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GPR17 Gene

protein-coding   GIFtS: 58
GCID: GC02P128403

G Protein-Coupled Receptor 17

  See GPR17-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
G Protein-Coupled Receptor 171 2
R122 3
G-Protein Coupled Receptor 172 3
P2Y-Like Receptor2 3
UDP/CysLT Receptor2 3
Uracil Nucleotide/Cysteinyl Leukotriene Receptor2

External Ids:    HGNC: 44711   Entrez Gene: 28402   Ensembl: ENSG000001442307   OMIM: 6030715   UniProtKB: Q133043   

Export aliases for GPR17 gene to outside databases

Previous GC identifers: GC02P125701 GC02P126328 GC02P128308 GC02P128497 GC02P128119 GC02P120709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for GPR17 Gene:
GPR17 (G protein-coupled receptor 17) is a protein-coding gene. Diseases associated with GPR17 include suppression amblyopia, and amblyopia. GO annotations related to this gene include chemokine receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: GPR17_HUMAN, Q13304
Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through
G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia

Gene Wiki entry for GPR17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the GPR17 gene promoter:
         c-Fos   AP-1   Pax-5   Lmo2   NF-kappaB   HEN1   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidGPR17 promoter sequence
   Search Chromatin IP Primers for GPR17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat GPR17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21

GPR17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
GPR17 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P128403:  view genomic region     (about GC identifiers)

Start:
128,403,439 bp from pter      End:
128,410,213 bp from pter
Size:
6,775 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GPR17_HUMAN, Q13304 (See protein sequence)
Recommended Name: Uracil nucleotide/cysteinyl leukotriene receptor  
Size: 367 amino acids; 40989 Da
Secondary accessions: A8K9L0 B2R9X0 Q8N5S7 Q9UDZ6 Q9UE21
Alternative splicing: 2 isoforms:  Q13304-1   Q13304-2   

Explore the universe of human proteins at neXtProt for GPR17: NX_Q13304

Explore proteomics data for GPR17 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn204, Asn282
  • Modification sites at PhosphoSitePlus

  • See GPR17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001154887.1  NP_001154888.1  NP_001154889.1  NP_005282.1  

    ENSEMBL proteins: 
     ENSP00000272644   ENSP00000387970   ENSP00000376741   ENSP00000442982  
    Reactome Protein details: Q13304

    GPR17 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for GPR17

     
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    antibodies-online proteins for GPR17 (3 products) 

     
    antibodies-online peptides for GPR17

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: GPR17
    Class A Orphans

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q13304

    ProtoNet protein and cluster: Q13304

    1 Blocks protein domain: IPB002286 P2 purinoceptor signature

    UniProtKB/Swiss-Prot: GPR17_HUMAN, Q13304
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with GPR17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GPR17_HUMAN, Q13304
    Function: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through
    G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004950chemokine receptor activity TAS8558062
         
    Find genes that share ontologies with GPR17           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for GPR17:
     Increased circadian period len 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Gpr17):
     behavior/neurological  cardiovascular system  nervous system 

    Find genes that share phenotypes with GPR17           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for GPR17

    miRNA
    Products:
        
    miRTarBase miRNAs that target GPR17:
    hsa-mir-26b-5p (MIRT029794), hsa-mir-335-5p (MIRT018345)

    Block miRNA regulation of human, mouse, rat GPR17 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate GPR17:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidGPR17 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GPR17_HUMAN, Q13304: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8558062
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with GPR17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for GPR17 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Eicosanoid ligand-binding receptors
    Eicosanoid ligand-binding receptors0.31
    Leukotriene receptors0.00
    5Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors
    P2Y receptors0.00


    Find genes that share SuperPaths with GPR17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for GPR17
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    4 Reactome Pathways for GPR17
        P2Y receptors
    Leukotriene receptors
    G alpha (q) signalling events
    G alpha (i) signalling events


        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPR17: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for GPR17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for GPR17 (Q133043 ENSP000002726444) via UniProtKB, MINT, STRING, and/or I2D (see all 247)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNA13Q143443, ENSP000004007174I2D: score=2 STRING: ENSP00000400717
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    APLNRENSP000002572544STRING: ENSP00000257254
    C5AR1ENSP000003471974STRING: ENSP00000347197
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8558062
    GO:0070098chemokine-mediated signaling pathway TAS8558062

    Find genes that share ontologies with GPR17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for GPR17

    1 HMDB Compound for GPR17    About this table
    CompoundSynonyms CAS #PubMed Ids
    Uracil2,4-Dihydroxypyrimidine (see all 8)66-22-8--

    Selected IUPHAR Ligands for GPR17 (GPR17) (see all 11)    About this table
    LigandTypeActionAffinityPubmed IDs
    ASN04885796
    AgonistAgonist9.9621744154
    ASN02563583
    AgonistAgonist9.9621744154
    ASN06917370
    AgonistAgonist9.5721744154
    UDP-glucose
    AgonistAgonist5.92 - 9.5220148890 16990797
    LTC4
    AgonistAgonist7.83 - 9.4816990797
    ASN04450772
    AgonistAgonist8.9321744154
    UDP-galactose
    AgonistAgonist5.96 - 8.9220148890 16990797
    UDP
    AgonistAgonist5.97 - 8.820148890 16990797
    ASN04421891
    AgonistAgonist8.4421744154
    LTD4
    AgonistAgonist8.14 - 8.3616990797



