Aliases for GNMT Gene
External Ids for GNMT Gene
Previous GeneCards Identifiers for GNMT Gene
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
GeneCards Summary for GNMT Gene
GNMT (Glycine N-Methyltransferase) is a Protein Coding gene. Diseases associated with GNMT include glycine n-methyltransferase deficiency and hypermethioninemia due to glycine n-methyltransferase deficiency. Among its related pathways are Glycine, serine and threonine metabolism. GO annotations related to this gene include folic acid binding and glycine N-methyltransferase activity.
UniProtKB/Swiss-Prot for GNMT Gene
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.