
  3. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. (PMID: 17251911) Ohnishi T. … Yoshikawa T. (Neuropsychopharmacology 2007) 3 23 25 26
  4. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. (PMID: 17340635) Arai R. … Yokoyama S. (Proteins 2007) 3 23
  5. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. (PMID: 17388992) Blair M.A. … Hedera P. (Eur. J. Neurol. 2007) 3 23

Products for IMPA2 Gene

Sources for IMPA2 Gene

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