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DRD2 Gene

protein-coding GIFtS: 74

GC11M112785

dopamine receptor D2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
D2DR ^²
D2R ^²

Descriptions
Dopamine D2 receptor ^³
dopamine receptor D2 ^²
dopamine receptor D2 isoform ^²
seven transmembrane helix receptor ^²

External Ids
HGNC: 3023¹
Entrez Gene: 1813²
UniProtKB: P14416³
Ensembl: ENSG00000149295⁷

Search outside databases for aliases for DRD2 gene

Previous GC identifers: GC11M115633 GC11M114792 GC11M113314 GC11M112817

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DRD2:

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits

adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other

mutations have been associated with schizophrenia. Alternative splicing of this gene results in

two transcript variants encoding different isoforms. A third variant has been described, but it

has not been determined whether this form is normal or due to aberrant splicing. [provided by

RefSeq]

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416

Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this

receptor is mediated by G proteins which inhibit adenylyl cyclase

Gene Wiki entry for DRD2 (Dopamine_receptor_D2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DRD2 gene

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q22-q23

DRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M112785: (about GC identifiers)

Start:	112,785,527 bp from pter
End:	112,851,103 bp from pter
Size:	65,577 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416 (See protein sequence)

Recommended Name: D(2) dopamine receptor

Size: 443 amino acids; 50619 Da

Subunit: Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structure from and Proteopedia :

1I15 (3D)

2HLB (3D)

Secondary accessions: Q9NZR3 Q9UPA9

Alternative splicing: 3 isoforms: P14416-1 P14416-2 P14416-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000786.1 NP_057658.2

ENSEMBL proteins:

ENSP00000347474 ENSP00000354859 ENSP00000278597

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant DRD2 Protein
	Sigma-Aldrich CompoZr ZFN for DRD2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dopamine D2 Receptor, Dopamine Receptor D2L, Dopamine Receptor D2 + D3)
	Human Recombinant Proteins from Abnova (DRD2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IDA	8413587
GO:0030424	axon	ISS	--
GO:0030425	dendrite	ISS	--

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Antibodies for DRD2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of DRD2
	Sigma-Aldrich Antibodies for DRD2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Dopamine D2 Receptor, Dopamine Receptor D2L, Dopamine Receptor D2 + D3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DRD2)
	Novus Biologicals Antibodies for DRD2

Assays for DRD2:

	Invitrogen Assays for DRD2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P14416

ProtoNet protein and cluster: P14416

2 Blocks protein families:

IPB000929 Dopamine receptor signature

IPB001922 Dopamine D2 receptor signature

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DRD2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DRD2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_016574

Applied Biosystems Silencer® siRNAs for DRD2

Sigma-Aldrich siRNA and siRNA Panels for DRD2

Sigma-Aldrich shRNA Panels and shRNA for DRD2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Millipore Clones for the Expression of DRD2

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000795
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000795
untagged cDNA clones in CMV expression vector (see all 3): BC021195

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC021195

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416

Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this

receptor is mediated by G proteins which inhibit adenylyl cyclase

Genatlas biochemistry entry for DRD2:

dopamine receptor D2 (two isoforms),adenylate cyclase inhibiting,G protein coupled receptor

superfamily,expressed in the basal ganglia (contradictory evidence for association of the S311C

variant with schizophrenia),regulated by DNA methylation,involved in the regulation of appetite

and growth hormone

12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Drd2):

behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
homeostasis/metabolism	lethality-postnatal	life span-post-weaning/aging	nervous system	pigmentation
reproductive system	skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001670	dopamine D2 receptor activity	IDA	8301582
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004952	dopamine receptor activity	IEA	--
GO:0005515	protein binding	IPI	10692483

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for DRD2 (Your Favorite Gene powered by Ingenuity)

Dopamine Receptor Signaling
cAMP-mediated Signaling
G-Protein Coupled Receptor Signaling

GeneDecks DRD2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DRD2

5/44 Interacting proteins for DRD2 (P14416² ENSP00000347474³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC6A3	Q01959², ENSP00000270349³	MINT-4789680 MINT-4789661 MINT-4789619 MINT-4789636 STRING (score=.985)
PPP1R9B	Q96SB3², ENSP00000320510³	MINT-4953534 STRING (score=.94)
COMT	ENSP00000207636³	STRING (score=.985)
FLNA	ENSP00000358879³	STRING (score=.984)
FREQ	ENSP00000361475³	STRING (score=.975)

