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Aliases & Descriptions for HTR1F
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 5-HT-1F 3 | | 5-HT1F 1, 2 | | 5HT6 2 | | HTR1EL 1, 2, 3, 5 | | MR77 2, 5 |
| | | Descriptions |
|---|
| 5-hydroxytryptamine (serotonin) receptor 1F 2 | | 5-hydroxytryptamine receptor 1F 2 | | Serotonin receptor 1F 3 |
|
| | Search outside databases for aliases for HTR1F genePrevious GC identifers: GC03P088567 GC03P090821 GC03P087919 GC03P087960 |
Summaries for HTR1F(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activityGene Wiki entry for HTR1F (5-HT1F_receptor) |
Genomic Location for HTR1F
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HTR1F gene 
Entrez Gene cytogenetic band: 3p12 Ensembl cytogenetic band: 3p11.2 HGNC cytogenetic band: 3p12HTR1F Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P088122:
(about GC identifiers)
Start:
|
88,114,416 bp from pter |
End:
|
88,125,609 bp from pter |
Size:
|
11,194 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022459.14
| Proteins for HTR1F
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 1F Size: 366 amino acids; 41709 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinREFSEQ proteins: NP_000857.1
ENSEMBL proteins: ENSP00000322924
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HTR1F: Assays for HTR1F: | Protein
Domains/ Families for HTR1F(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P30939
ProtoNet protein and cluster: P30939 2 Blocks protein families: IPB000450 5-hydroxytryptamine 1F receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for HTR1F
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000866
Applied Biosystems Silencer® siRNAs for HTR1F
Sigma-Aldrich siRNA and siRNA Panels for HTR1F  Sigma-Aldrich shRNA Panels and shRNA for HTR1F  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000866                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000866                                  untagged cDNA clone in CMV expression vector: NM_000866 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000866
UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activityGenatlas biochemistry entry for HTR1F:5-hydroxytryptamine (serotonin) receptor,subtype 1F,G protein coupled receptor superfamily3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Htr1f):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HTR1F
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR1F (Your Favorite Gene powered by Ingenuity) 
5/6 Interacting proteins for HTR1F (ENSP000003229243) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for HTR1F(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for HTR1F |
Compounds for HTR1F available from Tocris Bioscience About this table
|
Transcripts for HTR1F(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000866
Sigma-Aldrich siRNA and siRNA Panels for HTR1F  Sigma-Aldrich shRNA Panels and shRNA for HTR1F  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000866 REFSEQ mRNAs for HTR1F gene: NM_000866.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000866               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000866                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000866                                  untagged cDNA clone in CMV expression vector: NM_000866  Additional cDNA sequence: AF498981.1 BC069125.1 BC096838.1 CR606112.1 2 DOTS entries: DT.92061708 DT.100747290 10 AceView cDNA sequences:CR606112 NM_000866 AF498981 BC069125 CB565886 BM312885 CA942616 CA942859 BM313179 AV758122
highest scoring ESTs for HTR1F:AF498981 BC069125 CB565886 BC096838 BM313179 BX327154 CA942859 CR606112 NM_000866 BX329042 Unigene Cluster for HTR1F: 5-hydroxytryptamine (serotonin) receptor 1F Hs.248136 [show with all ESTs]Unigene Representative Sequence: NM_000866
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000319595
|
Expression for HTR1F
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HTR1F expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HTR1F
1 / 2 / 3 2 probe-sets matching HTR1F gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.248136
|
Orthologs for HTR1F
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HTR1F gene from 5/8 species (see all 8
)
About this table Species with no ortholog for HTR1F
ENSEMBL Gene Tree for HTR1F | Paralogs for HTR1F(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HTR1F gene
- HTR1D2 HTR1A2 HTR1E2 HTR1B2
|
SNPs/Variants for HTR1F(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HTR1F (up to first 250kb)
|
Disorders & Mutations for HTR1F
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 182134
1 Novoseek disease relationship for HTR1F gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| migraine |
55.56 |
3 |
9949863 (2), 9225282 (1) |
About this table
Genetic Association Database: HTR1F Human Genome Epidemiology Navigator: HTR1F (4 documents)
|
Medical News for HTR1F(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HTR1F (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/30 PubMed articles for HTR1F gene (see all 30
):- Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. (PubMed id 8380639)1, 2, 3, 4 Adham N....Branchek T.A. (1993)
- Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. (PubMed id 8384716)2, 3, 4 Lovenberg T.W.... Sutcliffe G.J. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)3, 6 Turecki G....Rouleau G.A. (2003)
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)3 Need A.C....Goldstein D.B. (2009)
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)3 GratacA^s M....Carracedo A. (2008)
- Association study of seven polymorphisms in four serotonin receptor genes on suicide victims. (PubMed id 16856120)3 Videtic A....Komel R. (2006)
- The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. (PubMed id 16254601)3 Hannula-Jouppi K....Kere J. (2005)
- Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. (PubMed id 15190056)3 Bhatnagar A....Roth B.L. (2004)
- Molecular, pharmacological and functional diversity of 5-HT receptors. (PubMed id 11888546)3 Hoyer D....Martin G.R. (2002)
|
Search for HTR1F
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HTR1F
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HTR1F
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR1F(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HTR1F(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HTR1F:

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|
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| | | | Tocris compounds for HTR1F |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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