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IL8 Gene

protein-coding GIFtS: 68

GC04P074845

interleukin 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
3-10C ^¹
AMCF-I ^¹
CXCL8 ^¹, ², ³
Emoctakin ^³
GCP-1 ^¹, ², ³
GCP1 ^²
IL-8 ^¹, ³
K60 ^¹
LECT ^¹, ²
LUCT ^¹, ²
LYNAP ^¹, ²
MDNCF ^¹, ², ³
MONAP ^¹, ², ³
NAF ^¹, ²
NAP-1 ^¹, ², ³
NAP1 ^²
SCYB8 ^¹
TSG-1 ^¹
b-ENAP ^¹
emoctakin ^²

Descriptions
C-X-C motif chemokine 8 ^³
Granulocyte chemotactic protein 1 ^², ³
Monocyte-derived neutrophil chemotactic factor ^², ³
Monocyte-derived neutrophil-activating peptide ^³
Neutrophil-activating protein 1 ^³
Protein 3-10C ^³
T cell chemotactic factor ^²
T-cell chemotactic factor ^³
beta-thromboglobulin-like protein ^²
chemokine (C-X-C motif) ligand 8 ^²
interleukin 8 ^²
lymphocyte-derived neutrophil-activating factor ^²
neutrophil-activating peptide 1 ^²
small inducible cytokine subfamily B, member 8 ^²

External Ids
HGNC: 6025¹
Entrez Gene: 3576²
UniProtKB: P10145³
Ensembl: ENSG00000169429⁷

Search outside databases for aliases for IL8 gene

Previous GC identifers: GC04P074595 GC04P075006 GC04P075072 GC04P074971

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL8:

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of

the major mediators of the inflammatory response. This chemokine is secreted by several cell

types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is

believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease

caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a

chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not

monocytes. It is also involved in neutrophil activation. It is released from several cell types in

response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil

activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher

affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Gene Wiki entry for IL8 (Interleukin_8)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL8 gene

Entrez Gene cytogenetic band: 4q13-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13-q21

IL8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P074845: (about GC identifiers)

Start:	74,825,122 bp from pter
End:	74,828,297 bp from pter
Size:	3,176 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006216.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IL8_HUMAN, P10145 (See protein sequence)

Recommended Name: Interleukin-8 precursor

Size: 99 amino acids; 11098 Da

Subunit: Homodimer

Subcellular location: Secreted

PDB structures from and Proteopedia :

1ICW (3D)

1IKL (3D)

1IKM (3D)

1IL8 (3D)

1ILP (3D)

1ILQ (3D)

1QE6 (3D)

1ROD (3D)

2IL8 (3D)

3IL8 (3D)

Secondary accessions: B2R4L8 Q6FGF6 Q6LAE6 Q96RG6 Q9C077 Q9UCE1 Q9UCR8 Q9UCR9 Q9UCS0

Alternative splicing: 2 isoforms: P10145-1 P10145-2

Post-translational modifications:

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at

least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is

referred to as interleukin-8. IL-8(6-77) is the most promiment form¹

REFSEQ proteins: NP_000575.1

ENSEMBL proteins:

ENSP00000385908 ENSP00000306512 ENSP00000379121

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IL8
	Millipore Purified and/or Recombinant IL8 Protein
	Sigma-Aldrich Proteins for IL8
	R&D Systems Recombinant & Natural Proteins for IL8 (CXCL8/IL-8)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IL8)
	Human Recombinant Proteins from Abnova (IL8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10823949

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Antibodies for IL8:

	Invitrogen Antibodies for IL8
	Millipore Mono- and Polyclonal Antibodies for the study of IL8
	Sigma-Aldrich Antibodies for IL8
	R&D Systems Antibodies for IL8 (CXCL8/IL-8)
	Antibodies from Abcam (IL8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IL8)
	Novus Biologicals Antibodies for IL8

Assays for IL8:

	Invitrogen Assays for IL8
	Millipore Kits and Assays for the Analysis of IL8
	R&D Systems Flow Cytometry Kits for IL8 (CXCL8/IL-8) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10145

ProtoNet protein and cluster: P10145

1 Blocks protein family: IPB002473 Interleukin-8 signature

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Similarity: Belongs to the intercrine alpha (chemokine CxC) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000584

Applied Biosystems Silencer® siRNAs for IL8

Sigma-Aldrich siRNA and siRNA Panels for IL8

Sigma-Aldrich shRNA Panels and shRNA for IL8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IL8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000584
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000584
untagged cDNA clone in CMV expression vector: NM_000584