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for GPR17 gene (4 alternative transcripts): 
    NM_001161415.1  NM_001161416.1  NM_001161417.1  NM_005291.2  

    Unigene Cluster for GPR17:

    G protein-coupled receptor 17
    Hs.46453  [show with all ESTs]
    Unigene Representative Sequence: AK126849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496086 ENST00000486700 ENST00000272644 ENST00000423019 ENST00000393018
    ENST00000544369(uc010yzn.2 uc002tpc.3 uc010yzo.2 uc002tpd.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate GPR17:
    hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidGPR17 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat GPR17

    Additional mRNA sequence: 

    AK126849.1 AK292725.1 AK313949.1 BC013202.1 BC031653.1 BC039595.1 JF810891.1 Y12546.1 
    Z94154.1 Z94155.1 

    7 DOTS entries:

    DT.92428447  DT.114539  DT.101985303  DT.121020343  DT.91875438  DT.100024465  DT.454095 

    Selected AceView cDNA sequences (see all 123):

    AA862286 BF530988 AI417819 AA297795 BC013202 BG820495 NM_005291 BG912322 
    AI378784 BF345996 BF345843 AI953187 BG911003 BG818500 BF527616 BF345709 
    AI382504 N63411 AA309544 Y12546 BC039595 Z94154 BF347607 BF528319 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    GPR17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATCGATGT
    GPR17 Expression
    About this image


    GPR17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Pre-myelinating Oligodendrocyte Cells Forebrain White Matter
             Medulla Oblongata
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte Precursor Cells Motor Neural Progenitor Domain
             Spinal Ventral Columns
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
    GPR17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    GPR17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46453

    UniProtKB/Swiss-Prot: GPR17_HUMAN, Q13304
    Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including GPR17: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat GPR17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for GPR17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for GPR17 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gpr171 , 5 G protein-coupled receptor 171, 5 84.37(n)1
    90.27(a)1
      18 (17.89 cM)5
    5744021  NM_001025381.21  NP_001020552.11 
     319429975 
    chicken
    (Gallus gallus)
    Aves GPR171 G protein-coupled receptor 17 74.01(n)
    79.82(a)
      769024  XM_001231869.2  XP_001231870.1 
    lizard
    (Anolis carolinensis)
    Reptilia GPR176
    G protein-coupled receptor 17
    75(a)
    1 ↔ 1
    3(36212139-36221708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia gpr171 G protein-coupled receptor 17 57.72(n)
    53.66(a)
      100491781  XM_004917860.1  XP_004917917.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-194h10.41 si:ch73-194h10.4 59.25(n)
    57.01(a)
      100331841  XM_005165958.1  XP_005166015.1 


    ENSEMBL Gene Tree for GPR17 (if available)
    TreeFam Gene Tree for GPR17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for GPR17 gene
    OXGR12  P2RY42  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for GPR17 using alignment to 3 protein entries:     GPR17_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M18273    CYSLTR1    P2RY1    LPAR4    ACKR3    CYSLTR2
    KPG_011    CCR-5    GPR183    LPAR6    CCR8    GPR18
    AGTR1    CCR2    F2RL1    GPR171    GPR34    OPRK1

    Find genes that share paralogs with GPR17           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for GPR17 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508864CNV Insertion20534489
    nsv517532CNV Loss19592680
    dgv4298n71CNV Loss21882294
    nsv875030CNV Loss21882294
    nsv470482CNV Loss18288195
    dgv4301n71CNV Loss21882294
    nsv518085CNV Loss19592680
    dgv4300n71CNV Loss21882294
    nsv875031CNV Loss21882294
    nsv875015CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603071    OMIM disorders: --

    3 diseases for GPR17:    
    About MalaCards
    suppression amblyopia    amblyopia    spinal cord injury

    1 disease from the University of Copenhagen DISEASES database for GPR17:
    Suppression amblyopia

    Find genes that share disorders with GPR17           About GenesLikeMe


    Export disorders for GPR17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for GPR17 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with GPR17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. New members of the chemokine receptor gene family. (PubMed id 8558062)1, 2, 3 Raport C.J.... Gray P.W. (J. Leukoc. Biol. 1996)
    2. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. (PubMed id 16990797)1, 2 Ciana P.... Abbracchio M.P. (EMBO J. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. (PubMed id 9523551)1, 2 Blaesius R.H.... Ogilvie A. (J. Neurochem. 1998)
    5. Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. (PubMed id 23801362)1 Franke H....Abbracchio M.P. (Purinergic Signal. 2013)
    6. Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. (PubMed id 23908386)1 Qi A.D....Nicholas R.A. (J. Pharmacol. Exp. Ther. 2013)
    7. The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells. (PubMed id 23288840)1 Fratangeli A....Rosa P. (J. Biol. Chem. 2013)
    8. Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands. (PubMed id 21531793)1 Daniele S....Martini C. (J. Pharmacol. Exp. Ther. 2011)
    9. EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors. (PubMed id 21261596)1 NA...Rosenkilde M.M. (Curr Top Med Chem 2011)
    10. Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. (PubMed id 20148890)1 Benned-Jensen T. and Rosenkilde M.M. (Br. J. Pharmacol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2840 HGNC: 4471 AceView: GPR17 Ensembl:ENSG00000144230 euGenes: HUgn2840
    ECgene: GPR17 H-InvDB: GPR17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for GPR17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for GPR17 gene:
    Search GeneIP for patents involving GPR17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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