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GABRA2 Gene

protein-coding GIFtS: 66

GC04M045946

gamma-aminobutyric acid (GABA) A receptor, alpha 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ97076 ^²
OTTHUMP00000125269 ^²

Descriptions
GABA(A) receptor subunit alpha-2 ^³
gamma-aminobutyric acid (GABA) A receptor, alpha 2 ^²
gamma-aminobutyric acid A receptor, alpha 2 ^²

External Ids
HGNC: 4076¹
Entrez Gene: 2555²
UniProtKB: P47869³
Ensembl: ENSG00000151834⁷

Search outside databases for aliases for GABRA2 gene

Previous GC identifers: GC04M046323 GC04M046561 GC04M046101 GC04M046167 GC04M046092

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for GABRA2:

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A

receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be

modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct

subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants

encoding the same protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: GBRA2_HUMAN, P47869

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Gene Wiki entry for GABRA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GABRA2 gene

Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p12

GABRA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M045946: (about GC identifiers)

Start:	45,946,341 bp from pter
End:	46,086,702 bp from pter
Size:	140,362 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006238.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GBRA2_HUMAN, P47869 (See protein sequence)

Recommended Name: Gamma-aminobutyric acid receptor subunit alpha-2 precursor

Size: 451 amino acids; 51326 Da

Subunit: Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A)

receptor chains: alpha, beta, gamma, delta, and rho

Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane

protein. Cell membrane; Multi-pass membrane protein

Secondary accessions: Q59G14

REFSEQ proteins (2 alternative transcripts):

NP_000798.2 NP_001107647.1

ENSEMBL proteins:

ENSP00000348897 ENSP00000371033

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GABA A Receptor alpha 2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0030285	integral to synaptic vesicle membrane	IDA	8391122
GO:0045202	synapse	IEA	--

About this table

Antibodies for GABRA2:

	Invitrogen Antibodies for GABRA2
	Millipore Mono- and Polyclonal Antibodies for the study of GABRA2
	Sigma-Aldrich Antibodies for GABRA2
	R&D Systems Antibodies for GABRA2 (GABA-A-R alpha 2)
	Antibodies from Abcam (GABA A Receptor alpha 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for GABRA2

Assays for GABRA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P47869

ProtoNet protein and cluster: P47869

4 Blocks protein families:

IPB001390 Gamma-aminobutyric-acid A receptor alpha subunit signature

IPB005432 Gamma-aminobutyric-acid A receptor alpha 2 subunit signature

IPB006028 Gamma-aminobutyric acid A (GABAA) receptor signature

IPB006201 Neurotransmitter-gated ion-channel

UniProtKB/Swiss-Prot: GBRA2_HUMAN, P47869

Similarity: Belongs to the ligand-gated ionic channel (TC 1.A.9) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001114175

Applied Biosystems Silencer® siRNAs for GABRA2

Sigma-Aldrich siRNA and siRNA Panels for GABRA2

Sigma-Aldrich shRNA for GABRA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for GABRA2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000807
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000807
untagged cDNA clones in CMV expression vector (see all 3): BC022488

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000807

UniProtKB/Swiss-Prot: GBRA2_HUMAN, P47869

Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal

inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

Genatlas biochemistry entry for GABRA2:

gamma-aminobutyric acid (GABA) A receptor,ionotropic,alpha 2,subunit,component of a pentameric

receptor mediating inhibitory neurotransmission

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Gabra2):

behavior/neurological	homeostasis/metabolism	lethality-postnatal	life span-post-weaning/aging	nervous system
no phenotypic analysis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004890	GABA-A receptor activity	IEA	--
GO:0005216	ion channel activity	IEA	--
GO:0005230	extracellular ligand-gated ion channel activity	IEA	--
GO:0005254	chloride channel activity	IEA	--
GO:0008503	benzodiazepine receptor activity	IMP	8391122

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for GABRA2 (Your Favorite Gene powered by Ingenuity)

GABA Receptor Signaling

GeneDecks GABRA2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for GABRA2

5/19 Interacting proteins for GABRA2 (ENSP00000348897³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GABRB3	ENSP00000372479³	STRING (score=.822)
GABRB2	ENSP00000274547³	STRING (score=.821)
GABRR1	ENSP00000358463³	STRING (score=.821)
GABRR2	ENSP00000229606³	STRING (score=.821)
GABRE	ENSP00000359353³	STRING (score=.82)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001505	regulation of neurotransmitter levels	IMP	8391122
GO:0006811	ion transport	IEA	--
GO:0006821	chloride transport	IEA	--
GO:0006836	neurotransmitter transport	IMP	8391122
GO:0007214	gamma-aminobutyric acid signaling pathway	IMP	8391122

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for GABRA2

Sigma-Aldrich Small Molecules for GABRA2:

Mixed Agonist/Antagonist Antagonist Allosteric Modulator Agonist Inhibitor Ligand

