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GATM Gene

protein-coding GIFtS: 59

GC15M043440

glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AGAT ^¹, ², ³, ⁵
AT ^², ³
EC 2.1.4.1 ^³
Transamidinase ^³
transamidinase ^²

Descriptions
L-arginine:glycine amidinotransferase ^², ³
glycine amidinotransferase (L-arginine:glycine amidinotransferase) ^²

External Ids
HGNC: 4175¹
Entrez Gene: 2628²
UniProtKB: P50440³
Ensembl: ENSG00000171766⁷

Search outside databases for aliases for GATM gene

Previous GC identifers: GC15M041211 GC15M038700 GC15M043232 GC15M043369

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GATM:

This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme

is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from

L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine.

Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of

creatine synthesis characterized by mental retardation, language impairment, and behavioral

disorders. [provided by RefSeq]

Gene Wiki entry for GATM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GATM gene

Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.1 HGNC cytogenetic band: 15q15.1

GATM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M043440: (about GC identifiers)

Start:	43,440,614 bp from pter
End:	43,458,272 bp from pter
Size:	17,659 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GATM_HUMAN, P50440 (See protein sequence)

Recommended Name: Glycine amidinotransferase, mitochondrial precursor

Size: 423 amino acids; 48455 Da

Subunit: Homodimer. There is an equilibrium between the monomeric and dimeric forms, shifted

towards the side of the monomer

Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side

(Potential). Cytoplasm. Note=The mitochondrial form is found in the intermembrane space probably

attached to the outer side of the inner membrane

PDB structures from and Proteopedia :

1JDW (3D)

1JDX (3D)

2JDW (3D)

2JDX (3D)

3JDW (3D)

4JDW (3D)

5JDW (3D)

6JDW (3D)

7JDW (3D)

8JDW (3D)

9JDW (3D)

Secondary accessions: Q53EQ4

Alternative splicing: 2 isoforms: P50440-1 P50440-2

REFSEQ proteins: NP_001473.1

ENSEMBL proteins:

ENSP00000303263 ENSP00000379895

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GATM)
	Human Recombinant Proteins from Abnova (GATM)

OriGene Purified Recombinant Human Protein: GATM

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005743	mitochondrial inner membrane	IEA	--
GO:0005758	mitochondrial intermembrane space	IDA	9218780
GO:0016020	membrane	IEA	--

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Antibodies for GATM:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for GATM
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (GATM), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GATM)
	Novus Biologicals Antibodies for GATM

Assays for GATM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50440

ProtoNet protein and cluster: P50440

1 Blocks protein family: IPB003198 Amidinotransferase

UniProtKB/Swiss-Prot: GATM_HUMAN, P50440

Domain: One chain folds into a compact single domain composed of repeating units, five

beta-beta-alpha-beta modules, which surround the central active site

Similarity: Belongs to the amidinotransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001482

Applied Biosystems Silencer® siRNAs for GATM

Sigma-Aldrich siRNA and siRNA Panels for GATM

Sigma-Aldrich shRNA for GATM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GATM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001482
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001482
untagged cDNA clone in CMV expression vector: NM_001482

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001482

UniProtKB/Swiss-Prot: GATM_HUMAN, P50440

Catalytic activity: L-arginine + glycine = L-ornithine + guanidinoacetate

Enzyme Number (IUBMB): EC 2.1.4.1

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015068	glycine amidinotransferase activity	IDA	9218780
GO:0016740	transferase activity	IEA	--
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for GATM (Your Favorite Gene powered by Ingenuity)

Glycine, Serine and Threonine Metabolism
Urea Cycle and Metabolism of Amino Groups
Arginine and Proline Metabolism

GeneDecks GATM for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: GATM_HUMAN, P50440

Pathway: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and

glycine: step 1/2

5/58 Interacting proteins for GATM (ENSP00000303263³) via UniProtKB, MINT, and/or STRING (see all 58 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GAMT	ENSP00000252288³	STRING (score=.99)
AGXT	ENSP00000302620³	STRING (score=.919)
AGXT2	ENSP00000231420³	STRING (score=.899)
ALAS1	ENSP00000309259³	STRING (score=.899)
ALAS2	ENSP00000332369³	STRING (score=.899)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006601	creatine biosynthetic process	IDA	9218780
GO:0006979	response to oxidative stress	IEA	--
GO:0007584	response to nutrient	IEA	--
GO:0009790	embryonic development	IEA	--
GO:0010033	response to organic substance	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GATM
4 Novoseek chemical compound relationships for GATM gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanidinoacetate	96.94	67	12324495 (6), 17928413 (3), 12597058 (2), 12701824 (2) (see all 23)
ornithine	56.53	4	17928413 (1), 9915841 (1)
atp	2.31	2	8720293 (1), 16343079 (1)
nitric oxide	0.00	2	15465778 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATM)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001482

