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GLRA1 Gene

protein-coding GIFtS: 66

GC05M151182

glycine receptor, alpha 1
(Previous names: glycine receptor, alpha 1 (startle disease/hyperekplexia) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: STHE)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC138878 ^²
MGC138879 ^²
OTTHUMP00000160616 ^²
STHE ^², ⁵

Descriptions
Glycine receptor 48 kDa subunit ^³
Glycine receptor strychnine-binding subunit ^³
glycine receptor, alpha 1 ^²
glycine receptor, alpha 1 (startle disease/hyperekplexia) ^¹

External Ids
HGNC: 4326¹
Entrez Gene: 2741²
UniProtKB: P23415³
Ensembl: ENSG00000145888⁷

Search outside databases for aliases for GLRA1 gene

Previous GC identifers: GC05M151270 GC05M151799 GC05M151230

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GLRA1:

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The

receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are

a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital

stiff-person syndrome. Two transcript variants encoding different isoforms have been found for

this gene.

UniProtKB/Swiss-Prot: GLRA1_HUMAN, P23415

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its

receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of

neuronal firing)

Gene Wiki entry for GLRA1 (Glycine_receptor%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GLRA1 gene

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q33

GLRA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M151182: (about GC identifiers)

Start:	151,182,361 bp from pter
End:	151,284,596 bp from pter
Size:	102,236 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GLRA1_HUMAN, P23415 (See protein sequence)

Recommended Name: Glycine receptor subunit alpha-1 precursor

Size: 457 amino acids; 52624 Da

Subunit: Pentamer composed of alpha and beta subunits

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Miscellaneous: The alpha subunit binds strychnine

PDB structure from and Proteopedia :

1MOT (3D)

1VRY (3D)

Secondary accessions: Q14C77 Q6DJV9

Alternative splicing: 2 isoforms: P23415-1 P23415-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000162.2 NP_001139512.1

ENSEMBL proteins:

ENSP00000274576

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant GLRA1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 1 Glycine Receptor, Glycine Receptor alpha 1 + alpha 2)
	Human Recombinant Proteins from Abnova (GLRA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	NAS	2155780

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Antibodies for GLRA1:

	Invitrogen Antibodies for GLRA1
	Millipore Mono- and Polyclonal Antibodies for the study of GLRA1
	Sigma-Aldrich Antibodies for GLRA1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (alpha 1 Glycine Receptor, Glycine Receptor alpha 1 + alpha 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for GLRA1

Assays for GLRA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P23415

ProtoNet protein and cluster: P23415

3 Blocks protein families:

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

IPB008128 Glycine receptor alpha 1 subunit signature

UniProtKB/Swiss-Prot: GLRA1_HUMAN, P23415

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLRA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLRA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000171

Applied Biosystems Silencer® siRNAs for GLRA1

Sigma-Aldrich siRNA and siRNA Panels for GLRA1

Sigma-Aldrich shRNA Panels and shRNA for GLRA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GLRA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000171
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000171
untagged cDNA clones in CMV expression vector (see all 2): NM_000171

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000171

UniProtKB/Swiss-Prot: GLRA1_HUMAN, P23415

Function: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its

receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of

neuronal firing)

Genatlas biochemistry entry for GLRA1:

glycine receptor,alpha 1 subunit,inhibitory

13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Glra1):

adipose tissue	behavior/neurological	growth/size	hearing/vestibular/ear	hematopoietic system
immune system	lethality-postnatal	life span-post-weaning/aging	muscle	nervous system
reproductive system	respiratory system	vision/eye

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005515	protein binding	IPI	11929858
GO:0016594	glycine binding	IDA	2155780 15748848

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Interacting proteins for GLRA1 (ENSP00000274576³) via UniProtKB, MINT, and/or STRING (see all 7 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPHN	ENSP00000303019³	STRING (score=.905)
ARHGEF9	ENSP00000253401³	STRING (score=.822)
GLRB	ENSP00000264428³	STRING (score=.816)
GLRA2	ENSP00000347123³	STRING (score=.805)
GLRA3	ENSP00000274093³	STRING (score=.804)

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001508	regulation of action potential	IEA	--
GO:0001964	startle response	IMP	8298642 11973623
GO:0002087	regulation of respiratory gaseous exchange by neurological process	IEA	--
GO:0006820	anion transport	IEA	--
GO:0006821	chloride transport	IDA	8137830

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for GLRA1:

Ligand

Compounds for GLRA1 available from Tocris Bioscience

Compound	Action	CAS number
Strychnine hydrochloride	Competitive glycine receptor antagonist	[1421-86-9]
Hypotaurine	Non-selective endogenous glycine receptor agonist	[300-84-5]
L-Serine	Weak endogenous glycine receptor agonist	[56-45-1]
Glycine	Endogenous potentiator, co-transmitter	[56-40-6]
beta-Alanine	Endogenous glycine agonist, more selective than Taurine (Cat. No. 0209)	[107-95-9]