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000584

UniProtKB/Swiss-Prot: IL8_HUMAN, P10145

Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not

monocytes. It is also involved in neutrophil activation. It is released from several cell types in

response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil

activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher

affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively

Genatlas biochemistry entry for IL8:

interleukin 8 (see IMC2@),neutrophil activating peptide 1,monocyte-derived neutrophil chemotactic

factor,with a direct growth potentiating activity in malignant mesothelioma

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005153	interleukin-8 receptor binding	IPI	1840701
GO:0005515	protein binding	IPI	10880251
GO:0008009	chemokine activity	TAS	10881932

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for IL8 (Your Favorite Gene powered by Ingenuity) (see all 11 )

Hepatic Fibrosis / Hepatic Stellate Cell Activation
Bladder Cancer Signaling
HMGB1 Signaling
Glucocorticoid Receptor Signaling
TREM1 Signaling

GeneDecks IL8 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for IL8

5/304 Interacting proteins for IL8 (ENSP00000306512³) via UniProtKB, MINT, and/or STRING (see all 304 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CADM3	ENSP00000357106³	STRING (score=.999)
IL8RA	ENSP00000295683³	STRING (score=.999)
IL8RB	ENSP00000319635³	STRING (score=.999)
RELA	ENSP00000311508³	STRING (score=.998)
EGFR	ENSP00000275493³	STRING (score=.994)

About this table

5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	TAS	11483765
GO:0006928	cell motion	TAS	10820279
GO:0006935	chemotaxis	TAS	10620615
GO:0006954	inflammatory response	TAS	11483765
GO:0006955	immune response	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IL8
10/39 Novoseek chemical compound relationships for IL8 gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	92.64	1260	9723955 (8), 17207890 (7), 10619832 (7), 16413378 (6) (see all 99)
groalpha	86.37	187	11495082 (7), 9641651 (7), 17922696 (5), 9889409 (4) (see all 77)
fmlp	80.33	467	7837814 (9), 16249234 (7), 15494208 (5), 9013980 (5) (see all 99)
leukotriene b4	78.46	535	8003341 (9), 8973284 (5), 9482389 (5), 9809497 (5) (see all 99)
endotoxin	73.73	255	2007851 (5), 11451261 (5), 18485432 (4), 16384605 (4) (see all 99)
grogamma	72.61	22	8702798 (3), 15832427 (2), 9553055 (2), 10695618 (1) (see all 10)
grobeta	68.52	25	10600366 (3), 8702798 (3), 15832427 (2), 9553055 (2) (see all 11)
n-formylmethionyl-leucylphenylalanine	66.58	82	16279571 (2), 1726709 (2), 7615691 (2), 9932682 (2) (see all 50)
lipoteichoic acid	66.42	81	10570304 (7), 16619004 (4), 8262617 (4), 16521278 (3) (see all 35)
il 10	64.90	57	18363812 (4), 9543183 (2), 15348314 (2), 9551188 (2) (see all 45)

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1 PharmGKB drug compound relationship for IL8 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	1370208

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (IL8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000584

Sigma-Aldrich siRNA and siRNA Panels for IL8

Sigma-Aldrich shRNA Panels and shRNA for IL8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000584

REFSEQ mRNAs for IL8 gene:

NM_000584.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000584

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000584
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000584
                                 untagged cDNA clone in CMV expression vector: NM_000584

Additional cDNA sequence:

AM919470.1 BC096106.3 BC096107.3 BC099628.3 BC099629.3 BC101570.1 BC101574.1 CR599802.1

M27819.1 S68680.1 X12609.1 X77737.1 XM_001726179.1

24/29 DOTS entries (see all 29 ):

DT.92451091 DT.452985 DT.91660672 DT.115918 DT.121222191 DT.100764374 DT.447791 DT.121222188

DT.100890247 DT.121222199 DT.97822713 DT.86995892 DT.121222180 DT.100722366 DT.121222165 DT.100743514

DT.100890251 DT.92451100 DT.95366903 DT.100890241 DT.100890254 DT.115919 DT.121222196 DT.92451094

24/756 AceView cDNA sequences (see all 756 ):

AW780211 AA381395 AA381177 BQ225540 BQ100994 BM955893 CB306060 CR623683

BM126840 BF445462 AA381931 CK904775 AA381700 BX358167 AW273112 AW467973

CR619554 BM069824 CR601533 BE042737 CA308318 CD364559 BU686095 AA381459

highest scoring ESTs for IL8:

AA082747 AA095727 AA102526 AA296403 AA305271 AA360958 AA361981 AA362132 AA362138 AA362139

Unigene Clusters for IL8:

Interleukin 8

Hs.624 [show with all ESTs], Hs.443948 [show with all ESTs]

Unigene Representative Sequences: NM_000584, NM_000342

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IL8

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b
SP1:
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for IL8

