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FASN Gene

protein-coding GIFtS: 68

GC17M077629

fatty acid synthase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.1.85 ^³
FAS ^¹, ², ³
MGC14367 ^²
MGC15706 ^²
OA-519 ^²
SDR27X1 ^¹, ²

Descriptions
fatty acid synthase ^²
short chain dehydrogenase/reductase family 27X, member 1 ^²

External Ids
HGNC: 3594¹
Entrez Gene: 2194²
UniProtKB: P49327³
Ensembl: ENSG00000169710⁷

Search outside databases for aliases for FASN gene

Previous GC identifers: GC17M079459 GC17M9J0077 GC17M080572

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FASN:

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the

synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain

saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with

estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the

C-terminus of ER-alpha. [provided by RefSeq]

UniProtKB/Swiss-Prot: FAS_HUMAN, P49327

Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA,

malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier

protein

Gene Wiki entry for FASN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FASN gene

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25

FASN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M077629: (about GC identifiers)

Start:	77,629,503 bp from pter
End:	77,649,395 bp from pter
Size:	19,893 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010663.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FAS_HUMAN, P49327 (See protein sequence)

Recommended Name: Fatty acid synthase

Size: 2511 amino acids; 273400 Da

Subunit: Homodimer which is arranged in a head to tail fashion

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Miscellaneous: The relatively low beta-ketoacyl synthase activity may be attributable to the low

4'-phosphopantetheine content of the protein

Sequence caution: Sequence=AAC50259.1; Type=Miscellaneous discrepancy; Note=Several sequencing

errors;

PDB structures from and Proteopedia :

1XKT (3D)

2CG5 (3D)

2JFD (3D)

2JFK (3D)

2PX6 (3D)

Secondary accessions: Q13479 Q16702 Q4LE83 Q6P4U5 Q6SS02 Q969R1 Q96C68 Q96IT0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004095.4

ENSEMBL proteins:

ENSP00000304592

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Fatty Acid Synthase)
	Human Recombinant Proteins from Abnova (FASN)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005829	cytosol	EXP	7567999 12815048
GO:0042470	melanosome	IEA	--
GO:0042587	glycogen granule	IEA	--

About this table

Antibodies for FASN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FASN
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FASN (Fatty acid Synthase)
	Antibodies from Abcam (Fatty Acid Synthase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FASN)
	Novus Biologicals Antibodies for FASN

Assays for FASN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49327

ProtoNet protein and cluster: P49327

5 Blocks protein families:

IPB000794 Beta-ketoacyl synthase

IPB001031 Thioesterase

IPB001227 Acyl transferase domain

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB006162 Phosphopantetheine attachment site

UniProtKB/Swiss-Prot: FAS_HUMAN, P49327

Similarity: Contains 1 acyl carrier domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FASN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FASN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC014631

Applied Biosystems Silencer® siRNAs for FASN

Sigma-Aldrich siRNA and siRNA Panels for FASN

Sigma-Aldrich shRNA Panels and shRNA for FASN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FASN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004104
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004104
untagged cDNA clones in CMV expression vector (see all 2): BC014631

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004104

UniProtKB/Swiss-Prot: FAS_HUMAN, P49327

Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA,

malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier

protein

Catalytic activity: Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n

CO(2) + 2n NADP(+)

Catalytic activity: Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]

Catalytic activity: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]

Catalytic activity: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] =

3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]

Catalytic activity: (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) =

3-oxoacyl-[acyl-carrier-protein] + NADPH

Catalytic activity: (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] =

hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O

Catalytic activity: Acyl-[acyl-carrier-protein] + NADP(+) =

trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH

Catalytic activity: Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate

Enzyme Number (IUBMB): EC 2.3.1.85

Genatlas biochemistry entry for FASN:

fatty acid ethyl ester synthase 1,NADPH dependent

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fasn):

adipose tissue	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	lethality-prenatal/perinatal	liver/biliary system	nervous system

