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Aliases & Descriptions for HTR1D
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 5-HT-1D 3 | | 5-HT-1D-alpha 3 | | 5-HT1D 1, 2 | | HT1DA 1, 2 | | HTR1DA 2, 3 | | HTRL 2, 3 | | OTTHUMP00000003270 2 | | RDC4 1, 2 |
| | | Descriptions |
|---|
| 5-hydroxytryptamine (serotonin) receptor 1D 2 | | Serotonin receptor 1D 3 |
|
| | Search outside databases for aliases for HTR1D genePrevious GC identifers: GC01M023088 GC01M022554 GC01M022664 GC01M022987 GC01M023263 |
Summaries for HTR1D(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activityGene Wiki entry for HTR1D (5-HT1D_receptor) |
Genomic Location for HTR1D
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HTR1D gene 
Entrez Gene cytogenetic band: 1p36.3-p34.3 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.3-p34.3HTR1D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M023389:
(about GC identifiers)
Start:
|
23,389,580 bp from pter |
End:
|
23,393,809 bp from pter |
Size:
|
4,230 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004610.18
| Proteins for HTR1D
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 1D Size: 377 amino acids; 41907 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinREFSEQ proteins: NP_000855.1
ENSEMBL proteins: ENSP00000363748 ENSP00000313661
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HTR1D: Assays for HTR1D: | Protein
Domains/ Families for HTR1D(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P28221
ProtoNet protein and cluster: P28221 2 Blocks protein families: IPB000505 5-hydroxytryptamine 1D receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for HTR1D
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000864
Applied Biosystems Silencer® siRNAs for HTR1D
Sigma-Aldrich siRNA and siRNA Panels for HTR1D  Sigma-Aldrich shRNA for HTR1D  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000864                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000864                                  untagged cDNA clones in CMV expression vector (see all 2): BC007720 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000864
UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activityGenatlas biochemistry entry for HTR1D:5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Htr1d):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HTR1D
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR1D (Your Favorite Gene powered by Ingenuity) 
5/14 Interacting proteins for HTR1D (ENSP000003637483) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for HTR1D(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for HTR1D |
Compounds for HTR1D available from Tocris Bioscience About this table
4 Novoseek chemical compound relationships for HTR1D gene
About this table
|
Transcripts for HTR1D(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000864
Sigma-Aldrich siRNA and siRNA Panels for HTR1D  Sigma-Aldrich shRNA for HTR1D  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000864 REFSEQ mRNAs for HTR1D gene: NM_000864.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000864               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000864                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000864                                  untagged cDNA clones in CMV expression vector (see all 2): BC007720  Additional cDNA sequence: AF498979.1 BC007720.2 BT007027.1 M81589.1 1 DOTS entry: DT.75136214 10 AceView cDNA sequences:BT007027 NM_000864 AF498979 BC007720 BX281878 M81589 BF196846 AA132509 BF688599 AW051032
highest scoring ESTs for HTR1D:M81589 AF498979 AW051032 BC007720 BF196846 BF688599 BT007027 BX281878 NM_000864 AA132509 Unigene Cluster for HTR1D: 5-hydroxytryptamine (serotonin) receptor 1D Hs.121482 [show with all ESTs]Unigene Representative Sequence: NM_000864
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000374619
ENST00000314113
|
Expression for HTR1D
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HTR1D expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HTR1D
1 / 2 / 3 3 probe-sets matching HTR1D gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCAAAAAAA
SOURCE GeneReport for Unigene cluster: Hs.121482
Expression variation in blood from EXPOLDB for HTR1D |
Orthologs for HTR1D
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HTR1D gene from 5/10 species (see all 10
)
About this table Species with no ortholog for HTR1D
ENSEMBL Gene Tree for HTR1D | Paralogs for HTR1D(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HTR1D gene
- HTR1A2 HTR1E2 HTR1B2 HTR1F2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for HTR1D(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HTR1D (up to first 250kb)
|
Disorders & Mutations for HTR1D
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 182133
4 Novoseek disease relationships for HTR1D gene
About this table
Genetic Association Database: HTR1D Human Genome Epidemiology Navigator: HTR1D (16 documents)
|
Medical News for HTR1D(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HTR1D (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/143 PubMed articles for HTR1D gene (see all 143
):- Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. (PubMed id 1565658)1, 3, 4 Weinshank R.L....Hartig P.R. (1992)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- [Lack of association between the G681C polimorphism in the 5-HT1D(beta) autoreceptor gene and schizophrenia.] (PubMed id 16059583)3, 6 Cordeiro Q. and Vallada H. (2005)
- Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms. (PubMed id 15109354)3, 6 Racchi M....Bussone G. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)3, 6 Turecki G....Rouleau G.A. (2003)
- Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. (PubMed id 12650952)3, 6 Hemmings S.M....Stein D.J. (2003)
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)3, 4 Cargill M....Lander E.S. (1999)
- Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PubMed id 1662665)2, 3 Libert F....Mattei M.G. (1991)
- Primary structure and functional characterization of a human 5-HT1D- type serotonin receptor. (PubMed id 1652050)3, 4 Hamblin M.W. and Metcalf M.A. (1991)
|
Search for HTR1D
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HTR1D
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HTR1D
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR1D(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HTR1D(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HTR1D:

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| | | | Tocris compounds for HTR1D |
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Incremental update: 13 Oct 2009
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