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Aliases for FMO2 Gene

Aliases for FMO2 Gene

  • Flavin Containing Monooxygenase 2 2 3 5
  • Flavin Containing Monooxygenase 2 (Non-Functional) 2 3
  • Pulmonary Flavin-Containing Monooxygenase 2 3 4
  • Dimethylaniline Oxidase 2 3 4
  • EC 1.14.13.8 4 63
  • FMO, Pulmonary 3
  • FMO 1B1 4
  • FMO1B1 3
  • FMO 2 4

External Ids for FMO2 Gene

Previous GeneCards Identifiers for FMO2 Gene

  • GC01P168718
  • GC01P166783
  • GC01P167735
  • GC01P168393
  • GC01P167886
  • GC01P169420
  • GC01P142377

Summaries for FMO2 Gene

Entrez Gene Summary for FMO2 Gene

  • This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

GeneCards Summary for FMO2 Gene

FMO2 (Flavin Containing Monooxygenase 2) is a Protein Coding gene. Diseases associated with FMO2 include trimethylaminuria and kabuki syndrome 1. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO2 Gene

  • Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.

Gene Wiki entry for FMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO2 Gene

Genomics for FMO2 Gene

Genomic Location for FMO2 Gene

Chromosome:
1
Start:
171,185,208 bp from pter
End:
171,212,683 bp from pter
Size:
27,476 bases
Orientation:
Plus strand

Genomic View for FMO2 Gene

Genes around FMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO2 Gene

Proteins for FMO2 Gene

  • Protein details for FMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99518-FMO2_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 2
    Protein Accession:
    Q99518
    Secondary Accessions:
    • Q5EBX4
    • Q86U73
    • Q9BRX1

    Protein attributes for FMO2 Gene

    Size:
    471 amino acids
    Molecular mass:
    53644 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO2 Gene

Proteomics data for FMO2 Gene at MOPED

Post-translational modifications for FMO2 Gene

Other Protein References for FMO2 Gene

Antibody Products

Domains & Families for FMO2 Gene

Suggested Antigen Peptide Sequences for FMO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99518

UniProtKB/Swiss-Prot:

FMO2_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO2: view

No data available for Gene Families for FMO2 Gene

Function for FMO2 Gene

Molecular function for FMO2 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 2,microsomal,pulmonary,protein catalyzing the N-oxidation of primary alkylamines
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.

Enzyme Numbers (IUBMB) for FMO2 Gene

Phenotypes for FMO2 Gene

GenomeRNAi human phenotypes for FMO2:
genes like me logo Genes that share phenotypes with FMO2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FMO2 Gene

Localization for FMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO2 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO2 Gene COMPARTMENTS Subcellular localization image for FMO2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
peroxisome 2
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for FMO2 Gene

Pathways & Interactions for FMO2 Gene

genes like me logo Genes that share pathways with FMO2: view

Pathways by source for FMO2 Gene

Interacting Proteins for FMO2 Gene

Gene Ontology (GO) - Biological Process for FMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 11744609
GO:0006805 xenobiotic metabolic process IDA,TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0072592 oxygen metabolic process IEA --
genes like me logo Genes that share ontologies with FMO2: view

No data available for SIGNOR curated interactions for FMO2 Gene

Drugs & Compounds for FMO2 Gene

(5) Drugs for FMO2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Imipramine Approved Pharma Antagonist 27
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 350
Magnesium Nutra 0

(11) Additional Compounds for FMO2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
  • Dimethylaniline N-oxide
  • N,N-Dimethylaniline N-oxide
  • Nn-dimethylaniline-N-oxide
874-52-2
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
N,N-Dimethylaniline
  • Dimethylaminobenzene
  • Dimethylaniline
  • Dimethylphenylamine
  • N,N-(Dimethylamino)benzene
  • N,N-Dimethyl-Benzenamine
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with FMO2: view

Transcripts for FMO2 Gene

Unigene Clusters for FMO2 Gene

Flavin containing monooxygenase 2 (non-functional):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3: - - - - - -
SP4: -
SP5: -

Relevant External Links for FMO2 Gene

GeneLoc Exon Structure for
FMO2
ECgene alternative splicing isoforms for
FMO2

Expression for FMO2 Gene

mRNA expression in normal human tissues for FMO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO2 Gene

This gene is overexpressed in Artery - Aorta (x7.1) and Lung (x5.5).

