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HTR1A Gene

protein-coding GIFtS: 65

GC05M063292

5-hydroxytryptamine (serotonin) receptor 1A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: ADRB2RL1, ADRBRL1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
5-HT-1A ^³
5-HT1A ^¹, ², ³
5HT1a ^²
ADRB2RL1 ^², ³, ⁵
ADRBRL1 ^², ³
G-21 ^³

Descriptions
5-HT1a receptor ^²
5-hydroxytryptamine (serotonin) receptor 1A ^²
G protein coupled receptor ^²
Serotonin receptor 1A ^³
guanine nucleotide-binding regulatory protein-coupled receptor ^²

External Ids
HGNC: 5286¹
Entrez Gene: 3350²
UniProtKB: P08908³
Ensembl: ENSG00000178394⁷

Search outside databases for aliases for HTR1A gene

Previous GC identifers: GC05M063417 GC05M064794 GC05M063226 GC05M063272

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of

this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Gene Wiki entry for HTR1A (5-HT1A_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HTR1A gene

Entrez Gene cytogenetic band: 5q11.2-q13 Ensembl cytogenetic band: 5q12.2 HGNC cytogenetic band: 5q11.2-q13

HTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M063292: (about GC identifiers)

Start:	63,292,034 bp from pter
End:	63,293,302 bp from pter
Size:	1,269 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 1A

Size: 422 amino acids; 46107 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6LAE7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000515.2

ENSEMBL proteins:

ENSP00000316244

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HTR1A Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (5HT1A Receptor)
	Human Recombinant Proteins from Abnova (HTR1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	3138543

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Antibodies for HTR1A:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HTR1A
	Sigma-Aldrich Antibodies for HTR1A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (5HT1A Receptor), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for HTR1A

Assays for HTR1A:

	Invitrogen Assays for HTR1A
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08908

ProtoNet protein and cluster: P08908

2 Blocks protein families:

IPB000610 5-hydroxytryptamine 1A receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR1A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000524

Applied Biosystems Silencer® siRNAs for HTR1A

Sigma-Aldrich siRNA and siRNA Panels for HTR1A

Sigma-Aldrich shRNA Panels and shRNA for HTR1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HTR1A
		Millipore Clones for the Expression of HTR1A

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000524
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000524
untagged cDNA clone in CMV expression vector: NM_000524

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000524

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a

biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of

this receptor is mediated by G proteins that inhibit adenylate cyclase activity

Genatlas biochemistry entry for HTR1A:

5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor

superfamily,inhibiting adenylate cyclase

5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Htr1a):

behavior/neurological

homeostasis/metabolism

life span-post-weaning/aging

nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004993	serotonin receptor activity	TAS	9736659

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for HTR1A (Your Favorite Gene powered by Ingenuity)

Serotonin Receptor Signaling
cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling

GeneDecks HTR1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HTR1A

5/24 Interacting proteins for HTR1A (ENSP00000316244³) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTR1D	ENSP00000363748³	STRING (score=.964)
HTR3A	ENSP00000347754³	STRING (score=.962)
CC2D1A	ENSP00000313601³	STRING (score=.935)
HES5	ENSP00000367714³	STRING (score=.915)
HTR5A	ENSP00000287907³	STRING (score=.911)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS	1330092
GO:0007610	behavior	TAS	9736659
GO:0008284	positive regulation of cell proliferation	TAS	1330092

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HTR1A

Sigma-Aldrich Small Molecules for HTR1A:

Mixed Agonist/Antagonist Metabolite Antagonist Blocker Allosteric Modulator Agonist

Precursor Inhibitor Ligand

Compounds for HTR1A available from Tocris Bioscience

Compound	Action	CAS number
Tandospirone hydrochloride	Selective 5-HT1A partial agonist	[87760-53-0]
(R)-(+)-8-Hydroxy-DPAT hydrobromide	More active enantiomer of Cat. No. 0529	[80300-09-0]
(S)-WAY 100135 dihydrochloride	Potent, selective 5-HT1A antagonist	[133025-23-7]
8-Hydroxy-DPAT hydrobromide	Selective 5-HT1A agonist. Also has moderate affinity for 5-HT7	[78950-78-4]

About this table

10/27 Novoseek chemical compound relationships for HTR1A gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
s 15535	84.73	4	9550290 (1), 8381359 (1), 8831111 (1)
pindobind	78.69	6	11360926 (1), 9817696 (1), 8919640 (1), 15016478 (1) (see all 5)
repinotan	78.13	6	15674237 (2), 16614737 (2), 11780862 (1), 16547395 (1)
nad-299	77.98	5	9336327 (2), 12503636 (1), 12632244 (1), 15829255 (1)
flibanserin	73.12	11	11243720 (4), 12177684 (4), 15447813 (1), 17897483 (1)
zalospirone	72.71	2	8497336 (1), 8784652 (1)
anpirtoline	72.70	1	10788764 (1)
lesopitron	72.07	4	15331910 (2), 10667616 (2)
(tfmpp)	70.55	3	1689472 (1), 1410132 (1), 8472752 (1)
roxindole	68.99	3	10431754 (2), 7604150 (1)