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5/49 Gene Ontology (GO) biological process terms (links to tree view) (see all 49 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001659	temperature homeostasis	ISS	--
GO:0001975	response to amphetamine	ISS	--
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	ISS	--
GO:0002027	regulation of heart rate	ISS	--
GO:0002028	regulation of sodium ion transport	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for DRD2

Sigma-Aldrich Small Molecules for DRD2:

Metabolite Mixed Agonist/Antagonist Antagonist Blocker Agonist Inhibitor

Ligand

Compounds for DRD2 available from Tocris Bioscience

Compound	Action	CAS number
L-741,626	High affinity D2 antagonist
Raclopride	Potent, selective D2/D3 antagonist	[84225-95-6]
(-)-Quinpirole hydrochloride	Selective D2-like agonist	[85760-74-3]

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7 Novoseek chemical compound relationships for DRD2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
(11c)-n-methylspiperone	81.27	14	10647606 (3), 7909948 (2), 17413189 (1), 9226735 (1) (see all 9)
2'-iodospiperone	80.19	9	8534585 (3), 7790943 (3), 1399682 (1)
epidepride	78.09	6	8970508 (2), 10473189 (2), 9374338 (1), 8278896 (1)
benzamide	75.78	18	8804920 (2), 1358662 (2), 2144583 (1), 9873388 (1) (see all 15)
fesp	70.55	2	8341311 (1), 8828616 (1)
bifeprunox	61.56	3	16554049 (3)
mp-11	52.28	1	9015795 (1)

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2 PharmGKB drug compound relationships for DRD2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
levodopa	GN	20201778
ziprasidone	PD	15610950

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DRD2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DRD2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_016574

Sigma-Aldrich siRNA and siRNA Panels for DRD2

Sigma-Aldrich shRNA Panels and shRNA for DRD2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000795 NM_016574

REFSEQ mRNAs for DRD2 gene (2 alternative transcripts):

NM_000795.3 NM_016574.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000795 NM_016574

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000795
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000795
                                 untagged cDNA clones in CMV expression vector (see all 3): BC021195

Additional cDNA sequence:

AB209832.1 AB451480.1 AF176812.1 AK308777.1 BC021195.2 M29066.1 M30625.1 S62137.1

S69899.1 X51362.1 X51645.1

5 DOTS entries:

DT.91757826 DT.99961527 DT.97836669 DT.91757824 DT.100775079

24/34 AceView cDNA sequences (see all 34 ):

BE795107 BC021195 NM_000795 NM_016574 BV203633 BM931977 BX283073 BE798784

BE266564 BM685017 AI732883 BG827135 M29066 BF311583 BF311952 AI369867

AF176812 X51645 BQ879192 BQ719305 AA316796 BI195997 BM711919 M30625

highest scoring ESTs for DRD2:

X51362 AI692402 AI693287 AI820631 AW139137 BC021195 BF437994 M30625 S69899 AA316796

Unigene Cluster for DRD2:

Dopamine receptor D2

Hs.73893 [show with all ESTs]

Unigene Representative Sequence: NM_000795

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DRD2 (see all 10 )

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:									-		-		-																								-
SP2:																					-																-
SP3:
SP4:									-		-		-																						-		-
SP5:			-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for DRD2

3 Ensembl transcripts including schematic representations:

ENST00000355319 ENST00000362072 ENST00000346454

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DRD2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DRD2

¹ / ² / ³

9 probe-sets matching DRD2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40371_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X51362	1.00	1.00	1.00	1
211624_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M30625	0.80	1.00	0.91	1
216938_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S69899	0.80	1.00	0.91	1
216924_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S62137	0.60	1.00	0.82	1
206590_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000795	0.60	1.00	0.82	1
211624_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216938_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216924_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206590_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DRD2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACCAAACTA

SOURCE GeneReport for Unigene cluster: Hs.73893
Expression variation in blood from EXPOLDB for DRD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DRD2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DRD2¹	--	dopamine receptor D2	93.98(n) 96.39(a)	403701 NM_001003110.1 NP_001003110.1
chimpanzee (Pan troglodytes)	DRD2¹	--	dopamine receptor D2	99.7(n) 99.77(a)	451553 NM_001033928.1 NP_001029100.1
cow (Bos taurus)	DRD2¹	--	dopamine receptor D2	93(n) 96.61(a)	281126 NM_174043.2 NP_776468.1
rat (Rattus norvegicus)	Drd2¹	--	dopamine receptor D2	90.29(n) 95.94(a)	24318 NM_012547.1 NP_036679.1
mouse (Mus musculus)	Drd2^{1, 5}	9 (28.00 cM)⁵	dopamine receptor 2^{1, 5}	90.9(n)¹ 95.94(a)¹	13489¹ NM_010077.1¹ NP_034207.1¹ BC105663⁵ BC105664⁵ (see all 8)

About this table Species with no ortholog for DRD2

ENSEMBL Gene Tree for DRD2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DRD2 gene

DRD4² DRD3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416

Polymorphism: Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism

[MIM:103780]. Genetic variations in DRD2 might be a protective factor against the development of

withdrawal symptoms but might also be a risk factor in a highly burdened subgroup of alcoholics

with a paternal and grandpaternal history of alcoholism and might contribute to suicide risk in

alcoholics

10/362 NCBI SNPs in DRD2 are shown (see all 362 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 189)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs6276^1,2	A,C,F,H	112786607(-)	`AGGCCA/GGCCAG`	2	--	ut3¹		11	MN CSAM EA EU WA	1076
--	rs2242591^1,2	A,C,F,H	112785131(-)	`GCCCCG/AACAAC`	2	--	ng5¹		4	EA WA	1766
	rs6279^1,2	A,C,F,H	112786283(-)	`TTTCTC/GTTTGT`	2	--	ut3¹ trp³		16	MN EA CA EU NA WA	2878
	rs12364283^1,2	C,F,H	112852165(+)	`GCCAGA/GTTCTG`	2	--	ng3¹		4	EU EA WA	420
	rs1799978^1,2	C,F,H	112851561(-)	`AGCTTA/GTTACT`	2	--	ng3¹ tfbs³		9	MN CSAM EA EU WA	814
	rs1800496^1,2	C,F,H	112788698(-)	`CCGACC/TCGTCC`	2	P/S	mis¹ ese³		9	MN CSAM EA WA NA	736
	rs6278^1,2	A,C,F	112785934(-)	`ACCCTG/TCTGCC`	2	--	ut3¹ ese³		5	MN NA	394
	rs6274^1,2	F,H	112786138(-)	`GCAGGT/GTGGAC`	2	--	ut3¹ ese³		5	MN EU EA WA	598
--	rs1801028^1,2	C,F	112788694(-)	`CCCGTC/GCCACC`	2	S/C	mis¹ ese³		6	MN CSAM EA NA	440
	rs2734842^1,2	F,H	112785484(-)	`TATAGC/GAAGAC`	2	--	ng5¹		4	EU EA WA	398

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HapMap Linkage Disequilibrium images for DRD2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126450 disorders: 159900

UniProtKB/Swiss-Prot: DRD2_HUMAN, P14416

It has been suggested that DRD2 is involved in psychiatric disorders; especially in

schizophrenia

Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as

alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of

sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is

characterized by involuntary lightning jerks and dystonic movements and postures alleviated by

alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement,

presence of myoclonus and response to alcohol are all variable

10/92 Novoseek disease relationships for DRD2 gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	83.62	308	2069495 (6), 8439241 (5), 17207969 (4), 9351493 (4) (see all 99)
alcoholism	76.81	275	10235293 (6), 11236830 (5), 8871803 (5), 17850642 (5) (see all 99)
parkinson disease	72.95	98	10647606 (4), 10990520 (4), 8489408 (3), 8543941 (3) (see all 62)
prolactinoma	68.15	19	7907340 (2), 12552124 (2), 7641411 (1), 12972179 (1) (see all 14)
parkinsonism	66.12	20	9452320 (1), 8534585 (1), 11993184 (1), 10416511 (1) (see all 20)
catalepsy	62.52	9	1975782 (1), 1358127 (1), 7901761 (1), 10958084 (1) (see all 8)
extrapyramidal syndrome	62.43	7	9949416 (2), 11606886 (1), 8103229 (1), 16867246 (1)
psychotic	60.92	17	10208638 (1), 11765615 (1), 15952869 (1), 7771917 (1) (see all 17)
hyperprolactinemia	60.54	15	16169407 (5), 19339912 (3), 12704865 (1), 17285098 (1) (see all 8)
schizoaffective disorder	59.59	2	8439241 (1), 18786813 (1)

