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C8orf37 Gene

protein-coding GIFtS: 37

GC08M096327

chromosome 8 open reading frame 37
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ30600 ^¹, ²

Descriptions
chromosome 8 open reading frame 37 ^²
hypothetical protein LOC157657 ^²

External Ids
HGNC: 27232¹
Entrez Gene: 157657²
UniProtKB: Q96NL8³
Ensembl: ENSG00000156172⁷

Search outside databases for aliases for C8orf37 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the C8orf37 gene

Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1

C8orf37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M096327: (about GC identifiers)

Start:	96,326,324 bp from pter
End:	96,350,613 bp from pter
Size:	24,290 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CH037_HUMAN, Q96NL8 (See protein sequence)

Recommended Name: Uncharacterized protein C8orf37

Size: 207 amino acids; 23381 Da

REFSEQ proteins: NP_808880.1

ENSEMBL proteins:

ENSP00000286688

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for C8orf37:

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	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for C8orf37
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for C8orf37

Assays for C8orf37:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96NL8

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C8orf37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177965

Applied Biosystems Silencer® siRNAs for C8orf37

Sigma-Aldrich siRNA for C8orf37

Sigma-Aldrich shRNA for C8orf37

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_177965
Myc/DDK tagged cDNA clone in CMV expression vector: NM_177965
untagged cDNA clone in CMV expression vector: NM_177965

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_177965

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for C8orf37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (C8orf37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177965

Sigma-Aldrich siRNA for C8orf37

Sigma-Aldrich shRNA for C8orf37

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_177965

REFSEQ mRNAs for C8orf37 gene:

NM_177965.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_177965

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_177965
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_177965
                                 untagged cDNA clone in CMV expression vector: NM_177965

Additional cDNA sequence:

AK055162.1 BC036855.2 BC150301.1

4 DOTS entries:

DT.40127304 DT.100748146 DT.97809873 DT.102821088

23 AceView cDNA sequences:

AA972183 BX089757 BC036855 AA018056 BX100102 BE220870 BM543014 AK055162

AA782091 AI911357 AL134492 BI088674 NM_177965 N92755 AI885321 BU679782

AA399492 BE670614 AI142618 AI473651 AA897574 AA018237 R93855

highest scoring ESTs for C8orf37:

AA018237 AI885321 AK055162 BC036855 BM543014 R93855 AA972183 AI911357 BE220870 BE670614

Unigene Cluster for C8orf37:

Chromosome 8 open reading frame 37

Hs.548157 [show with all ESTs]

Unigene Representative Sequence: BC150301

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000286688

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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C8orf37 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for C8orf37

¹ / ² / ³

4 probe-sets matching C8orf37 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
77322_at²^{, 3}	U95-D	1	1.00	1.00	0.73	0.89	AI885321	0.80	1.00	0.91	1
53299_r_at²^{, 3}	U95-C	1	1.00	1.00	0.76	1.14	N92755	0.60	1.00	0.82	1
244569_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N92755	0.60	1.00	0.82	1
244569_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTATTGGCA

SOURCE GeneReport for Unigene cluster: Hs.548157

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C8orf37 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC611815¹	--	hypothetical protein LOC611815	81.7(n) 75.72(a)	611815 XM_849528.1 XP_854621.1
chimpanzee (Pan troglodytes)	LOC739460¹	--	hypothetical protein LOC739460	99.36(n) 99.52(a)	739460 XM_001144875.1 XP_001144875.1
cow (Bos taurus)	LOC614744¹	--	similar to Uncharacterized protein C8orf37 homolog	87.76(n) 81.64(a)	614744 XM_866332.2 XP_871425.1
rat (Rattus norvegicus)	MGC94199¹	--	similar to RIKEN cDNA 2610301B20; EST AI428449	85.19(n) 80.19(a)	362483 NM_001007746.1 NP_001007747.1
mouse (Mus musculus)	2610301B20Rik^{1, 5}	4⁵	RIKEN cDNA 2610301B20 gene^{1, 5}	85.02(n)¹ 78.26(a)¹	67157¹ NM_026005.2¹ NP_080281.2¹ AI428449⁵ AI840411⁵ (see all 13)

