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GLRB Gene

protein-coding GIFtS: 69

GC04P158216

glycine receptor, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Descriptions
Glycine receptor 58 kDa subunit ^³
glycine receptor, beta ^²
glycine receptor, beta subunit ^²

External Ids
HGNC: 4329¹
Entrez Gene: 2743²
UniProtKB: P48167³
Ensembl: ENSG00000109738⁷

Search outside databases for aliases for GLRB gene

Previous GC identifers: GC04P158877 GC04P158427 GC04P158574 GC04P158354

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GLRB:

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other

regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM

138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM]

UniProtKB/Swiss-Prot: GLRB_HUMAN, P48167

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its

receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of

neuronal firing)

Gene Wiki entry for GLRB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GLRB gene

Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q31.3

GLRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P158216: (about GC identifiers)

Start:	158,216,788 bp from pter
End:	158,312,304 bp from pter
Size:	95,517 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GLRB_HUMAN, P48167 (See protein sequence)

Recommended Name: Glycine receptor subunit beta precursor

Size: 497 amino acids; 56122 Da

Subunit: Pentamer composed of alpha and beta subunits. Interacts with GPHN (By similarity)

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000815.1

ENSEMBL proteins:

ENSP00000264428

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GLRB)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	NAS	8717357
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

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Antibodies for GLRB:

	Invitrogen Antibodies for GLRB
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GLRB), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for GLRB

Assays for GLRB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P48167

ProtoNet protein and cluster: P48167

3 Blocks protein families:

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

IPB008060 Glycine receptor beta subunit signature

UniProtKB/Swiss-Prot: GLRB_HUMAN, P48167

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLRB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLRB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000824

Applied Biosystems Silencer® siRNAs for GLRB

Sigma-Aldrich siRNA and siRNA Panels for GLRB

Sigma-Aldrich shRNA for GLRB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GLRB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000824
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000824
untagged cDNA clone in CMV expression vector: NM_000824

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000824

UniProtKB/Swiss-Prot: GLRB_HUMAN, P48167

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its

receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of

neuronal firing)

Genatlas biochemistry entry for GLRB:

glycine receptor,beta subunit

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Glrb):

	behavior/neurological	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
homeostasis/metabolism	lethality-postnatal	muscle	nervous system	reproductive system
skeleton

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005515	protein binding	IPI	11929858 15215304
GO:0016594	contributes to glycine binding	IMP	15748848
GO:0016934	contributes to extracellular-glycine-gated chloride channel activity	IDA	8717357

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for GLRB

5/6 Interacting proteins for GLRB (ENSP00000264428³) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPHN	ENSP00000303019³	STRING (score=.968)
ARHGEF9	ENSP00000253401³	STRING (score=.859)
GLRA1	ENSP00000274576³	STRING (score=.816)
GLRA3	ENSP00000274093³	STRING (score=.816)
GLRA2	ENSP00000347123³	STRING (score=.814)

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001964	startle response	IMP	11929858
GO:0006811	ion transport	IDA	8717357
GO:0006821	chloride transport	IEA	--
GO:0007218	neuropeptide signaling pathway	IDA	8717357
GO:0007268	synaptic transmission	IMP	11929858

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for GLRB available from Tocris Bioscience

Compound	Action	CAS number
Strychnine hydrochloride	Competitive glycine receptor antagonist	[1421-86-9]
Hypotaurine	Non-selective endogenous glycine receptor agonist	[300-84-5]
L-Serine	Weak endogenous glycine receptor agonist	[56-45-1]
Glycine	Endogenous potentiator, co-transmitter	[56-40-6]
beta-Alanine	Endogenous glycine agonist, more selective than Taurine (Cat. No. 0209)	[107-95-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLRB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLRB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000824

Sigma-Aldrich siRNA and siRNA Panels for GLRB

Sigma-Aldrich shRNA for GLRB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000824

REFSEQ mRNAs for GLRB gene:

NM_000824.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000824

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000824
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000824
                                 untagged cDNA clone in CMV expression vector: NM_000824

Additional cDNA sequence:

AF094754.1 AF094755.1 AK290617.1 BC022502.1 BC032635.1 U33267.1

6 DOTS entries:

DT.411213 DT.75157112 DT.99938014 DT.91749554 DT.95375567 DT.95251107

24/81 AceView cDNA sequences (see all 81 ):

U33267 BM129318 BI762384 CF265034 AI732779 CD013911 AI300991 BC032635

BF447633 AI734165 AI268011 AA464733 NM_000824 BQ723049 BI552703 AI307336

AA297476 AW189120 AI796407 BI546378 BI913857 BE165514 AW129988 BQ416784

highest scoring ESTs for GLRB:

U33267 AA464024 AA464733 AF094754 AF094755 AI205516 AI268011 AI300991 AI307336 AI701428

Unigene Cluster for GLRB:

Glycine receptor, beta

Hs.32973 [show with all ESTs]

Unigene Representative Sequence: NM_000824

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for GLRB

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c
SP1:					-
SP2:
SP3:																					-
SP4:					-				-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for GLRB

1 Ensembl transcript including schematic representation:

ENST00000264428

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GLRB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GLRB

¹ / ² / ³

8 probe-sets matching GLRB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39665_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.29	U33267	1.00	1.00	1.00	1
52682_at²^{, 3}	U95-C	1	0.69	1.00	0.89	0.76	AI701428	0.80	1.00	0.91	1
244680_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI701428	0.80	1.00	0.91	1
205279_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF094754	0.80	1.00	0.91	1
205280_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_000824	0.60	1.00	0.82	1
244680_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205279_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205280_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks GLRB for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATTTCATTT

SOURCE GeneReport for Unigene cluster: Hs.32973
Expression variation in blood from EXPOLDB for GLRB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GLRB gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GLRB¹	--	glycine receptor, beta	92.56(n) 99.2(a)	475477 XM_532701.2 XP_532701.1
chimpanzee (Pan troglodytes)	GLRB¹	--	glycine receptor, beta	99.6(n) 99.8(a)	461569 XM_517504.2 XP_517504.1
cow (Bos taurus)	GLRB¹	--	glycine receptor, beta	89.81(n) 98.39(a)	281198 NM_174071.2 NP_776496.1
rat (Rattus norvegicus)	Glrb¹	--	glycine receptor, beta	88.37(n) 97.38(a)	25456 NM_053296.1 NP_445748.1
mouse (Mus musculus)	Glrb^{1, 5}	3 (36.00 cM)⁵	glycine receptor, beta subunit^{1, 5}	88.31(n)¹ 96.98(a)¹	14658¹ NM_010298.4¹ NP_034428.2¹ AF016099⁵ AI853901⁵ (see all 18)

About this table Species with no ortholog for GLRB

ENSEMBL Gene Tree for GLRB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/431 NCBI SNPs in GLRB are shown (see all 431 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 151)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1129304^1,2	A,C,F,H,O	158311872(+)	`CAAAAT/AATATT`	1	--	ut3¹		5		MN EU EA WA	602
	rs4690879^1,2	A,C,F,H	158215162(+)	`CCTGGT/CTGCAT`	1	--	ng5¹		4		EU EA WA	412
	rs10517662^1,2	C,F,H	158312511(+)	`ACCACC/TATTTC`	1	--	ut3¹		16		NS EU EA WA NA	1076
--	rs11941419^1,2	A,C	158312370(+)	`ATTAAA/GTAAAT`	1	--	ut3¹		0	--	--	--	--
	rs17035824^1,2	F,H	158312697(+)	`CCATAT/CGTAAT`	1	--	ng3¹		7		NA EU EA WA	536
--	rs6840903^1,2	A,C	158215754(+)	`actctA/Gctagg`	1	--	ng5¹		0	--	--	--	--
	rs6841174^1,2	A,H	158215604(+)	`tgtaaT/Gccccc`	1	--	ng5¹		4		EU EA WA	414
--	rs11937778^1,2	A,C	158215820(+)	`gatgaC/Ttgtgc`	1	--	ng5¹		0	--	--	--	--
--	rs4690878^1,2	A,C	158214959(+)	`TGGCAC/TAGAAA`	1	--	ng5¹		0	--	--	--	--
--	rs4690876^1,2	C	158214798(+)	`TTTCAA/GAATTC`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for GLRB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138492 disorders: 149400

