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F10 Gene

protein-coding GIFtS: 66

GC13P112825

coagulation factor X
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.4.21.6 ^³
FX ^²
FXA ^²
OTTHUMP00000018735 ^²
prothrombinase ^²

Descriptions
Stuart factor ^³
Stuart-Prower factor ^², ³
coagulation factor X ^²
factor Xa ^²

External Ids
HGNC: 3528¹
Entrez Gene: 2159²
UniProtKB: P00742³
Ensembl: ENSG00000126218⁷

Search outside databases for aliases for F10 gene

Previous GC identifers: GC13P112387 GC13P108414 GC13P112863 GC13P111725

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for F10:

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade.

This factor undergoes multiple processing steps before its preproprotein is converted to a mature

two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together

by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain

contains the catalytic domain which is structurally homologous to those of the other hemostatic

serine proteases. The mature factor is activated by the cleavage of the activation peptide by

factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated

factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid

during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic

condition of variable severity. [provided by RefSeq]

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in

the presence of factor Va, calcium and phospholipid during blood clotting

Gene Wiki entry for F10 (Factor_X)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the F10 gene

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

F10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P112825: (about GC identifiers)

Start:	112,825,114 bp from pter
End:	112,851,844 bp from pter
Size:	26,731 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_027140.6

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742 (See protein sequence)

Recommended Name: Coagulation factor X precursor

Size: 488 amino acids; 54732 Da

Subunit: The two chains are formed from a single-chain precursor by the excision of two Arg

residues and are held together by 1 or more disulfide bonds

Subcellular location: Secreted

PDB structures from and Proteopedia :

1C5M (3D)

1EZQ (3D)

1F0R (3D)

1F0S (3D)

1FAX (3D)

1FJS (3D)

1FXY (3D)

1G2L (3D)

1G2M (3D)

1HCG (3D)

1IOE (3D)

1IQE (3D)

1IQF (3D)

1IQG (3D)

1IQH (3D)

1IQI (3D)

1IQJ (3D)

1IQK (3D)

1IQL (3D)

1IQM (3D)

1IQN (3D)

1KSN (3D)

1KYE (3D)

1LPG (3D)

1LPK (3D)

1LPZ (3D)

1LQD (3D)

1MQ5 (3D)

1MQ6 (3D)

1MSX (3D)

1NFU (3D)

1NFW (3D)

1NFX (3D)

1NFY (3D)

1NL8 (3D)

1P0S (3D)

1V3X (3D)

1WU1 (3D)

1XKA (3D)

1XKB (3D)

1Z6E (3D)

2BMG (3D)

2BOH (3D)

2BOK (3D)

2BQ6 (3D)

2BQ7 (3D)

2BQW (3D)

2CJI (3D)

2D1J (3D)

2EI6 (3D)

2EI7 (3D)

2EI8 (3D)

2FZZ (3D)

2G00 (3D)

2GD4 (3D)

2H9E (3D)

2J2U (3D)

2J34 (3D)

2J38 (3D)

2J4I (3D)

2J94 (3D)

2J95 (3D)

2JKH (3D)

2P16 (3D)

2P3F (3D)

2P3T (3D)

2P3U (3D)

2P93 (3D)

2P94 (3D)

2P95 (3D)

2PHB (3D)

2PR3 (3D)

2Q1J (3D)

2RA0 (3D)

2UWL (3D)

2UWO (3D)

2UWP (3D)

2VH0 (3D)

2VH6 (3D)

2W26 (3D)

2W3I (3D)

2W3K (3D)

3CEN (3D)

3CS7 (3D)

3ENS (3D)

Secondary accessions: Q14340

Post-translational modifications:

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified

protein to bind calcium¹

N- and O-glycosylated¹

The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in

the extrinsic pathway)¹

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R)

stereospecific within EGF domains¹

REFSEQ proteins: NP_000495.1

ENSEMBL proteins:

ENSP00000386320 ENSP00000387092 ENSP00000364701 ENSP00000364709

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for F10 (Coagulation Factor X)
	Enzo Life Sciences proteins for F10
	Recombinant Proteins from Abcam (Factor Xa, Factor X + Xa, Factor X, Factor Xa Heavy Chain)
	Human Recombinant Proteins from Abnova (F10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005886	plasma membrane	EXP	2271516 3052293 14982929