5/16 Gene Ontology (GO) molecular function terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000036	acyl carrier activity	IEA	--
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	IEA	--
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	IEA	--
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	IEA	--
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for FASN (Your Favorite Gene powered by Ingenuity) (see all 7 )

FXR/RXR Activation
Fatty Acid Biosynthesis
LXR/RXR Activation
TR/RXR Activation
PPAR&alpha

GeneDecks FASN for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FASN

5/7 Interacting proteins for FASN (P49327^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 7 )
Interactant Interaction Details
GeneCard External ID(s)
NDRG1 Q92597¹ EBI-356658, EBI-716486
MAP3K3 Q99759² MINT-48440 MINT-48461
HSP90AB1 P08238² MINT-72654
IKBKG Q9Y6K9² MINT-48192
MAP3K1 Q13233² MINT-48311
About this table
2 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation reduction IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for FASN:

Inhibitor

Browse Tocris compounds for FASN
10/51 Novoseek chemical compound relationships for FASN gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty acid	94.03	1405	15920554 (9), 18639282 (7), 15751987 (6), 18555493 (6) (see all 99)
acetyl-coa	87.99	106	12213084 (4), 18760332 (2), 8944144 (2), 12759350 (2) (see all 76)
sterol	83.96	74	16603153 (2), 8605019 (2), 11064454 (2), 18420801 (2) (see all 50)
4'-phosphopantetheine	80.75	5	12815048 (1), 10206962 (1), 9405069 (1), 2318831 (1) (see all 5)
3-hydroxy-3-methylglutaryl-coa	67.23	19	8999918 (2), 8833906 (1), 11323427 (1), 12754279 (1) (see all 10)
lipid	64.58	61	12646257 (2), 16048908 (1), 17413110 (1), 16788566 (1) (see all 44)
glycerol 3-phosphate	64.32	23	9706228 (2), 12643487 (1), 8944144 (1), 9492058 (1) (see all 15)
fabb	62.25	2	16390449 (1), 17485508 (1)
malonyl-coa	61.74	1	11388772 (1)
vibriobactin	60.74	1	15366944 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FASN)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FASN)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC014631

Sigma-Aldrich siRNA and siRNA Panels for FASN

Sigma-Aldrich shRNA Panels and shRNA for FASN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004104

REFSEQ mRNAs for FASN gene:

NM_004104.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004104

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004104
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004104
                                 untagged cDNA clones in CMV expression vector (see all 2): BC014631

Additional cDNA sequence:

AB209988.1 AY451392.1 BC007267.1 BC007305.2 BC007909.1 BC014631.2 BC014634.2 BC021544.2

BC063242.1 CR599966.1 S80437.1 U29344.1

24/28 DOTS entries (see all 28 ):

DT.100059743 DT.448160 DT.95110371 DT.100688445 DT.91871472 DT.100059746 DT.120978580 DT.100648786

DT.120889547 DT.100835114 DT.95110373 DT.120873367 DT.120978641 DT.97821899 DT.100648788 DT.100773814

DT.120978591 DT.120978593 DT.75170060 DT.91780266 DT.95110370 DT.95110375 DT.95110377 DT.95110384

24/885 AceView cDNA sequences (see all 885 ):

CA421099 BF527190 CF540981 AI129371 BE562987 CA406132 BU616733 BQ649866

AW071956 AA827039 BI195732 BQ918008 BU689471 AA339804 AI929663 BU557094

AI655666 BQ424870 BG250599 BG115934 BQ957144 BG674267 BU156868 BQ924717

highest scoring ESTs for FASN:

U29344 BC063242 BU173262 BX384927 AA045488 AA058907 AA069032 AA081439 AA084417 AA101216

Unigene Cluster for FASN:

Fatty acid synthase

Hs.83190 [show with all ESTs]

Unigene Representative Sequence: NM_004104

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FASN (see all 6 )

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36	^	37a	·	37b	·	37c	^	38	^	39a	·	39b	·	39c	^	40a	·	40b	·	40c	^	41	^	42	^
SP1:
SP2:																			-		-		-		-		-
SP3:
SP4:																																											-
SP5:																																	-		-		-		-		-		-		-

