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HRH1 Gene

protein-coding GIFtS: 66

GC03P011223

histamine receptor H1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
H1-R ^²
OTTHUMP00000160133 ^²
hisH1 ^²

Descriptions
histamine H(1) receptor ^²
histamine receptor H1 ^²
histamine receptor, subclass H1 ^²

External Ids
HGNC: 5182¹
Entrez Gene: 3269²
UniProtKB: P35367³
Ensembl: ENSG00000196639⁷

Search outside databases for aliases for HRH1 gene

Previous GC identifers: GC03P011270 GC03P011271 GC03P011272

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HRH1:

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells,

and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene

was thought to be intronless until recently. The protein encoded by this gene is an integral

membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the

contraction of smooth muscles, the increase in capillary permeability due to contraction of

terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the

central nervous system. Multiple alternatively spliced variants, encoding the same protein, have

been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of

smooth muscles, increase in capillary permeability due to contraction of terminal venules, and

catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central

nervous system

Gene Wiki entry for HRH1 (Histamine_H1_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HRH1 gene

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25

HRH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P011223: (about GC identifiers)

Start:	11,153,779 bp from pter
End:	11,280,243 bp from pter
Size:	126,465 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367 (See protein sequence)

Recommended Name: Histamine H1 receptor

Size: 487 amino acids; 55784 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Post-translational modifications:

Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in

regulating signal transduction through the receptor molecule¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000852.1 NP_001091681.1 NP_001091682.1 NP_001091683.1

ENSEMBL proteins:

ENSP00000380247 ENSP00000347299

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HRH1 Protein
	Sigma-Aldrich CompoZr ZFN for HRH1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HRH1)
	Human Recombinant Proteins from Abnova (HRH1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	7925364

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Antibodies for HRH1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HRH1
	Sigma-Aldrich Antibodies for HRH1
	R&D Systems Antibodies for HRH1 (Histamine H1 R)
	Antibodies from Abcam (HRH1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HRH1)
	Novus Biologicals Antibodies for HRH1

Assays for HRH1:

	Invitrogen Assays for HRH1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P35367

ProtoNet protein and cluster: P35367

1 Blocks protein family: IPB000921 Histamine H1 receptor signature

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HRH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HRH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000861

Applied Biosystems Silencer® siRNAs for HRH1

Sigma-Aldrich siRNA and siRNA Panels for HRH1

Sigma-Aldrich shRNA Panels and shRNA for HRH1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HRH1
		Millipore Clones for the Expression of HRH1

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000861
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000861
untagged cDNA clones in CMV expression vector (see all 4): NM_000861

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001098211

UniProtKB/Swiss-Prot: HRH1_HUMAN, P35367

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of

smooth muscles, increase in capillary permeability due to contraction of terminal venules, and

catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central

nervous system

Genatlas biochemistry entry for HRH1:

histamine H1 receptor,ubiquitous,G protein coupled receptor superfamily,activating adenylate

cyclase,stimulating contraction on smooth muscle in the gut and bronchs and decreasing blood

pressure

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hrh1):

adipose tissue	behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism
immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	7925364
GO:0004969	histamine receptor activity	TAS	10818238

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for HRH1 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling

GeneDecks HRH1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for HRH1

5/13 Interacting proteins for HRH1 (ENSP00000347299³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KIAA0101	ENSP00000300035³	STRING (score=.878)
TMEFF2	ENSP00000272771³	STRING (score=.858)
HRH4	ENSP00000256906³	STRING (score=.849)
IGF2R	ENSP00000349437³	STRING (score=.849)
HRH2	ENSP00000366506³	STRING (score=.847)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	10818238
GO:0007165	signal transduction	IEA	--
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	8280179
GO:0007268	synaptic transmission	IEA	--
GO:0045429	positive regulation of nitric oxide biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for HRH1

Sigma-Aldrich Small Molecules for HRH1:

Metabolite Mixed Agonist/Antagonist Antagonist Blocker Agonist Ligand

Compounds for HRH1 available from Tocris Bioscience

Compound	Action	CAS number
HTMT dimaleate	H1 / H2 agonist	[195867-54-0]
Loratidine	Peripheral H1 antagonist; anti-allergic agent	[79794-75-5]
2-Pyridylethylamine dihydrochloride	H1 receptor agonist	[3343-39-3]
Fexofenadine hydrochloride	H1 receptor antagonist; non-sedating antiallergic agent	[153439-40-8]
Mepyramine maleate	Selective H1 inverse agonist	[59-33-6]

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10/33 Novoseek chemical compound relationships for HRH1 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-methylhistamine	75.91	4	8523041 (1), 8982654 (1), 16219299 (1)
homochlorcyclizine	71.22	2	12657913 (2)
rupatadine	63.35	3	12944997 (2), 15160440 (1)
calcium	44.10	58	2059991 (2), 7556415 (2), 1408146 (1), 8390920 (1) (see all 38)
carbon-11	43.90	3	1613494 (2), 2259465 (1)
ltd4	42.12	2	16753444 (1), 15590629 (1)
phosphoinositide	37.13	8	1685127 (2), 1845968 (1), 7889313 (1), 15590629 (1) (see all 6)
rantes	35.75	2	17016623 (1)
inositol 1,4,5 trisphosphate	33.97	2	7881738 (1), 7556415 (1)
inositol 1,3,4,5-tetrakisphosphate	31.93	3	7556415 (2), 7881738 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HRH1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HRH1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000861

Sigma-Aldrich siRNA and siRNA Panels for HRH1

Sigma-Aldrich shRNA Panels and shRNA for HRH1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000861 NM_001098211 NM_001098212 NM_001098213

REFSEQ mRNAs for HRH1 gene (4 alternative transcripts):

NM_000861.3 NM_001098211.1 NM_001098212.1 NM_001098213.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000861 NM_001098211 NM_001098212 NM_001098213

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000861
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000861
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000861

Additional cDNA sequence:

AF026261.1 AK289412.1 AK292157.1 AK312879.1 AY136743.1 BC060802.1 D28481.1 Z34897.1

5 DOTS entries:

DT.108434 DT.120856026 DT.120856016 DT.405455 DT.75141601

24/51 AceView cDNA sequences (see all 51 ):

AY136743 Z34897 BQ017843 BQ014690 BQ019585 AA582697 AW452821 AI203543

BF513144 BX436453 D28481 BU187066 AA373094 AF026261 AI005319 BE908331

AI926322 AW003867 CB114530 CA309435 BG287152 CB115769 AI954670 AI122972

highest scoring ESTs for HRH1:

AA410933 AI889049 AW003867 Z34897 AA373094 AA582697 AA613545 AF026261 AI005319 AI122972

Unigene Cluster for HRH1:

Histamine receptor H1

Hs.1570 [show with all ESTs]

Unigene Representative Sequence: NM_001098213

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000397056 ENST00000355172

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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HRH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HRH1

¹ / ² / ³

10 probe-sets matching HRH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
73483_at²^{, 3}	U95-E	1	1.00	1.00	0.90	1.05	AA410933	1.00	1.00	1.00	1
71189_at²^{, 3}	U95-E	1	1.00	1.00	0.83	1.15	AW003867	1.00	1.00	1.00	1
35384_at²^{, 3}	U95-A	1	1.00	1.00	0.42	0.37	Z34897	1.00	1.00	1.00	1
74590_at²^{, 3}	U95-E	1	1.00	1.00	0.17	1.41	AI889049	1.00	1.00	1.00	1
55477_r_at²^{, 3}	U95-C	1	0.88	1.00	0.36	0.84	H05322	0.20	1.00	0.72	1
55475_i_at²^{, 3}	U95-C	1	0.73	1.00	0.75	0.59	H05322	0.20	1.00	0.72	1
205579_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000861	0.60	1.00	0.82	1
205580_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D28481	0.80	1.00	0.91	1
205579_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205580_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks HRH1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATCTGTCAAA

SOURCE GeneReport for Unigene cluster: Hs.1570
Expression variation in blood from EXPOLDB for HRH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HRH1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HRH1¹	--	histamine receptor H1	86.65(n) 86.24(a)	403813 XM_541769.2 XP_541769.2
chimpanzee (Pan troglodytes)	HRH1¹	--	histamine receptor H1	99.11(n) 98.77(a)	470746 XM_001152422.1 XP_001152422.1
cow (Bos taurus)	HRH1¹	--	histamine receptor H1	84.87(n) 82.55(a)	281231 NM_174083.2 NP_776508.1
rat (Rattus norvegicus)	Hrh1¹	--	histamine receptor H 1	80.3(n) 79.34(a)	24448 NM_017018.1 NP_058714.1
mouse (Mus musculus)	Hrh1^{1, 5}	6 (49.00 cM)⁵	histamine receptor H1^{1, 5}	80.66(n)¹ 78.4(a)¹	15465¹ NM_008285.3¹ NP_032311.2¹ AB444632⁵ AF387890⁵ (see all 27)

About this table Species with no ortholog for HRH1

ENSEMBL Gene Tree for HRH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HRH1 gene

HRH4² HRH3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/750 NCBI SNPs in HRH1 are shown (see all 750 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs184700^1,2	A,C,F,H	11268061(-)	`tccacG/Accttt`	4	--	int¹ ng5¹		4	EU EA WA	410
	rs346076^1,2	A,C,F,H	11267682(-)	`catgcA/Gagagg`	4	--	int¹ ng5¹		8	EU EA WA	836
	rs1809049^1,2	C,F,H,O	11277884(+)	`CCATCG/ATCTTT`	4	--	ut3¹		13	MN EU EA WA	1442
--	rs12490160^1,2	A,C,F,H	11153165(+)	`CACCTT/CGGGAG`	1	--	ng5¹		8	EU EA WA	840
	rs901865^1,2	C,F,H,O	11275707(-)	`CAGCCG/ACCAGT`	4	--	ut5¹		15	EA NA EU WA	1118
	rs346074^1,2	A,C,F,H	11269310(-)	`gtaatG/Agattt`	4	--	int¹ ng5¹ tfbs³		6	EA WA NA	406
--	rs6778270^1,2	A,C,F,H	11151867(+)	`ACCTGA/GGAACA`	1	--	ng5¹		12	EU EA WA NA	1048
	rs346068^1,2	C,F,H	11277933(+)	`AAAAGG/ACATCC`	4	--	ut3¹		12	MN EU EA WA NA	1164
--	rs13064530^1,2	C,F,H	11240914(+)	`ttccaG/Accaaa`	3	--	int¹ ng5¹		8	EU EA WA	840
	rs346070^1,2	C,F,H	11278874(+)	`TAGCAC/TATGGA`	4	--	ut3¹ ese³		9	EA NA MN EU WA	756

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HapMap Linkage Disequilibrium images for HRH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600167

10/43 Novoseek disease relationships for HRH1 gene (see all 43 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
allergic rhinitis	75.71	12	9664202 (1), 18498711 (1), 8732234 (1), 8753840 (1) (see all 12)
urticaria chronic	75.19	2	8828024 (1), 1685361 (1)
rhinitis allergic perennial	71.45	2	8828024 (1), 12269652 (1)
conjunctivitis allergic	68.75	3	12431041 (1), 17075271 (1)
chronic rhinitis	68.19	1	10879992 (1)
rhinitis allergic seasonal	66.08	3	15160440 (1), 16882083 (1), 9585822 (1)
urticaria	56.62	5	17902729 (1), 14727529 (1), 2083605 (1), 12269652 (1) (see all 5)
rhinitis	55.96	2	9923056 (1), 1972050 (1)
asthma	50.78	9	1976343 (1), 11243501 (1), 15661077 (1), 16484687 (1) (see all 9)
torsades de pointes	42.18	2	10597864 (1), 10597866 (1)