About this table Species with no ortholog for C8orf37

ENSEMBL Gene Tree for C8orf37

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/153 NCBI SNPs in C8orf37 are shown (see all 153 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 78)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2452476^1,2	A,C,F,H	96351716(-)	`CTATGG/CACAGT`	1	--	ng3¹		12		EU EA WA	1256
	rs2452475^1,2	A,C,F,H	96351897(-)	`tatcaG/Ctgggt`	1	--	ng3¹		8		EU EA WA	836
	rs2514557^1,2	A,C,F,H	96352337(+)	`CTCTAG/TTTATT`	1	--	ng3¹ tfbs³		12		EU EA WA NA	1196
	rs10956944^1,2	C,F,H	96352102(+)	`ctttcC/Tattca`	1	--	ng3¹		12		EU EA WA	1254
	rs36096184^1,2	C,F	96350539(+)	`GTCAGG/CTGTGC`	1	A/P	mis¹		5		NA EU EA WA	490
	rs9297955^1,2	A,C	96352563(+)	`CATGTA/GTTACC`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs13270004^1,2	A,C,F,H	96342431(+)	`AATGTG/TCAAGG`	1	--	int¹		8		EU EA WA	836
	rs7844993^1,2	A,C,F,H	96337465(+)	`TGTGAT/CAGGAG`	1	--	int¹		12		EA NA EU WA	1052
	rs2165498^1,2	A,C,F,H	96333085(-)	`AAGGAC/TATGtt`	1	--	int¹		4		EU EA WA	414
	rs7815255^1,2	A,C,F,H	96344479(+)	`ATAGAA/GTAGGA`	1	--	int¹		19		EU EA WA NA	1760

About this table

HapMap Linkage Disequilibrium images for C8orf37 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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2 PubMed articles for C8orf37 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 157657	HGNC: 27232	AceView: LOC157657	Ensembl:ENSG00000156172	euGenes: HUgn157657
ECgene: C8orf37	H-InvDB: C8orf37

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for C8orf37
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for C8orf37:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for C8orf37-related products

	Millipore Custom Antibody & Bulk Services
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C8orf37 Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for C8orf37

Summaries
for C8orf37

Genomic Location
for C8orf37

Proteins
for C8orf37

Protein Domains/
Families
for C8orf37

Gene Function
for C8orf37

Pathways & Interactions
for C8orf37

Drugs & Compounds
for C8orf37

Transcripts
for C8orf37

Expression
for C8orf37

Orthologs
for C8orf37

Paralogs
for C8orf37

SNPs/Variants
for C8orf37

Disorders & Mutations
for C8orf37

Medical News
for C8orf37

Publications
for C8orf37

Search for C8orf37

Genome Databases showing C8orf37

Other Databases showing C8orf37

Specialized Databases showing C8orf37

Licensable Technologies
for C8orf37

Services
for C8orf37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

C8orf37 Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor C8orf37

Summariesfor C8orf37

Genomic Locationfor C8orf37

Proteinsfor C8orf37

Protein Domains/Familiesfor C8orf37

Gene Functionfor C8orf37

Pathways & Interactionsfor C8orf37

Drugs & Compoundsfor C8orf37

Transcriptsfor C8orf37

Expression for C8orf37

Orthologsfor C8orf37

Paralogsfor C8orf37

SNPs/Variantsfor C8orf37

Disorders & Mutationsfor C8orf37

Medical Newsfor C8orf37

Publicationsfor C8orf37

Search for C8orf37

Genome Databases showing C8orf37

Other Databases showing C8orf37

Specialized Databases showing C8orf37

Licensable Technologiesfor C8orf37

Servicesfor C8orf37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for C8orf37

Summaries
for C8orf37

Genomic Location
for C8orf37

Proteins
for C8orf37

Protein Domains/
Families
for C8orf37

Gene Function
for C8orf37

Pathways & Interactions
for C8orf37

Drugs & Compounds
for C8orf37

Transcripts
for C8orf37

Expression
for C8orf37

Orthologs
for C8orf37

Paralogs
for C8orf37

SNPs/Variants
for C8orf37

Disorders & Mutations
for C8orf37

Medical News
for C8orf37

Publications
for C8orf37

Licensable Technologies
for C8orf37

Services
for C8orf37