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FMO2 Gene

protein-coding   GIFtS: 62
GCID: GC01P171154

Flavin Containing Monooxygenase 2 (Non-Functional)

(Previous name: flavin containing monooxygenase 2)
  See FMO2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Flavin Containing Monooxygenase 2 (Non-Functional)1 2     EC 1.14.13.83 8
Dimethylaniline Oxidase 22 3     Flavin Containing Monooxygenase 21
Pulmonary Flavin-Containing Monooxygenase 22 3     FMO1B12
FMO 1B12 3     Dimethylaniline Monooxygenase [N-Oxide-Forming] 22
FMO 22 3     FMO, Pulmonary2

External Ids:    HGNC: 37701   Entrez Gene: 23272   Ensembl: ENSG000000949637   OMIM: 6039555   UniProtKB: Q995183   

Export aliases for FMO2 gene to outside databases

Previous GC identifers: GC01P168718 GC01P166783 GC01P167735 GC01P168393 GC01P167886 GC01P169420 GC01P142377


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FMO2 Gene:
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and
xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some
primary alkylamines through an N-hydroxylamine intermediate. However, in some human populations, this enzyme is
truncated and likely degraded rapidly. The protein encoded by this gene represents the truncated form and
apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no
sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3,
and FMO4 genes on chromosome 1. (provided by RefSeq, Jun 2013)

GeneCards Summary for FMO2 Gene:
FMO2 (flavin containing monooxygenase 2 (non-functional)) is a protein-coding gene. Diseases associated with FMO2 include trimethylaminuria. GO annotations related to this gene include monooxygenase activity and flavin adenine dinucleotide binding. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518
Function: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine
intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the
S-oxidation of methimazole. The truncated form is catalytically inactive

Gene Wiki entry for FMO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMO2 gene promoter:
         C/EBPbeta   p53   Pax-6   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E2F-1   E2F   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFMO2 promoter sequence
   Search Chromatin IP Primers for FMO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.3   Ensembl cytogenetic band:  1q24.3   HGNC cytogenetic band: 1q24.3

FMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P171154:  view genomic region     (about GC identifiers)

Start:
171,154,347 bp from pter      End:
171,181,822 bp from pter
Size:
27,476 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518 (See protein sequence)
Recommended Name: Dimethylaniline monooxygenase [N-oxide-forming] 2  
Size: 471 amino acids; 53644 Da
Cofactor: FAD
Cofactor: Magnesium
Secondary accessions: Q5EBX4 Q86U73 Q9BRX1

Explore the universe of human proteins at neXtProt for FMO2: NX_Q99518

Explore proteomics data for FMO2 at MOPED

Post-translational modifications: 

  • The truncated form is probably unable to fold correctly and is rapidly degraded1
  • FMO2*1 is sumoylated at 'Lys-492'1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FMO2 (Q99518) (see all 34)
     DIIKRNE  FDLLKYI  FATGYSF  QSQTLQT 


    See FMO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001451.1  
    ENSEMBL proteins: 
     ENSP00000209929   ENSP00000405905  
    Reactome Protein details: Q99518

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    antibodies-online proteins for FMO2 (5 products) 

     
    antibodies-online peptides for FMO2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002254 Flavin_mOase_2
     IPR020946 Flavin_mOase-like
     IPR000960 Flavin_mOase

    Graphical View of Domain Structure for InterPro Entry Q99518

    ProtoNet protein and cluster: Q99518

    3 Blocks protein domains:
    IPB000960 Flavin-containing monooxygenase (FMO) signature
    IPB001327 Pyridine nucleotide-disulphide oxidoreductase
    IPB002254 Flavin-containing monooxygenase (FMO) 2 signature


    UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518
    Similarity: Belongs to the FMO family


    Find genes that share domains with FMO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMO2_HUMAN, Q99518
    Function: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine
    intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the
    S-oxidation of methimazole. The truncated form is catalytically inactive
    Catalytic activity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O

         Genatlas biochemistry entry for FMO2:
    flavin containing monooxygenase 2,microsomal,pulmonary,protein catalyzing the N-oxidation of primary alkylamines

         Enzyme Number (IUBMB): EC 1.14.13.81 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity TAS--
    GO:0004499N,N-dimethylaniline monooxygenase activity IDA11744609
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding IEA--
    GO:0050661NADP binding IEA--
         
    Find genes that share ontologies with FMO2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FMO2