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Genetic Association Database: HRH1
Human Genome Epidemiology Navigator: HRH1 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/302 PubMed articles for HRH1 gene (see all 302 ):

Molecular cloning of the human histamine H1 receptor gene. (PubMed id 8003029)^{2, 3, 4} Fukui K.... Ito S. (1994)
Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor. (PubMed id 8280179)^{1, 3, 4} de Backer M.D.... Luyten W.H.M.L. (1993)
Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. (PubMed id 7925364)^{1, 3, 4} Moguilevsky N.... Bollen A. (1994)
Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. (PubMed id 15953854)^{3, 6} Choi J.H....Park H.S. (2005)
Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. (PubMed id 12429384)^{3, 6} Mancama D....Kerwin R. (2002)
Genetic variant of the histamine-1 receptor (glu349asp) and body weight change during clozapine treatment. (PubMed id 12218662)^{3, 6} Hong C.J....Tsai S.J. (2002)
Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. (PubMed id 11603849)^{1, 3} Brew O.B. and Sullivan M.H. (2001)
Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor. (PubMed id 17547532)^{1, 3} Pochampally R.R....Prockop D.J. (2007)
Down-regulation of histamine H1 receptors by beta2-adrenoceptor-mediated inhibition of H1 receptor gene transcription. (PubMed id 18498711)^{1, 3} Miyoshi K....Fukui H. (2008)
Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. (PubMed id 18446005)^{1, 3} Hishinuma S....Saito M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3269	HGNC: 5182	AceView: HRH1	Ensembl:ENSG00000196639	euGenes: HUgn3269
ECgene: HRH1	H-InvDB: HRH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for HRH1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HRH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HRH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HRH1		Antibodies for HRH1
	Explore super-pooled esiRNAs		Proteins for HRH1
	Lentivirus-delivered shRNAs for HRH1		Small molecules for HRH1
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HRH1 Gene at Home site.
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HRH1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for HRH1

Summaries
for HRH1

Genomic Location
for HRH1

Proteins
for HRH1

Protein Domains/
Families
for HRH1

Gene Function
for HRH1

Pathways & Interactions
for HRH1

Drugs & Compounds
for HRH1

Transcripts
for HRH1

Expression
for HRH1

Orthologs
for HRH1

Paralogs
for HRH1

SNPs/Variants
for HRH1

Disorders & Mutations
for HRH1

Medical News
for HRH1

Publications
for HRH1

Search for HRH1

Genome Databases showing HRH1

Other Databases showing HRH1

Specialized Databases showing HRH1

Licensable Technologies
for HRH1

Services
for HRH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HRH1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor HRH1

Summariesfor HRH1

Genomic Locationfor HRH1

Proteinsfor HRH1

Protein Domains/Familiesfor HRH1

Gene Functionfor HRH1

Pathways & Interactionsfor HRH1

Drugs & Compoundsfor HRH1

Transcriptsfor HRH1

Expression for HRH1

Orthologsfor HRH1

Paralogsfor HRH1

SNPs/Variantsfor HRH1

Disorders & Mutationsfor HRH1

Medical Newsfor HRH1

Publicationsfor HRH1

Search for HRH1

Genome Databases showing HRH1

Other Databases showing HRH1

Specialized Databases showing HRH1

Licensable Technologiesfor HRH1

Servicesfor HRH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HRH1

Summaries
for HRH1

Genomic Location
for HRH1

Proteins
for HRH1

Protein Domains/
Families
for HRH1

Gene Function
for HRH1

Pathways & Interactions
for HRH1

Drugs & Compounds
for HRH1

Transcripts
for HRH1

Expression
for HRH1

Orthologs
for HRH1

Paralogs
for HRH1

SNPs/Variants
for HRH1

Disorders & Mutations
for HRH1

Medical News
for HRH1

Publications
for HRH1

Licensable Technologies
for HRH1

Services
for HRH1