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1 Novoseek chemical compound relationship for GLRA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
picrotoxin	37.87	1	11744711 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GLRA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GLRA1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000171

Sigma-Aldrich siRNA and siRNA Panels for GLRA1

Sigma-Aldrich shRNA Panels and shRNA for GLRA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000171

REFSEQ mRNAs for GLRA1 gene (2 alternative transcripts):

NM_000171.3 NM_001146040.1

NM_000171

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000171
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000171
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000171

Additional cDNA sequence:

AK308539.1 AK312702.1 BC074980.2 BC114947.1 X52009.1

2 DOTS entries:

DT.92014914 DT.120823005

3 AceView cDNA sequences:

BC074980 NM_000171 X52009

highest scoring ESTs for GLRA1:

X52009 NM_000171 BC074980 AA355139 BE926355 BP418791 CV309719 H54901 AK226046 BC114947

Unigene Cluster for GLRA1:

Glycine receptor, alpha 1

Hs.121490 [show with all ESTs]

Unigene Representative Sequence: NM_000171

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for GLRA1

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9
SP1:
SP2:			-

About this scheme

ECgene alternative splicing isoforms for GLRA1

1 Ensembl transcript including schematic representation:

ENST00000274576

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GLRA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GLRA1

¹ / ² / ³

3 probe-sets matching GLRA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31310_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X52009	1.00	0.90	0.95	1
207972_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000171	0.60	1.00	0.82	1
207972_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.121490
Expression variation in blood from EXPOLDB for GLRA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GLRA1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GLRA1¹	--	glycine receptor, alpha 1	93.24(n) 99.78(a)	489172 XM_546290.2 XP_546290.2
chimpanzee (Pan troglodytes)	GLRA1¹	--	glycine receptor, alpha 1	99.85(n) 100(a)	471712 XM_001169235.1 XP_001169235.1
cow (Bos taurus)	GLRA1¹	--	glycine receptor, alpha 1	92.06(n) 99.78(a)	281783 NM_174321.2 NP_776746.1
rat (Rattus norvegicus)	Glra1¹	--	glycine receptor, alpha 1	90.27(n) 98.44(a)	25674 NM_013133.1 NP_037265.1
mouse (Mus musculus)	Glra1^{1, 5}	11 (30.00 cM)⁵	glycine receptor, alpha 1 subunit^{1, 5}	90.79(n)¹ 98.89(a)¹	14654¹ NM_020492.3¹ NP_065238.2¹ AK045685⁵ AK046482⁵ (see all 21)

About this table Species with no ortholog for GLRA1

ENSEMBL Gene Tree for GLRA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GLRA1 gene

GLRA2² GLRA4² GLRA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/488 NCBI SNPs in GLRA1 are shown (see all 488 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 178)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2071220^1,2	A,C,F,H	151284953(-)	`GGACCA/GGGAAA`	1	--	ng3¹		9		EA EU WA	2126
	rs2071221^1,2	A,C,F,H	151284499(-)	`CCTCGT/CAGCCG`	1	--	ut5¹ ese³		5		EA EU WA	1876
--	rs7710098^1,2	A,C	151286321(+)	`TACAAA/TAGCAT`	1	--	ng3¹		0	--	--	--	--
--	rs6579913^1,2	C	151286248(+)	`AAGCAA/GAAAGG`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs919262^1,2	A,C,F,H,O	151246277(-)	`AAAATA/GGCCAA`	1	--	int¹		15		EA NA EU WA	2524
	rs919263^1,2	A,C,F,H,O	151246046(-)	`GTAAAA/GAAGTT`	1	--	int¹		11		EU EA WA NA	972
	rs2915890^1,2	A,C,F,H,O	151184851(-)	`tAGGTG/AGCACA`	1	--	int¹		7		EU EA WA NA	526
	rs2915888^1,2	A,C,F,H,O	151185293(-)	`TTCCAA/GTAAGA`	1	--	int¹		16		EA NA EU WA	1474
	rs2913889^1,2	A,C,F,H,O	151236096(+)	`TTTGAG/ACATGG`	1	--	int¹		7		NA EU EA WA	538
	rs2915885^1,2	A,C,F,H,O	151187261(-)	`ATCAGA/GGGATG`	1	--	int¹		7		NA EU EA WA	558

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HapMap Linkage Disequilibrium images for GLRA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 138491