SOURCE GeneReport for Unigene cluster for FMO2 Gene Hs.144912

mRNA Expression by UniProt/SwissProt for FMO2 Gene

Q99518-FMO2_HUMAN
Tissue specificity: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
genes like me logo Genes that share expression patterns with FMO2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FMO2 Gene

Orthologs for FMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO2 36
  • 88 (a)
OneToOne
FMO2 35
  • 99.36 (n)
  • 99.58 (a)
cow
(Bos Taurus)
Mammalia FMO2 35
  • 87.02 (n)
  • 85.32 (a)
FMO2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO2 36
  • 73 (a)
OneToOne
FMO2 35
  • 88.61 (n)
  • 87.69 (a)
mouse
(Mus musculus)
Mammalia Fmo2 16
Fmo2 35
  • 82.94 (n)
  • 86.2 (a)
Fmo2 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMO2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMO2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo2 35
  • 82.52 (n)
  • 86.2 (a)
lizard
(Anolis carolinensis)
Reptilia FMO2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89174 35
  • 63.88 (n)
  • 59.01 (a)
zebrafish
(Danio rerio)
Actinopterygii fmo5 36
  • 46 (a)
ManyToMany
si:dkey-239i20.2 36
  • 44 (a)
ManyToMany
si:dkey-239i20.4 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fmo-1 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fmo-1 36
  • 36 (a)
ManyToMany
fmo-2 36
  • 36 (a)
ManyToMany
fmo-3 36
  • 39 (a)
ManyToMany
fmo-4 36
  • 31 (a)
ManyToMany
fmo-5 36
  • 39 (a)
ManyToMany
C01H6.4 37
  • 33 (a)
fmo-11 37
  • 42 (a)
fmo-12 37
  • 40 (a)
fmo-13 37
  • 42 (a)
fmo-14 37
  • 36 (a)
fmo-15 37
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for FMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FMO2 Gene

ENSEMBL:
Gene Tree for FMO2 (if available)
TreeFam:
Gene Tree for FMO2 (if available)

Paralogs for FMO2 Gene

Paralogs for FMO2 Gene

(6) SIMAP similar genes for FMO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FMO2: view

Variants for FMO2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FMO2 Gene

Q99518-FMO2_HUMAN
The sequence shown is that of the allele FMO2*2A. There are two alleles; one major, FMO2*2A (truncated form) and one minor, FMO2*1 (full-length form similar to the protein found in other mammals) (PubMed:9804831). A nonsense mutation transforms the Gln-472 of FMO2*1 in a premature stop codon (PubMed:9804831). FMO2*2A occurs in essentially 100% of Caucasians and Asians (PubMed:9804831). FMO2*1 is present at a frequency of approximately 4% to 13% in the sample of population of African descent (PubMed:9804831, PubMed:11042094, PubMed:18794725). FMO2*2A is catalytically inactive (PubMed:9804831).

Sequence variations from dbSNP and Humsavar for FMO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_014840 -
VAR_014841 -
VAR_014842 -
VAR_014843 -
VAR_014844 -

Structural Variations from Database of Genomic Variants (DGV) for FMO2 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
nsv831882 CNV Loss 17160897
esv2719450 CNV Deletion 23290073
esv2090208 CNV Deletion 18987734
esv1702263 CNV Deletion 17803354
esv2719461 CNV Deletion 23290073
esv259635 OTHER Complex 20981092

Variation tolerance for FMO2 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 25.28; 99.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FMO2 Gene

HapMap Linkage Disequilibrium report
FMO2
Human Gene Mutation Database (HGMD)
FMO2

Disorders for FMO2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FMO2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
trimethylaminuria
  • fish malodor syndrome
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FMO2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FMO2

Genetic Association Database (GAD)
FMO2
Human Genome Epidemiology (HuGE) Navigator
FMO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FMO2
genes like me logo Genes that share disorders with FMO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FMO2 Gene

Publications for FMO2 Gene

  1. Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. (PMID: 11042094) Whetstine J.R. … Hines R.N. (Toxicol. Appl. Pharmacol. 2000) 3 4 23 48 67
  2. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. (PMID: 9804831) Dolphin C.T. … Phillips I.R. (J. Biol. Chem. 1998) 2 3 23
  3. Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K. (PMID: 19420133) Krueger S.K. … Williams D.E. (Drug Metab. Dispos. 2009) 3 23
  4. The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa. (PMID: 18794725) Veeramah K.R. … Phillips I.R. (Pharmacogenet. Genomics 2008) 3 23
  5. Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. (PMID: 15864117) Krueger S.K. … Williams D.E. (Pharmacogenet. Genomics 2005) 3 23

Products for FMO2 Gene

Sources for FMO2 Gene

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