Sigma-Aldrich siRNA and siRNA Panels for GATM

Sigma-Aldrich shRNA for GATM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001482

REFSEQ mRNAs for GATM gene:

NM_001482.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001482

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001482
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001482
                                 untagged cDNA clone in CMV expression vector: NM_001482

Additional cDNA sequence:

AK056979.1 AK098393.1 AK223585.1 AK294995.1 AK298350.1 BC004141.2 CR601436.1 CR622786.1

S68805.1 X65706.1

20 DOTS entries:

DT.101974230 DT.40293240 DT.451607 DT.100807698 DT.95196170 DT.100807689 DT.100807693 DT.100658771

DT.92453964 DT.91657024 DT.92453949 DT.102843044 DT.92453963 DT.95196169 DT.100682772 DT.100807691

DT.92453959 DT.95196173 DT.95358893 DT.100716325

24/368 AceView cDNA sequences (see all 368 ):

BP348504 BQ934423 BM826468 AI241106 BM663495 AV649899 BM766875 AV654903

BG428961 CR622786 AV646315 AV648741 CB055285 BM853138 F04111 AV654480

AV649811 AV662110 AV649851 AI985520 BG719271 F07852 AV654085 AV662107

highest scoring ESTs for GATM:

S68805 AA442452 AI223328 AK098055 AK098393 AU099726 AU118598 AV645621 AV648741 AV648826

Unigene Cluster for GATM:

Glycine amidinotransferase (L-arginine:glycine amidinotransferase)

Hs.75335 [show with all ESTs]

Unigene Representative Sequence: NM_001482

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for GATM (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b
SP1:							-		-				-		-																						-
SP2:													-		-																						-
SP3:																									-
SP4:
SP5:							-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for GATM

2 Ensembl transcripts including schematic representations:

ENST00000305575 ENST00000396659

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GATM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GATM

¹ / ² / ³

6 probe-sets matching GATM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36596_r_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.07	S68805	1.00	1.00	1.00	1
36595_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.94	S68805	1.00	1.00	1.00	1
216733_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X86401	0.60	1.00	0.82	1
203178_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001482	0.60	1.00	0.82	1
216733_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203178_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GATM for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.75335
Expression variation in blood from EXPOLDB for GATM
UniProtKB/Swiss-Prot: GATM_HUMAN, P50440
Tissue specificity: Kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GATM gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GATM¹	--	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	93.85(n) 96.45(a)	414733 XM_544663.2 XP_544663.2
chimpanzee (Pan troglodytes)	GATM¹	--	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	99.61(n) 99.76(a)	453401 XM_001163621.1 XP_001163621.1
cow (Bos taurus)	GATM¹	--	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	92.43(n) 94.09(a)	414732 NM_001045878.1 NP_001039343.1
rat (Rattus norvegicus)	Gatm¹	--	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	89.51(n) 92.59(a)	81660 XM_575224.1 XP_575224.1
mouse (Mus musculus)	Gatm^{1, 5}	2 (69.00 cM)⁵	glycine amidinotransferase (L-arginine:glycine amidinotransferase)^{1, 5}	90.86(n)¹ 95.74(a)¹	67092¹ NM_025961.3¹ NP_080237.1¹ AI314789⁵ AI844626⁵ (see all 19)

About this table Species with no ortholog for GATM

ENSEMBL Gene Tree for GATM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/118 NCBI SNPs in GATM are shown (see all 118 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1049508^1,2	A,C,F,H,O	43440884(+)	`GAGAGG/AAAAAG`	1	--	ut3¹ trp³		8		MN NA EU EA WA	744
	rs7164602^1,2	A,C,F,H	43458617(+)	`GCCATG/ATGCCC`	1	--	ng3¹ tfbs³		8		EU EA WA MN	1144
	rs1288775^1,2	C,F,H,O	43448970(+)	`CCTCCA/TTGCTT`	1	Q/H	mis¹ ese³		17		MN NA EA EU WA	2854
	rs1049518^1,2	A,C,F,H	43440659(-)	`GATACT/CGTATG`	1	--	ut3¹		7		EU EA WA NA	552
	rs4395020^1,2	A,C,F,H	43440181(+)	`ATCCAC/AACAAC`	1	--	ng5¹		6		EA WA NA	414
--	rs8024550^1,2	A,C	43457973(+)	`GCGGAA/CTGTTC`	1	--	ut5¹		0	--	--	--	--
--	rs4534782^1,2	A,C	43440225(+)	`TGTAGA/GACTAA`	1	--	ng5¹		0	--	--	--	--
	rs1049503^1,2	C,F	43440999(-)	`CATCAA/GAGTGA`	1	--	ut3¹		4		MN NA	326
--	rs4625670^1,2	A,C	43440218(+)	`GTCCAC/TGTGTA`	1	--	ng5¹		0	--	--	--	--
	rs17618637^1,2	F,H	43440686(+)	`CACATC/TGCATT`	1	--	ut3¹		7		NA EU EA WA	554