ExUns:	43a	·	43b	·	43c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for FASN

1 Ensembl transcript including schematic representation:

ENST00000306749

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FASN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FASN

¹ / ² / ³

5 probe-sets matching FASN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38429_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	U29344	1.00	1.00	1.00	1
212218_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AI954041	0.60	1.00	0.82	1
217006_x_at²	U133-A	1	0.73	1.00	--	--	--	--	--	--	--
212218_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
217006_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGATCTCCAA

SOURCE GeneReport for Unigene cluster: Hs.83190
Expression variation in blood from EXPOLDB for FASN
UniProtKB/Swiss-Prot: FAS_HUMAN, P49327
Tissue specificity: Ubiquitous. Prominent expression in brain, lung, and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FASN gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FASN¹	--	fatty acid synthase	83.22(n) 81.65(a)	483378 XM_540497.2 XP_540497.2
chimpanzee (Pan troglodytes)	FASN¹	--	fatty acid synthase	98.79(n) 98.79(a)	454986 XM_001167297.1 XP_001167297.1
cow (Bos taurus)	FASN¹	--	fatty acid synthase	81.77(n) 79.47(a)	281152 NM_001012669.1 NP_001012687.1
mouse (Mus musculus)	Fasn^{1, 5}	11 (72.00 cM)⁵	fatty acid synthase^{1, 5}	80.91(n)¹ 81.61(a)¹	14104¹ NM_007988.3¹ NP_032014.3¹ AA755295⁵ AF127033⁵ (see all 23)
chicken (Gallus gallus)	FASN¹	--	fatty acid synthase	64.19(n) 65.5(a)	396061 NM_205155.1 NP_990486.1

About this table Species with no ortholog for FASN

ENSEMBL Gene Tree for FASN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FASN gene

OXSM²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/186 NCBI SNPs in FASN are shown (see all 186 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs15324^1,2	C,F,H	77629648(-)	`TTGTTT/CTTCAA`	1	--	ut3¹ ese³		5		MN EU EA WA	562
--	rs11550611^1,2	A,C	77630166(-)	`CTAGAC/TGTAGG`	1	--	ut3¹		0	--	--	--	--
	rs2228307^1,2	C,F	77634184(-)	`GCTACA/GTCATC`	1	I/V	mis¹		1		MN	66
	rs2228306^1,2	C	77633323(-)	`CAGGGT/CGACCC`	1	A/V	mis¹ ese³		1		MN	66
	rs17848956^1,2	C	77629107(-)	`CACCAA/GGACGG`	1	--	ng5¹		0	--	--	--	--
--	rs7222326^1,2	A	77650561(+)	`CGCGCC/TTGCGG`	1	--	ng3¹		0	--	--	--	--
--	rs2229424^1,2	F	77635157(-)	`CTGCYG/ACGTCT`	1	H/R	mis¹ ese³		1		MN	50
	rs2228305^1,2	F	77636081(-)	`CCCACG/ATCCCG`	1	I/V	mis¹ ese³		1		MN	66
--	rs4485435^1,2	A,C,F,H	77638375(+)	`CCTCCG/CGCCAC`	1	A/A	syn¹ ese³		4		EU EA WA	406
	rs1140616^1,2	C,F,H	77632770(-)	`CACATC/TCTGGG`	1	I/I	syn¹		5		MN EU EA WA	462

About this table

HapMap Linkage Disequilibrium images for FASN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600212