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    hsa-miR-1290 hsa-miR-452* hsa-miR-4282 hsa-miR-1911* hsa-miR-1262 hsa-miR-3667-3p hsa-miR-146a* hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidFMO2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FMO2_HUMAN, Q99518: Microsome membrane. Endoplasmic reticulum membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    peroxisome2
    extracellular1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016020membrane IDA9804831
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FMO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FMO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics
    FMO oxidizes nucleophiles0.00
    Catalytic cycle of mammalian FMOs0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    4Chemical carcinogenesis
    Drug metabolism - cytochrome P4500.69
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with FMO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for FMO2
        Catalytic cycle of mammalian FMOs
    metapathway biotransformation


    1 Reactome Pathway for FMO2
        FMO oxidizes nucleophiles

    1 PharmGKB Pathway for FMO2
        Busulfan Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FMO2):
        Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO2: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for FMO2 (ENSP000002099294) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    CYP3A7ENSP000003374504STRING: ENSP00000337450
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006082organic acid metabolic process IDA11744609
    GO:0006739NADP metabolic process IDA11744609
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009404toxin metabolic process IDA11744609
    GO:0017144drug metabolic process IDA11744609

    Find genes that share ontologies with FMO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMO2

    9 HMDB Compounds for FMO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethylaniline-N-oxideDimethylaniline N-oxide (see all 4)874-52-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    ImipramineAntideprin (see all 27)50-49-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    N,N-DimethylanilineDimethylaminobenzene (see all 9)121-69-7--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for FMO2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methimazole 78.5 1 17942081 (1)
    thimet 77.6 1 15294458 (1)



    Find genes that share compounds with FMO2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FMO2 gene: 
    NM_001460.3  

    Unigene Cluster for FMO2:

    Flavin containing monooxygenase 2 (non-functional)
    Hs.144912  [show with all ESTs]
    Unigene Representative Sequence: NM_001460
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000209929(uc010pmd.1) ENST00000462643 ENST00000489354 ENST00000529935
    ENST00000493513 ENST00000483192 ENST00000488431 ENST00000441535(uc001ghk.1)

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    hsa-miR-1290 hsa-miR-452* hsa-miR-4282 hsa-miR-1911* hsa-miR-1262 hsa-miR-3667-3p hsa-miR-146a* hsa-miR-4314
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    Additional mRNA sequence: 

    AK098145.1 AK304385.1 AK312877.1 AL833218.1 BC005894.1 BT006979.1 Y09267.1 

    7 DOTS entries:

    DT.120587  DT.121453402  DT.100010038  DT.100010037  DT.100665132  DT.121453424  DT.91708801 

    Selected AceView cDNA sequences (see all 101):

    BM978911 BQ016071 BF432999 BE464168 AI821378 BQ004808 NM_001460 BI489722 
    AW301644 BM979138 Y09267 AA485450 BC005894 CA444972 CD678723 CB321742 
    CA390431 BU683843 CA447599 BQ045419 AI349371 AI375922 CD677670 BQ002500 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FMO2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:              -           -                                                         
    SP2:              -           -                                                         
    SP3:              -     -     -           -     -     -                                 
    SP4:                          -                                                         
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for FMO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGATTAA
    FMO2 Expression
    About this image


    FMO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells (family)
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    FMO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144912

    UniProtKB/Swiss-Prot: FMO2_HUMAN, Q99518
    Tissue specificity: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser
    extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FMO2: 
              Nephrotoxicity in human mouse rat
              Oxidative Stress in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FMO2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmo21 , 5 flavin containing monooxygenase 21, 5 82.94(n)1
    86.2(a)1
      1 (70.34 cM)5
    559901  NM_018881.31  NP_061369.21 
     1628743175 
    lizard
    (Anolis carolinensis)
    Reptilia FMO26
    flavin containing monooxygenase 2 (non-functional)...
    56(a)
    1 ↔ 1
    GL343300.1(1612158-1631991)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC060427.12   -- 71.71(n)    BC060427.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fmo56
    si:dkey-239i20.26
    (see all 3)
    si:dkey-239i20.2
    (see all 3)
    46(a)
    44(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    20(15099468-15110570) ENSDARG00000016357
    20(15090312-15096721) ENSDARG00000043518
    fruit fly
    (Drosophila melanogaster)
    Insecta Fmo-16
    Flavin-containing monooxygenase 1
    29(a)
    many ↔ many
    2R(19850498-19852164)
    worm
    (Caenorhabditis elegans)
    Secernentea fmo-113 flavin-containing monoxygenase 42(a)
    (best of 6)
      IV(10662222-10664313)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMO16
    Flavin-containing monooxygenase, localized to the ...
    26(a)
    1 → many
    VIII(454229-455527) YHR176W


