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Aliases & Descriptions for HTR2B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 5-HT(2B) 1, 2 | | 5-HT-2B 3 | | 5-HT2B 1, 2 |
| | | Descriptions |
|---|
| 5-HT 2B receptor 2 | | 5-hydroxytryptamine (serotonin) receptor 2B 2 | | 5-hydroxytryptamine 2B receptor 2 | | Serotonin receptor 2B 3 |
|
| | Search outside databases for aliases for HTR2B genePrevious GC identifers: GC02M230030 GC02M230704 GC02M231936 GC02M232175 GC02M231798 |
Summaries for HTR2B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HTR2B: Multiple receptor subtypes of serotonin neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens.[supplied by OMIM] UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger systemGene Wiki entry for HTR2B (5-HT2B_receptor) |
Genomic Location for HTR2B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HTR2B gene 
Entrez Gene cytogenetic band: 2q36.3-q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q36.3-q37.1HTR2B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M231681:
(about GC identifiers)
Start:
|
231,681,199 bp from pter |
End:
|
231,698,068 bp from pter |
Size:
|
16,870 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005403.16
| Proteins for HTR2B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 2B Size: 481 amino acids; 54298 Da
Subunit: Interacts with MPDZ
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q53TI1 Q62221 Q6P523REFSEQ proteins: NP_000858.3
ENSEMBL proteins: ENSP00000258400
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HTR2B: Assays for HTR2B: | Protein
Domains/ Families for HTR2B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P41595
ProtoNet protein and cluster: P41595 2 Blocks protein families: IPB000482 5-hydroxytryptamine 2B receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for HTR2B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000867
Applied Biosystems Silencer® siRNAs for HTR2B
Sigma-Aldrich siRNA and siRNA Panels for HTR2B  Sigma-Aldrich shRNA Panels and shRNA for HTR2B  Explore Sigma-Aldrich super-pooled esiRNAs 
| Clones: |  | Invitrogen Clones for HTR2B | |  | Millipore Clones for the Expression of HTR2B |               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000867                                  untagged cDNA clone in CMV expression vector: NM_000867 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000867
UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger systemGenatlas biochemistry entry for HTR2B:5-hydroxytryptamine (serotonin) receptor,subtype 2B,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Htr2b):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HTR2B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR2B (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for HTR2B 
5/11 Interacting proteins for HTR2B (P415952 ENSP000002584003) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007200 | activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger |
TAS | 8143856 | | GO:0007507 | heart development |
IEA | -- | | GO:0008015 | blood circulation |
TAS | 7926008 | | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade |
IEP | 12761501 | About this table
|
Drugs & Compounds for HTR2B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for HTR2B |
Compounds for HTR2B available from Tocris Bioscience About this table
10/11 Novoseek chemical compound relationships for HTR2B gene (see all 11
)
About this table
|
Transcripts for HTR2B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000867
Sigma-Aldrich siRNA and siRNA Panels for HTR2B  Sigma-Aldrich shRNA Panels and shRNA for HTR2B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000867 REFSEQ mRNAs for HTR2B gene: NM_000867.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000867               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000867                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000867                                  untagged cDNA clone in CMV expression vector: NM_000867  Additional cDNA sequence: AK313741.1 AY136751.1 BC063123.1 X77307.1 Z36748.1 1 DOTS entry: DT.209532 24 AceView cDNA sequences:BU620850 BX280117 AY136751 X77307 AI245235 AI167519 BQ019778 N44163 BC063123 AY114103 AI042025 AW299447 AL702991 AI868853 AA588822 NM_000867 N36174 Z36748 CD246183 BQ301544 AI290224 AI264038 H99362 AW027765
highest scoring ESTs for HTR2B:BC063123 CD000896 X77307 AA588822 AI042025 AI167519 AI245235 AI264038 AI290224 AI868853 Unigene Cluster for HTR2B: 5-hydroxytryptamine (serotonin) receptor 2B Hs.421649 [show with all ESTs]Unigene Representative Sequence: BC063123
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000258400
|
Expression for HTR2B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HTR2B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HTR2B
1 / 2 / 3 3 probe-sets matching HTR2B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTTGACTGTG
SOURCE GeneReport for Unigene cluster: Hs.421649
Expression variation in blood from EXPOLDB for HTR2B UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595Tissue specificity: Detected in most peripheral organs. Only low expression levels were found in the brain |
Orthologs for HTR2B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HTR2B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for HTR2B
ENSEMBL Gene Tree for HTR2B | Paralogs for HTR2B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HTR2B gene
- HTR2C2 HTR2A2
|
SNPs/Variants for HTR2B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations for HTR2B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601122
2 Novoseek disease relationships for HTR2B gene
About this table
1 PharmGKB disease relationship for HTR2B geneAbout this table
Human Gene Mutation Database: HTR2B Human Genome Epidemiology Navigator: HTR2B (4 documents)
|
Medical News for HTR2B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HTR2B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/92 PubMed articles for HTR2B gene (see all 92
):- The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. (PubMed id 15608559)1, 3, 7 Lin Z....Uhl G.R. (2004)
- Cloning and functional characterization of the human 5-HT2B serotonin receptor. (PubMed id 8143856)2, 3, 4 Schmuck K.... Luebbert H. (1994)
- The human serotonin 5-HT2B receptor: pharmacological link between 5- HT2 and 5-HT1D receptors. (PubMed id 7926008)1, 3, 4 Choi D.S.... Maroteaux L. (1994)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. (PubMed id 11150294)3, 4 Becamel C.... Ullmer C. (2001)
- Mutation screening of human 5-HT(2B) receptor gene in early-onset obsessive-compulsive disorder. (PubMed id 10722792)3, 4 Kim S.J.... Cook E.H. Jr. (2000)
- Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. (PubMed id 8078486)3, 4 Kursar J.D.... Baez M. (1994)
- The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. (PubMed id 11859080)1, 3 Manivet P....Launay J.M. (2002)
- The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. (PubMed id 7582481)1, 3 Bonhaus D.W....Eglen R.M. (1995)
|
Search for HTR2B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HTR2B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HTR2B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR2B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HTR2B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HTR2B:

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 |  |  |
| | | | Tocris compounds for HTR2B |
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Incremental update: 13 Oct 2009
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