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Aliases for HDAC1 Gene

Aliases for HDAC1 Gene

  • Histone Deacetylase 1 2 3
  • RPD3L1 3 4 6
  • EC 3.5.1.98 4 64
  • HD1 3 4
  • Reduced Potassium Dependency, Yeast Homolog-Like 1 3
  • GON-10 3
  • RPD3 3

External Ids for HDAC1 Gene

Previous Symbols for HDAC1 Gene

  • RPD3L1

Summaries for HDAC1 Gene

Entrez Gene Summary for HDAC1 Gene

  • Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HDAC1 Gene

HDAC1 (Histone Deacetylase 1) is a Protein Coding gene. Diseases associated with HDAC1 include atrichia with papular lesions and chromosome 1p deletion. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is HDAC8.

UniProtKB/Swiss-Prot for HDAC1 Gene

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

Tocris Summary for HDAC1 Gene

  • Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

Gene Wiki entry for HDAC1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HDAC1 Gene

Genomics for HDAC1 Gene

Genomic Location for HDAC1 Gene

Start:
32,292,086 bp from pter
End:
32,333,635 bp from pter
Size:
41,550 bases
Orientation:
Plus strand

Genomic View for HDAC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HDAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HDAC1 Gene

Regulatory Elements for HDAC1 Gene

Transcription factor binding sites by QIAGEN in the HDAC1 gene promoter:

Proteins for HDAC1 Gene

  • Protein details for HDAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13547-HDAC1_HUMAN
    Recommended name:
    Histone deacetylase 1
    Protein Accession:
    Q13547
    Secondary Accessions:
    • Q92534

    Protein attributes for HDAC1 Gene

    Size:
    482 amino acids
    Molecular mass:
    55103 Da
    Quaternary structure:
    • Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Component of a RCOR/GFI/KDM1A/HDAC complex. Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with the non-histone region of H2AFY. Interacts with TRIM28; the interaction recruits HDAC1 to E2F1 and inhibits its acetylation. Interacts with SP1; the interaction deacetylates SP1 and regulates its transcriptional activity. Interacts with SP3; the interaction deacetylates SP3 and regulates its transcriptional activity. In vitro, C(18) ceramides increase this interaction and the subsequent SP3 deacetylation and SP3-mediated repression of the TERT promoter. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with C10orf90/FATS (via its N-terminal); the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21. Interacts with CDK5 complexed to CDK5R1 (p25). Interacts directly with GFI1 and GFI1B. Interacts with NR1D2 (via C-terminus). Interacts with TSC22D3 isoform 1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity. Interacts with BAZ2A/TIP5, BANP, BCL6, BCOR, BHLHE40/DEC1, BRMS1, BRMS1L, CBFA2T3, CHFR, CIART, CRY1, DAXX, DDIT3/CHOP, DDX5, DNMT1, E4F1, EP300, HCFC1, HDAC9, INSM1, NFE4, NR4A2/NURR1, MIER1, KDM4A, KDM5B, KLF1, MINT, NRIP1, PCAF, PHB2, PRDM6, PRDM16, RB1, RERE, SAMSN1, SAP30L, SETDB1, SMAD3, SMARCA4/BRG1, SMYD2, SUV39H1, TGIF, TGIF2, TRAF6, UHRF1, UHRF2, ZMYND15, ZNF431 and ZNF541. Interacts with KDM5A (By similarity). Interacts with DNTTIP1 (PubMed:25653165). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165).

    Three dimensional structures from OCA and Proteopedia for HDAC1 Gene

neXtProt entry for HDAC1 Gene

Proteomics data for HDAC1 Gene at MOPED

Post-translational modifications for HDAC1 Gene

  • Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
  • Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
  • Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys10, Lys66, Lys74, Lys89, Lys126, Lys200, Lys279, and Lys361

Other Protein References for HDAC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for HDAC1 Gene

UniProtKB/Swiss-Prot:

HDAC1_HUMAN
Family:
  • Belongs to the histone deacetylase family. HD type 1 subfamily.:
    • Q13547
genes like me logo Genes that share domains with HDAC1: view

No data available for Gene Families for HDAC1 Gene

Function for HDAC1 Gene

Molecular function for HDAC1 Gene

GENATLAS Biochemistry: histone deacetyltransferase 1,modulator of chromatin structure,involved in repression of gene expression,through interaction with RB1,also downregulating MEF2 activity after being recruited by MITR
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
UniProtKB/Swiss-Prot Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

Enzyme Numbers (IUBMB) for HDAC1 Gene

Gene Ontology (GO) - Molecular Function for HDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0001047 core promoter binding IDA 18974119
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
genes like me logo Genes that share ontologies with HDAC1: view
genes like me logo Genes that share phenotypes with HDAC1: view

Animal Models for HDAC1 Gene

MGI Knock Outs for HDAC1:

No data available for Transcription Factor Targeting and HOMER Transcription for HDAC1 Gene

Localization for HDAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HDAC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HDAC1 Gene COMPARTMENTS Subcellular localization image for HDAC1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 12711221
GO:0000785 chromatin IDA 16731528
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IDA 10846170
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HDAC1: view