UniProtKB/Swiss-Prot: GLRB_HUMAN, P48167

Defects in GLRB are a cause of startle disease (STHE) [MIM:149400]; also known as

hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous

neurologic disorder characterized by muscular rigidity of central nervous system origin,

particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic

or tactile stimuli. Inheritance can be autosomal dominant or recessive

1 Novoseek disease relationship for GLRB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperekplexia	94.72	11	11929858 (3), 9676428 (1), 12427512 (1), 10651857 (1)

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GeneTests: GLRB

Hyperekplexia

Human Gene Mutation Database: GLRB
Genetic Association Database: GLRB
Human Genome Epidemiology Navigator: GLRB (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/27 PubMed articles for GLRB gene (see all 27 ):

The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism. (PubMed id 9676428)^{1, 2, 3, 4} Milani N.... Becker C.-M. (1998)
The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. (PubMed id 8717357)^{1, 2, 3, 4} Handford C.A....Schofield P.R. (1996)
Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB). (PubMed id 11929858)^{1, 3, 4} Rees M.I.... Owen M.J. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic variation of the human glycine receptor subunit genes GLRA3 and GLRB and susceptibility to idiopathic generalized epilepsies. (PubMed id 11496371)^{3, 6} Sobetzko D....Becker C.M. (2001)
Identification of a gephyrin binding motif on the glycine receptor beta subunit. (PubMed id 7546736)^{1, 3} Meyer G....Langosch D. (1995)
Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)³ GratacA^s M....Carracedo A. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The beta subunit determines the ligand binding properties of synaptic glycine receptors. (PubMed id 15748848)³ Grudzinska J....Laube B. (2005)
The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. (PubMed id 15215304)³ Harvey K.... Harvey R.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2743	HGNC: 4329	AceView: GLRB	Ensembl:ENSG00000109738	euGenes: HUgn2743
ECgene: GLRB	H-InvDB: GLRB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=GLRB

Licensable Technologies for GLRB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GLRB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GLRB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GLRB		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GLRB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for GLRB

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GLRB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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GLRB Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for GLRB

Summaries
for GLRB

Genomic Location
for GLRB

Proteins
for GLRB

Protein Domains/
Families
for GLRB

Gene Function
for GLRB

Pathways & Interactions
for GLRB

Drugs & Compounds
for GLRB

Transcripts
for GLRB

Expression
for GLRB

Orthologs
for GLRB

Paralogs
for GLRB

SNPs/Variants
for GLRB

Disorders & Mutations
for GLRB

Medical News
for GLRB

Publications
for GLRB

Search for GLRB

Genome Databases showing GLRB

Other Databases showing GLRB

Specialized Databases showing GLRB

Licensable Technologies
for GLRB

Services
for GLRB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GLRB Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor GLRB

Summariesfor GLRB

Genomic Locationfor GLRB

Proteinsfor GLRB

Protein Domains/Familiesfor GLRB

Gene Functionfor GLRB

Pathways & Interactionsfor GLRB

Drugs & Compoundsfor GLRB

Transcriptsfor GLRB

Expression for GLRB

Orthologsfor GLRB

Paralogsfor GLRB

SNPs/Variantsfor GLRB

Disorders & Mutationsfor GLRB

Medical Newsfor GLRB

Publicationsfor GLRB

Search for GLRB

Genome Databases showing GLRB

Other Databases showing GLRB

Specialized Databases showing GLRB

Licensable Technologiesfor GLRB

Servicesfor GLRB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GLRB

Summaries
for GLRB

Genomic Location
for GLRB

Proteins
for GLRB

Protein Domains/
Families
for GLRB

Gene Function
for GLRB

Pathways & Interactions
for GLRB

Drugs & Compounds
for GLRB

Transcripts
for GLRB

Expression
for GLRB

Orthologs
for GLRB

Paralogs
for GLRB

SNPs/Variants
for GLRB

Disorders & Mutations
for GLRB

Medical News
for GLRB

Publications
for GLRB

Licensable Technologies
for GLRB

Services
for GLRB