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DAD1 Gene

protein-coding   GIFtS: 66
GCID: GC14M023033

Defender Against Cell Death 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Defender Against Cell Death 11 2 3     OST22
Oligosaccharyltransferase Subunit 2 (Non-Catalytic)1 2     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit
DAD12
Oligosaccharyl Transferase Subunit DAD12 3     Oligosaccharyltransferase 2 Homolog2
DAD-12 3     EC 2.4.99.183
Oligosaccharyltransferase 2 Homolog (S. Cerevisiae)1     EC 2.4.1.1198

External Ids:    HGNC: 26641   Entrez Gene: 16032   Ensembl: ENSG000001295627   OMIM: 6002435   UniProtKB: P618033   

Export aliases for DAD1 gene to outside databases

Previous GC identifers: GC14M020406 GC14M016821 GC14M021023 GC14M022103 GC14M003152


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAD1 Gene:
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed
cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive
cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered
apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact
membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in
eukaryotes. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAD1 Gene:
DAD1 (defender against cell death 1) is a protein-coding gene. GO annotations related to this gene include oligosaccharyl transferase activity and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity)

Gene Wiki entry for DAD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAD1 gene promoter:
         TBP   Sp1   p53   Pax-2   Pax-2a   POU3F2   CREB   Pax-2b   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAD1 promoter sequence
   Search Chromatin IP Primers for DAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAD1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023033:  view genomic region     (about GC identifiers)

Start:
23,033,805 bp from pter      End:
23,058,175 bp from pter
Size:
24,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1  
Size: 113 amino acids; 12497 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which
contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes
with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity)
Secondary accessions: D3DS25 O08552 O70364 P46966 P46968 Q6FGA3 Q96GB7

Explore the universe of human proteins at neXtProt for DAD1: NX_P61803

Explore proteomics data for DAD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for DAD1 (P61803)
     LTGALQFGYCL  SVISRFLEEYLS  FQGISPERAFADFLFA  YCLLVGTFPFNSFLSGFIS 


    See DAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001335.1  
    ENSEMBL proteins: 
     ENSP00000250498   ENSP00000442074   ENSP00000440242   ENSP00000440821  
    Reactome Protein details: P61803

    DAD1 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for DAD1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003038 DAD/Ost2

    Graphical View of Domain Structure for InterPro Entry P61803

    ProtoNet protein and cluster: P61803

    UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
    Similarity: Belongs to the DAD/OST2 family


    Find genes that share domains with DAD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAD1_HUMAN, P61803
    Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a
    high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an
    Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the
    complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein
    translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity)
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a
    glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Genatlas biochemistry entry for DAD1:
    defender against apoptosis

         Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576contributes to oligosaccharyl transferase activity ISS--
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC15835887
         
    Find genes that share ontologies with DAD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DAD1:
     Increased cell number in S 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dad1):
     cellular  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  mortality/aging 

    Find genes that share phenotypes with DAD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DAD1: Dad1tm1Brw Dad1tm1Wnt Dad1tm1Kni

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAD1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAD1_HUMAN, P61803: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0008250oligosaccharyltransferase complex TAS15835887
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DAD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Post-translational protein modification0.43
    N-Glycan biosynthesis0.49
    Metabolism of proteins0.30
    2Metabolism
    Metabolic pathways0.38
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with DAD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DAD1
        CFTR folding and maturation (norm and CF)


    1 Reactome Pathway for DAD1
        Asparagine N-linked glycosylation


    3 Kegg Pathways  (Kegg details for DAD1):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAD1: 

              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAD1 (P618033 ENSP000002504984) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MCL1Q078203, ENSP000003580224I2D: score=3 STRING: ENSP00000358022
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    TUBG1P232583I2D: score=5 
    ATG5Q9H1Y03I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006486protein glycosylation ISS--
    GO:0006915apoptotic process IEA--
    GO:0007584response to nutrient IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    Find genes that share ontologies with DAD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for DAD1

    2 HMDB Compounds for DAD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAD1 gene: 
    NM_001344.3  

    Unigene Cluster for DAD1:

    Defender against cell death 1
    Hs.82890  [show with all ESTs]
    Unigene Representative Sequence: BF697316
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250498(uc001wgl.2) ENST00000489532 ENST00000535847 ENST00000538631
    ENST00000543337
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DAD1

    Additional mRNA sequence: 

    AK223129.1 BC007403.2 BC009798.1 BC038575.1 CR407682.1 CR542204.1 D15057.1 

    14 DOTS entries:

    DT.100888251  DT.429755  DT.92450253  DT.92450280  DT.120746489  DT.95112068  DT.100888242  DT.91730842 
    DT.95112072  DT.92450252  DT.92450281  DT.40130038  DT.86859396  DT.95296965 

    Selected AceView cDNA sequences (see all 334):

    BX283525 CA422002 CR593103 AA321526 CR542204 CD678608 AA345135 BM773447 
    AI270037 AI088579 BG105475 D57150 CR407682 AA382956 AA736454 BG285584 
    BQ644712 AA446415 BX281531 BQ778023 W58480 BF515500 BF793814 BG753090 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DAD1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                            -                           
    SP2:                                      -     -                           
    SP3:                    -                 -     -                           
    SP4:                                                                        
    SP5:                          -     -     -     -                           