About this table

1 PharmGKB drug compound relationship for HTR1A gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
fluvoxamine	CO GN	15148501

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HTR1A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HTR1A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000524

Sigma-Aldrich siRNA and siRNA Panels for HTR1A

Sigma-Aldrich shRNA Panels and shRNA for HTR1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000524

REFSEQ mRNAs for HTR1A gene:

NM_000524.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000524

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000524
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000524
                                 untagged cDNA clone in CMV expression vector: NM_000524

Additional cDNA sequence:

AF498978.1 AK291429.1 AK311460.1 AK314187.1 BC069159.1 BC136263.1 S64045.1

2 DOTS entries:

DT.102820664 DT.410273

7 AceView cDNA sequences:

AF498978 BC069159 CD608772 NM_000524 CD608776 S64045 CD608773

highest scoring ESTs for HTR1A:

AF498978 BC069159 CD608772 CD608776 S64045 CD608771 CD608774 CD608775 NM_000524 CD608773

Unigene Cluster for HTR1A:

5-hydroxytryptamine (serotonin) receptor 1A

Hs.247940 [show with all ESTs]

Unigene Representative Sequence: AK314187

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000323865

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HTR1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HTR1A

¹ / ² / ³

2 probe-sets matching HTR1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221351_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000524	0.60	1.00	0.82	1
221351_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.247940

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HTR1A gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HTR1A¹	--	5-hydroxytryptamine (serotonin) receptor 1A	89.1(n) 91.71(a)	487230 NM_001012397.1 NP_001012397.1
chimpanzee (Pan troglodytes)	HTR1A¹	--	5-hydroxytryptamine (serotonin) receptor 1A	99.68(n) 99.53(a)	471533 XM_526911.2 XP_526911.2
cow (Bos taurus)	HTR1A¹	--	5-hydroxytryptamine (serotonin) receptor 1A	88.31(n) 91.71(a)	407137 XM_600535.2 XP_600535.2
rat (Rattus norvegicus)	Htr1a¹	--	5-hydroxytryptamine (serotonin) receptor 1A	85.47(n) 89.81(a)	24473 NM_012585.1 NP_036717.1
mouse (Mus musculus)	Htr1a^{1, 5}	13 (58.00 cM)⁵	5-hydroxytryptamine (serotonin) receptor 1A^{1, 5}	85.59(n)¹ 88.36(a)¹	15550¹ NM_008308.3¹ NP_032334.2¹ AK034017⁵ AK043668⁵ (see all 17)

About this table Species with no ortholog for HTR1A

ENSEMBL Gene Tree for HTR1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HTR1A gene

HTR1D² HTR1E² HTR1B² HTR1F²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/20 NCBI SNPs in HTR1A are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 34)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs878567^1,2	A,C,F,H	63291747(-)	`CCCAGC/TAATTG`	1	--	ng5¹		16		EA NA EU WA	1338
	rs6449693^1,2	A,C,F,H	63291774(+)	`CAGGCA/GAAGTC`	1	--	ng5¹		8		EU EA WA	838
	rs6295^1,2	A,C,F	63294321(-)	`AAAAAC/GGAAGA`	1	--	ng3¹ trp³		1		MN	78
	rs1799921^1,2	C,F	63293221(-)	`CTGGTA/GTCTCC`	1	I/V	mis¹		1		--	384
	rs1800041^1,2	C	63293256(-)	`ACCACC/TGGCTC`	1	P/L	mis¹		0	--	--	--	--
	rs6294^1,2	C,F	63293009(-)	`CAGGTG/ACTCAA`	1	V/V	syn¹		7		MN NA	802
--	rs34118353^1,2	F	63292751(-)	`GACCCC/TGACGC`	1	P/P	syn¹		1		--	384
	rs34158987^1,2	--	63292504(-)	`TGGGCG/ATGGAG`	1	M/V	mis¹		1		--	384
--	rs34979174^1,2	--	63291989(+)	`TGAAT-/GGGGAC`	1	--	ng5¹		0	--	--	--	--
	rs1800046^1,2	--	63293454(-)	`CCCTTC/GGCCGA`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for HTR1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109760

10/81 Novoseek disease relationships for HTR1A gene (see all 81 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
major depression	65.77	59	9736659 (3), 16139805 (3), 15534042 (2), 18387740 (2) (see all 37)
mood disorders	62.50	19	16467535 (2), 16863269 (1), 16756688 (1), 15262317 (1) (see all 14)
catalepsy	56.72	21	12398907 (3), 9774248 (3), 10379620 (2), 15906386 (1) (see all 6)
anxiety disorders	56.47	13	16979141 (3), 18047755 (2), 1763190 (2), 18163385 (2) (see all 6)
schizophrenia	54.91	59	15023569 (5), 11277607 (4), 16831468 (3), 18849890 (3) (see all 31)
serotonin syndrome	48.08	8	1387164 (2), 9696181 (1), 10090793 (1), 15743927 (1)
panic disorder	44.55	11	8888384 (2), 10870873 (1), 15534042 (1), 15683551 (1) (see all 9)
generalized anxiety disorder	43.52	7	10356651 (1), 18344738 (1), 16856115 (1), 14985704 (1) (see all 7)
obsessive-compulsive disorder	41.94	4	2188516 (1), 1763190 (1), 1686817 (1), 8056999 (1)
reflex bradycardia	40.25	2	9070389 (1), 15604109 (1)