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HapMap Linkage Disequilibrium images for GATM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602360 disorders: 612718

UniProtKB/Swiss-Prot: GATM_HUMAN, P50440

Defects in GATM are the cause of L-arginine:glycine amidinotransferase deficiency (AGAT

deficiency) [MIM:602360]. AGAT deficiency is a defect in creatine metabolism leading to mental

retardation

3 Novoseek disease relationships for GATM gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mental retardation	66.76	5	12468279 (1), 12597058 (1), 11555793 (1), 16769397 (1)
language disorders	54.65	1	12597058 (1)
acute pancreatitis	21.19	1	2329743 (1)

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GeneTests: GATM

Creatine Deficiency Syndromes

Human Gene Mutation Database: GATM
Human Genome Epidemiology Navigator: GATM (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/54 PubMed articles for GATM gene (see all 54 ):

The amino acid sequences of human and pig L-arginine:glycine amidinotransferase. (PubMed id 8313955)^{1, 2, 3, 4} Humm A.... Mann K. (1994)
Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. (PubMed id 11555793)^{1, 3, 4} Item C.B.... Cioni G. (2001)
The ligand-induced structural changes of human L-arginine:glycine amidinotransferase. A mutational and crystallographic study. (PubMed id 9915841)^{1, 3, 4} Fritsche E.... Huber R. (1999)
Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue. (PubMed id 9148748)^{1, 3, 4} Humm A.... Huber R. (1997)
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. (PubMed id 9218780)^{1, 3, 4} Humm A.... Huber R. (1997)
Structure and reaction mechanism of L-arginine:glycine amidinotransferase. (PubMed id 9165070)^{1, 3, 4} Humm A.... Steinbacher S. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Creatine depletion in a new case with AGAT deficiency: clinical and genetic study in a large pedigree. (PubMed id 12468279)^{1, 3} Battini R....Cioni G. (2002)
Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies. (PubMed id 12324495)^{1, 3} Carducci C....Antonozzi I. (2002)
Arginine:glycine amidinotransferase (AGAT) deficiency in a newborn: early treatment can prevent phenotypic expression of the disease. (PubMed id 16769397)^{1, 3} Battini R....Cioni G. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2628	HGNC: 4175	AceView: GATM	Ensembl:ENSG00000171766	euGenes: HUgn2628
ECgene: GATM	H-InvDB: GATM

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=GATM

Licensable Technologies for GATM
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GATM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GATM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GATM		Antibodies for GATM
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GATM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GATM)
	Antibodies (GATM)
	Search for Chimera RNAi
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GATM)
	Antibodies (GATM)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GATM

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for GATM

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GATM Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for GATM

Summaries
for GATM

Genomic Location
for GATM

Proteins
for GATM

Protein Domains/
Families
for GATM

Gene Function
for GATM

Pathways & Interactions
for GATM

Drugs & Compounds
for GATM

Transcripts
for GATM

Expression
for GATM

Orthologs
for GATM

Paralogs
for GATM

SNPs/Variants
for GATM

Disorders & Mutations
for GATM

Medical News
for GATM

Publications
for GATM

Search for GATM

Genome Databases showing GATM

Other Databases showing GATM

Specialized Databases showing GATM

Licensable Technologies
for GATM

Services
for GATM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GATM Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor GATM

Summariesfor GATM

Genomic Locationfor GATM

Proteinsfor GATM

Protein Domains/Familiesfor GATM

Gene Functionfor GATM

Pathways & Interactionsfor GATM

Drugs & Compoundsfor GATM

Transcriptsfor GATM

Expression for GATM

Orthologsfor GATM

Paralogsfor GATM

SNPs/Variantsfor GATM

Disorders & Mutationsfor GATM

Medical Newsfor GATM

Publicationsfor GATM

Search for GATM

Genome Databases showing GATM

Other Databases showing GATM

Specialized Databases showing GATM

Licensable Technologiesfor GATM

Servicesfor GATM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GATM

Summaries
for GATM

Genomic Location
for GATM

Proteins
for GATM

Protein Domains/
Families
for GATM

Gene Function
for GATM

Pathways & Interactions
for GATM

Drugs & Compounds
for GATM

Transcripts
for GATM

Expression
for GATM

Orthologs
for GATM

Paralogs
for GATM

SNPs/Variants
for GATM

Disorders & Mutations
for GATM

Medical News
for GATM

Publications
for GATM

Licensable Technologies
for GATM

Services
for GATM