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HTR1D Gene

protein-coding   GIFtS: 68

GC01M023389
5-hydroxytryptamine (serotonin) receptor 1D
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HTRL)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
5-HT-1D 3
5-HT-1D-alpha 3
5-HT1D 1, 2
HT1DA 1, 2
HTR1DA 2, 3
HTRL 2, 3
OTTHUMP00000003270 2
RDC4 1, 2
Descriptions
5-hydroxytryptamine (serotonin) receptor 1D 2
Serotonin receptor 1D 3
External Ids
HGNC: 52891
Entrez Gene: 33522
UniProtKB: P282213
Ensembl: ENSG000001795467
Search outside databases for aliases for HTR1D gene

Previous GC identifers: GC01M023088 GC01M022554 GC01M022664 GC01M022987 GC01M023263

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a
biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of
this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Gene Wiki entry for HTR1D (5-HT1D_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HTR1D gene  

Entrez Gene cytogenetic band: 1p36.3-p34.3   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.3-p34.3

HTR1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023389:     (about GC identifiers)

Start:
23,389,580 bp from pter
End:
23,393,809 bp from pter
Size:
4,230 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004610.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1D  
Size: 377 amino acids; 41907 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

REFSEQ proteins: NP_000855.1  

ENSEMBL proteins: 
ENSP00000363748 ENSP00000313661 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (5HT1D Receptor)
Human Recombinant Proteins from Abnova (HTR1D)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0005887 integral to plasma membrane TAS1652050
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Antibodies for HTR1D: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of HTR1D
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (5HT1D Receptor), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Novus Biologicals Antibodies for HTR1D

Assays for HTR1D: 
Invitrogen Assays for HTR1D
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR000505 5HT1D_rcpt
 IPR017452 GPCR_Rhodpsn_supfam
 IPR002231 5HT_rcpt
 IPR000276 7TM_GPCR_Rhodpsn


   GeneDecks  HTR1D for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P28221

ProtoNet protein and cluster: P28221

2 Blocks protein families:
IPB000505 5-hydroxytryptamine 1D receptor signature
IPB002231 5-hydroxytryptamine receptor signature


UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (HTR1D)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HTR1D)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000864

              Applied Biosystems Silencer® siRNAs for HTR1D

              Sigma-Aldrich siRNA and siRNA Panels for HTR1D  
                     Sigma-Aldrich shRNA for HTR1D  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for HTR1D
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000864
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000864
                                 untagged cDNA clones in CMV expression vector (see all 2): BC007720 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000864

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a
biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of
this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Genatlas biochemistry entry for HTR1D:
5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein
coupled receptor superfamily,inhibiting adenylate cyclase

1 MGI mutant phenotype (inferred from 1 allele(MGI details for Htr1d):

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
GO:0004993 serotonin receptor activity TAS1565658
GO:0051378 serotonin binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


3 Sigma-Aldrich "Your Favorite Gene" Pathways for  HTR1D  (Your Favorite Gene powered by Ingenuity) 
 G-Protein Coupled Receptor Signaling
 Serotonin Receptor Signaling
 cAMP-mediated Signaling

   GeneDecks  HTR1D for the pathways selected above  
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1 Kegg Pathway  (Kegg details for HTR1D):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  HTR1D for the pathways selected above  
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5/14 Interacting proteins for HTR1D (ENSP000003637483) via UniProtKB, MINT, and/or STRING (see all 14 )
InteractantInteraction Details
GeneCardExternal ID(s)
HTR1AENSP000003162443STRING (score=.964)
HTR3AENSP000003477543STRING (score=.957)
HTR5AENSP000002879073STRING (score=.91)
HTR1EENSP000003585973STRING (score=.906)
HTR1FENSP000003229243STRING (score=.905)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger TAS1565658
GO:0007268 synaptic transmission TAS1565658
GO:0009636 response to toxin IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HTR1D
Sigma-Aldrich Small Molecules for HTR1D:
Metabolite Mixed Agonist/Antagonist Antagonist Agonist Allosteric Modulator Blocker
Precursor Inhibitor Ligand

Compounds for HTR1D available from Tocris Bioscience
CompoundAction CAS number
L-703,664 succinateSelective 5-HT1D receptor agonist[144776-01-2]
GR 466115-HT1D agonist[185259-85-2]
LY 310762 hydrochloride5-HT1D-preferring antagonist[192927-92-7]
PNU 109291Potent and selective 5-HT1D agonist[187665-60-7]
BRL 15572 hydrochlorideSelective h5-HT1D antagonist[193611-72-2]
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4 Novoseek chemical compound relationships for HTR1D gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ly 344864 89.48 3 12434581 (1), 10711348 (1), 15320857 (1)
indole 42.32 4 8496922 (1), 8386498 (1), 9986723 (1)
amine 24.73 1 1678720 (1)
cyclic amp 0.00 1 8978753 (1)
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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (HTR1D)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HTR1D)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000864

              Sigma-Aldrich siRNA and siRNA Panels for HTR1D  
                     Sigma-Aldrich shRNA for HTR1D  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000864  

REFSEQ mRNAs for HTR1D gene: 

NM_000864.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000864  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000864
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000864
                                 untagged cDNA clones in CMV expression vector (see all 2): BC007720 

