V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

HTR2C Gene

protein-coding GIFtS: 72

GC0XP113641

5-hydroxytryptamine (serotonin) receptor 2C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HTR1C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
5-HT-2C ^³
5-HT2C ^¹, ², ³
5-HTR2C ^², ³
5HT-1C ^³
HTR1C ^², ³
OTTHUMP00000023868 ^²
OTTHUMP00000023869 ^²

Descriptions
5-hydroxytryptamine (serotonin) receptor 2C ^²
Serotonin receptor 2C ^², ³
serotonin 5-HT-2C receptor ^²

External Ids
HGNC: 5295¹
Entrez Gene: 3358²
UniProtKB: P28335³
Ensembl: ENSG00000147246⁷

Search outside databases for aliases for HTR2C gene

Previous GC identifers: GC0XP108837 GC0XP110943 GC0XP111854 GC0XP112582

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HTR2C:

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological

effects by binding to several receptor subtypes, including the 5-HT2 family of

seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D

signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject

to multiple RNA editing events, where genomically encoded adenosine residues are converted to

inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of

the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G

proteins and the activation of phospholipase C and D signaling cascades, thus modulating

serotonergic neurotransmission in the central nervous system. Studies in humans have reported

abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor

mediates its action by association with G proteins that activate a phosphatidylinositol-calcium

second messenger system

Gene Wiki entry for HTR2C (5-HT2C_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HTR2C gene

Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq24

HTR2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP113641: (about GC identifiers)

Start:	113,724,807 bp from pter
End:	114,050,880 bp from pter
Size:	326,074 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_028405.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 2C

Size: 458 amino acids; 51821 Da

Subunit: Interacts with MPDZ

Subcellular location: Cell membrane; Multi-pass membrane protein

Rna editing: Modified_positions=156, 158, 160; Note=Partially edited. RNA editing generates

receptor isoforms that differ in their ability to interact with the phospholipase C signaling

cascade in a transfected cell line, suggesting that this RNA processing event may contribute to

the modulation of serotonergic neurotransmission in the central nervous system

Secondary accessions: Q5VUF8 Q9NP28

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000859.1

ENSEMBL proteins:

ENSP00000361018 ENSP00000276198 ENSP00000361019

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HTR2C Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (5HT2C Receptor)
	Human Recombinant Proteins from Abnova (HTR2C)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for HTR2C:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HTR2C
	Sigma-Aldrich Antibodies for HTR2C
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (5HT2C Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for HTR2C

Assays for HTR2C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P28335

ProtoNet protein and cluster: P28335

2 Blocks protein families:

IPB000377 5-hydroxytryptamine 2C receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335

Domain: The PDZ domain-binding motif is involved in the interaction with MPDZ

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR2C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR2C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000868

Applied Biosystems Silencer® siRNAs for HTR2C

Sigma-Aldrich siRNA and siRNA Panels for HTR2C

Sigma-Aldrich shRNA Panels and shRNA for HTR2C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of HTR2C

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000868
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000868
untagged cDNA clone in CMV expression vector: NM_000868

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000868

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor

mediates its action by association with G proteins that activate a phosphatidylinositol-calcium

second messenger system

Genatlas biochemistry entry for HTR2C:

5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein

coupled receptor superfamily,activating the phosphatidylinositol cycle

7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Htr2c):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	lethality-postnatal
life span-post-weaning/aging	nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004993	serotonin receptor activity	IEA	--
GO:0005515	protein binding	IPI	16319069

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR2C (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling
Serotonin Receptor Signaling

GeneDecks HTR2C for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HTR2C

5/108 Interacting proteins for HTR2C (ENSP00000276198³ P28335^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 108 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MPDZ	O75970²	STRING (score=.98) MINT-73153 MINT-73189
Arrb2 Arrb2 (xeno)	Q91YI4¹	EBI-994141, EBI-994161
HTR3A	ENSP00000347754³	STRING (score=.956)
TPH1	ENSP00000343550³	STRING (score=.956)
POMC	ENSP00000370171³	STRING (score=.954)

About this table

5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007208	activation of phospholipase C activity by serotonin receptor signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	9241279
GO:0007631	feeding behavior	TAS	7700379
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HTR2C