3 Ensembl transcripts including schematic representations:

ENST00000401931 ENST00000307407 ENST00000395775

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IL8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL8

¹ / ² / ³

6 probe-sets matching IL8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1369_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.06	M28130	0.20	1.00	0.72	1
35372_r_at²^{, 3}	U95-A	2	1.00	0.97	0.99	0.95	M28130	0.20	1.00	0.72	1
211506_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF043337	0.20	1.00	0.72	1
202859_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000584	0.60	1.00	0.82	1
211506_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202859_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IL8 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGAAGCACT

SOURCE GeneReport for Unigene clusters: Hs.624 Hs.443948
Expression variation in blood from EXPOLDB for IL8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL8 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL8¹	--	interleukin 8	81.44(n) 77.32(a)	403850 XM_850481.1 XP_855574.1
chimpanzee (Pan troglodytes)	IL8¹	--	interleukin 8	99.33(n) 100(a)	471205 XM_001156432.1 XP_001156432.1
cow (Bos taurus)	IL8¹	--	interleukin 8	83.51(n) 79.38(a)	280828 NM_173925.2 NP_776350.1
chicken (Gallus gallus)	IL8¹	--	interleukin 8	60.76(n) 52.08(a)	396495 NM_205498.1 NP_990829.1

About this table Species with no ortholog for IL8

ENSEMBL Gene Tree for IL8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IL8 gene

PF4² PPBP² CXCL1² PF4V1² CXCL6² CXCL3² CXCL5² CXCL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/58 NCBI SNPs in IL8 are shown (see all 58 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2227534^1,2	C,F,H	74824846(+)	`GTCACA/GTGGTA`	1	--	ng5¹		11	NS EU EA WA MN CSAM	904
	rs2227532^1,2	C,F,O	74824396(+)	`ATTAAT/CGTCTT`	1	--	ng5¹		8	NS	732
	rs4073^1,2	A,C,F	74824888(+)	`ATACAA/TTTGAT`	1	--	ng5¹ tfbs³		17	NS MN CSAM EA NA	2480
--	rs1126647^1,2	A,C,F	74827909(+)	`AGATAA/TACAAC`	1	--	ut3¹		8	NS MN CSAM EA NA	514
	rs2227537^1,2	C,F,H	74825212(+)	`CCACCG/AGAAGG`	1	--	ut5¹ ese³		11	NS EU EA WA MN CSAM	900
	rs2227538^1,2	C,F,H	74825239(+)	`GTAAAC/TATGAC`	1	--	ut5¹		28	NS MN CSAM EA EU WA NA	3068
--	rs2227528^1,2	C,F	74823415(+)	`CCTGT-/TATTGT`	1	--	ng5¹ tfbs³		2	NS	84
	rs12420^1,2	C,H	74827277(+)	`CAAAAA/TACAAC`	1	--	ut3¹		10	MN CSAM EA EU WA	958
	rs2227546^1,2	C,H	74827851(+)	`ATCAGG/AGTTTT`	1	--	ut3¹ ese³		11	NS EU EA WA MN CSAM	872
--	rs2227545^1,2	F	74827591(+)	`AAAGTA/CTTAGC`	1	--	ut3¹		2	NS	92

About this table

HapMap Linkage Disequilibrium images for IL8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146930

10/98 Novoseek disease relationships for IL8 gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	91.52	3651	9462219 (9), 8601968 (6), 10740342 (5), 1702929 (4) (see all 99)
inflammation	89.81	1065	12697917 (4), 10680520 (4), 15104334 (4), 15901266 (4) (see all 99)
tumors	81.42	3653	11181444 (8), 8601968 (6), 12471616 (6), 16088182 (5) (see all 99)
bronchoalveolar lavage fluid	72.84	151	7712280 (4), 10933164 (3), 16077402 (3), 15909061 (3) (see all 99)
systemic inflammatory response syndrome	69.36	28	8143477 (2), 9558403 (2), 9038289 (2), 16227031 (2) (see all 19)
pulmonary disease chronic obstructive	66.65	38	8563494 (2), 12915744 (2), 17441351 (2), 16181530 (2) (see all 26)
sepsis	65.58	227	1612748 (6), 17368039 (5), 15730597 (5), 9120108 (4) (see all 99)
cystic fibrosis	63.85	96	7940424 (6), 7639556 (3), 8476069 (3), 17880760 (2) (see all 60)
rheumatoid arthritis	63.72	129	1932367 (2), 8961381 (2), 14750259 (2), 8003057 (2) (see all 93)
gastritis	63.55	108	11119492 (4), 17466292 (4), 8651162 (4), 17309748 (3) (see all 60)