    ENSEMBL Gene Tree for FMO2 (if available)
    TreeFam Gene Tree for FMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FMO2 gene
    FMO42  FMO32  FMO52  FMO6P2  FMO12  
    6 SIMAP similar genes for FMO2 using alignment to 1 protein entry:     FMO2_HUMAN:
    DKFZp667E137    FMO5    FMO6P    FMO4    FMO1    FMO3

    Find genes that share paralogs with FMO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FMO2_HUMAN, Q99518: The sequence shown is that of the allele FMO2*2A. There are two alleles; one major, FMO2*2A
    (truncated form) and one minor, FMO2*1 (full-length form similar to the protein found in other mammals). A
    nonsense mutation transforms the Gln-472 of FMO2*1 in a premature stop codon. FMO2*2A occurs in essentially 100%
    of Caucasians and Asians. FMO2*1 is present at a frequency of approximately 4% to 13% in the sample of population
    of African descent. FMO2*2A is catalytically inactive


    Selected SNPs for FMO2 (see all 752)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400811791,2
    --171152446(+) CACATA/CAGTTA 1 -- us2k10--------
    rs745472541,2
    C,F--171152551(+) CTGTAT/GGTTGG 1 -- us2k14Minor allele frequency- G:0.20NA CSA WA 242
    rs1496254701,2
    --171152674(+) CAACTA/GCCAAT 1 -- us2k10--------
    rs748084621,2
    C--171152699(+) TTTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs3692654921,2
    C--171152699(+) TTTTT-/CTTTTT 1 -- us2k10--------
    rs37544931,2
    C,F--171152759(+) GACACG/AGTCTC 1 -- us2k18Minor allele frequency- A:0.12NA WA EA 368
    rs1821807381,2
    --171152818(+) AGTCTC/TGACCT 1 -- us2k10--------
    rs1871544661,2
    --171152984(+) GCCTCC/TCAAAC 1 -- us2k10--------
    rs1916019431,2
    --171153001(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1838680191,2
    --171153029(+) CCTTTC/TTTCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FMO2 (171154347 - 171181822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FMO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1702263CNV Deletion17803354
    esv2090208CNV Deletion18987734
    esv2719450CNV Deletion23290073
    esv2719461CNV Deletion23290073
    nsv831882CNV Loss17160897
    esv28731CNV Gain+Loss19812545
    esv259635OTHER Complex20981092

    Human Gene Mutation Database (HGMD): FMO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FMO2
    DNA2.0 Custom Variant and Variant Library Synthesis for FMO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603955    OMIM disorders: --

    1 disease for FMO2:    
    About MalaCards
    trimethylaminuria


    Find genes that share disorders with FMO2           About GenesLikeMe

    Genetic Association Database (GAD): FMO2
    Human Genome Epidemiology (HuGE) Navigator: FMO2 (8 documents)

    Export disorders for FMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FMO2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with FMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. (PubMed id 11042094)1, 2, 4, 9 Whetstine J.R....Hines R.N. (Toxicol. Appl. Pharmacol. 2000)
    2. The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa. (PubMed id 18794725)1, 2, 4, 9 Veeramah K.R.... Phillips I.R. (Pharmacogenet. Genomics 2008)
    3. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. (PubMed id 9804831)1, 2, 3, 9 Dolphin C.T.... Phillips I.R. (J. Biol. Chem. 1998)
    4. Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. (PubMed id 15864117)1, 4, 9 Krueger S.K....Williams D.E. (Pharmacogenet. Genomics 2005)
    5. Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent. (PubMed id 15355885)1, 4, 9 Krueger S.K....Williams D.E. (Drug Metab. Dispos. 2004)
    6. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PubMed id 12527699)1, 2 Furnes B.... Schlenk D. (Drug Metab. Dispos. 2003)
    10. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PubMed id 1417778)1, 3 Dolphin C.T.... Phillips I.R. (Biochem. J. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2327 HGNC: 3770 AceView: FMO2 Ensembl:ENSG00000094963 euGenes: HUgn2327
    ECgene: FMO2 Kegg: 2327 H-InvDB: FMO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FMO2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/fmo2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FMO2 gene:
    Search GeneIP for patents involving FMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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