Compounds for GABRA2 available from Tocris Bioscience

Compound	Action	CAS number
Muscimol	Potent GABAA agonist	[2763-96-4]
(+)-Bicuculline	Potent GABAA antagonist	[485-49-4]
Indiplon	Subtype-selective GABAA receptor positive allosteric modulator	[325715-02-4]
L-655,708	Selective for alpha5-containing GABAA receptors	[130477-52-0]
SR 95531 hydrobromide	Selective, competitive GABAA receptor antagonist	[104104-50-9]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GABRA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GABRA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001114175

Sigma-Aldrich siRNA and siRNA Panels for GABRA2

Sigma-Aldrich shRNA for GABRA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000807 NM_001114175

REFSEQ mRNAs for GABRA2 gene (2 alternative transcripts):

NM_000807.2 NM_001114175.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000807 NM_001114175

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000807
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000807
                                 untagged cDNA clones in CMV expression vector (see all 3): BC022488

Additional cDNA sequence:

AB209295.1 AK125179.1 AK289662.1 AK293466.1 AK307128.1 BC022488.1 S62907.1

11 DOTS entries:

DT.100730139 DT.40118515 DT.451945 DT.121227076 DT.121231246 DT.40240103 DT.40122528 DT.101983883

DT.101983881 DT.101983887 DT.95254812

24/37 AceView cDNA sequences (see all 37 ):

AI634558 AL134748 R39763 AK125179 AI801878 CD014117 CD014111 BC022488

CD014113 CD014109 CD014115 CD014110 CD014108 CD014112 BF594289 S62907

CD014107 NM_000807 BI757084 CD014114 BG699503 AW043891 R16175 T65530

highest scoring ESTs for GABRA2:

S62907 BC022488 BG699503 N46354 AB209295 AI634558 AI801878 AK125179 AL134748 AW043891

Unigene Cluster for GABRA2:

Gamma-aminobutyric acid (GABA) A receptor, alpha 2

Hs.116250 [show with all ESTs]

Unigene Representative Sequence: NM_001114175

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for GABRA2 (see all 14 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b
SP1:											-														-
SP2:			-		-						-
SP3:											-														-		-
SP4:											-										-				-		-
SP5:											-												-		-		-

About this scheme

ECgene alternative splicing isoforms for GABRA2

2 Ensembl transcripts including schematic representations:

ENST00000356504 ENST00000381620

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

GABRA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GABRA2

¹ / ² / ³

6 probe-sets matching GABRA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
42070_i_at²^{, 3}	U95-B	1	1.00	1.00	0.88	1.19	N46354	0.80	1.00	0.91	1
37062_at²^{, 3}	U95-A	1	1.00	1.00	0.80	1.03	S62907	1.00	1.00	1.00	1
42071_r_at²^{, 3}	U95-B	1	1.00	1.00	0.72	0.94	N46354	0.80	1.00	0.91	1
207014_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000807	0.60	1.00	0.82	1
207014_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554308_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATAAATAT

SOURCE GeneReport for Unigene cluster: Hs.116250
Expression variation in blood from EXPOLDB for GABRA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for GABRA2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GABRA2¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 2	91.25(n) 94.34(a)	482131 XM_853830.1 XP_858923.1
chimpanzee (Pan troglodytes)	GABRA2¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 2	94.09(n) 93.13(a)	461355 XM_517321.2 XP_517321.2
cow (Bos taurus)	GABRA2¹	--	gamma-aminobutyric acid (GABA) A receptor, alpha 2	94.31(n) 98.23(a)	282236 NM_174541.2 NP_776966.1
rat (Rattus norvegicus)	Gabra2¹	--	gamma-aminobutyric acid (GABA-A) receptor, subunit more	89.58(n) 97.12(a)	289606 XM_223378.4 XP_223378.4
mouse (Mus musculus)	Gabra2^{1, 5}	5 (40.00 cM)⁵	gamma-aminobutyric acid (GABA) A receptor, subunit more⁵ gamma-aminobutyric acid (GABA-A) receptor, subunit more¹	90.69(n)¹ 97.56(a)¹	14395¹ NM_008066.3¹ NP_032092.1¹ AK021280⁵ AK036049⁵ (see all 14)

About this table Species with no ortholog for GABRA2

ENSEMBL Gene Tree for GABRA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for GABRA2 gene

GABRA5² GABRA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: GBRA2_HUMAN, P47869

Polymorphism: Genetic variations in GABRA2 determine the genetic susceptibility to alcoholism

[MIM:103780]