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Human Gene Mutation Database: IL8
Genetic Association Database: IL8
Human Genome Epidemiology Navigator: IL8 (164 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/5657 PubMed articles for IL8 gene (see all 5657 ):

The neutrophil-activating proteins interleukin 8 and beta- thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. (PubMed id 2145175)^{1, 3, 4} van Damme J.... Billiau A. (1990)
Polymorphisms of the IL-8 and CXCR2 genes are not associated with Behcet's disease. (PubMed id 15630732)^{1, 3, 6} Duymaz-Tozkir J....Gul A. (2005)
Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (PubMed id 16038986)^{1, 3, 6} Diaz-Cueto L....Arechavaleta-Velasco F. (2005)
Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. (PubMed id 15902922)^{1, 3, 6} Gonzalez-Quintela A....Perez L.F. (2004)
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. (PubMed id 15356575)^{1, 3, 6} Heinzmann A....Deichmann K.A. (2004)
Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. (PubMed id 15708897)^{1, 3, 6} Kawahara C....Loughlin J. (2005)
Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)^{1, 3, 6} Howell W.M....Bateman A.C. (2005)
Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 15598788)^{1, 3, 6} Savage S.A....Chanock S.J. (2004)
Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. (PubMed id 12415593)^{1, 3, 6} Amoli M.M....Gonzalez-Gay M.A. (2002)
The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. (PubMed id 15710978)^{1, 3, 6} Ohyauchi M....Shimosegawa T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3576	HGNC: 6025	AceView: IL8	Ensembl:ENSG00000169429	euGenes: HUgn3576
ECgene: IL8	H-InvDB: IL8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IL8	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_8
SeattleSNPs	http://pga.gs.washington.edu/data/il8/

Licensable Technologies for IL8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IL8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL8		Antibodies for IL8
	Explore super-pooled esiRNAs		Proteins for IL8
	Lentivirus-delivered shRNAs for IL8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL8)
	Antibodies (IL8)
	Chimera RNAi (IL8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IL8)
	Antibodies (IL8)

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Search Tocris compounds for IL8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL8

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IL8 Gene at Home site.
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IL8 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for IL8

Summaries
for IL8

Genomic Location
for IL8

Proteins
for IL8

Protein Domains/
Families
for IL8

Gene Function
for IL8

Pathways & Interactions
for IL8

Drugs & Compounds
for IL8

Transcripts
for IL8

Expression
for IL8

Orthologs
for IL8

Paralogs
for IL8

SNPs/Variants
for IL8

Disorders & Mutations
for IL8

Medical News
for IL8

Publications
for IL8

Search for IL8

Genome Databases showing IL8

Other Databases showing IL8

Specialized Databases showing IL8

Licensable Technologies
for IL8

Services
for IL8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL8 (Gene Symbol)
3-10C
AMCF-I
CXCL8
Emoctakin
GCP-1
GCP1
IL-8
K60
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
SCYB8
TSG-1
b-ENAP
emoctakin
C-X-C motif chemokine 8
Granulocyte chemotactic protein 1
Monocyte-derived neutrophil chemotactic factor
Monocyte-derived neutrophil-activating peptide
Neutrophil-activating protein 1
Protein 3-10C
T cell chemotactic factor
T-cell chemotactic factor
beta-thromboglobulin-like protein
chemokine (C-X-C motif) ligand 8
interleukin 8
lymphocyte-derived neutrophil-activating factor
neutrophil-activating peptide 1
small inducible cytokine subfamily B, member 8

IL8 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor IL8

Summariesfor IL8

Genomic Locationfor IL8

Proteinsfor IL8

Protein Domains/Familiesfor IL8

Gene Functionfor IL8

Pathways & Interactionsfor IL8

Drugs & Compoundsfor IL8

Transcriptsfor IL8

Expression for IL8

Orthologsfor IL8

Paralogsfor IL8

SNPs/Variantsfor IL8

Disorders & Mutationsfor IL8

Medical Newsfor IL8

Publicationsfor IL8

Search for IL8

Genome Databases showing IL8

Other Databases showing IL8

Specialized Databases showing IL8

Licensable Technologiesfor IL8

Servicesfor IL8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL8

Summaries
for IL8

Genomic Location
for IL8

Proteins
for IL8

Protein Domains/
Families
for IL8

Gene Function
for IL8

Pathways & Interactions
for IL8

Drugs & Compounds
for IL8

Transcripts
for IL8

Expression
for IL8

Orthologs
for IL8

Paralogs
for IL8

SNPs/Variants
for IL8

Disorders & Mutations
for IL8

Medical News
for IL8

Publications
for IL8

Licensable Technologies
for IL8

Services
for IL8