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Aliases for GPR17 Gene

Aliases for GPR17 Gene

  • G Protein-Coupled Receptor 17 2 3
  • G-Protein Coupled Receptor 17 3 4
  • UDP/CysLT Receptor 3 4
  • P2Y-Like Receptor 3 4
  • R12 3 4

External Ids for GPR17 Gene

Previous GeneCards Identifiers for GPR17 Gene

  • GC02P125701
  • GC02P126328
  • GC02P128308
  • GC02P128497
  • GC02P128119
  • GC02P128403
  • GC02P120709

Summaries for GPR17 Gene

GeneCards Summary for GPR17 Gene

GPR17 (G Protein-Coupled Receptor 17) is a Protein Coding gene. Diseases associated with GPR17 include ureteral benign neoplasm and suppression amblyopia. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for GPR17 Gene

  • Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Wiki entry for GPR17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR17 Gene

Genomics for GPR17 Gene

Regulatory Elements for GPR17 Gene

Genomic Location for GPR17 Gene

Chromosome:
2
Start:
127,645,864 bp from pter
End:
127,652,639 bp from pter
Size:
6,776 bases
Orientation:
Plus strand

Genomic View for GPR17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR17 Gene

Proteins for GPR17 Gene

  • Protein details for GPR17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13304-GPR17_HUMAN
    Recommended name:
    Uracil nucleotide/cysteinyl leukotriene receptor
    Protein Accession:
    Q13304
    Secondary Accessions:
    • A8K9L0
    • B2R9X0
    • Q8N5S7
    • Q9UDZ6
    • Q9UE21

    Protein attributes for GPR17 Gene

    Size:
    367 amino acids
    Molecular mass:
    40989 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR17 Gene

Proteomics data for GPR17 Gene at MOPED

Post-translational modifications for GPR17 Gene

  • Glycosylation at Asn 42, Asn 204, and Asn 282
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR17 Gene

Antibody Products

No data available for DME Specific Peptides for GPR17 Gene

Domains & Families for GPR17 Gene

Gene Families for GPR17 Gene

Protein Domains for GPR17 Gene

Suggested Antigen Peptide Sequences for GPR17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13304

UniProtKB/Swiss-Prot:

GPR17_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR17: view

Function for GPR17 Gene

Molecular function for GPR17 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Gene Ontology (GO) - Molecular Function for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view
genes like me logo Genes that share phenotypes with GPR17: view

Animal Model Products

miRNA for GPR17 Gene

miRTarBase miRNAs that target GPR17

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR17

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR17 Gene

Localization for GPR17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR17 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR17 Gene COMPARTMENTS Subcellular localization image for GPR17 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8558062
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR17: view

Pathways & Interactions for GPR17 Gene

genes like me logo Genes that share pathways with GPR17: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GPR17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0070098 chemokine-mediated signaling pathway TAS 8558062
genes like me logo Genes that share ontologies with GPR17: view

No data available for SIGNOR curated interactions for GPR17 Gene

Drugs & Compounds for GPR17 Gene

(12) Drugs for GPR17 Gene - From: IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uracil Experimental Pharma 0
ASN02563583 Pharma Agonist 0
ASN04421891 Pharma Agonist 0
ASN04450772 Pharma Agonist 0
ASN04885796 Pharma Agonist 0

(1) Additional Compounds for GPR17 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
UDP
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR17: view

Transcripts for GPR17 Gene

Unigene Clusters for GPR17 Gene

G protein-coupled receptor 17:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GPR17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR17 Gene

No ASD Table

Relevant External Links for GPR17 Gene

GeneLoc Exon Structure for
GPR17
ECgene alternative splicing isoforms for
GPR17

Expression for GPR17 Gene

mRNA expression in normal human tissues for GPR17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR17 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for GPR17 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR17 Gene



SOURCE GeneReport for Unigene cluster for GPR17 Gene Hs.46453

mRNA Expression by UniProt/SwissProt for GPR17 Gene

Q13304-GPR17_HUMAN
Tissue specificity: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
genes like me logo Genes that share expression patterns with GPR17: view

Protein tissue co-expression partners for GPR17 Gene

Primer Products

In Situ Assay Products

Orthologs for GPR17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR17 35
  • 87.32 (n)
  • 88.79 (a)
GPR17 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR17 35
  • 90.46 (n)
  • 91.45 (a)
GPR17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr17 35
  • 84.37 (n)
  • 90.27 (a)
Gpr17 16
Gpr17 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR17 35
  • 99.46 (n)
  • 99.46 (a)
GPR17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr17 35
  • 83.78 (n)
  • 89.68 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR17 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR17 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR17 35
  • 74.01 (n)
  • 79.82 (a)
GPR17 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR17 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr17 35
  • 57.72 (n)
  • 53.66 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-194h10.4 35
  • 59.25 (n)
  • 57.01 (a)
GPR17 36
  • 55 (a)
OneToOne
Species with no ortholog for GPR17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR17 Gene

ENSEMBL:
Gene Tree for GPR17 (if available)
TreeFam:
Gene Tree for GPR17 (if available)

Paralogs for GPR17 Gene

genes like me logo Genes that share paralogs with GPR17: view

Variants for GPR17 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR17 Gene

Variant ID Type Subtype PubMed ID
nsv875015 CNV Loss 21882294
dgv4298n71 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv518085 CNV Loss 19592680
nsv508864 CNV Insertion 20534489
nsv470482 CNV Loss 18288195
dgv4300n71 CNV Loss 21882294
nsv875026 CNV Loss 21882294
nsv517532 CNV Loss 19592680
nsv875027 CNV Loss 21882294
nsv875028 CNV Gain 21882294
dgv4301n71 CNV Loss 21882294
nsv875030 CNV Loss 21882294
nsv875031 CNV Loss 21882294

Variation tolerance for GPR17 Gene

Residual Variation Intolerance Score: 90.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR17 Gene

HapMap Linkage Disequilibrium report
GPR17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for GPR17 Gene

Disorders for GPR17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPR17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ureteral benign neoplasm
  • ureteral tumor
suppression amblyopia
  • strabismic amblyopia
- elite association
Search GPR17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GPR17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR17
genes like me logo Genes that share disorders with GPR17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR17 Gene

Publications for GPR17 Gene

  1. The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. (PMID: 19528093) Ceruti S. … Abbracchio M.P. (Brain 2009) 23 67
  2. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. (PMID: 16242142) Banfi C. … Abbracchio M.P. (J. Mol. Cell. Cardiol. 2005) 23 67
  3. New members of the chemokine receptor gene family. (PMID: 8558062) Raport C.J. … Gray P.W. (J. Leukoc. Biol. 1996) 2 67
  4. GPR17 gene disruption does not alter food intake or glucose homeostasis in mice. (PMID: 25624481) Mastaitis J. … Gromada J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 67
  5. Does GRK-I^ arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? (PMID: 24613411) Daniele S. … Martini C. (Cell. Signal. 2014) 67

Products for GPR17 Gene

Sources for GPR17 Gene

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