UniProtKB/Swiss-Prot: GLRA1_HUMAN, P23415

Defects in GLRA1 are a cause of startle disease (STHE) [MIM:149400]; also known as

hereditary hyperekplexia or congenital stiff-person syndrome. STHE is a genetically heterogeneous

neurologic disorder characterized by muscular rigidity of central nervous system origin,

particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic

or tactile stimuli. Inheritance can be autosomal dominant or recessive

2 Novoseek disease relationships for GLRA1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperekplexia	98.59	65	8651283 (3), 10514101 (3), 7611730 (3), 14580232 (3) (see all 35)
neurological disorders	60.29	4	7620586 (1), 12359314 (1), 11781706 (1), 7925268 (1)

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GeneTests: GLRA1

Hyperekplexia

Human Gene Mutation Database: GLRA1
Human Genome Epidemiology Navigator: GLRA1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/120 PubMed articles for GLRA1 gene (see all 120 ):

Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. (PubMed id 8298642)^{1, 2, 3, 4} Shiang R....Wasmuth J.J. (1993)
Mutational analysis of familial and sporadic hyperekplexia. (PubMed id 7611730)^{1, 3, 4} Shiang R.... Wasmuth J.J. (1995)
Hyperekplexia phenotype due to compound heterozygosity for GLRA1 gene mutations. (PubMed id 10514101)^{1, 3, 4} Vergouwe M.N.... Frants R.R. (1999)
Novel GLRA1 missense mutation (P250T) in dominant hyperekplexia defines an intracellular determinant of glycine receptor channel gating. (PubMed id 9920650)^{1, 3, 4} Saul B....Becker C.-M. (1999)
Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis. (PubMed id 8733061)^{1, 3, 4} Elmslie F.V.... Rees M. (1996)
A novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexia. (PubMed id 8571969)^{1, 3, 4} Milani N.... Larizza L. (1996)
Startle disease, or hyperekplexia: response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis. (PubMed id 1355335)^{1, 2, 3} Ryan S.G....Mackey R.W. (1992)
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. (PubMed id 7925268)^{1, 3, 4} Langosch D....Betz H. (1994)
Structure and dynamics of the second and third transmembrane domains of human glycine receptor. (PubMed id 15952785)^{3, 4} Ma D.... Xu Y. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2741	HGNC: 4326	AceView: GLRA1	Ensembl:ENSG00000145888	euGenes: HUgn2741
ECgene: GLRA1	H-InvDB: GLRA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=GLRA1

Licensable Technologies for GLRA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GLRA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GLRA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GLRA1		Antibodies for GLRA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GLRA1		Small molecules for GLRA1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GLRA1)
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	Recombinant Proteins (alpha 1 Glycine Receptor, Glycine Receptor alpha 1 + alpha 2)
	Antibodies (alpha 1 Glycine Receptor, Glycine Receptor alpha 1 + alpha 2)

Search OriGene for GLRA1

Tocris compounds for GLRA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GLRA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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GLRA1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GLRA1

Summaries
for GLRA1

Genomic Location
for GLRA1

Proteins
for GLRA1

Protein Domains/
Families
for GLRA1

Gene Function
for GLRA1

Pathways & Interactions
for GLRA1

Drugs & Compounds
for GLRA1

Transcripts
for GLRA1

Expression
for GLRA1

Orthologs
for GLRA1

Paralogs
for GLRA1

SNPs/Variants
for GLRA1

Disorders & Mutations
for GLRA1

Medical News
for GLRA1

Publications
for GLRA1

Search for GLRA1

Genome Databases showing GLRA1

Other Databases showing GLRA1

Specialized Databases showing GLRA1

Licensable Technologies
for GLRA1

Services
for GLRA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GLRA1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GLRA1

Summariesfor GLRA1

Genomic Locationfor GLRA1

Proteinsfor GLRA1

Protein Domains/Familiesfor GLRA1

Gene Functionfor GLRA1

Pathways & Interactionsfor GLRA1

Drugs & Compoundsfor GLRA1

Transcriptsfor GLRA1

Expression for GLRA1

Orthologsfor GLRA1

Paralogsfor GLRA1

SNPs/Variantsfor GLRA1

Disorders & Mutationsfor GLRA1

Medical Newsfor GLRA1

Publicationsfor GLRA1

Search for GLRA1

Genome Databases showing GLRA1

Other Databases showing GLRA1

Specialized Databases showing GLRA1

Licensable Technologiesfor GLRA1

Servicesfor GLRA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GLRA1

Summaries
for GLRA1

Genomic Location
for GLRA1

Proteins
for GLRA1

Protein Domains/
Families
for GLRA1

Gene Function
for GLRA1

Pathways & Interactions
for GLRA1

Drugs & Compounds
for GLRA1

Transcripts
for GLRA1

Expression
for GLRA1

Orthologs
for GLRA1

Paralogs
for GLRA1

SNPs/Variants
for GLRA1

Disorders & Mutations
for GLRA1

Medical News
for GLRA1

Publications
for GLRA1

Licensable Technologies
for GLRA1

Services
for GLRA1