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HTR2A Gene

protein-coding GIFtS: 69

GC13M046305

5-hydroxytryptamine (serotonin) receptor 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HTR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
5-HT-2 ^³
5-HT-2A ^³
5-HT2A ^¹, ²
HTR2 ^², ³
OTTHUMP00000018378 ^²

Descriptions
5-HT2 receptor ^²
5-hydroxytryptamine (serotonin) receptor 2A ^²
Serotonin receptor 2A ^³

External Ids
HGNC: 5293¹
Entrez Gene: 3356²
UniProtKB: P28223³
Ensembl: ENSG00000102468⁷

Search outside databases for aliases for HTR2A gene

Previous GC identifers: GC13M045407 GC13M041394 GC13M046344 GC13M045205

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor

mediates its action by association with G proteins that activate a phosphatidylinositol-calcium

second messenger system. This receptor is involved in tracheal smooth muscle contraction,

bronchoconstriction, and control of aldosterone production

Gene Wiki entry for HTR2A (5-HT2A_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HTR2A gene

Entrez Gene cytogenetic band: 13q14-q21 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14-q21

HTR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M046305: (about GC identifiers)

Start:	46,305,514 bp from pter
End:	46,368,176 bp from pter
Size:	62,663 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 2A

Size: 471 amino acids; 52603 Da

Subunit: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and

MAGI2

Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes to

the post-synaptic thickening of axo-dendritic synapses (By similarity)

Secondary accessions: Q5T8C0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000612.1

ENSEMBL proteins:

ENSP00000367959

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HTR2A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (5HT2A Receptor)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9109547
GO:0030425	dendrite	IEA	--

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Antibodies for HTR2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HTR2A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (5HT2A Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for HTR2A

Assays for HTR2A:

	Invitrogen Assays for HTR2A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P28223

ProtoNet protein and cluster: P28223

2 Blocks protein families:

IPB000455 5-hydroxytryptamine 2A receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223

Domain: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1

and DLG4

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000621

Applied Biosystems Silencer® siRNAs for HTR2A

Sigma-Aldrich siRNA and siRNA Panels for HTR2A

Sigma-Aldrich shRNA Panels and shRNA for HTR2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of HTR2A

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000621
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000621
untagged cDNA clone in CMV expression vector: NM_000621

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000621

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor

mediates its action by association with G proteins that activate a phosphatidylinositol-calcium

second messenger system. This receptor is involved in tracheal smooth muscle contraction,

bronchoconstriction, and control of aldosterone production

Genatlas biochemistry entry for HTR2A:

5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor

superfamily,activating the phosphatidylinositol cycle,paternally imprinted in some individuals

(polymorphic imprinting),not associated with schizophrenia

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Htr2a):

behavior/neurological

digestive/alimentary

endocrine/exocrine gland

muscle

skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004993	serotonin receptor activity	TAS	9109547
GO:0032403	protein complex binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR2A (Your Favorite Gene powered by Ingenuity)

Serotonin Receptor Signaling
G-Protein Coupled Receptor Signaling

GeneDecks HTR2A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HTR2A

5/30 Interacting proteins for HTR2A (P28223² ENSP00000367959³) via UniProtKB, MINT, and/or STRING (see all 30 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MPDZ	O75970², ENSP00000370410³	MINT-73187 STRING (score=.707)
GNAQ	ENSP00000286548³	STRING (score=.974)
BDNF	ENSP00000320002³	STRING (score=.967)
TPH1	ENSP00000343550³	STRING (score=.956)
HTR3A	ENSP00000347754³	STRING (score=.954)

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5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001659	temperature homeostasis	IEA	--
GO:0006950	response to stress	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007208	activation of phospholipase C activity by serotonin receptor signaling pathway	IEA	--
GO:0007268	synaptic transmission	TAS	9109547

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HTR2A

Sigma-Aldrich Small Molecules for HTR2A:

Metabolite Mixed Agonist/Antagonist Antagonist Blocker Allosteric Modulator Agonist

