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Aliases & Descriptions for GABRA3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC33793 2 | | OTTHUMP00000025897 2 | | OTTHUMP00000025898 2 |
| | | Descriptions |
|---|
| GABA(A) receptor subunit alpha-3 3 | | gamma-aminobutyric acid (GABA) A receptor, alpha 3 2 | | gamma-aminobutyric acid A receptor, alpha 3 2 | | gamma-animobutyric acid (GABA) A receptor, alpha 3 2 |
|
| | Search outside databases for aliases for GABRA3 genePrevious GC identifers: GC0XM145671 GC0XM147993 GC0XM149084 GC0XM149954 GC0XM151007 |
Summaries for GABRA3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for GABRA3: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq] UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelGene Wiki entry for GABRA3 |
Genomic Location for GABRA3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the GABRA3 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28GABRA3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM151085:
(about GC identifiers)
Start:
|
151,086,290 bp from pter |
End:
|
151,370,993 bp from pter |
Size:
|
284,704 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins for GABRA3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903 (See
protein sequence)Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-3 precursor Size: 492 amino acids; 55165 Da
Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Secondary accessions: Q8TAF9Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_000799.1
ENSEMBL proteins: ENSP00000359337 ENSP00000359334
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7
): About this table
Antibodies for GABRA3: Assays for GABRA3: | Protein
Domains/ Families for GABRA3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P34903
ProtoNet protein and cluster: P34903 4 Blocks protein families: IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature IPB005433 Gamma-aminobutyric-acid A receptor alpha 3 subunit signature IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family | Gene Function for GABRA3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000808
Applied Biosystems Silencer® siRNAs for GABRA3
Sigma-Aldrich siRNA and siRNA Panels for GABRA3  Sigma-Aldrich shRNA for GABRA3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000808                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000808                                  untagged cDNA clone in CMV expression vector: NM_000808 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000808
UniProtKB/Swiss-Prot: GBRA3_HUMAN, P34903Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channelGenatlas biochemistry entry for GABRA3:gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 3,subunit,component of a pentameric receptor mediating inhibitory neurotransmission5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Gabra3):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for GABRA3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRA3 (Your Favorite Gene powered by Ingenuity) 
5/34 Interacting proteins for GABRA3 (ENSP000003593373 P349031) via UniProtKB, MINT, and/or STRING (see all 34
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for GABRA3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for GABRA3 |
Compounds for GABRA3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Muscimol | Potent GABAA agonist | [2763-96-4] | | (+)-Bicuculline | Potent GABAA antagonist | [485-49-4] | | Indiplon | Subtype-selective GABAA receptor positive allosteric modulator | [325715-02-4] | | L-655,708 | Selective for alpha5-containing GABAA receptors | [130477-52-0] | | SR 95531 hydrobromide | Selective, competitive GABAA receptor antagonist | [104104-50-9] | About this table
|
Transcripts for GABRA3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000808
Sigma-Aldrich siRNA and siRNA Panels for GABRA3  Sigma-Aldrich shRNA for GABRA3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000808 REFSEQ mRNAs for GABRA3 gene: NM_000808.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000808               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000808                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000808                                  untagged cDNA clone in CMV expression vector: NM_000808  Additional cDNA sequence: AK312404.1 BC028629.1 S62908.1 3 DOTS entries: DT.40125283 DT.91933487 DT.91755251 2 AceView cDNA sequences:BX951994 BI546888
highest scoring ESTs for GABRA3:S62908 AA300701 AW291443 BG218138 BI913879 BX281041 NM_000808 BC028629 BI546888 AI198163 Unigene Cluster for GABRA3: Gamma-aminobutyric acid (GABA) A receptor, alpha 3 Hs.123024 [show with all ESTs]Unigene Representative Sequence: NM_000808
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000370314
ENST00000370311
|
Expression for GABRA3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| GABRA3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for GABRA3
1 / 2 / 3 3 probe-sets matching GABRA3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.123024
Expression variation in blood from EXPOLDB for GABRA3 |
Orthologs for GABRA3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for GABRA3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for GABRA3
ENSEMBL Gene Tree for GABRA3 | Paralogs for GABRA3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for GABRA3 gene
- GABRA42 GABRA62
|
SNPs/Variants for GABRA3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for GABRA3 (up to first 250kb)
|
Disorders & Mutations for GABRA3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 305660
Genetic Association Database: GABRA3 Human Genome Epidemiology Navigator: GABRA3 (12 documents)
|
Medical News for GABRA3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for GABRA3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/31 PubMed articles for GABRA3 gene (see all 31
):- Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts. (PubMed id 14751442)1, 3, 6 Baca-Garcia E....de Leon J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study. (PubMed id 15048654)3, 6 Henkel V....Bondy B. (2004)
- Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. (PubMed id 11840313)3, 6 Massat I....Mendlewicz J. (2002)
- Lack of association between GABRA3 and unipolar affective disorder: a multicentre study. (PubMed id 11602034)3, 6 Massat I....Mendlewicz J. (2001)
- GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome 15q11-q13 and bipolar disorder: a genetic association study. (PubMed id 11378843)3, 6 Papadimitriou G.N....Stefanis C.N. (2001)
- Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq. (PubMed id 10602120)3, 4 Amir R.... Zoghbi H.Y. (2000)
- Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma- aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. (PubMed id 8391122)3, 4 Hadingham K.L.... Whiting P.J. (1993)
- Gamma-aminobutyric acid promotes human hepatocellular carcinoma growth through overexpressed gamma-aminobutyric acid A receptor alpha 3 subunit. (PubMed id 19084931)1, 3 Liu Y....Li G.C. (2008)
- Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population. (PubMed id 17970773)1, 3 Jongjaroenprasert W....Ongphiphadhanakul B. (2008)
|
Search for GABRA3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing GABRA3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing GABRA3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing GABRA3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Protein Spotlight | http://www.expasy.org/spotlight/back_issues/sptlt056.shtml |
|
| | | About This Section
| --
| Services for GABRA3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for GABRA3:

|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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