About this table

Antibodies for F10:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of F10
	Sigma-Aldrich Antibodies for F10
	R&D Systems Antibodies for F10 (Coagulation Factor X)
	Antibodies from Abcam (Factor Xa, Factor X + Xa, Factor X, Factor Xa Heavy Chain), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (F10)
	Search Novus for antibodies for F10

Assays for F10:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00742

ProtoNet protein and cluster: P00742

5/7 Blocks protein families (see all 7 ):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

IPB001438 Type II EGF-like signature

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Similarity: Belongs to the peptidase S1 family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain

Similarity: Contains 1 peptidase S1 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000504

Applied Biosystems Silencer® siRNAs for F10

Sigma-Aldrich siRNA and siRNA Panels for F10

Sigma-Aldrich shRNA Panels and shRNA for F10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000504
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000504
untagged cDNA clone in CMV expression vector: NM_000504

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000504

UniProtKB/Swiss-Prot: FA10_HUMAN, P00742

Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in

the presence of factor Va, calcium and phospholipid during blood clotting

Catalytic activity: Selective cleavage of Arg- -Thr and then Arg- -Ile bonds in prothrombin to form

thrombin

Enzyme Number (IUBMB): EC 3.4.21.6

Genatlas biochemistry entry for F10:

coagulation factor X (Stuart Prower),vitamin K-dependent

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for F10):

	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging
reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	TAS	3011603
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	18267072
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for F10 (Your Favorite Gene powered by Ingenuity)

TR/RXR Activation
Coagulation System

GeneDecks F10 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for F10

5/59 Interacting proteins for F10 (P00742^{1, 2} ENSP00000364709³) via UniProtKB, MINT, and/or STRING (see all 59 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
- - (xeno)	Q16938¹	EBI-719750, EBI-1646347 EBI-719750, EBI-1646299
PII PII (xeno)	P04133¹	EBI-719750, EBI-1646019
F3	ENSP00000334145³	STRING (score=.999)
SERPINC1	ENSP00000356671³	STRING (score=.999)
TFPI	ENSP00000233156³	STRING (score=.999)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0007598	blood coagulation, extrinsic pathway	EXP	7598447

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for F10:

Inhibitor

Browse Tocris compounds for F10
10/37 Novoseek chemical compound relationships for F10 gene (see all 37 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rivaroxaban	93.30	92	17938768 (3), 18307374 (3), 17595891 (3), 17873238 (2) (see all 50)
apixaban	89.88	19	18315548 (3), 17868430 (2), 18393142 (1), 18814828 (1) (see all 14)
heparin pentasaccharide	88.62	11	12353073 (2), 11854268 (1), 14532267 (1), 12871328 (1) (see all 8)
otamixaban	82.09	11	17139573 (3), 17178269 (2), 16493482 (2), 15841331 (1) (see all 7)
gamma-carboxyglutamic acid	80.80	41	8226763 (4), 17387172 (3), 9780208 (2), 8355279 (1) (see all 18)
phospholipid	79.34	245	10456458 (7), 16403024 (4), 1989997 (3), 9538022 (3) (see all 99)
spectrozyme	77.57	9	10995746 (2), 12540961 (1), 11389008 (1), 1579892 (1) (see all 6)
dabigatran	77.27	8	18393142 (1), 18814828 (1), 18257025 (1), 18835010 (1) (see all 5)
dabigatran etexilate	76.56	8	18473863 (1), 19204837 (1), 16906775 (1), 19229800 (1) (see all 5)
p-amino benzamidine	74.06	6	8993332 (4), 1606162 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (F10)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (F10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000504

Sigma-Aldrich siRNA and siRNA Panels for F10

Sigma-Aldrich shRNA Panels and shRNA for F10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000504

REFSEQ mRNAs for F10 gene:

NM_000504.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000504

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000504
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000504
                                 untagged cDNA clone in CMV expression vector: NM_000504

Additional cDNA sequence:

AK310772.1 AK310775.1 AK313798.1 BC040125.1 BC046125.1 CR603372.1 CR607773.1 CR623031.1

K01886.1 K03194.1 M22613.1 M57285.1

3 DOTS entries:

DT.313355 DT.100676340 DT.120780844

24/72 AceView cDNA sequences (see all 72 ):

CB158437 BC046125 CR623031 BU846186 BP339855 BU849949 CD676150 M57285

CD014138 CB162539 CD013940 CR603372 BQ018853 K01886 BQ027447 BM709916

CA444781 CR607773 NM_000504 M22613 CD518821 BC040125 BM987312 BU848686

highest scoring ESTs for F10:

AA484793 AA554502 AA635569 AA635577 AA724725 AA970666 AI033477 AI052362 AI160870 AI192868

Unigene Cluster for F10:

Coagulation factor X

Hs.361463 [show with all ESTs]

Unigene Representative Sequence: BC040125

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for F10 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c
SP1:									-						-						-
SP2:									-						-		-				-
SP3:									-						-
SP4:															-						-						-
SP5:																					-

About this scheme

ECgene alternative splicing isoforms for F10

4 Ensembl transcripts including schematic representations:

ENST00000410083 ENST00000409306 ENST00000375551 ENST00000375559

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

F10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for F10

¹ / ² / ³

3 probe-sets matching F10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39979_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L29433	0.20	1.00	0.72	1
205620_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_000504	0.60	1.00	0.82	1
205620_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks F10 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCCGGAGGT

SOURCE GeneReport for Unigene cluster: Hs.361463
Expression variation in blood from EXPOLDB for F10
UniProtKB/Swiss-Prot: FA10_HUMAN, P00742
Tissue specificity: Plasma; synthesized in the liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for F10 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	F10¹	--	coagulation factor X	77.22(n) 74.63(a)	476993 XM_850853.1 XP_855946.1
chimpanzee (Pan troglodytes)	F10¹	--	coagulation factor X	99.52(n) 100(a)	452679 XM_509746.2 XP_509746.2
cow (Bos taurus)	F10¹	--	coagulation factor X	77.25(n) 72.29(a)	790178 XM_001256721.1 XP_001256722.1
rat (Rattus norvegicus)	F10¹	--	coagulation factor X	77.31(n) 75.69(a)	29243 NM_017143.2 NP_058839.1
mouse (Mus musculus)	F10^{1, 5}	8 (7.00 cM)⁵	coagulation factor X^{1, 5}	77.97(n)¹ 77.54(a)¹	14058¹ NM_007972.3¹ NP_031998.3¹ AF087644⁵ AF211347⁵ (see all 14)

About this table Species with no ortholog for F10

ENSEMBL Gene Tree for F10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for F10 gene

F9² F7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/243 NCBI SNPs in F10 are shown (see all 243 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 142)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3093261^1,2	A,C,F,H	112824083(+)	`GCAGTC/TGGGTG`	1	--	ng5¹		20	NS EU EA WA NA	1528
	rs5961^1,2	C,F,H	112831786(+)	`GAGCAG/CGCCAA`	1	H/Q	mis¹ ese³		13	MN NA EU EA WA	1272
	rs3212994^1,2	C,F,H	112825131(+)	`GCAGCC/TTGTCC`	1	--	ut5¹ ese³		7	NS EU EA WA	554
	rs11841132^1,2	C,F,H	112852137(+)	`GTTGGC/GGCAGC`	1	--	ng3¹		4	EU EA WA	418
	rs3211803^1,2	C,F,H	112852192(+)	`GGGAAT/GTGGAC`	1	--	ng3¹		15	NS NA EU EA WA	1314
	rs563064^1,2	C,F,H	112824372(+)	`GAGACG/ACTCAG`	1	--	ng5¹		12	EA NA NS EU WA	686
--	rs563964^1,2	C,F,H	112824948(+)	`GGTTCT/CGCGGG`	1	--	ng5¹		6	NS EA WA	428
	rs3212991^1,2	C,F,H	112824386(+)	`CTTGTG/CATGGG`	1	--	ng5¹		10	NS EU EA WA NA	688
	rs3212990^1,2	C,F,H	112823876(+)	`GCCATG/AAGCAT`	1	--	ng5¹		7	NS EU EA WA	552
--	rs3211772^1,2	F,H	112843317(+)	`CCTGCG/ACCCGC`	1	T/A	mis¹ ese³		6	NS EU EA WA	504

About this table

HapMap Linkage Disequilibrium images for F10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 227600