Precursor Inhibitor Ligand

Compounds for HTR2A available from Tocris Bioscience

Compound	Action	CAS number
TCB-2	Potent, high affinity 5-HT2A agonist
Fananserin	5-HT2A antagonist. Also D4 antagonist	[127625-29-0]
Ketanserin tartrate	Selective 5-HT2A antagonist. Also antagonist at 5-HT1D	[83846-83-7]
DOI hydrochloride	Mixed 5-HT2A/2C agonist	[42203-78-1]

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10/20 Novoseek chemical compound relationships for HTR2A gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(11c)-n-methylspiperone	77.72	4	7530376 (1), 10894088 (1), 11313155 (1)
2-methyl-5-ht	75.56	4	1425972 (1), 2150179 (1), 7984294 (1), 2299641 (1) (see all 5)
sergolexole	74.45	3	1560366 (1), 8667223 (1)
(tfmpp)	72.97	3	8788479 (1), 1292966 (1), 10515319 (1)
amesergide	69.84	3	8027933 (1), 8667223 (1)
altanserin	69.84	1	10587097 (1)
alpha methyl 5 hydroxytryptamine	69.24	3	9522163 (1), 2141111 (1), 2150179 (1)
ly 215840	69.10	8	1560366 (5), 8667223 (1)
5-methoxy-alpha-methyltryptamine	67.91	1	12676887 (1)
benzoylpiperidine	65.93	1	1479590 (1)

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3 PharmGKB drug compound relationships for HTR2A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
clozapine	CO PD GN	99229027
neuroleptics	CO PD GN	99229027
risperidone	PD GN	12202283

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000621

Sigma-Aldrich siRNA and siRNA Panels for HTR2A

Sigma-Aldrich shRNA Panels and shRNA for HTR2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000621

REFSEQ mRNAs for HTR2A gene:

NM_000621.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000621

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000621
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000621
                                 untagged cDNA clone in CMV expression vector: NM_000621

Additional cDNA sequence:

AF498982.1 AK302787.1 AK314132.1 BC069356.1 BC069576.1 BC074848.2 BC074849.2 BC096839.1

BX647777.1 M86841.1 S71229.1 X57830.1

3 DOTS entries:

DT.456099 DT.209624 DT.95108653

22 AceView cDNA sequences:

AF498982 BC069576 AI379882 BC069356 S71229 BX108650 BC074849 BC074848

X57830 AI565418 CA393776 AA954285 CB565885 AW117542 NM_000621 M86841

BX647777 AI005152 BG703062 CD105069 AA166934 AA166746

highest scoring ESTs for HTR2A:

AA418537 AA418604 AF498982 BC069356 BC069576 BX647777 CB565885 M86841 S71229 X57830

Unigene Cluster for HTR2A:

5-hydroxytryptamine (serotonin) receptor 2A

Hs.654586 [show with all ESTs]

Unigene Representative Sequence: X57830

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000378688

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HTR2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HTR2A

¹ / ² / ³

6 probe-sets matching HTR2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35469_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.53	X57830	0.80	1.00	0.91	1
35471_g_at²^{, 3}	U95-A	1	1.00	1.00	0.57	1.83	AA418537	0.80	1.00	0.91	1
211616_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M86841	0.80	1.00	0.91	1
207135_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000621	0.60	1.00	0.82	1
211616_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207135_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654586
Expression variation in blood from EXPOLDB for HTR2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for HTR2A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HTR2A¹	--	5-hydroxytryptamine (serotonin) receptor 2A	89.22(n) 93.83(a)	403882 NM_001005869.1 NP_001005869.1
chimpanzee (Pan troglodytes)	HTR2A¹	--	5-hydroxytryptamine (serotonin) receptor 2A	99.29(n) 99.79(a)	467355 XM_522752.2 XP_522752.2
cow (Bos taurus)	HTR2A¹	--	5-hydroxytryptamine (serotonin) receptor 2A	90.35(n) 94.47(a)	407230 NM_001001157.1 NP_001001157.1
rat (Rattus norvegicus)	Htr2a¹	--	5-hydroxytryptamine (serotonin) receptor 2A	87.47(n) 91.3(a)	29595 NM_017254.1 NP_058950.1
mouse (Mus musculus)	Htr2a^{1, 5}	14 (41.50 cM)⁵	5-hydroxytryptamine (serotonin) receptor 2A^{1, 5}	87.54(n)¹ 91.51(a)¹	15558¹ NM_172812.1¹ NP_766400.1¹ AK053140⁵ BC108972⁵ (see all 7)