Pathways for HDAC1 Gene

SuperPathways for HDAC1 Gene

Superpath Contained pathways
1 Loss of Function of SMAD2/3 in Cancer
2 Signaling by NOTCH1 PEST Domain Mutants in Cancer
3 RNA Polymerase I Promoter Opening
4 Notch signaling pathway (KEGG)
5 Development NOTCH1-mediated pathway for NF-KB activity modulation
genes like me logo Genes that share pathways with HDAC1: view

Gene Ontology (GO) - Biological Process for HDAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IC 16762839
GO:0006351 transcription, DNA-templated TAS --
genes like me logo Genes that share ontologies with HDAC1: view

Compounds for HDAC1 Gene

(29) ApexBio Compounds for HDAC1 Gene

Compound Action Cas Number
AR-42 (OSU-HDAC42) Pan-HDAC inhibitor [935881-37-1]
Belinostat (PXD101) Novel and potent hydroxamate-type HDAC inhibitor [414864-00-9]
CI994 (Tacedinaline) HDAC1 and 3 inhibitor [112522-64-2]
CUDC-101 Multitargeted HDAC inhibitor [1012054-59-9]
CUDC-907 dual PI3K and HDAC inhibitor [1339928-25-4]
Droxinostat Selective HDAC inhibitor [99873-43-5]
Entinostat (MS-275,SNDX-275) Entinostat inhibits HDAC1 and HDAC3 but not HDAC8 [209783-80-2]
ITF2357 (Givinostat) HDAC inhibitor, inhibits class I and class II HDACs [732302-99-7]
JNJ-26481585 Potent pan-HDAC inhibitor [875320-29-9]
LAQ824 (NVP-LAQ824,Dacinostat) Novel and potent HDAC inhibitor [404951-53-7]
M344 Cell-permeable HDAC inhibitor [251456-60-7]
MC1568 Selective class IIa HDAC inhibitor [852475-26-4]
Mocetinostat (MGCD0103, MG0103) Class I selective HDAC inhibitor [726169-73-9]
Panobinostat (LBH589) Broad spectrum HDAC inhibitor, inhibits HDAC1-11 [404950-80-7]
PCI-24781 (CRA-024781) Novel pan-HDAC inhibitor [783355-60-2]
PCI-34051 Potent, specific HDAC8 inhibitor [950762-95-5]
Pracinostat (SB939) Pan-HDAC inhibitor, inhibits all HDAC isozymes except HDAC6 and HDAC7 [929016-96-6]
Resminostat (RAS2410) Potent inhibitor of HDAC classes I and II [864814-88-0]
RG2833 Brain-penetrant HDAC inhibitor [1215493-56-3]
RGFP966 Specific HDAC3 inhibitor [1396841-57-8]
Rocilinostat (ACY-1215) Selective HDAC6 inhibitor [1316214-52-4]
Romidepsin (FK228, depsipeptide) Potent HDAC1 and HDAC2 inhibitor [128517-07-7]
Scriptaid Cell-permeable HDAC inhibitor [287383-59-9]
Trichostatin A (TSA) Cell-permeable, non-competitive, and reversible HDAC inhibitor [58880-19-6]
Tubacin Selective HDAC6 inhibitor [1350555-93-9]
Tubastatin A Potent and selective HDAC6 inhibitor [1252003-15-8]
Tubastatin A HCl Potent and selective HDAC6 inhibitor [1310693-92-5]
Valproic acid sodium salt HDAC inhibitor [1069-66-5]
Vorinostat (SAHA, MK0683) Class I and II HDAC inhibitor [149647-78-9]

(5) Tocris Compounds for HDAC1 Gene

Compound Action Cas Number
LMK 235 Selective HDAC4/HDAC5 inhibitor [1418033-25-6]
Sodium 4-Phenylbutyrate Histone deacetylase inhibitor [1716-12-7]
TCS HDAC6 20b Selective HDAC6 inhibitor [956154-63-5]
Trichostatin A Histone deacetylase inhibitor [58880-19-6]
Tubacin HDAC6 inhibitor; inhibits alpha-tubulin deacetylation [1350555-93-9]

(1) HMDB Compounds for HDAC1 Gene

Compound Synonyms Cas Number PubMed IDs
Butyric acid
  • 1-Butyrate
107-92-6

(1) Drugbank Compounds for HDAC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vorinostat
  • MK0683
149647-78-9 target inhibitor

(35) Novoseek inferred chemical compound relationships for HDAC1 Gene

Compound -log(P) Hits PubMed IDs
9-hydroxystearic acid 85.9 8
trapoxin 80.4 5
suberoylanilide hydroxamic acid 80.3 5
apicidin 69.2 5
butyrate 66.2 7
genes like me logo Genes that share compounds with HDAC1: view

Transcripts for HDAC1 Gene

Unigene Clusters for HDAC1 Gene

Histone deacetylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HDAC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
SP1: - - - - - -
SP2:
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: - -
SP9:

ExUns: 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for HDAC1 Gene

GeneLoc Exon Structure for
HDAC1
ECgene alternative splicing isoforms for
HDAC1

Expression for HDAC1 Gene

mRNA expression in normal human tissues for HDAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HDAC1 Gene

SOURCE GeneReport for Unigene cluster for HDAC1 Gene Hs.88556

mRNA Expression by UniProt/SwissProt for HDAC1 Gene

Q13547-HDAC1_HUMAN
Tissue specificity: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain
genes like me logo Genes that share expressions with HDAC1: view

Orthologs for HDAC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HDAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HDAC1 36
  • 99.45 (n)
  • 99.79 (a)
HDAC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HDAC1 36
  • 93.91 (n)
  • 99.17 (a)
HDAC1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HDAC1 36
  • 94.12 (n)
  • 99.17 (a)
HDAC1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10093 37
  • 99 (a)
OneToMany
Hdac1 36
  • 90.46 (n)
  • 99.38 (a)
Hdac1 16
Hdac1 37
  • 99 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HDAC1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hdac1 36
  • 90.94 (n)
  • 99.17 (a)
chicken
(Gallus gallus)
Aves HDAC1 36
  • 81.45 (n)
  • 93.93 (a)
HDAC1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HDAC1 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hdac1 36
  • 79.18 (n)
  • 93.26 (a)
Str.6529 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
hdac1 37
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006511 36
  • 72.76 (n)
  • 83.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rpd3 36
  • 72.17 (n)
  • 82.11 (a)
Rpd3 37
  • 71 (a)
OneToMany
HDAC3 38
  • 57 (a)
Rpd3 38
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea hda-1 37
  • 64 (a)
ManyToMany
hda-3 36
  • 63.51 (n)
  • 69.47 (a)
hda-3 37
  • 61 (a)
ManyToMany
hda-1 38
  • 64 (a)
hda-2 38
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR395W 36
  • 62.19 (n)
  • 65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPD3 36
  • 60.28 (n)
  • 64.83 (a)
RPD3 37
  • 59 (a)
OneToMany
RPD3 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01981g 36
  • 61.15 (n)
  • 65.35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HD1 36
  • 63.36 (n)
  • 67.62 (a)
corn
(Zea mays)
Liliopsida Zm.13633 36
rice
(Oryza sativa)
Liliopsida Os06g0583400 36
  • 65.37 (n)
  • 69.17 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23826 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00824 36
  • 62.75 (n)
  • 66.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes clr6 36
  • 63.16 (n)
  • 64.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10476 37
  • 83 (a)
OneToMany
Species with no ortholog for HDAC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HDAC1 Gene

ENSEMBL:
Gene Tree for HDAC1 (if available)
TreeFam:
Gene Tree for HDAC1 (if available)

Paralogs for HDAC1 Gene

Paralogs for HDAC1 Gene

Selected SIMAP similar genes for HDAC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HDAC1 Gene

genes like me logo Genes that share paralogs with HDAC1: view

Variants for HDAC1 Gene

Sequence variations from dbSNP and Humsavar for HDAC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs471372 -- 32,318,084(-) tactc(A/G)ggagg intron-variant
rs552686 -- 32,318,937(-) ttcac(C/T)atgtt intron-variant
rs552732 -- 32,318,917(-) ggtct(C/T)aaact intron-variant
rs552733 -- 32,318,916(-) gtctc(A/G)aactc intron-variant
rs690006 -- 32,318,873(-) ccaaa(C/G)tgctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HDAC1 Gene

Variant ID Type Subtype PubMed ID
dgv211n71 CNV Loss 21882294

Relevant External Links for HDAC1 Gene

HapMap Linkage Disequilibrium report
HDAC1

Disorders for HDAC1 Gene

(1) University of Copenhagen DISEASES for HDAC1 Gene

(36) Novoseek inferred disease relationships for HDAC1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 61.8 7
cancer 54.4 33
leukemogenesis 51.4 1
tumors 48.4 37
colon cancer 43.1 6

Relevant External Links for HDAC1

Genetic Association Database (GAD)
HDAC1
Human Genome Epidemiology (HuGE) Navigator
HDAC1
genes like me logo Genes that share disorders with HDAC1: view

No data available for UniProtKB/Swiss-Prot for HDAC1 Gene

Publications for HDAC1 Gene

  1. Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae. (PMID: 8646880) Furukawa Y. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 3 4 23
  2. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. (PMID: 10846170) Cai R.L. … Cohen D. (J. Biol. Chem. 2000) 3 4 23
  3. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. (PMID: 11602581) Pflum M.K.H. … Schreiber S.L. (J. Biol. Chem. 2001) 3 4 23
  4. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. (PMID: 15199155) Cheng J. … Yeh E.T.H. (Mol. Cell. Biol. 2004) 3 4 23
  5. ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. (PMID: 15361834) Unoki M. … Nakamura Y. (Oncogene 2004) 3 4 23

Products for HDAC1 Gene

  • Addgene plasmids for HDAC1

Sources for HDAC1 Gene

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