Additional cDNA sequence: 

AF498979.1 BC007720.2 BT007027.1 M81589.1 

1 DOTS entry:

DT.75136214 

10 AceView cDNA sequences:

BT007027 NM_000864 AF498979 BC007720 BX281878 M81589 BF196846 AA132509 
BF688599 AW051032 

highest scoring ESTs for HTR1D:

M81589 AF498979 AW051032 BC007720 BF196846 BF688599 BT007027 BX281878 NM_000864 AA132509 

Unigene Cluster for HTR1D:

5-hydroxytryptamine (serotonin) receptor 1D
Hs.121482  [show with all ESTs]
Unigene Representative Sequence: NM_000864


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000374619  ENST00000314113  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HTR1D expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HTR1D

1 / 2 / 3

3 probe-sets matching HTR1D gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

32494_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M81589 1.00 1.00 1.00 1

207368_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000864 0.60 1.00 0.82 1

207368_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCCAAAAAAA

SOURCE GeneReport for Unigene cluster: Hs.121482

Expression variation in blood from EXPOLDB for HTR1D

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for HTR1D gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
HTR1D1   -- 5-hydroxytryptamine (serotonin) receptor 1D 87.09(n)
88.06(a)
403963  NM_001003280.1  NP_001003280.1 
chimpanzee
(Pan troglodytes)
HTR1D1   -- 5-hydroxytryptamine (serotonin) receptor 1D 99.29(n)
99.47(a)
469219  XM_524604.2  XP_524604.1 
cow
(Bos taurus)
HTR1D1   -- 5-hydroxytryptamine (serotonin) receptor 1D 88.24(n)
90.45(a)
407136  XM_587002.2  XP_587002.1 
rat
(Rattus norvegicus)
Htr1d1   -- 5-hydroxytryptamine (serotonin) receptor 1D 85.74(n)
90.91(a)
25323  NM_012852.1  NP_036984.1 
mouse
(Mus musculus)
Htr1d1, 5 4 (66.00 cM)5
5-hydroxytryptamine (serotonin) receptor 1D1, 5 85.47(n)1
90.91(a)1
155521  NM_008309.31  NP_032335.21 
 AI8536475  AK0820165  (see all 12)
About this table        Species with no ortholog for HTR1D

ENSEMBL Gene Tree for HTR1D
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for HTR1D gene
HTR1A2  HTR1E2  HTR1B2  HTR1F2  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/40 NCBI SNPs in HTR1D are shown (see all 40 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 31)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs6040301,2
A,C,F,H,O23390814(+) CATCAT/CGCTAT 1 -- ng5111Minor allele frequency- C:0.34EU EA WA NA 956
rs6766431,2
A,C,F,H23393927(+) ATCCTG/AAGCTA 1 -- ng3119Minor allele frequency- A:0.22EA NS EU WA MN CSAM 2824
rs6743861,2
A,C,F,H23394422(+) GGAAAG/AAAACC 1 -- ng31 trp315Minor allele frequency- A:0.29NS EA EU WA MN CSAM 2226
rs62991,2
C,F,H23392506(-) GCACTC/TGCACT 1 S/L mis1 ese310Minor allele frequency- T:0.01MN EU EA WA 1098
rs6053671,2
A,C,F23391111(+) TGCGGT/CGGGTG 1 -- ut31 ese39Minor allele frequency- C:0.42EA NA MN CSAM 526
--
rs6643011,2
A,H23395109(+) agaggC/Tagggt 1 -- ng314Minor allele frequency- T:0.00EU EA WA 398
rs6239881,2
A,C23392064(-) TCATGA/GTATCT 1 -- ut31 ese31Minor allele frequency- G:0.00MN 184
--
rs6369401,2
A,C23395554(+) AGCTAA/TACCTG 1 -- ng310--------
--
rs32159061,2
C,F23391058(-) TTTTTT/-AACAT 1 -- ut315Minor allele frequency- -:0.16MN CSAM EA 396
--
rs92827071,2
C,F23394460(-) CCCCCC/-ATACT 1 -- ng31 tfbs35Minor allele frequency- -:0.41MN CSAM EA 404
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HapMap Linkage Disequilibrium images for HTR1D (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182133

4 Novoseek disease relationships for HTR1D gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
migraine 68.04 12 9949863 (3), 1871321 (1), 1326402 (1), 7658443 (1) (see all 10)
schizophrenia 15.77 1 8104876 (1)
genetic susceptibility 2.86 1 17572793 (1)
inflammation 0.00 2 9071266 (1), 9243618 (1)
About this table

Genetic Association Database: HTR1D
Human Genome Epidemiology Navigator: HTR1D (16 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/143 PubMed articles for HTR1D gene (see all 143 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3352 HGNC: 5289 AceView: HTR1D Ensembl:ENSG00000179546 euGenes: HUgn3352
ECgene: HTR1D H-InvDB: HTR1D
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for HTR1D Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for HTR1D:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HTR1D-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for HTR1D Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for HTR1D Small molecules for HTR1D
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(5HT1D Receptor)
 Antibodies (5HT1D Receptor)
 Search OriGene for HTR1D
 Tocris compounds for HTR1D




 Drugs for HTR1D
 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for HTR1D

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