About this table Species with no ortholog for HTR2A

ENSEMBL Gene Tree for HTR2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HTR2A gene

HTR2C² HTR2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/451 NCBI SNPs in HTR2A are shown (see all 451 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 250)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1328685^1,2	A,C,F,H,O	46369891(+)	`TCCCTA/GGACAA`	1	--	ng3¹		11	EU EA WA NA	976
	rs6312^1,2	A,C,F,H,O	46368825(-)	`GTGTGA/GACCCT`	1	--	ng3¹		9	MN EU EA WA NA	820
	rs1805055^1,2	C,F,H,O	46367969(-)	`TGACAC/ACAGGC`	1	N/T	mis¹ ese³		13	NA MN EA WA EU	1500
	rs3803189^1,2	A,C,F,H	46306571(-)	`GCTATA/CAATAG`	1	--	ut3¹		4	EU EA WA	408
	rs3125^1,2	C,F,H,O	46306852(-)	`TATCTG/CTATGC`	1	--	ut3¹		14	MN EU EA WA NA	1248
	rs6316^1,2	C,F,H,O	46369224(-)	`TACACA/GTAGAG`	1	--	ng3¹		12	MN NA EU EA WA	1052
	rs6310^1,2	A,C,F,H	46368353(-)	`CCCGAA/GCGCTC`	1	--	ng3¹		8	MN NA EU EA WA	636
	rs6311^1,2	A,C,F,H	46369479(+)	`GTGTCC/TGGCAC`	1	--	ng3¹		8	MN EU EA WA NA	630
	rs6314^1,2	C,F,H	46307035(-)	`AGCAGC/TATTCT`	1	H/Y	mis¹ ese³		14	MN NA EU EA WA	1300
	rs6307^1,2	C,F,H	46368442(-)	`CCATCG/AGCATA`	1	--	ng3¹		5	MN EU EA WA	604

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HapMap Linkage Disequilibrium images for HTR2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182135 disorders: 181500 164230 608516 103780 606788 608516

10/87 Novoseek disease relationships for HTR2A gene (see all 87 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	76.66	153	14744462 (3), 17069769 (3), 15048642 (3), 9264136 (3) (see all 93)
major depression	63.80	28	11311507 (3), 2310804 (2), 19428704 (2), 7865496 (2) (see all 20)
psychotic	56.70	18	10686558 (2), 18712714 (1), 10087520 (1), 10192823 (1) (see all 11)
mood disorders	55.91	33	10758249 (3), 11992560 (3), 17884017 (3), 19428704 (2) (see all 18)
obsessive-compulsive disorder	55.17	19	11239910 (3), 18339223 (2), 1624756 (1), 12476319 (1) (see all 11)
catalepsy	51.09	3	10188965 (1), 8935798 (1)
bipolar disorder	47.76	19	9341875 (4), 12622403 (2), 19428704 (2), 11093065 (2) (see all 11)
schizoaffective disorder	47.58	3	19142110 (1), 15121646 (1), 17500207 (1)
migraine	46.32	25	8675433 (5), 2045831 (4), 1871321 (1), 1337765 (1) (see all 14)
seasonal affective disorder	42.95	4	10089016 (1), 7811842 (1), 9109547 (1), 12167522 (1)

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2 PharmGKB disease relationships for HTR2A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Autistic Disorder	GN	11920848
Schizophrenia	CO PD GN	99229027

About this table

Human Gene Mutation Database: HTR2A
Genetic Association Database: HTR2A
Human Genome Epidemiology Navigator: HTR2A (276 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Success or Failure of Antidepressant Citalopram Predicted By Gene Variation

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/979 PubMed articles for HTR2A gene (see all 979 ):

Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. (PubMed id 12202283)^{3, 6, 7} Lane H.Y....Chang W.H. (2002)
Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. (PubMed id 8655141)^{3, 4, 6} Erdmann J....Noethen M.M. (1996)
Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. (PubMed id 8035173)^{2, 3, 4} Cook E.H. Jr....Leventhal B.L. (1994)
102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. (PubMed id 15048642)^{1, 3, 6} Zhang X.N....Zhang L.N. (2004)
Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder. (PubMed id 15005715)^{1, 3, 6} Meira-Lima I....Vallada H. (2004)
The serotonin-2A receptor polymorphism and smoking behavior in Japan. (PubMed id 15564892)^{1, 3, 6} Terayama H....Iwahashi K. (2004)
Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia. (PubMed id 11317228)^{1, 3, 6} Basile V.S....Kennedy J.L. (2001)
[Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome] (PubMed id 11172633)^{1, 3, 6} Huang Y....Collier D.A. (2001)
Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. (PubMed id 1330647)^{1, 3, 4} Stam N.J.... Olijve W. (1992)
Association study of MAO-A, COMT, 5-HT2A, DRD2, and DRD4 polymorphisms with illness time course in mood disorders. (PubMed id 11992560)^{1, 3, 6} Cusin C....Smeraldi E. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3356	HGNC: 5293	AceView: HTR2A	Ensembl:ENSG00000102468	euGenes: HUgn3356
ECgene: HTR2A	H-InvDB: HTR2A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HTR2A

Licensable Technologies for HTR2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HTR2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HTR2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HTR2A		Antibodies for HTR2A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HTR2A		Small molecules for HTR2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
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	Chimera RNAi (HTR2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (5HT2A Receptor)
	Antibodies (5HT2A Receptor)

Search OriGene for HTR2A

Tocris compounds for HTR2A

	Drugs for HTR2A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for HTR2A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HTR2A Gene at Home site.
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HTR2A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for HTR2A

Summaries
for HTR2A

Genomic Location
for HTR2A

Proteins
for HTR2A

Protein Domains/
Families
for HTR2A

Gene Function
for HTR2A

Pathways & Interactions
for HTR2A

Drugs & Compounds
for HTR2A

Transcripts
for HTR2A

Expression
for HTR2A

Orthologs
for HTR2A

Paralogs
for HTR2A

SNPs/Variants
for HTR2A

Disorders & Mutations
for HTR2A

Medical News
for HTR2A

Publications
for HTR2A

Search for HTR2A

Genome Databases showing HTR2A

Other Databases showing HTR2A

Specialized Databases showing HTR2A

Licensable Technologies
for HTR2A

Services
for HTR2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HTR2A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor HTR2A

Summariesfor HTR2A

Genomic Locationfor HTR2A

Proteinsfor HTR2A

Protein Domains/Familiesfor HTR2A

Gene Functionfor HTR2A

Pathways & Interactionsfor HTR2A

Drugs & Compoundsfor HTR2A

Transcriptsfor HTR2A

Expression for HTR2A

Orthologsfor HTR2A

Paralogsfor HTR2A

SNPs/Variantsfor HTR2A

Disorders & Mutationsfor HTR2A

Medical Newsfor HTR2A

Publicationsfor HTR2A

Search for HTR2A

Genome Databases showing HTR2A

Other Databases showing HTR2A

Specialized Databases showing HTR2A

Licensable Technologiesfor HTR2A

Servicesfor HTR2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HTR2A

Summaries
for HTR2A

Genomic Location
for HTR2A

Proteins
for HTR2A

Protein Domains/
Families
for HTR2A

Gene Function
for HTR2A

Pathways & Interactions
for HTR2A

Drugs & Compounds
for HTR2A

Transcripts
for HTR2A

Expression
for HTR2A

Orthologs
for HTR2A

Paralogs
for HTR2A

SNPs/Variants
for HTR2A

Disorders & Mutations
for HTR2A

Medical News
for HTR2A

Publications
for HTR2A

Licensable Technologies
for HTR2A

Services
for HTR2A