10/80 Novoseek disease relationships for F10 gene (see all 80 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
factor x deficiency	78.69	3	9799000 (1), 8449937 (1), 15569527 (1)
thromboembolism	78.11	47	16409461 (2), 16241946 (2), 14650860 (2), 12172443 (1) (see all 38)
thrombosis	74.79	69	10604970 (2), 11554940 (2), 12829728 (2), 15338955 (2) (see all 52)
scott syndrome	74.31	5	1730083 (2), 9054648 (1), 19408196 (1), 11421293 (1)
deep vein thrombosis	68.47	8	15091002 (1), 15554723 (1), 8029801 (1), 12750119 (1) (see all 8)
arterial thrombosis	67.49	16	10813384 (1), 11177336 (1), 11342132 (1), 17729190 (1) (see all 13)
bleeding	64.85	42	11554940 (2), 12829728 (2), 14633255 (2), 11177336 (1) (see all 36)
venous thrombosis	63.03	24	11434677 (3), 9241747 (2), 9336303 (1), 10813384 (1) (see all 13)
hemophilia a	62.01	3	2130929 (1), 14717973 (1), 16409469 (1)
quebec platelet disorder	59.12	2	19408196 (1), 11421293 (1)

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Genatlas disease: F10

bleeding diathesis (FX deficiency)

Human Gene Mutation Database: F10
Human Genome Epidemiology Navigator: F10 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1073 PubMed articles for F10 gene (see all 1073 ):

Structural basis for chemical inhibition of human blood coagulation factor Xa. (PubMed id 9618463)^{1, 3, 4} Kamata K.... Kim S.H. (1998)
Structure of human des(1-45) factor Xa at 2.2-A resolution. (PubMed id 8355279)^{1, 3, 4} Padmanabhan K.... Kisiel W. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{3, 4} Cargill M....Lander E.S. (1999)
Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X. (PubMed id 8243461)^{3, 4} Inoue K. and Morita T. (1993)
Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. (PubMed id 1902434)^{3, 4} Messier T.L.... Church W.R. (1991)
Cloning and characterization of the 5' end (exon 1) of the gene encoding human factor X. (PubMed id 2612918)^{3, 4} Jagadeeswaran P.... Lyman G. (1989)
Isolation and characterization of human blood-coagulation factor X cDNA. (PubMed id 3011603)^{3, 4} Kaul R.K.... Jagadeeswaran P. (1986)
Gene for human factor X: a blood coagulation factor whose gene organization is essentially identical with that of factor IX and protein C. (PubMed id 3768336)^{3, 4} Leytus S.P.... Davie E.W. (1986)
Characterization of an almost full-length cDNA coding for human blood coagulation factor X. (PubMed id 2582420)^{3, 4} Fung M.R.... McGillivray R.T.A. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2159	HGNC: 3528	AceView: F10	Ensembl:ENSG00000126218	euGenes: HUgn2159
ECgene: F10	H-InvDB: F10

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Factor_X
SeattleSNPs	http://pga.gs.washington.edu/data/f10/

Licensable Technologies for F10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for F10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for F10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for F10		Antibodies for F10
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Chimera RNAi (F10)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Factor Xa, Factor X + Xa, Factor X, Factor Xa Heavy Chain)
	Antibodies (Factor Xa, Factor X + Xa, Factor X, Factor Xa Heavy Chain)

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	Proteins for F10
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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F10 Gene at Home site.
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F10 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for F10

Summaries
for F10

Genomic Location
for F10

Proteins
for F10

Protein Domains/
Families
for F10

Gene Function
for F10

Pathways & Interactions
for F10

Drugs & Compounds
for F10

Transcripts
for F10

Expression
for F10

Orthologs
for F10

Paralogs
for F10

SNPs/Variants
for F10

Disorders & Mutations
for F10

Medical News
for F10

Publications
for F10

Search for F10

Genome Databases showing F10

Other Databases showing F10

Specialized Databases showing F10

Licensable Technologies
for F10

Services
for F10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

F10 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor F10

Summariesfor F10

Genomic Locationfor F10

Proteinsfor F10

Protein Domains/Familiesfor F10

Gene Functionfor F10

Pathways & Interactionsfor F10

Drugs & Compoundsfor F10

Transcriptsfor F10

Expression for F10

Orthologsfor F10

Paralogsfor F10

SNPs/Variantsfor F10

Disorders & Mutationsfor F10

Medical Newsfor F10

Publicationsfor F10

Search for F10

Genome Databases showing F10

Other Databases showing F10

Specialized Databases showing F10

Licensable Technologiesfor F10

Servicesfor F10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for F10

Summaries
for F10

Genomic Location
for F10

Proteins
for F10

Protein Domains/
Families
for F10

Gene Function
for F10

Pathways & Interactions
for F10

Drugs & Compounds
for F10

Transcripts
for F10

Expression
for F10

Orthologs
for F10

Paralogs
for F10

SNPs/Variants
for F10

Disorders & Mutations
for F10

Medical News
for F10

Publications
for F10

Licensable Technologies
for F10

Services
for F10