Sigma-Aldrich Small Molecules for HTR2C:

Metabolite Mixed Agonist/Antagonist Antagonist Blocker Agonist Allosteric Modulator

Precursor Inhibitor Ligand

Compounds for HTR2C available from Tocris Bioscience

Compound	Action	CAS number
SB 206553 hydrochloride	Potent, selective 5-HT2C/5-HT2B antagonist. Orally active	[158942-04-2]
SB 242084	Selective 5-HT2C antagonist; brain penetrant	[181632-25-7]
DOI hydrochloride	Mixed 5-HT2A/2C agonist	[42203-78-1]
WAY 161503 hydrochloride	Potent, selective 5-HT2C agonist	[75704-24-4]
Ro 60-0175 fumarate	Potent, selective 5-HT2C agonist	[169675-09-6]

About this table

10/14 Novoseek chemical compound relationships for HTR2C gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sb242084	62.69	3	10685880 (1), 11103887 (1)
mcpp	59.63	5	8944393 (1), 15467976 (1), 12588512 (1), 8570772 (1)
butyrophenone	56.83	1	10425088 (1)
melatonin	39.19	6	18704977 (1), 16869122 (1), 14567168 (1), 16436936 (1) (see all 6)
amine	30.09	1	8027974 (1)
inosine	14.73	1	15087490 (1)
phosphoinositide	14.40	2	10217294 (1), 8526967 (1)
lipid	5.11	1	19142110 (1)
lithium	0.82	3	9681934 (1), 10758249 (1)
oligonucleotide	0.00	1	9316030 (1)

About this table

1 PharmGKB drug compound relationship for HTR2C gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
clozapine	PD	8742444

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR2C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR2C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000868

Sigma-Aldrich siRNA and siRNA Panels for HTR2C

Sigma-Aldrich shRNA Panels and shRNA for HTR2C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000868

REFSEQ mRNAs for HTR2C gene:

NM_000868.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000868

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000868
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000868
                                 untagged cDNA clone in CMV expression vector: NM_000868

Additional cDNA sequence:

AF208053.1 AF498983.1 AK295753.1 AK308766.1 AY114104.1 BC028688.1 BC095543.1 BX648587.1

M81778.1 U49516.1

4 DOTS entries:

DT.108661 DT.100727990 DT.92416684 DT.92416685

20 AceView cDNA sequences:

U49516 NM_000868 AF498983 Z40928 AF208053 CB565884 AI970140 N47111

BX648587 BX118108 BG704515 BC028688 M81778 AW002513 BX505080 CD657722

N50321 AI825491 CD103423 AY114104

highest scoring ESTs for HTR2C:

M81778 U49516 AI970140 AW002513 AY114104 BX118108 BX505080 BX648587 CD103423 CD657722

Unigene Cluster for HTR2C:

5-hydroxytryptamine (serotonin) receptor 2C

Hs.149037 [show with all ESTs]

Unigene Representative Sequence: U49516

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6
SP1:
SP2:													-

About this scheme

ECgene alternative splicing isoforms for HTR2C

3 Ensembl transcripts including schematic representations:

ENST00000371950 ENST00000276198 ENST00000371951

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HTR2C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HTR2C

¹ / ² / ³

6 probe-sets matching HTR2C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33550_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U49516	1.00	0.87	0.94	1
33551_s_at²^{, 3}	U95-A	1	1.00	1.00	-0.19	0.35	M81778	1.00	0.87	0.94	1
207307_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000868	0.60	1.00	0.82	1
211479_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M81778	1.00	0.87	0.94	1
207307_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211479_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HTR2C for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTACAAAG

SOURCE GeneReport for Unigene cluster: Hs.149037
Expression variation in blood from EXPOLDB for HTR2C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HTR2C gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HTR2C¹	--	5-hydroxytryptamine (serotonin) receptor 2C	90.47(n) 94.76(a)	450240 NM_001006648.1 NP_001006649.1
chimpanzee (Pan troglodytes)	HTR2C¹	--	5-hydroxytryptamine (serotonin) receptor 2C	99.49(n) 99.56(a)	473740 NM_001033932.1 NP_001029104.1
rat (Rattus norvegicus)	Htr2c¹	--	5-hydroxytryptamine (serotonin) receptor 2C	86.65(n) 90.81(a)	25187 NM_012765.2 NP_036897.2
mouse (Mus musculus)	Htr2c^{1, 5}	X (66.15 cM)⁵	5-hydroxytryptamine (serotonin) receptor 2C^{1, 5}	86.21(n)¹ 90.37(a)¹	15560¹ NM_008312.3¹ NP_032338.2¹ AK034512⁵ AK079648⁵ (see all 18)
chicken (Gallus gallus)	HTR2C¹	--	5-hydroxytryptamine (serotonin) receptor 2C	64.92(n) 62.79(a)	428707 XM_426265.2 XP_426265.2

About this table Species with no ortholog for HTR2C

ENSEMBL Gene Tree for HTR2C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HTR2C gene

HTR2A² HTR2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335

Polymorphism: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys

and 0.13 for Ser

10/1265 NCBI SNPs in HTR2C are shown (see all 1265 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 336)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1801412^1,2	A,C,F,H,O	114048960(+)	`GACAGT/GGTTCA`	1	--	ut3¹ ese³		5	NA EU EA WA	510
	rs5987830^1,2	A,C,F,H	114050885(+)	`GGCTAA/CTATGT`	1	--	ng3¹		4	EU EA WA	418
	rs518147^1,2	C,F,H,O	113724838(-)	`TCCTCC/GGCAAG`	1	--	ut5¹ ese³		9	MN EA NA EU WA	787
	rs498207^1,2	C,F,H,O	113724372(-)	`CATTCT/CTCCAA`	1	--	ng5¹		11	NA EU EA WA	768
	rs6318^1,2	C,F,H,O	113871991(+)	`GCAATG/CTGATA`	1	S/C	mis¹		10	MN EU EA WA	1084
	rs521018^1,2	A,C,F,H	113724164(-)	`AGACAA/CCTTGA`	1	--	ng5¹		4	EU EA WA	420
	rs3795182^1,2	C,F,H	113723074(+)	`TCCATA/GTTTAT`	1	--	ng5¹		4	EU EA WA	418
	rs3813929^1,2	C,F,H	113724776(+)	`CATCCC/TGCTTT`	1	--	ng5¹		6	NA EA WA	436
	rs3813928^1,2	C,F,H	113724538(+)	`TGAGGG/ATACAT`	1	--	ng5¹		11	NA EU EA WA	766
--	rs45469398^1,2	F	114047733(+)	`AAGAAAAG/-GAGAC`	2	K/KE KR/KE	fra¹ mis¹		1	--	384

About this table

HapMap Linkage Disequilibrium images for HTR2C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 312861

10/19 Novoseek disease relationships for HTR2C gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	65.95	24	15717293 (5), 12673575 (2), 14643089 (2), 18855532 (1) (see all 15)
bipolar disorder	54.49	6	18504633 (2), 9342201 (1), 12853111 (1), 8823764 (1)
major depression	54.39	6	12853111 (2), 17477886 (1), 11526472 (1), 17477888 (1) (see all 5)
mood disorders	36.04	3	11526472 (1), 18715570 (1)
psychiatric disorder	33.93	10	12853111 (3), 18379171 (2), 16199765 (1), 7786883 (1) (see all 5)
attention-deficit hyperactivity disorder	33.82	2	14574222 (1), 15303127 (1)
alcoholism	33.07	7	15304380 (3), 10776672 (2), 14574222 (1), 8612062 (1)
psychotic	30.85	2	9700207 (1)
migraine	27.10	11	12555241 (2), 8743744 (1), 15109354 (1), 7622823 (1) (see all 6)
anxiety disorders	24.02	1	7622823 (1)

About this table

1 PharmGKB disease relationship for HTR2C gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Schizophrenia	PD	8742444

About this table

Human Gene Mutation Database: HTR2C
Genetic Association Database: HTR2C
Human Genome Epidemiology Navigator: HTR2C (96 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/344 PubMed articles for HTR2C gene (see all 344 ):

Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. (PubMed id 10206230)^{3, 4, 6} Samochowiec J.... Sander T. (1999)
Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. (PubMed id 7895773)^{2, 3, 4} Stam N.J.... Olijve W. (1994)
A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. (PubMed id 15048662)^{1, 3, 6} Pooley E.C....Harrison P.J. (2004)
A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. (PubMed id 16157158)^{1, 3, 6} Praschak-Rieder N....Levitan R. (2005)
Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. (PubMed id 15304380)^{1, 3, 6} Mottagui-Tabar S....Heilig M. (2004)
Depression in Alzheimer's disease: the effect of serotonin receptor gene variation. (PubMed id 12707936)^{1, 3, 6} Holmes C....Lovestone S. (2003)
Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). (PubMed id 7557992)^{1, 3, 4} Lappalainen J.... Goldman D. (1995)
Serotonin-2A and 2C receptor gene polymorphisms in Japanese patients with obstructive sleep apnea. (PubMed id 16258205)^{1, 3, 6} Sakai K....Gejyo F. (2005)
Analysis of SNP profiles in patients with major depressive disorder. (PubMed id 15927089)^{1, 3, 6} Koks S....Vasar E. (2006)
Gene-environment interaction analysis of serotonin system markers with adolescent depression. (PubMed id 15241435)^{1, 3, 6} Eley T.C....Craig I.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3358	HGNC: 5295	AceView: HTR2C	Ensembl:ENSG00000147246	euGenes: HUgn3358
ECgene: HTR2C	H-InvDB: HTR2C

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HTR2C
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HTR2C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HTR2C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HTR2C		Antibodies for HTR2C
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HTR2C		Small molecules for HTR2C
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HTR2C)
	Search for Antibodies
	Chimera RNAi (HTR2C)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (5HT2C Receptor)
	Antibodies (5HT2C Receptor)

Search OriGene for HTR2C

Tocris compounds for HTR2C

	Drugs for HTR2C
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HTR2C

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HTR2C Gene at Home site.
Version 2.41.1
server4.xennexinc.com

HTR2C Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for HTR2C

Summaries
for HTR2C

Genomic Location
for HTR2C

Proteins
for HTR2C

Protein Domains/
Families
for HTR2C

Gene Function
for HTR2C

Pathways & Interactions
for HTR2C

Drugs & Compounds
for HTR2C

Transcripts
for HTR2C

Expression
for HTR2C

Orthologs
for HTR2C

Paralogs
for HTR2C

SNPs/Variants
for HTR2C

Disorders & Mutations
for HTR2C

Medical News
for HTR2C

Publications
for HTR2C

Search for HTR2C

Genome Databases showing HTR2C

Other Databases showing HTR2C

Specialized Databases showing HTR2C

Licensable Technologies
for HTR2C

Services
for HTR2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HTR2C Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor HTR2C

Summariesfor HTR2C

Genomic Locationfor HTR2C

Proteinsfor HTR2C

Protein Domains/Familiesfor HTR2C

Gene Functionfor HTR2C

Pathways & Interactionsfor HTR2C

Drugs & Compoundsfor HTR2C

Transcriptsfor HTR2C

Expression for HTR2C

Orthologsfor HTR2C

Paralogsfor HTR2C

SNPs/Variantsfor HTR2C

Disorders & Mutationsfor HTR2C

Medical Newsfor HTR2C

Publicationsfor HTR2C

Search for HTR2C

Genome Databases showing HTR2C

Other Databases showing HTR2C

Specialized Databases showing HTR2C

Licensable Technologiesfor HTR2C

Servicesfor HTR2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HTR2C

Summaries
for HTR2C

Genomic Location
for HTR2C

Proteins
for HTR2C

Protein Domains/
Families
for HTR2C

Gene Function
for HTR2C

Pathways & Interactions
for HTR2C

Drugs & Compounds
for HTR2C

Transcripts
for HTR2C

Expression
for HTR2C

Orthologs
for HTR2C

Paralogs
for HTR2C

SNPs/Variants
for HTR2C

Disorders & Mutations
for HTR2C

Medical News
for HTR2C

Publications
for HTR2C

Licensable Technologies
for HTR2C

Services
for HTR2C