10/57 Novoseek disease relationships for FASN gene (see all 57 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	53.04	10	14642615 (3), 10549164 (1), 9629539 (1), 18395093 (1) (see all 6)
obesity	52.47	21	15220220 (3), 16611078 (1), 16788566 (1), 17847090 (1) (see all 13)
prostate cancer	52.00	64	17477363 (5), 18774944 (4), 18817351 (3), 14689581 (3) (see all 31)
breast cancer	51.88	137	15870863 (7), 17786307 (6), 15583825 (5), 12531699 (5) (see all 49)
cancer	51.25	182	17168665 (7), 15607569 (6), 10716717 (4), 15533929 (3) (see all 88)
breast carcinoma	49.44	20	8630954 (3), 11447743 (2), 8022791 (1), 10228495 (1) (see all 13)
insulin resistance	44.25	3	18483661 (1), 19181734 (1)
tumors	43.80	123	9191002 (5), 18796435 (4), 10705076 (3), 15897909 (3) (see all 60)
carcinoma	38.20	23	15051923 (2), 9815604 (2), 11323104 (1), 17409402 (1) (see all 15)
hyperlipidemia	32.83	1	9575816 (1)

About this table

Human Gene Mutation Database: FASN
Human Genome Epidemiology Navigator: FASN (6 documents)
Tumor Gene Database: FASN

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/551 PubMed articles for FASN gene (see all 551 ):

Human fatty acid synthase: properties and molecular cloning. (PubMed id 7567999)^{1, 2, 3, 4} Jayakumar A....Wakil S.J. (1995)
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. (PubMed id 15507492)^{1, 3, 4} Chakravarty B.... Quiocho F.A. (2004)
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. (PubMed id 17618296)^{1, 3, 4} Pemble C.W....Lowther W.T. (2007)
Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation. (PubMed id 7595075)^{1, 3, 4} Semenkovich C.F.... Fiedorek F.T. Jr. (1995)
Fatty acid synthesis: a potential selective target for antineoplastic therapy. (PubMed id 8022791)^{1, 3, 4} Kuhajda F.P.... Pasternack G.R. (1994)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{2, 3} Persson B....Oppermann U. (2008)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2194	HGNC: 3594	AceView: FASN	Ensembl:ENSG00000169710	euGenes: HUgn2194
ECgene: FASN	H-InvDB: FASN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FASN	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FASN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FASN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FASN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FASN		Antibodies for FASN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FASN		Small molecules for FASN
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FASN)
	Antibodies (FASN)
	Chimera RNAi (FASN)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FASN (Fatty acid Synthase)

	Recombinant Proteins (Fatty Acid Synthase)
	Antibodies (Fatty Acid Synthase)

Search OriGene for FASN

Search Tocris compounds for FASN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FASN

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FASN Gene at Home site.
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FASN Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for FASN

Summaries
for FASN

Genomic Location
for FASN

Proteins
for FASN

Protein Domains/
Families
for FASN

Gene Function
for FASN

Pathways & Interactions
for FASN

Drugs & Compounds
for FASN

Transcripts
for FASN

Expression
for FASN

Orthologs
for FASN

Paralogs
for FASN

SNPs/Variants
for FASN

Disorders & Mutations
for FASN

Medical News
for FASN

Publications
for FASN

Search for FASN

Genome Databases showing FASN

Other Databases showing FASN

Specialized Databases showing FASN

Licensable Technologies
for FASN

Services
for FASN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FASN Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor FASN

Summariesfor FASN

Genomic Locationfor FASN

Proteinsfor FASN

Protein Domains/Familiesfor FASN

Gene Functionfor FASN

Pathways & Interactionsfor FASN

Drugs & Compoundsfor FASN

Transcriptsfor FASN

Expression for FASN

Orthologsfor FASN

Paralogsfor FASN

SNPs/Variantsfor FASN

Disorders & Mutationsfor FASN

Medical Newsfor FASN

Publicationsfor FASN

Search for FASN

Genome Databases showing FASN

Other Databases showing FASN

Specialized Databases showing FASN

Licensable Technologiesfor FASN

Servicesfor FASN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FASN

Summaries
for FASN

Genomic Location
for FASN

Proteins
for FASN

Protein Domains/
Families
for FASN

Gene Function
for FASN

Pathways & Interactions
for FASN

Drugs & Compounds
for FASN

Transcripts
for FASN

Expression
for FASN

Orthologs
for FASN

Paralogs
for FASN

SNPs/Variants
for FASN

Disorders & Mutations
for FASN

Medical News
for FASN

Publications
for FASN

Licensable Technologies
for FASN

Services
for FASN