About this table

1 PharmGKB disease relationship for HTR1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Depression	CO GN	15148501

About this table

Human Gene Mutation Database: HTR1A
Genetic Association Database: HTR1A
Human Genome Epidemiology Navigator: HTR1A (80 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/700 PubMed articles for HTR1A gene (see all 700 ):

The effects of a 5-hydroxytryptamine 1A receptor gene polymorphism on the clinical response to fluvoxamine in depressed patients. (PubMed id 15148501)^{3, 6, 7} Suzuki Y....Someya T. (2004)
Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. (PubMed id 9754630)^{3, 4, 6} Kawanishi Y.... Shiraishi H. (1998)
The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. (PubMed id 15458611)^{1, 3, 6} Serretti A....Zanardi R. (2004)
Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5- hydroxytryptamine. (PubMed id 8393041)^{1, 3, 4} Aune T.M.... Kelley K.A. (1993)
Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. (PubMed id 12969265)^{1, 2, 3} Hsiung S.C....Liu K.P. (2003)
Evidence for a combined genetic effect of the 5-HT(1A) receptor and serotonin transporter genes in the clinical outcome of major depressive patients treated with citalopram. (PubMed id 15728438)^{1, 3, 6} Arias B....Fananas L. (2005)
Investigation of serotonin-related genes in antidepressant response. (PubMed id 15052272)^{1, 3, 6} Peters E.J....Hamilton S.P. (2004)
Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. (PubMed id 16302021)^{1, 3, 6} Hong C.J....Tsai S.J. (2006)
Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. (PubMed id 14984628)^{1, 3, 6} Rothe C....Lesch K.P. (2004)
Association analysis for the C-1019G promoter variant of the 5-HT1A receptor gene with auditory evoked potentials in major depression. (PubMed id 15539859)^{1, 3, 6} Chen T.J....Tsai S.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3350	HGNC: 5286	AceView: HTR1A	Ensembl:ENSG00000178394	euGenes: HUgn3350
ECgene: HTR1A	H-InvDB: HTR1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HTR1A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HTR1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HTR1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HTR1A		Antibodies for HTR1A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HTR1A		Small molecules for HTR1A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HTR1A)
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	Antibodies (5HT1A Receptor)

Search OriGene for HTR1A

Tocris compounds for HTR1A

	Drugs for HTR1A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HTR1A

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HTR1A Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for HTR1A

Summaries
for HTR1A

Genomic Location
for HTR1A

Proteins
for HTR1A

Protein Domains/
Families
for HTR1A

Gene Function
for HTR1A

Pathways & Interactions
for HTR1A

Drugs & Compounds
for HTR1A

Transcripts
for HTR1A

Expression
for HTR1A

Orthologs
for HTR1A

Paralogs
for HTR1A

SNPs/Variants
for HTR1A

Disorders & Mutations
for HTR1A

Medical News
for HTR1A

Publications
for HTR1A

Search for HTR1A

Genome Databases showing HTR1A

Other Databases showing HTR1A

Specialized Databases showing HTR1A

Licensable Technologies
for HTR1A

Services
for HTR1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HTR1A Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor HTR1A

Summariesfor HTR1A

Genomic Locationfor HTR1A

Proteinsfor HTR1A

Protein Domains/Familiesfor HTR1A

Gene Functionfor HTR1A

Pathways & Interactionsfor HTR1A

Drugs & Compoundsfor HTR1A

Transcriptsfor HTR1A

Expression for HTR1A

Orthologsfor HTR1A

Paralogsfor HTR1A

SNPs/Variantsfor HTR1A

Disorders & Mutationsfor HTR1A

Medical Newsfor HTR1A

Publicationsfor HTR1A

Search for HTR1A

Genome Databases showing HTR1A

Other Databases showing HTR1A

Specialized Databases showing HTR1A

Licensable Technologiesfor HTR1A

Servicesfor HTR1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HTR1A

Summaries
for HTR1A

Genomic Location
for HTR1A

Proteins
for HTR1A

Protein Domains/
Families
for HTR1A

Gene Function
for HTR1A

Pathways & Interactions
for HTR1A

Drugs & Compounds
for HTR1A

Transcripts
for HTR1A

Expression
for HTR1A

Orthologs
for HTR1A

Paralogs
for HTR1A

SNPs/Variants
for HTR1A

Disorders & Mutations
for HTR1A

Medical News
for HTR1A

Publications
for HTR1A

Licensable Technologies
for HTR1A

Services
for HTR1A