10/737 NCBI SNPs in GABRA2 are shown (see all 737 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 229)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs572227^1,2	A,C,F,H,O	45946150(-)	`ACACTG/ATGACA`	1	--	ng5¹		9		MN EA NA EU WA	2212
	rs573400^1,2	A,C,F,H,O	45946823(-)	`TTCAAA/GTGACC`	2	--	ut3¹ ese³		24		EA NA EU WA	4180
	rs894269^1,2	A,C,F,H	46088369(+)	`ACATTC/TGCTCT`	1	--	ng3¹ tfbs³		17		MN EU EA WA NA	1628
	rs6856130^1,2	A,C,F,H	46087917(+)	`CGATAA/GAATCC`	1	--	ng3¹		8		EU EA WA	838
	rs11503014^1,2	C,F,H	46085622(+)	`GGACTC/GTGTGT`	2	--	int¹ ut5¹ ese³		14		NA EA EU WA	1188
	rs3756007^1,2	C,F,H	46085821(+)	`AATAAT/CAACAC`	2	--	int¹ ut5¹		8		EA NA EU WA	2018
--	rs3775288^1,2	C	46086578(+)	`TTGGGA/GGAGAG`	1	--	ut5¹ ese³ trp³		0	--	--	--	--
	rs519972^1,2	H	45947219(-)	`CTGAAG/ACAAAG`	2	T/A	mis¹		7		NA EA EU WA	670
	rs279858^1,2	A,C,F,H,O	46009350(-)	`GGGAAA/GAAATC`	2	K/K	syn¹		14		MN EU EA WA NA	1908
	rs279840^1,2	A,C,F,H,O	46035163(+)	`CATCTG/TCATAT`	1	--	int¹		12		NS NA EU EA WA	666

About this table

HapMap Linkage Disequilibrium images for GABRA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 137140 disorders: 103780

Genetic Association Database: GABRA2
Human Genome Epidemiology Navigator: GABRA2 (23 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/39 PubMed articles for GABRA2 gene (see all 39 ):

Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. (PubMed id 15024690)^{3, 4, 6} Edenberg H.J.... Begleiter H. (2004)
Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. (PubMed id 16395124)^{3, 6} Fehr C....Szegedi A. (2006)
GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. (PubMed id 15702134)^{3, 6} Pierucci-Lagha A....Kranzler H.R. (2005)
Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. (PubMed id 15834213)^{3, 6} Lappalainen J....Gelernter J. (2005)
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. (PubMed id 16080114)^{3, 6} Ma D.Q....Pericak-Vance M.A. (2005)
Allelic and haplotypic association of GABRA2 with alcohol dependence. (PubMed id 15274050)^{3, 6} Covault J....Kranzler H.R. (2004)
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma- aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors. (PubMed id 8391122)^{3, 4} Hadingham K.L.... Whiting P.J. (1993)
GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. (PubMed id 17207817)^{1, 3} Soyka M....Bondy B. (2008)
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and FagerstrAPm Test for Nicotine Dependence. (PubMed id 19207358)³ Agrawal A....Madden P.A. (2009)
Association of childhood trauma exposure and GABRA2 polymorphisms with risk of posttraumatic stress disorder in adults. (PubMed id 19229201)³ Nelson E.C....Madden P.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2555	HGNC: 4076	AceView: GABRA2	Ensembl:ENSG00000151834	euGenes: HUgn2555
ECgene: GABRA2	H-InvDB: GABRA2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt056.shtml

Licensable Technologies for GABRA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for GABRA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GABRA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GABRA2		Antibodies for GABRA2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GABRA2		Small molecules for GABRA2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GABA A Receptor alpha 2)
	Antibodies (GABA A Receptor alpha 2)

Search OriGene for GABRA2

Tocris compounds for GABRA2

	Drugs for GABRA2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for GABRA2

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GABRA2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GABRA2

Summaries
for GABRA2

Genomic Location
for GABRA2

Proteins
for GABRA2

Protein Domains/
Families
for GABRA2

Gene Function
for GABRA2

Pathways & Interactions
for GABRA2

Drugs & Compounds
for GABRA2

Transcripts
for GABRA2

Expression
for GABRA2

Orthologs
for GABRA2

Paralogs
for GABRA2

SNPs/Variants
for GABRA2

Disorders & Mutations
for GABRA2

Medical News
for GABRA2

Publications
for GABRA2

Search for GABRA2

Genome Databases showing GABRA2

Other Databases showing GABRA2

Specialized Databases showing GABRA2

Licensable Technologies
for GABRA2

Services
for GABRA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GABRA2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GABRA2

Summariesfor GABRA2

Genomic Locationfor GABRA2

Proteinsfor GABRA2

Protein Domains/Familiesfor GABRA2

Gene Functionfor GABRA2

Pathways & Interactionsfor GABRA2

Drugs & Compoundsfor GABRA2

Transcriptsfor GABRA2

Expression for GABRA2

Orthologsfor GABRA2

Paralogsfor GABRA2

SNPs/Variantsfor GABRA2

Disorders & Mutationsfor GABRA2

Medical Newsfor GABRA2

Publicationsfor GABRA2

Search for GABRA2

Genome Databases showing GABRA2

Other Databases showing GABRA2

Specialized Databases showing GABRA2

Licensable Technologiesfor GABRA2

Servicesfor GABRA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GABRA2

Summaries
for GABRA2

Genomic Location
for GABRA2

Proteins
for GABRA2

Protein Domains/
Families
for GABRA2

Gene Function
for GABRA2

Pathways & Interactions
for GABRA2

Drugs & Compounds
for GABRA2

Transcripts
for GABRA2

Expression
for GABRA2

Orthologs
for GABRA2

Paralogs
for GABRA2

SNPs/Variants
for GABRA2

Disorders & Mutations
for GABRA2

Medical News
for GABRA2

Publications
for GABRA2

Licensable Technologies
for GABRA2

Services
for GABRA2