    ECgene alternative splicing isoforms for DAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTCCTCA
    DAD1 Expression
    About this image


    DAD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Zeugopod Long Bone
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Colon (Gastrointestinal Tract)
    DAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.82890
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAD1: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DAD1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dad11 , 5 defender against cell death 11, 5 91.45(n)1
    100(a)1
      14 (27.70 cM)5
    131351  NM_010015.41  NP_034145.11 
     542354795 
    chicken
    (Gallus gallus)
    Aves DAD11 defender against cell death 1 74.7(n)
    82.14(a)
      395343  NM_001007473.1  NP_001007474.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAD16
    defender against cell death 1
    75(a)
    1 ↔ 1
    GL343979.1(72160-76574)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977212 DAD-1 76.01(n)    D15059.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dad11 defender against cell death 1 70.5(n)
    83.19(a)
      566527  NM_001100439.1  NP_001093909.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133933
    l(2)k129141
    anti-apoptosis oligosaccharyl
    transferase3
    lethal (2) k129141
    71(a)3
    63.55(n)1
    71.96(a)1
      29B43
    341591  NM_135378.41  NP_609222.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dad-11 , 3 dad-11 61(a)3
    61.65(n)1
    61.95(a)1
      I(6561574-6562591)3
    1723701  NM_059488.61  NP_491889.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OST2(YOR103C)4 Epsilon subunit of the oligosaccharyltransferase complex more   --   15(516841-516449) 854270  NP_014746.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATDAD11 ATDAD1 55.56(n)
    52.94(a)
      840113  NM_102954.3  NP_174500.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03970001 Os04g0397000 56.67(n)
    52(a)
      4335701  NM_001059199.1  NP_001052664.1 


    ENSEMBL Gene Tree for DAD1 (if available)
    TreeFam Gene Tree for DAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAD1 gene

    Find genes that share paralogs with DAD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DAD1
    PGOHUM00000239371


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAD1 (see all 708)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57428781,2
    C,F,H--23033390(-) TATGTG/TTTGAC 1 -- ds500118Minor allele frequency- T:0.11NS EA NA WA 1254
    rs20622751,2
    C,F,A,H--23033425(+) CTACAT/CTGCCT 1 -- ds500124Minor allele frequency- C:0.26NS EA NA WA CSA 1070
    rs57428771,2
    C,F,H--23033454(-) TAGTGG/TTAAAA 1 -- ds50015Minor allele frequency- T:0.00NS EA 590
    rs57428761,2
    C,F,H--23033488(-) GTGCTA/TCCACA 1 -- ds500112Minor allele frequency- T:0.11NS EA NA WA 830
    rs57428751,2
    C,F,H--23033543(-) AGTGCA/GTTCCT 1 -- ds500127Minor allele frequency- G:0.13NS EA NA WA 2806
    rs57428741,2
    C,F,H--23033608(-) TCTTCC/GTGGAG 1 -- ds50016Minor allele frequency- G:0.02NS EA NA 718
    rs1809631631,2
    C--23033617(+) GAAGAC/TAAAGG 1 -- ds50010--------
    rs57428731,2
    C,F,H--23033652(-) AAAAGG/ACAGTG 1 -- ds50016Minor allele frequency- A:0.04NS EA WA 718
    rs20668201,2
    C,F,A,H--23033776(-) TCTTTG/ACTGGT 1 -- ds500123Minor allele frequency- A:0.14NA NS EA WA 2496
    rs1863836151,2
    --23033832(+) TTAATC/TTGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DAD1 (23033805 - 23058175 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DAD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678511CNV Deletion23128226
    nsv519534CNV Loss19592680
    nsv832746CNV Gain17160897
    nsv832748CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for DAD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600243    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DAD1:
    Schizophrenia

    Find genes that share disorders with DAD1           About GenesLikeMe

    1 Novoseek inferred disease relationship for DAD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 18383209 (1)

    Genetic Association Database (GAD): DAD1
    Human Genome Epidemiology (HuGE) Navigator: DAD1 (5 documents)

    Export disorders for DAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAD1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with DAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. (PubMed id 8413235)1, 2, 9 Nakashima T.... Nishimoto T. (Mol. Cell. Biol. 1993)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs. (PubMed id 7737422)1, 9 Apte S.S....Olsen B.R. (FEBS Lett. 1995)
    8. The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. (PubMed id 7601483)1, 9 Yulug I.G....Ylug I.G. (Genomics 1995)
    9. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. (PubMed id 18383209)1, 9 Kulke M.H....Shivdasani R.A. (amp 2008)
    10. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PubMed id 24068947)1 Brandler W.M....Paracchini S. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1603 HGNC: 2664 AceView: DAD1 Ensembl:ENSG00000129562 euGenes: HUgn1603
    ECgene: DAD1 Kegg: 1603 H-InvDB: DAD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAD1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dad1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAD1 gene:
    Search GeneIP for patents involving DAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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