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1 PharmGKB disease relationship for DRD2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Parkinson's	GN	20201778

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GeneTests: DRD2

Myoclonus-Dystonia

Human Gene Mutation Database: DRD2
Genetic Association Database: DRD2
Human Genome Epidemiology Navigator: DRD2 (635 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1219 PubMed articles for DRD2 gene (see all 1219 ):

Association of a missense change in the D2 dopamine receptor with myoclonus dystonia. (PubMed id 10220438)^{1, 3, 4, 6} Klein C.... Ozelius L.J. (1999)
Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. (PubMed id 15084894)^{1, 3, 6} Huang S.Y....Lu R.B. (2004)
Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorder. (PubMed id 11236830)^{1, 3, 6} Lu R.B....Lin W.W. (2001)
Association and excess of transmission of a DRD2 haplotype in a sample of French schizophrenic patients. (PubMed id 11343878)^{1, 3, 6} Dubertret C....Ades J. (2001)
Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (PubMed id 15389757)^{1, 3, 4} Johann M.... Wodarz N. (2005)
Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of affective disorders. (PubMed id 11857579)^{1, 3, 6} Massat I....Mendlewicz J. (2002)
A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys). (PubMed id 7902708)^{1, 3, 4} Itokawa M.... Toru M. (1993)
Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment. (PubMed id 15383158)^{1, 3, 6} Lattuada E....Smeraldi E. (2004)
L -dopa-induced adverse effects in PD and dopamine transporter gene polymorphism. (PubMed id 12796525)^{1, 3, 6} Kaiser R....Brockmoller J. (2003)
Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression. (PubMed id 12834818)^{1, 3, 6} Benedetti F....Smeraldi E. (2003)

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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1813	HGNC: 3023	AceView: DRD2	Ensembl:ENSG00000149295	euGenes: HUgn1813
ECgene: DRD2	H-InvDB: DRD2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=DRD2

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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DRD2 Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for DRD2

Summaries
for DRD2

Genomic Location
for DRD2

Proteins
for DRD2

Protein Domains/
Families
for DRD2

Gene Function
for DRD2

Pathways & Interactions
for DRD2

Drugs & Compounds
for DRD2

Transcripts
for DRD2

Expression
for DRD2

Orthologs
for DRD2

Paralogs
for DRD2

SNPs/Variants
for DRD2

Disorders & Mutations
for DRD2

Medical News
for DRD2

Publications
for DRD2

Search for DRD2

Genome Databases showing DRD2

Other Databases showing DRD2

Specialized Databases showing DRD2

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for DRD2

Services
for DRD2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DRD2 Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor DRD2

Summariesfor DRD2

Genomic Locationfor DRD2

Proteinsfor DRD2

Protein Domains/Familiesfor DRD2

Gene Functionfor DRD2

Pathways & Interactionsfor DRD2

Drugs & Compoundsfor DRD2

Transcriptsfor DRD2

Expression for DRD2

Orthologsfor DRD2

Paralogsfor DRD2

SNPs/Variantsfor DRD2

Disorders & Mutationsfor DRD2

Medical Newsfor DRD2

Publicationsfor DRD2

Search for DRD2

Genome Databases showing DRD2

Other Databases showing DRD2

Specialized Databases showing DRD2

Licensable Technologiesfor DRD2

Servicesfor DRD2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DRD2

Summaries
for DRD2

Genomic Location
for DRD2

Proteins
for DRD2

Protein Domains/
Families
for DRD2

Gene Function
for DRD2

Pathways & Interactions
for DRD2

Drugs & Compounds
for DRD2

Transcripts
for DRD2

Expression
for DRD2

Orthologs
for DRD2

Paralogs
for DRD2

SNPs/Variants
for DRD2

Disorders & Mutations
for DRD2

Medical News
for DRD2

Publications
for DRD2

Licensable Technologies
for DRD2

Services
for DRD2